EP 4389736 A1 20240626 - UREA COMPOUND CONTAINING 2-HETEROAROMATIC RING SUBSTITUTION, PREPARATION METHOD THEREFOR AND USE THEREOF
Title (en)
UREA COMPOUND CONTAINING 2-HETEROAROMATIC RING SUBSTITUTION, PREPARATION METHOD THEREFOR AND USE THEREOF
Title (de)
HARNSTOFFVERBINDUNG MIT 2-HETEROAROMATISCHER RINGSUBSTITUTION, HERSTELLUNGSVERFAHREN DAFÜR UND VERWENDUNG DAVON
Title (fr)
COMPOSÉ D'URÉE CONTENANT UNE SUBSTITUTION DU CYCLE 2-HÉTÉROAROMATIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
Publication
Application
Priority
- CN 202110936628 A 20210816
- CN 2022107742 W 20220726
Abstract (en)
The present invention relates to a urea compound containing 2-heteroaromatic ring substitution represented by formula (I), its enantiomers, diastereomers, racemates or mixtures thereof, or pharmaceutically acceptable salts thereof, solvate, metabolite or prodrug. The compound of formula (I) of the present invention has inhibitory activity against CDK9, and representative compounds have significant anti-tumor activity against CDK9 high-expressing tumor cells. Representative compounds have plasma stability and low clearance.
IPC 8 full level
C07D 213/75 (2006.01); A61K 31/506 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP)
A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/4985 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); A61K 31/55 (2013.01); A61P 9/00 (2018.01); A61P 31/12 (2018.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07D 213/75 (2013.01); C07D 213/85 (2013.01); C07D 239/42 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 487/04 (2013.01); C07D 487/10 (2013.01); C07D 498/04 (2013.01); Y02P 20/55 (2015.11)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
Designated validation state (EPC)
KH MA MD TN
DOCDB simple family (publication)
EP 4389736 A1 20240626; AU 2022331646 A1 20240222; CA 3228228 A1 20230223; CN 115703738 A 20230217; CN 115703738 B 20240621; WO 2023020209 A1 20230223
DOCDB simple family (application)
EP 22857522 A 20220726; AU 2022331646 A 20220726; CA 3228228 A 20220726; CN 202110936628 A 20210816; CN 2022107742 W 20220726