EP 4301743 A1 20240110 - PYRIDINE DERIVATES USEFUL AS HCN2 MODULATORS
Title (en)
PYRIDINE DERIVATES USEFUL AS HCN2 MODULATORS
Title (de)
PYRIDINDERIVATE ALS HCN2-MODULATOREN
Title (fr)
DÉRIVÉS DE PYRIDINE UTILES EN TANT QUE MODULATEURS DE HCN2
Publication
Application
Priority
- GB 202103017 A 20210303
- GB 2022050555 W 20220302
Abstract (en)
[origin: WO2022185058A1] Compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the substituents are defined in the specification. The compounds are hyperpolarisation activated cyclic-nucleotide modulated ion channel 2 (HCN2) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and the use of the compounds for the treatment or prevention of medical conditions mediated by HCN2, including neuropathic pain.
IPC 8 full level
C07D 401/04 (2006.01); A61K 31/444 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 401/14 (2006.01)
CPC (source: EP US)
A61K 31/4439 (2013.01 - US); A61K 31/444 (2013.01 - US); A61P 27/00 (2018.01 - US); A61P 29/00 (2018.01 - EP US); A61P 43/00 (2018.01 - EP); C07D 401/04 (2013.01 - EP); C07D 401/10 (2013.01 - US); C07D 401/14 (2013.01 - EP US); C07D 471/04 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022185058 A1 20220909; EP 4301743 A1 20240110; GB 202103017 D0 20210414; JP 2024509143 A 20240229; US 2024174639 A1 20240530
DOCDB simple family (application)
GB 2022050555 W 20220302; EP 22709781 A 20220302; GB 202103017 A 20210303; JP 2023553155 A 20220302; US 202218279796 A 20220302