EP 4352085 A1 20240417 - METHOD AND COMPOSITIONS FOR NEURONAL REPROGRAMMING
Title (en)
METHOD AND COMPOSITIONS FOR NEURONAL REPROGRAMMING
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR NEURONALEN REPROGRAMMIERUNG
Title (fr)
PROCÉDÉ ET COMPOSITIONS POUR UNE REPROGRAMMATION NEURONALE
Publication
Application
Priority
- US 202163208627 P 20210609
- CA 2022050923 W 20220609
Abstract (en)
[origin: WO2022256933A1] The present application provides a mutant basic‐helix‐loop‐helix (bHLH) transcription factor that comprises a mutation of one or more phosphoacceptor site for proline‐directed serine‐threonine kinases alone or together with a mutation in a conserved PKA site in the HLH domain, found in the corresponding wild‐type bHLH transcription factor, and exhibits reduced phosphorylation by proline‐directed serine‐threonine kinases and PKA. Also provided are nucleic acids encoding the mutant bHLH transcription factor, and vectors comprising the encoding nucleic acids. Use of the mutant bHLH transcription factor or nucleic acid encoding the mutant bHLH transcription factor for therapeutic purposes can efficiently induce neuronal lineage conversion of glial cells, even in an inhibitory environment, and are useful in preventing or treating neurodegenerative diseases and disorders, and for treating CNS injuries. Further provided a use a ZBTB18 transcription factor or a nucleic acid encoding the ZBTB18 transcription factor for neuronal lineage conversion of glial cells.
IPC 8 full level
C07K 14/47 (2006.01); A61K 38/17 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); C12N 15/12 (2006.01); C12N 15/85 (2006.01); C12N 15/864 (2006.01)
CPC (source: EP IL KR)
A61K 38/00 (2013.01 - IL); A61K 48/005 (2013.01 - EP IL KR); A61P 25/00 (2018.01 - EP IL); A61P 25/28 (2018.01 - EP IL KR); C07K 14/4705 (2013.01 - EP IL KR); C12N 15/86 (2013.01 - EP IL KR); A61K 38/00 (2013.01 - EP KR); C12N 2750/14143 (2013.01 - EP IL KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022256933 A1 20221215; AU 2022288230 A1 20231221; BR 112023025888 A2 20240227; CA 3222129 A1 20221215; CN 117881692 A 20240412; EP 4352085 A1 20240417; IL 309190 A 20240201; JP 2024521401 A 20240531; KR 20240032021 A 20240308; MX 2023014769 A 20240130
DOCDB simple family (application)
CA 2022050923 W 20220609; AU 2022288230 A 20220609; BR 112023025888 A 20220609; CA 3222129 A 20220609; CN 202280051836 A 20220609; EP 22819038 A 20220609; IL 30919023 A 20231207; JP 2023575711 A 20220609; KR 20247000754 A 20220609; MX 2023014769 A 20220609