EP 4314041 A1 20240207 - MODIFIED PLASMA CLOTTING FACTOR VIII AND METHOD OF USE THEREOF
Title (en)
MODIFIED PLASMA CLOTTING FACTOR VIII AND METHOD OF USE THEREOF
Title (de)
MODIFIZIERTER PLASMAGERINNUNGSFAKTOR VIII UND VERFAHREN ZU DESSEN VERWENDUNG
Title (fr)
FACTEUR VIII DE COAGULATION PLASMATIQUE MODIFIÉ ET SON PROCÉDÉ D'UTILISATION
Publication
Application
Priority
US 2021024916 W 20210330
Abstract (en)
[origin: WO2022211791A1] Modified hum 1. an factor VIII polypeptides with enhanced factor VIII activity are described. In some embodiments, the modified human factor VIII polypeptides comprise one or more amino acid substitutions at positions A20, T21, F57, L69, I80, L178, R199, H212, I215, R269, I310, L318, S332, R378, I610 and/or I661. Such polypeptides and viral vectors encoding such polypeptides may be used for treatment of FVIII deficiencies, such as hemophilia A.
IPC 8 full level
C07K 14/755 (2006.01); A61K 38/00 (2006.01); A61P 7/04 (2006.01)
CPC (source: EP)
A61P 7/04 (2018.01); C07K 14/755 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022211791 A1 20221006; CN 117157316 A 20231201; EP 4314041 A1 20240207; JP 2024511851 A 20240315
DOCDB simple family (application)
US 2021024916 W 20210330; CN 202180096784 A 20210330; EP 21720353 A 20210330; JP 2023560378 A 20210330