EP 4346833 A1 20240410 - ((1S,9S)-11-{[4-(1,3-BENZODIOXOL-5-YLAMINO)-8-METHYL-2-QUINAZOLINYL]METHYL} -7,11-DIAZATRICYCLO[7.3.1.0~2,7~]TRIDECA-2,4-DIEN-6-ONE) AS A STABILIZER OF CRYS FOR THE TREATMENT OF CIRCADIAN RHYTHM ASSOCIATED DISEASES AND DISORDERS
Title (en)
((1S,9S)-11-{[4-(1,3-BENZODIOXOL-5-YLAMINO)-8-METHYL-2-QUINAZOLINYL]METHYL} -7,11-DIAZATRICYCLO[7.3.1.0~2,7~]TRIDECA-2,4-DIEN-6-ONE) AS A STABILIZER OF CRYS FOR THE TREATMENT OF CIRCADIAN RHYTHM ASSOCIATED DISEASES AND DISORDERS
Title (de)
((1S,9S)-11-{[4-(1,3-BENZODIOXOL-5-YLAMINO)-8-METHYL-2-CHINAZOLINYL)METHYL}-7-,11-DIAZATRICYCLO[7.1.0!-2,4-TRIDECA-2,4-DIEN-6-ON ZUR BEHANDLUNG VON ZIRKADIANEN RHYTHMUSSTÖRUNGEN
Title (fr)
((1S,9S)-11-{[4-(1,3-BENZODIOXOL-5-YLAMINO)-8-MÉTHYL-2-QUINAZOLINYL]MÉTHYL} -7,11-DIAZATRICYCLO[7.3.1.0~2,7~]TRIDECA-2,4-DIÈN-6-ONE) EN TANT QUE STABILISANT DE CRYS POUR LE TRAITEMENT DE MALADIES ET DE TROUBLES ASSOCIÉS AU RYTHME CIRCADIEN
Publication
Application
Priority
TR 2021050513 W 20210531
Abstract (en)
[origin: WO2022255955A1] The present invention relates to ((1S,9S)-11-{[4-(1,3-benzodioxol-5-ylamino)-8-methyl-2-quinazolinyl]methyl}-7,11-diazatricyclo[7.3.1.0~2,7~] trideca-2,4-dien-6-one) compound and related derivatives. The compound of the invention is a CRY1/2-binding small molecule and also a stabilizer of CRY1 and CRY2 proteins, and is therefore useful, as pharmaceutical agent, especially in the treatment and/or prevention of disorders associated with the circadian rhythm, including CRY1-mediated diseases such as diabetes.
IPC 8 full level
A61K 31/517 (2006.01); A61P 3/10 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 31/517 (2013.01); A61P 3/10 (2018.01); A61P 43/00 (2018.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
TR 2021050513 W 20210531; EP 21736769 A 20210531