EP 4355867 A2 20240424 - ENGINEERED POLYMERASES
Title (en)
ENGINEERED POLYMERASES
Title (de)
MANIPULIERTE POLYMERASEN
Title (fr)
POLYMÉRASES MODIFIÉES
Publication
Application
Priority
- US 202163212540 P 20210618
- US 202217705043 A 20220325
- US 202217705011 A 20220325
- US 202217705020 A 20220325
- US 2022034021 W 20220617
Abstract (en)
[origin: WO2022266462A2] Provided herein are engineered variants of archaeal, prokaryotic, and eukaryotic polymerases that exhibit enhanced thermostability, enhanced incorporation of 3' modified nucleotides, and improved uracil-tolerance, in polymerase-catalyzed nucleotide extension reactions relative to wild type polymerase enzymes. Also provided are uses of the engineered polymerases for forming complexed polymerases, forming binding complexes and forming ternary complexes, and uses for conducting nucleic acid sequencing reactions.
IPC 8 full level
C12N 9/12 (2006.01); C12Q 1/6869 (2018.01)
CPC (source: EP IL KR)
C12N 9/1252 (2013.01 - EP IL KR); C12N 15/52 (2013.01 - EP IL); C12Q 1/48 (2013.01 - EP IL); C12Q 1/6869 (2013.01 - KR); C12Y 207/07007 (2013.01 - EP IL KR); C12Q 2521/101 (2013.01 - KR); C12Q 2527/101 (2013.01 - KR); C12Q 2563/107 (2013.01 - KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2022266462 A2 20221222; WO 2022266462 A3 20230504; WO 2022266462 A9 20230713; AU 2022291874 A1 20240118; CA 3223112 A1 20221222; EP 4355867 A2 20240424; IL 309440 A 20240201; JP 2024522795 A 20240621; KR 20240055718 A 20240429; TW 202317760 A 20230501
DOCDB simple family (application)
US 2022034021 W 20220617; AU 2022291874 A 20220617; CA 3223112 A 20220617; EP 22741923 A 20220617; IL 30944023 A 20231217; JP 2023577945 A 20220617; KR 20247001936 A 20220617; TW 111122750 A 20220617