Global Patent Index - EP 4267121 A1

EP 4267121 A1 20231101 - KETONE BODY ESTERS OF S-BETA-HYDROXYBUTYRATE AND/OR S-1,3-BUTANEDIOL FOR MODIFYING METABOLIC FUNCTION

Title (en)

KETONE BODY ESTERS OF S-BETA-HYDROXYBUTYRATE AND/OR S-1,3-BUTANEDIOL FOR MODIFYING METABOLIC FUNCTION

Title (de)

KETONKÖRPERESTER VON S-BETA-HYDROXYBUTYRAT UND/ODER S-1,3-BUTANDIOL ZUR MODIFIZIERUNG DER STOFFWECHSELFUNKTION

Title (fr)

ESTERS DE CORPS CÉTONIQUES DE S-BÊTA-HYDROXYBUTYRATE ET/OU DE S-1,3-BUTANEDIOL POUR MODIFIER LA FONCTION MÉTABOLIQUE

Publication

EP 4267121 A1 20231101 (EN)

Application

EP 21911907 A 20211215

Priority

  • US 202017130498 A 20201222
  • US 2021063559 W 20211215

Abstract (en)

[origin: WO2022140130A1] Compositions and methods for producing elevated blood levels of ketone bodies and modifying metabolic function in a mammal. Compositions include at least one ester of S-beta-hydroxybutyrate or a non-racemic ester mixture enriched in S-beta-hydroxybutyrate relative to R-beta-hydroxybutyrate and/or a mono- or di-ester of S-1,3-butanediol or a non-racemic ester mixture enriched in S-1,3-butanediol relative to R-1,3-butanediol and at least one ketone body component. The ketone body component includes beta-hydroxybutyrate, acetoacetate, or both. The beta-hydroxybutyrate is R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, or both. When the ketone body component is S-beta-hydroxybutyrate, the 1,3-butanediol is R-1,3-butanediol, S-1,3-butanediol, or both. Compositions may comprise a keto stack of multiple forms of ketone bodies, such as one or more ketone body salts and/or one or more ketone body acids.

IPC 8 full level

A61K 31/121 (2006.01); A61K 31/215 (2006.01); A61K 31/22 (2006.01)

CPC (source: EP)

A61K 31/19 (2013.01); A61K 31/215 (2013.01); A61K 31/22 (2013.01); A61P 3/00 (2018.01)

C-Set (source: EP)

  1. A61K 31/19 + A61K 2300/00
  2. A61K 31/22 + A61K 2300/00
  3. A61K 31/215 + A61K 2300/00

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

Designated validation state (EPC)

KH MA MD TN

DOCDB simple family (publication)

WO 2022140130 A1 20220630; CA 3205942 A1 20220630; CN 116829140 A 20230929; EP 4267121 A1 20231101

DOCDB simple family (application)

US 2021063559 W 20211215; CA 3205942 A 20211215; CN 202180087356 A 20211215; EP 21911907 A 20211215