EP 4306955 A3 20240306 - INTEGRATED FUNCTIONAL AND MOLECULAR PROFILING OF CELLS
Title (en)
INTEGRATED FUNCTIONAL AND MOLECULAR PROFILING OF CELLS
Title (de)
INTEGRIERTE FUNKTIONELLE UND MOLEKULARE PROFILIERUNG VON ZELLEN
Title (fr)
PROFILAGE FONCTIONNEL ET MOLÉCULAIRE INTÉGRÉ DE CELLULES
Publication
Application
Priority
- US 201562138813 P 20150326
- US 201562157174 P 20150505
- EP 16769835 A 20160328
- US 2016024519 W 20160328
Abstract (en)
Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.
IPC 8 full level
G01N 33/58 (2006.01); C12Q 1/68 (2018.01); G01N 33/50 (2006.01); G01N 33/52 (2006.01)
CPC (source: CN EP US)
A61K 39/4611 (2023.05 - CN EP); A61K 39/4631 (2023.05 - CN EP); A61K 39/464412 (2023.05 - CN EP); A61K 39/464838 (2023.05 - CN EP); C12Q 1/68 (2013.01 - CN US); C12Q 1/6869 (2013.01 - US); G01N 33/5005 (2013.01 - EP US); G01N 33/56966 (2013.01 - CN EP US); C07K 14/7051 (2013.01 - EP); C07K 2319/03 (2013.01 - EP); G01N 2570/00 (2013.01 - EP US)
Citation (search report)
- [A] WO 2012103025 A2 20120802 - EPIC SCIENCES INC [US], et al
- [A] WO 2007076865 A1 20070712 - DRUGMODE APS [DK], et al
- [A] US 2005181354 A1 20050818 - ESTEP PRESTON W III [US]
- [A] MATTHIAS MEHLING ET AL: "Real-time tracking, retrieval and gene expression analysis of migrating human T cells", LAB ON A CHIP, vol. 15, no. 5, 1 January 2015 (2015-01-01) - 5 December 2014 (2014-12-05), UK, pages 1276 - 1283, XP055318755, ISSN: 1473-0197, DOI: 10.1039/C4LC01038H
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2016154620 A1 20160929; CN 107667178 A 20180206; EP 3274720 A1 20180131; EP 3274720 A4 20181003; EP 3274720 B1 20231227; EP 4306955 A2 20240117; EP 4306955 A3 20240306; JP 2018514195 A 20180607; JP 6855382 B2 20210414; US 10746736 B2 20200818; US 11774449 B2 20231003; US 2018217146 A1 20180802; US 2021018503 A1 20210121; US 2024175870 A1 20240530
DOCDB simple family (application)
US 2016024519 W 20160328; CN 201680030653 A 20160328; EP 16769835 A 20160328; EP 23212078 A 20160328; JP 2017550160 A 20160328; US 201615560018 A 20160328; US 202016995559 A 20200817; US 202318235751 A 20230818