EP 4281034 A1 20231129 - INHIBITORS OF ATP SYNTHASE - COSMETIC AND THERAPEUTIC USES
Title (en)
INHIBITORS OF ATP SYNTHASE - COSMETIC AND THERAPEUTIC USES
Title (de)
INHIBITOREN DER ATP-SYNTHASE KOSMETISCHE UND THERAPEUTISCHE VERWENDUNGEN
Title (fr)
INHIBITEURS D?UTILISATIONS COSMÉTIQUES ET THÉRAPEUTIQUES D?ATP SYNTHASE
Publication
Application
Priority
IB 2021050529 W 20210124
Abstract (en)
[origin: WO2022157548A1] With supporting experimental data, this disclosure teaches that IF1 protein activity is a molecular determinant of lifespan, therein explaining why different species have different maximal lifespans, and it teaches a IF1 protein/fragment (or sequence variant thereof), or a fusion protein thereof, optionally a fusion protein comprising a Cell Penetrating Peptide (CPP) sequence, as an agent to slow/delay/reduce aging in a subject, optionally as a component of a cosmetic, optionally to treat an age-correlated disease/disorder. Moreover it teaches other inhibitors of F1F0 ATP hydrolysis, including small molecules, of a number of different scaffolds, for this purpose. Furthermore, with supporting experimental data, it teaches that compounds that slow the ATP-hydrolysing mode of ATP synthase are useful for treating various diseases and disorders, including cancer, particularly cancers that utilise the Warburg effect.
IPC 8 full level
A61K 8/64 (2006.01); A61K 38/00 (2006.01); A61Q 19/08 (2006.01)
CPC (source: EP IL KR)
A61K 8/606 (2013.01 - KR); A61K 8/64 (2013.01 - EP IL KR); A61K 38/00 (2013.01 - IL); A61K 38/16 (2013.01 - KR); A61K 48/005 (2013.01 - KR); A61P 35/00 (2018.01 - KR); A61Q 19/08 (2013.01 - EP IL KR); A61K 38/00 (2013.01 - EP); A61K 2800/86 (2013.01 - KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022157548 A1 20220728; AU 2021421391 A1 20230720; BR 112023012422 A2 20231212; CA 3206148 A1 20220728; CN 117157049 A 20231201; CO 2023008442 A2 20230918; EP 4281034 A1 20231129; IL 303969 A 20230801; KR 20230135586 A 20230925; MX 2023007788 A 20231117
DOCDB simple family (application)
IB 2021050529 W 20210124; AU 2021421391 A 20210124; BR 112023012422 A 20210124; CA 3206148 A 20210124; CN 202180091199 A 20210124; CO 2023008442 A 20230627; EP 21704609 A 20210124; IL 30396923 A 20230622; KR 20237025217 A 20210124; MX 2023007788 A 20210124