EP 4297759 A1 20240103 - IN VIVO CRISPR SCREENING SYSTEM FOR DISCOVERING THERAPEUTIC TARGETS IN CD8 T CELLS
Title (en)
IN VIVO CRISPR SCREENING SYSTEM FOR DISCOVERING THERAPEUTIC TARGETS IN CD8 T CELLS
Title (de)
IN-VIVO-CRISPR-SCREENINGSYSTEM ZUR ENTDECKUNG THERAPEUTISCHER ZIELE IN CD8-T-ZELLEN
Title (fr)
<SMALLCAPS/>? ? ? ? ? ? ? ?SYSTÈME DE CRIBLAGE CRISPR IN VIVO POUR DÉCOUVRIR DES CIBLES THÉRAPEUTIQUES DANS DES LYMPHOCYTES T CD8
Publication
Application
Priority
- US 202163153191 P 20210224
- US 2022017564 W 20220223
Abstract (en)
[origin: WO2022182788A1] The present disclosure provides modified immune cells or precursors thereof comprising disrupted Fli1. Compositions and methods of treatment are also provided. The disclosure also provides methods for screening T cells, including assessing T cell exhaustion.
IPC 8 full level
A61K 35/17 (2015.01); C12N 15/113 (2010.01)
CPC (source: EP)
A61K 39/4611 (2023.05); A61K 39/464452 (2023.05); A61K 39/464838 (2023.05); A61P 35/00 (2018.01); C07K 14/4705 (2013.01); C07K 14/82 (2013.01); C12N 5/0636 (2013.01); C12N 15/113 (2013.01); C12N 9/22 (2013.01); C12N 2310/20 (2017.05); C12N 2320/12 (2013.01); C12N 2510/00 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022182788 A1 20220901; CN 117120062 A 20231124; EP 4297759 A1 20240103; JP 2024512261 A 20240319
DOCDB simple family (application)
US 2022017564 W 20220223; CN 202280026712 A 20220223; EP 22760353 A 20220223; JP 2023551129 A 20220223