EP 4320437 A1 20240214 - METHOD FOR ANALYZING A BLOOD SAMPLE FOR A DISEASE
Title (en)
METHOD FOR ANALYZING A BLOOD SAMPLE FOR A DISEASE
Title (de)
VERFAHREN FÜR DIE ANALYSE EINER BLUTPROBE AUF EINE ERKRANKUNG
Title (fr)
PROCÉDÉ D'ANALYSE D'UN ÉCHANTILLON DE SANG POUR DÉTECTER UNE MALADIE
Publication
Application
Priority
- DE 102021203480 A 20210408
- EP 2022058377 W 20220330
Abstract (en)
[origin: WO2022214371A1] The present invention relates to a method for analyzing a blood sample from a human for a disease, especially a bacteria-based disease, comprising: - stimulating provided cells from the blood sample with bacterial antigens to induce at least one presence marker on T cells of the provided cells, - labeling at least one of the induced presence markers on T cells in the provided cells, which presence marker is specifically formed on T cells which recognized bacterial antigen during the stimulation, - labeling a first status marker and a further status marker on T cells in the provided cells that are specific for the activation status thereof, said status markers differing from one another and from the presence marker, - evaluating a first labeling event of the labeling steps by analysis of the frequency of T cells having a labeled first status marker and a labeled presence marker based on a reference value and making a comparison with a first combination limit, - evaluating at least one further labeling event of the labeling steps by analysis of the frequency of T cells having a labeled further status marker and a labeled presence marker based on a reference value and making a comparison with a further combination limit, - forming an overall result from the evaluated labeling events and comparing the overall result with an overall limit.
IPC 8 full level
G01N 33/569 (2006.01)
CPC (source: EP)
G01N 33/569 (2013.01); G01N 33/5695 (2013.01); G01N 2333/70539 (2013.01); G01N 2333/70575 (2013.01); G01N 2333/70596 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DE 102021203480 A1 20221013; EP 4320437 A1 20240214; WO 2022214371 A1 20221013; ZA 202309330 B 20240530
DOCDB simple family (application)
DE 102021203480 A 20210408; EP 2022058377 W 20220330; EP 22718983 A 20220330; ZA 202309330 A 20231005