EP 4334338 A1 20240313 - MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES
Title (en)
MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES
Title (de)
MOLEKULARER ENTWURF VON GLUCOSESENSOREN IN AUF GLUCOSE REAGIERENDEN INSULINANALOGA
Title (fr)
CONCEPTION MOLÉCULAIRE DE CAPTEURS DE GLUCOSE DANS DES ANALOGUES D'INSULINE SENSIBLES AU GLUCOSE
Publication
Application
Priority
- US 202163183325 P 20210503
- US 2022027504 W 20220503
Abstract (en)
[origin: WO2022235691A1] A two-chain insulin analogue is provided containing (a) a B chain modified by the addition of a C-terminal diol element in combination with (b) a glucose-binding element attached to the A chain at or near its N terminus, optionally linked to a D-amino acid. A "flipped" set of insulin analogues wherein the A chain is modified by addition of an N-terminal diol element whereas the glucose-binding element is attached at or near the C terminus of the B chain is also provided. Compositions comprising such insulin analogues are used in methods of treating a patient with diabetes mellitus.
IPC 8 full level
C07K 14/62 (2006.01)
CPC (source: EP)
C07K 14/62 (2013.01)
Citation (search report)
See references of WO 2022235691A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022235691 A1 20221110; CN 117337299 A 20240102; EP 4334338 A1 20240313
DOCDB simple family (application)
US 2022027504 W 20220503; CN 202280032806 A 20220503; EP 22799444 A 20220503