EP 4278185 A1 20231122 - METHOD FOR PREDICTING THE RESPONSE TO CDK4/6 INHIBITOR THERAPY IN CANCER PATIENTS
Title (en)
METHOD FOR PREDICTING THE RESPONSE TO CDK4/6 INHIBITOR THERAPY IN CANCER PATIENTS
Title (de)
VERFAHREN ZUR VORHERSAGE DER REAKTION AUF EINE CDK4/6-INHIBITORTHERAPIE BEI KREBSPATIENTEN
Title (fr)
MÉTHODE DE PRÉDICTION DE LA RÉPONSE À UNE THÉRAPIE PAR INHIBITEUR DE CDK4/6 CHEZ DES PATIENTS ATTEINTS D'UN CANCER
Publication
Application
Priority
- EP 21152186 A 20210118
- EP 2022050876 W 20220117
Abstract (en)
[origin: WO2022152899A1] The present invention relates to a method for predicting a response or resistance to and/or a benefit from treatment with an inhibitor of cyclin-dependent kinases 4 (CDK4/6 inhibitor) in a subject suffering from a neoplastic disease, particularly breast cancer, comprising the step of: determining in a sample obtained from said subject the expression level of at least one marker selected from the group consisting of PD-L1, PIAS2, MAP2K6, DSG3, ABCC12, IFT52, ABCB6, ABCC1, ABCA5, ABCC6, ABCC11, CHUK, SUMO1, TDG, AURKA, SMC3, IKBKG and XPC, wherein the expression level of the at least one marker is indicative for predicting the response or resistance to and/or the benefit from the treatment with the CDK4/6 inhibitor in said subject. The invention further pertains to a CDK4/6 inhibitor for use in the treatment of neoplastic disease, particularly breast cancer, in a subject, wherein the subject has been determined to have a benefit from treatment with a CDK4/6 inhibitor in a method of the invention.
IPC 8 full level
G01N 33/574 (2006.01)
CPC (source: EP US)
C12Q 1/6886 (2013.01 - US); G01N 33/57415 (2013.01 - EP); G01N 33/57492 (2013.01 - EP); C12Q 2600/106 (2013.01 - US); C12Q 2600/158 (2013.01 - US); G01N 2800/52 (2013.01 - EP)
Citation (search report)
See references of WO 2022152899A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022152899 A1 20220721; EP 4278185 A1 20231122; US 2024093301 A1 20240321
DOCDB simple family (application)
EP 2022050876 W 20220117; EP 22700658 A 20220117; US 202218261329 A 20220117