EP 4304715 A1 20240117 - ACTRII-ALK4 ANTAGONISTS AND METHODS OF TREATING HEART FAILURE
Title (en)
ACTRII-ALK4 ANTAGONISTS AND METHODS OF TREATING HEART FAILURE
Title (de)
ACTRII-ALK4-ANTAGONISTEN UND VERFAHREN ZUR BEHANDLUNG VON HERZINSUFFIZIENZ
Title (fr)
ANTAGONISTES DE L'ACTRII-ALK4 ET MÉTHODES DE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE
Publication
Application
Priority
- US 202163159059 P 20210310
- US 2022019557 W 20220309
Abstract (en)
[origin: WO2022192404A1] In some aspects, the disclosure relates to ActRII-ALK4 antagonists and methods of using ActRII-ALK4 antagonists to treat, prevent, or reduce the progression rate and/or severity of heart failure (HF), particularly treating, preventing or reducing the progression rate and/or severity of one or more HF-associated comorbidities. The disclosure also provides methods of using an ActRII-ALK4 antagonist to treat, prevent, or reduce the progression rate and/or severity of heart failure associated with a variety of conditions including, but not limited to, heart failure associated with aging.
IPC 8 full level
A61P 9/04 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01)
CPC (source: EP KR US)
A61K 38/177 (2013.01 - EP); A61K 38/179 (2013.01 - KR); A61K 47/68 (2017.08 - EP); A61K 47/6811 (2017.08 - KR US); A61P 9/04 (2018.01 - EP KR US); C07K 14/71 (2013.01 - EP KR); C07K 2319/02 (2013.01 - EP); C07K 2319/30 (2013.01 - KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022192404 A1 20220915; AU 2022235082 A1 20230921; BR 112023018256 A2 20231031; CA 3211515 A1 20220915; CN 117396224 A 20240112; EP 4304715 A1 20240117; JP 2024511315 A 20240313; KR 20230169123 A 20231215; MX 2023010442 A 20231122; US 2024197902 A1 20240620
DOCDB simple family (application)
US 2022019557 W 20220309; AU 2022235082 A 20220309; BR 112023018256 A 20220309; CA 3211515 A 20220309; CN 202280034554 A 20220309; EP 22767900 A 20220309; JP 2023554808 A 20220309; KR 20237034038 A 20220309; MX 2023010442 A 20220309; US 202218549461 A 20220309