EP 4332219 A1 20240306 - CARGO MOLECULE TRANDUCTION DOMAIN RMAD1, VARIANT THEREOF, RECOMBINANT CARGO MOLECULE, AND METHOD FOR TRANDUCING CARGO MOLECULE USING SAME
Title (en)
CARGO MOLECULE TRANDUCTION DOMAIN RMAD1, VARIANT THEREOF, RECOMBINANT CARGO MOLECULE, AND METHOD FOR TRANDUCING CARGO MOLECULE USING SAME
Title (de)
CARGOMOLEKÜL-TRANSDUKTIONSDOMÄNE RMAD1, VARIANTE DAVON, REKOMBINANTES CARGOMOLEKÜL UND VERFAHREN ZUM TRANSDUKTIEREN EINES CARGOMOLEKÜLS DAMIT
Title (fr)
DOMAINE DE TRANSDUCTION DE MOLÉCULE CARGO RMAD1, VARIANT DE CELUI-CI, MOLÉCULE CARGO RECOMBINÉE, ET PROCÉDÉ DE TRANSFERT DE MOLÉCULE CARGO L'UTILISANT
Publication
Application
Priority
- KR 20210062397 A 20210514
- KR 20220053247 A 20220429
- KR 2022006340 W 20220503
Abstract (en)
The present invention relates to a human ADARB2-derived cell-penetrating peptide and a cargo-molecule delivery system using the same, and provides a method for delivering cargo molecules into a cell, the method comprising a step for bringing a cargo-molecule transduction domain including the human ADARB2-derived RMAD1 or a variant thereof and a recombinant cargo molecule fused with the cargo molecule transduction domain into contact with cells. The cargo molecule transduction domain of the present invention not only can introduce cargo molecules into cells at a higher efficiency than existing cell-penetrating peptides, but is a polypeptide sequence derived from human proteins, and thus also has no risk of causing immune response problems. Thus the cargo molecule transduction domain is useful for delivering various polymer materials into human cells.
IPC 8 full level
C12N 9/78 (2006.01); A61K 8/64 (2006.01); A61K 38/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C12N 15/63 (2006.01)
CPC (source: EP US)
A61K 8/64 (2013.01 - EP US); C07K 7/06 (2013.01 - EP US); C07K 7/08 (2013.01 - EP US); C07K 14/47 (2013.01 - EP); C12N 15/87 (2013.01 - EP US); C12Y 305/04 (2013.01 - EP); A61K 38/00 (2013.01 - EP); C07K 2319/03 (2013.01 - EP); C07K 2319/09 (2013.01 - US); C07K 2319/10 (2013.01 - EP US); C12N 15/70 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
EP 4332219 A1 20240306; EP 4332219 A4 20241023; US 2024207162 A1 20240627; WO 2022240055 A1 20221117
DOCDB simple family (application)
EP 22807703 A 20220503; KR 2022006340 W 20220503; US 202218288824 A 20220503