EP 4335513 A3 20240508 - CRYSTAL CHARACTERISTICS, PREPARATION PROCESSES AND ANTICANCER APPLICATIONS OF 17BETA-NERIIFOLIN CRYSTAL FORMS
Title (en)
CRYSTAL CHARACTERISTICS, PREPARATION PROCESSES AND ANTICANCER APPLICATIONS OF 17BETA-NERIIFOLIN CRYSTAL FORMS
Title (de)
KRISTALLEIGENSCHAFTEN, HERSTELLUNGSVERFAHREN UND ANTIKREBSANWENDUNGEN VON 17BETA-NERIIFOLIN-KRISTALLFORMEN
Title (fr)
CARACTÉRISTIQUES CRISTALLINES, PROCÉDÉS DE PRÉPARATION ET APPLICATIONS ANTICANCÉREUSES DE FORMES CRISTALLINES DE 17BÊTA-NERIIFOLINE
Publication
Application
Priority
- CN 201710358086 A 20170519
- EP 18802832 A 20180516
- CN 2018087031 W 20180516
Abstract (en)
The present invention provides the preparation processes for several crystal forms of the compound 17beta-Neriifolin (17bNF) and use thereof in anti-tumor applications. The present invention provides preparation processes for four kinds of non-solvated crystal forms, amorphous powders and eleven kinds of solvated crystalline solids, including ethanol-solvated ones, of 17bNF that are not present in nature, and the identification and characterization of these crystal forms by crystallographic research methods such as X-ray powder diffraction. In addition, through vivo anti-tumor experiments with five of the crystal forms in nude mice, we provide anti-tumor and anti-cancer applications of the crystal forms of 17bNF.
IPC 8 full level
C07J 19/00 (2006.01); A61K 31/58 (2006.01); A61P 35/00 (2006.01)
CPC (source: CN EP US)
A61P 35/00 (2018.01 - EP); C07J 19/005 (2013.01 - CN EP US); C07B 2200/13 (2013.01 - CN EP US)
Citation (search report)
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- [I] SUCHADA CHANTRAPROMMA ET AL: "Bis[14b-hydroxy-3b-O-(L-thevetosyl)- 5b-card-20(22)-enolide] methanol solvate monohydrate and 3b-O-(L-20 - o-acetylthevetosyl)-14b-hydroxy-5bcard-20(22)-enolide", ACTA CRYSTALLOGRAPHICA SECTION C. CRYSTAL STRUCTURE COMMUNICATIONS, vol. C59, no. 2, 18 January 2003 (2003-01-18), DK, pages o68 - o70, XP055766514, ISSN: 0108-2701, DOI: 10.1107/S0108270102023065
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Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018210252 A1 20181122; CA 3100875 A1 20181122; CN 108948119 A 20181207; CN 108948119 B 20231121; CN 117756875 A 20240326; EP 3625242 A1 20200325; EP 3625242 A4 20210707; EP 4335513 A2 20240313; EP 4335513 A3 20240508; US 11091510 B2 20210817; US 2020157139 A1 20200521
DOCDB simple family (application)
CN 2018087031 W 20180516; CA 3100875 A 20180516; CN 201710358086 A 20170519; CN 202311447249 A 20170519; EP 18802832 A 20180516; EP 24150900 A 20180516; US 201916688169 A 20191119