EP 4267121 A1 20231101 - KETONE BODY ESTERS OF S-BETA-HYDROXYBUTYRATE AND/OR S-1,3-BUTANEDIOL FOR MODIFYING METABOLIC FUNCTION
Title (en)
KETONE BODY ESTERS OF S-BETA-HYDROXYBUTYRATE AND/OR S-1,3-BUTANEDIOL FOR MODIFYING METABOLIC FUNCTION
Title (de)
KETONKÖRPERESTER VON S-BETA-HYDROXYBUTYRAT UND/ODER S-1,3-BUTANDIOL ZUR MODIFIZIERUNG DER STOFFWECHSELFUNKTION
Title (fr)
ESTERS DE CORPS CÉTONIQUES DE S-BÊTA-HYDROXYBUTYRATE ET/OU DE S-1,3-BUTANEDIOL POUR MODIFIER LA FONCTION MÉTABOLIQUE
Publication
Application
Priority
- US 202017130498 A 20201222
- US 2021063559 W 20211215
Abstract (en)
[origin: WO2022140130A1] Compositions and methods for producing elevated blood levels of ketone bodies and modifying metabolic function in a mammal. Compositions include at least one ester of S-beta-hydroxybutyrate or a non-racemic ester mixture enriched in S-beta-hydroxybutyrate relative to R-beta-hydroxybutyrate and/or a mono- or di-ester of S-1,3-butanediol or a non-racemic ester mixture enriched in S-1,3-butanediol relative to R-1,3-butanediol and at least one ketone body component. The ketone body component includes beta-hydroxybutyrate, acetoacetate, or both. The beta-hydroxybutyrate is R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, or both. When the ketone body component is S-beta-hydroxybutyrate, the 1,3-butanediol is R-1,3-butanediol, S-1,3-butanediol, or both. Compositions may comprise a keto stack of multiple forms of ketone bodies, such as one or more ketone body salts and/or one or more ketone body acids.
IPC 8 full level
A61K 31/121 (2006.01); A61K 31/215 (2006.01); A61K 31/22 (2006.01)
CPC (source: EP)
A61K 31/19 (2013.01); A61K 31/215 (2013.01); A61K 31/22 (2013.01); A61P 3/00 (2018.01)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022140130 A1 20220630; CA 3205942 A1 20220630; CN 116829140 A 20230929; EP 4267121 A1 20231101
DOCDB simple family (application)
US 2021063559 W 20211215; CA 3205942 A 20211215; CN 202180087356 A 20211215; EP 21911907 A 20211215