EP 4337216 A1 20240320 - COMBINATION THERAPIES
Title (en)
COMBINATION THERAPIES
Title (de)
KOMBINATIONSTHERAPIEN
Title (fr)
MULTITHÉRAPIES
Publication
Application
Priority
- CN 2021093036 W 20210511
- CN 2021100523 W 20210617
- CN 2022086004 W 20220411
- CN 2022091679 W 20220509
Abstract (en)
[origin: WO2022237720A1] Disclosed are combinations comprising a therapeutically effective amount of a menin-MLL inhibitor of Formula (I) or a pharmaceutically acceptable salt or a solvate thereof; and a therapeutically effective amount of a BCL-2 inhibitor; and optionally, a therapeutically effective amount of at least one other antineoplastic agent. Also disclosed are methods for treating a subject who has been diagnosed with a hematopoietic disorder using such combinations. Compounds are represented by Formula (I) as follows: wherein R 1a, R 1b, R 2, R 3, R 4, U, Y 1, X 1, X 2, n1, n2, n3 and n4 are defined herein.
IPC 8 full level
A61K 31/53 (2006.01); A61P 35/02 (2006.01)
CPC (source: EP IL KR)
A61K 31/53 (2013.01 - EP IL KR); A61K 31/635 (2013.01 - KR); A61K 31/706 (2013.01 - KR); A61K 45/06 (2013.01 - KR); A61P 35/02 (2018.01 - EP IL KR); A61K 2300/00 (2013.01 - KR)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022237720 A1 20221117; AU 2022274071 A1 20240104; CA 3215313 A1 20221117; CL 2023003239 A1 20240607; CN 117460513 A 20240126; CO 2023014322 A2 20231120; DO P2023000246 A 20240430; EP 4337216 A1 20240320; IL 308335 A 20240101; JP 2024518497 A 20240501; KR 20240006631 A 20240115; MX 2023013410 A 20231206; PE 20240593 A1 20240321; TW 202308643 A 20230301; UY 39761 A 20221130
DOCDB simple family (application)
CN 2022091679 W 20220509; AU 2022274071 A 20220509; CA 3215313 A 20220509; CL 2023003239 A 20231031; CN 202280034525 A 20220509; CO 2023014322 A 20231025; DO 2023000246 A 20231108; EP 22725158 A 20220509; IL 30833523 A 20231106; JP 2023569789 A 20220509; KR 20237042402 A 20220509; MX 2023013410 A 20220509; PE 2023003030 A 20220509; TW 111117441 A 20220510; UY 39761 A 20220510