(19)
(11)EP 4 253 536 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
20.12.2023 Bulletin 2023/51

(43)Date of publication A2:
04.10.2023 Bulletin 2023/40

(21)Application number: 23184439.0

(22)Date of filing:  29.12.2016
(51)International Patent Classification (IPC): 
A61B 5/1473(2006.01)
A61B 5/00(2006.01)
A61B 5/145(2006.01)
C08G 18/75(2006.01)
A61K 33/00(2006.01)
C08G 18/12(2006.01)
C08G 18/40(2006.01)
C12N 11/08(2020.01)
G01N 27/327(2006.01)
C12N 11/089(2020.01)
A61B 5/1486(2006.01)
A61K 38/28(2006.01)
C08G 18/48(2006.01)
C12Q 1/00(2006.01)
C08G 18/08(2006.01)
C08G 18/38(2006.01)
C08G 18/44(2006.01)
C08L 75/04(2006.01)
C08L 39/06(2006.01)
C12N 11/093(2020.01)
(52)Cooperative Patent Classification (CPC):
A61B 5/002; G01N 27/3275; A61B 2562/12; C08G 18/4833; C08G 18/755; C08G 18/0828; C08G 18/12; C08G 18/3857; C08G 18/4018; C08G 18/44; C12Q 1/002; C12Q 1/006; A61B 5/0004; A61B 5/14532; A61B 5/14546; A61B 5/14865; A61B 5/1486; A61K 33/00; A61K 38/28; A61B 5/1473; C12N 11/089; C12N 11/093
 
C-Sets:
C08G 18/12, C08G 18/3234;
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)Priority: 30.12.2015 US 201562273219 P
30.12.2015 US 201562273155 P
30.12.2015 US 201562273142 P

(62)Application number of the earlier application in accordance with Art. 76 EPC:
16882712.9 / 3397163

(71)Applicant: DexCom, Inc.
San Diego, CA 92121 (US)

(72)Inventors:
  • Zou, Jiong
    San Diego, CA, 92121 (US)
  • Boock, Robert J.
    San Diego, CA, 92121 (US)
  • Lee, Ted Tang
    San Diego, CA, 92121 (US)
  • Suri, Jeff T.
    San Diego, CA, 92121 (US)
  • Sze, David
    San Diego, CA, 92121 (US)
  • Tapsak, Mark A.
    San Diego, CA, 92121 (US)
  • Wang, Shanger
    San Diego, CA, 92121 (US)
  • Zhang, Huashi
    San Diego, CA, 92121 (US)

(74)Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)

  


(54)DIFFUSION RESISTANCE LAYER FOR ANALYTE SENSORS


(57) Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.







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