EP 4349859 A1 20240410 - METHOD TO PURIFY ANTI-D IMMUNOGLOBULIN G FROM PLASMA
Title (en)
METHOD TO PURIFY ANTI-D IMMUNOGLOBULIN G FROM PLASMA
Title (de)
VERFAHREN ZUR REINIGUNG VON ANTI-D-IMMUNOGLOBULIN G AUS PLASMA
Title (fr)
MÉTHODE DE PURIFICATION DE L'IMMUNOGLOBULINE G ANTI-D À PARTIR DU PLASMA
Publication
Application
Priority
EP 23153815 A 20230127
Abstract (en)
The invention provides a process for reducing protease activity in a solution comprising anti-D immunoglobulin G comprising the steps of i) providing a solution comprising anti-D immunoglobulin G; ii) contacting said solution with aluminium hydroxide gel at a pH of 4.70 to 4.90; and iii) separating the solution from the solid components. The use of these conditions reduces protease activity, preferably without reducing yield of anti-D immunoglobulin G.
IPC 8 full level
C07K 16/06 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP)
C07K 16/065 (2013.01); C07K 16/28 (2013.01)
Citation (applicant)
- STUCKI ET AL., JOURNAL OF CHROMATOGRAPHY, 1997, pages 241 - 248
- "Annex 4 Guidelines on viral inactivation and removal procedures intended to assure the viral safety of human blood plasma products", WHO TECHNICAL REPORT, vol. 924, 2004, pages 151 - 224
- P FRIBERGER, SCAND J CLIN LAB INVEST SUPPL, vol. 162, 1982, pages 1 - 298
- REMINGTON'S PHARMACEUTICAL SCIENCES, 1980
- "Assay of human anti-D immunoglobulin", EUROPEAN PHARMACOPOEIA
Citation (search report)
- [I] US 5593675 A 19970114 - HODLER GERHARD [CH], et al
- [I] US 2793203 A 19570521 - SCHULTZE HERMANN E, et al
- [I] STUCKI M ET AL: "Characterisation of a chromatographically produced anti-D immunoglobulin product", JOURNAL OF CHROMATOGRAPHY B, ELSEVIER, AMSTERDAM, NL, vol. 700, no. 1-2, 24 October 1997 (1997-10-24), pages 241 - 248, XP004095061, ISSN: 1570-0232, DOI: 10.1016/S0378-4347(97)00319-8
- [A] MACKENZIE I Z ET AL: "Efficacy and safety of a new, chromatographically purified rhesus (D) immunoglobulin", EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, ELSEVIER IRELAND LTD, IE, vol. 117, no. 2, 1 December 2004 (2004-12-01), pages 154 - 161, XP004638826, ISSN: 0301-2115, DOI: 10.1016/J.EJOGRB.2004.03.009
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
DOCDB simple family (application)
EP 23153815 A 20230127