(19)
(11)EP 0 458 064 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
17.06.1992 Bulletin 1992/25

(43)Date of publication A2:
27.11.1991 Bulletin 1991/48

(21)Application number: 91106224.8

(22)Date of filing:  18.04.1991
(51)International Patent Classification (IPC)5C07K 17/08, A61K 47/48, C07C 233/31, C07C 237/22, C08G 65/32
(84)Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30)Priority: 04.05.1990 US 519047

(71)Applicant: AMERICAN CYANAMID COMPANY
Wayne, NJ 07470-8426 (US)

(72)Inventors:
  • Buckwalter, Brian Lee
    Yardley, Pennsylvania (US)
  • Cady, Susan Mancini
    Yardley, Pennsylvania (US)
  • Daley, Michael Joseph
    Yardley, Pennsylvania (US)
  • Shieh, Hong-Ming
    Langhorne, Pennsylvania (US)

(74)Representative: Wächtershäuser, Günter, Prof. Dr. et al
Patentanwalt, Tal 29
80331 München
80331 München (DE)


(56)References cited: : 
  
      


    (54)Stabilization of somatotropins and other proteins by modification of cysteine residues


    (57) The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.





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