EP 4320153 A1 20240214 - METHODS FOR THE TREATMENT OF ANAPLASTIC LARGE CELL LYMPHOMA
Title (en)
METHODS FOR THE TREATMENT OF ANAPLASTIC LARGE CELL LYMPHOMA
Title (de)
VERFAHREN ZUR BEHANDLUNG VON ANAPLASTISCHEM GROSSZELLIGEM LYMPHOM
Title (fr)
MÉTHODES DE TRAITEMENT D'UN LYMPHOME ANAPLASIQUE À GRANDES CELLULES
Publication
Application
Priority
- EP 21305467 A 20210409
- EP 2022059497 W 20220408
Abstract (en)
[origin: WO2022214681A1] Anaplastic large cell lymphoma (ALCL) is a rare and aggressive peripheral T-cell lymphoma affects lymph nodes and extra-nodal sites with characteristic skin lesions. Approximatively half of the tumors express the NPM1-ALK fusion from the translocation t(2;5)(p23;q32). In the present study, the inventors identify ROR2 as progressively up regulated thought tumorigenesis. Patient samples show a significantly high ROR2 expression (transcriptomic data) as well as a strong ROR2 protein expression (IHC) with some tumors displaying a clear membrane signal. ROR2 mRNA expression level is also positively correlated to NPM-ALK expression level in tumor cells and is not expressed in normal T cells. In addition, ROR2 protein level is significantly increased in resistant cells to the ALK inhibitor, crizotinib, used in clinical trials for children with refractory tumors. This result opens the road to ROR2 specific therapies: ROR2 inhibitors, monoclonal antibodies therapies or even ROR2 specific CAR cells, including for ALCL ALK(+) resistant tumors.
IPC 8 full level
C07K 16/28 (2006.01); A61K 31/4545 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01)
CPC (source: EP)
A61K 31/437 (2013.01); A61K 31/4545 (2013.01); A61K 31/5377 (2013.01); A61K 39/395 (2013.01); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464402 (2023.05); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); C12N 5/0646 (2013.01); A61K 2039/505 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05); C07K 2317/31 (2013.01); C07K 2317/73 (2013.01); C07K 2319/03 (2013.01)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2022059497 W 20220408; EP 22714900 A 20220408