EP 4388012 A1 20240626 - ANTIBODIES THAT TARGET HLA-E-HOST PEPTIDE COMPLEXES AND USES THEREOF
Title (en)
ANTIBODIES THAT TARGET HLA-E-HOST PEPTIDE COMPLEXES AND USES THEREOF
Title (de)
AUF HLA-E-WIRT-PEPTIDKOMPLEXE GERICHTETE ANTIKÖRPER UND VERWENDUNGEN DAVON
Title (fr)
ANTICORPS CIBLANT DES COMPLEXES PEPTIDIQUES HLA-E-HÔTE ET LEURS UTILISATIONS
Publication
Application
Priority
- US 202163235535 P 20210820
- US 2021050537 W 20210915
- US 2022075241 W 20220819
Abstract (en)
[origin: WO2023023663A1] The present invention provides affinity matured recombinant monoclonal antibodies (mAbs) and fragments that bind specifically to an HLA-E- peptide complex, including HLA-E-VL9 complexes, and. regulate the cytotoxicity effector cell function of NK and/or CD8+ T-cells positive for cell-surface expression of NKG2A ("NKG2A+"). Herein, monoclonal antibodies were recombinant.lv derived from isolated functional HLA-E- VL9-specific mAbs from HLA-E- VL9 peptide- immunized HLA-B transgenic mice and from the naive human B cell repertoire. Such antibodies are capable of regulating effector cell cytotoxicity' and can preferentially recognize HLA-E- VL9 peptide complexes expressed on the surface of tumor cells. The monoclonal antibodies were subject to one or more rounds of affinity7 maturation. The invention provides methods for using affinity matured HLA-E- VL9 mAbs to modulate NK and/or CD8+T- cell function as part of immunotherapeutic strategies.
IPC 8 full level
C07K 16/28 (2006.01); G01N 33/569 (2006.01)
CPC (source: EP)
C07K 16/2833 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/52 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
WO 2023023663 A1 20230223; CA 3229447 A1 20230223; EP 4388012 A1 20240626
DOCDB simple family (application)
US 2022075241 W 20220819; CA 3229447 A 20220819; EP 22859437 A 20220819