EP 4347804 A1 20240410 - DNASE I VARIANTS, COMPOSITIONS, METHODS, AND KITS
Title (en)
DNASE I VARIANTS, COMPOSITIONS, METHODS, AND KITS
Title (de)
DNASE I-VARIANTEN, ZUSAMMENSETZUNGEN, VERFAHREN UND KITS
Title (fr)
VARIANTS DE DNASE I, COMPOSITIONS, PROCÉDÉS ET KITS
Publication
Application
Priority
US 2021034605 W 20210527
Abstract (en)
[origin: WO2022250676A1] The present disclosure relates, according to some embodiments, to systems, apparatus, compositions, methods, and workflows that include DNase I variants with desirable properties including, for example, salt tolerance. A DNase I variant, in some embodiments, may have an amino acid sequence that is at least 85% identical, at least 90% identical, at least 95% identical, and/or at least 98% identical to SEQ ID NO: 1 and may be identical to SEQ ID NO: 1 at one or more positions selected from the group of positions corresponding to L29, A35, D87, Q88, S94, P103, T108, P121, P132, A135, D145, E161, G172, P190, H208, and A224 of SEQ ID NO:1.
IPC 8 full level
C12N 9/22 (2006.01); C12N 15/10 (2006.01)
CPC (source: EP)
C12N 9/22 (2013.01); C12Y 301/21001 (2013.01)
Citation (search report)
See references of WO 2022250676A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
US 2021034605 W 20210527; EP 21736777 A 20210527