(19)
(11)EP 1 829 481 B1

(12)EUROPEAN PATENT SPECIFICATION

(45)Mention of the grant of the patent:
11.01.2017 Bulletin 2017/02

(21)Application number: 07004062.1

(22)Date of filing:  27.02.2007
(51)Int. Cl.: 
A61B 6/00  (2006.01)
A61B 6/03  (2006.01)

(54)

X-ray imaging device and x-ray imaging method

Röntgenaufnahmevorrichtung und -verfahren

Dispositif et procédé d'imagerie par rayons X


(84)Designated Contracting States:
DE NL

(30)Priority: 01.03.2006 JP 2006055163

(43)Date of publication of application:
05.09.2007 Bulletin 2007/36

(73)Proprietor: Toshiba Medical Systems Corporation
Otawara-Shi, Tochigi-Ken 324-8550 (JP)

(72)Inventors:
  • Sakaguchi, Takuya Intellectual Prop. Dept.
    Otawara-shi Tochigi 324-8550 (JP)
  • Ohishi, Satoru Intellectual Prop. Dept.
    Otawara-shi Tochigi 324-8550 (JP)

(74)Representative: Kramer Barske Schmidtchen Patentanwälte PartG mbB 
European Patent Attorneys Landsberger Strasse 300
80687 München
80687 München (DE)


(56)References cited: : 
EP-A- 1 785 092
US-A- 5 841 830
US-A1- 2004 131 156
WO-A-03/041583
US-A1- 2002 191 735
US-A1- 2005 046 644
  
      
    Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).


    Description


    [0001] The present invention relates to an X-ray imaging device and an X-ray imaging method, by which a plurality of two-dimensional images is acquired by performing imaging during the rotation of an X-ray generation unit and an X-ray detection unit around a sample as a rotation center, and a three-dimensional soft tissue image or the like of the sample is acquired by performing a reconstruction of the two-dimensional images.

    [0002] The X-ray imaging device equips a C arm. The C arm is provided with an X-ray generation unit and an X-ray detection unit facing one another. There has been proposed a technique of acquiring a three-dimensional soft tissue image of a sample with the use of the X-ray imaging device. The soft tissue image of the sample acquired according to such technique shows soft tissues of internal organs, etc., inside the sample such as tissues having low X-ray absorption. It has been understood as that the soft tissue image is capable of showing, for example, a difference of a substance X-ray absorption coefficient by 10 H.U. in approximate with a CT value expressed in a relative value from a reference substance.

    [0003] The X-ray imaging device rotates the X-ray generation unit and the X-ray detection unit around a sample as a rotation center by rotating the C arm. The X-ray imaging device images at every rotary move by predetermined angle while rotating the X-ray generation unit and the X-ray detection unit. The X-ray imaging device acquires a plurality of two-dimensional images by performing the imaging at every rotary movement, and reconstructs a three-dimensional soft tissue image of the sample from the two-dimensional images. For the reconstruction, a three-dimensional soft tissue image is reconstructed by applying the reconstruction theory such as Feldkamp method, or the like. In order to reconstruct the three-dimensional soft tissue image, it is necessary to acquire about 400 frames of two-dimensional images by imaging from about 400 directions of an imaging angle direction.

    [0004] While surgical operation, the three-dimensional soft tissue image of the sample acquired by the X-ray imaging device is shown on a display. When there is confirmed, for example, a bleeding from vessel, a treatment to stop the bleeding is carried out. In this case, there is a demand to identify a bleeding blood vessel in the sample and observe the blood vessel image and the soft tissue image by overlaying them for a display.

    [0005] In order to acquire the blood vessel image, it is necessary to inject a contrast agent into a blood vessel and obtain the flow of the contrast agent by an X-ray imaging. For the blood vessel image, as shown in FIG. 17 for example, the rotation of X-ray generation unit and X-ray detection unit is initiated under a condition of without a contrast where the contrast agent is not injected. At this time, the X-ray generation unit and the x-ray detection unit start rotate from a rotation start angle position s to a rotation end angle position e around a sample 1 as a rotation center within the imaging range of θ. The imaging is performed at imaging angle positions k1, k2, ..., kn, respectively, whereat the X-ray generation unit and the X-ray detection unit step each by a predetermined angle. Accordingly, there can be obtained, for example, 400 directions of a two-dimensional image 2 without a contrast. The rotation angle of the imaging range θ is obtained by adding 180° with a Fan angle F. Thus obtained 400 frames of a two-dimensional image 2 without a contrast are recombined to acquire a three-dimensional soft tissue image 3 showing soft tissues.

    [0006] Alternatively, in the presence of a contrast where the contrasting agent is injected, the X-ray generation unit and the x-ray detection unit are rotated around the sample 1 as a rotation center within the imaging range of θ. Then, the imaging is performed at imaging angle positions k1, k2, ..., kn, respectively, whereat the units step each by predetermined angle as above, thereby obtaining, for example, 400 frames of a two-dimensional image with a contrast.

    [0007] Next, images 4 which are the subtraction between 400 frames of the two-dimensional image 2 without a contrast and 400 frames of the two-dimensional image 3 with a contrast are obtained. The subtraction images 4 are recombined to acquire a three-dimensional blood vessel image 5 showing blood vessels.

    [0008] However, since it is necessary to acquire total 800 frames of images, which are 400 frames of a two-dimensional image 2 without a contrast and 400 frames of a two-dimensional image with a contrast, such to acquire the blood vessel image 5, there may be a possibility of increase dose against the sample 1.

    [0009] An example of the X-ray imaging device is disclosed in JP-A-2005-80285.

    [0010] WO 03/041583 A1 describes a system for time resolved CT Angiography comprising an X-ray generation unit adapted to emit X-rays to a sample; an X-ray detection unit adapted to detect the amount of X-rays passing through the sample; an imaging control unit which two or more times rotates the X-ray generation unit and the X-ray detection unit around the sample as a rotation center and imaging the sample at a plurality of rotation angles different from each other during the rotations; and an image calculation unit adapted to acquire a three-dimensional image of the sample by performing a calculation process including at least a reconstruction based on the plurality of two-dimensional images which are acquired by performing imaging during the rotations of the X-ray generation unit and the X-ray detection unit.

    [0011] US 5 841 830 is an example of another CT system, useful for 3D fluoroscopy.

    [0012] EP 1 785 092 forms part of the state of the art according to Article 54(3) EPC for DE and NL and describes an X-ray angiography apparatus.

    [0013] It is an object of the invention to provide an X-ray imaging device and a method thereof, by which an image at least showing soft tissues is acquired with the reduced amount of exposure against a sample. This object is achieved by the subject-matters of claims 1 and 17. Further developments are given in the dependent claims.

    [0014] The invention can be more fully understood from the following detailed description when taken in conjunction with the accompanying drawings, in which:

    FIG. 1 is a diagram illustrating an outer shape of a first embodiment of an X-ray imaging device according to the invention.

    FIG. 2 is a block diagram illustrating a mechanism of the device.

    FIG. 3 is a functional block diagram illustrating an image acquisition of the device.

    FIG. 4 is a functional block diagram illustrating an image acquisition in a second embodiment of an X-ray imaging device according to the invention.

    FIG. 5A is a diagram schematically showing a modified example in rotary imaging of the device.

    FIG. 5B is a diagram schematically showing a modified example in rotary imaging of the device.

    FIG. 5C is a diagram schematically showing a modified example in rotary imaging of the device.

    FIG. 6A is a diagram schematically showing a modified example in rotary imaging of the device.

    FIG. 6B is a diagram schematically showing a modified example in rotary imaging of the device.

    FIG. 7 is a diagram illustrating a method of acquiring a two-dimensional image data in the device.

    FIG. 8 is a diagram illustrating a modified example of a rotation direction of an X-ray generation unit and an X-ray detection unit in the device.

    FIG. 9 is a diagram illustrating a modified example of a rotation direction of the X-ray generation unit and the X-ray detection unit in the device.

    FIG. 10 is a diagram schematically showing that the X-ray generation unit and the X-ray detection unit in the device rotate in the same plane.

    FIG. 11 is a diagram schematically showing that the X-ray generation unit and the X-ray detection unit in the device rotate in the different plane.

    FIG. 12 is a functional block diagram illustrating a reconstruction in a third embodiment of an X-ray imaging device according to the invention.

    FIG. 13 is a functional block diagram illustrating a reconstruction of an X-ray imaging device according to an example.

    FIG. 14 is a functional block diagram illustrating a reconstruction of an X-ray imaging device according to an example.

    FIG. 15 is a functional block diagram illustrating a reconstruction of an X-ray imaging device according to an example.

    FIG. 16 is a flow diagram illustrating an application of image acquisition of an X-ray imaging device according to an example.

    FIG. 17 is a diagram illustrating the passage of acquiring images of soft tissues and blood vessels in accordance with a known X-ray imaging method.



    [0015] Hereinafter, the first embodiment of the invention will be described with preference to the accompanying drawings.

    [0016] FIG. 1 is a diagram illustrating an overview of an X-ray imaging device. Onto a stand 10, a bed 11 for laying a sample 1 such as patient, etc., is provided. On a ceiling, a support 12 is placed for a C arm 20 to be rotatable. The C arm 20 is capable of rotating in directions D1, D2, and D3 of three orthogonal axes. At each end of the C arm 20, an X-ray generation unit 21 and an X-ray detection unit 22 are provided, respectively, which are facing one another. A plurality of monitors 23 is provided.

    [0017] The X-ray generation unit 21 equips an X-ray tube. The X-ray generation unit 21 emits an X-ray beam by supplying a voltage and an electric current to the X-ray tube. The X-ray detection unit 22 detects the amount of X-ray beam that is emitted from the X-ray generation unit 21 and passing through the sample 1, and outputs the X-ray image data corresponding to the X-ray detected amount. For the X-ray detection unit 22, a Flat Panel Detector (FPD) or an Image Intensifier (I.I) can be employed.

    [0018] FIG. 2 is a block diagram illustrating a mechanism of the device. The C arm 20 is provided with a drive unit 25. The drive unit 25 rotates the C arm 20. Accordingly, the X-ray generation unit 21 and the X-ray detection unit 22 rotate around the sample 1 as a rotation center.

    [0019] A calculation processor body 26 is formed with a computer. The calculation processor body 26 performs a series of operation controls including allowing imaging during the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center by processing an image imaging program preliminarily stored to acquire a plurality of two-dimensional image data, and allowing recombining the two-dimensional image data to acquire a three-dimensional soft tissue image data of the sample 1.

    [0020] In specific, the calculation processor body 26 operates an X-ray generation control unit 28, an image acquisition unit 29, a mechanism control unit 30, an imaging control unit 31, an imaging calculation unit 32, an image storage unit 33, and the monitor 23, in accordance with each command given from a main control unit 27. The X-ray generation control unit 28 gives a command to the X-ray generation unit 21 to generate the X-ray beam. The command to generate the X-ray beam is given by a voltage value applied to the X-ray tube of the X-ray generation unit 21 or the X-ray condition information instructing a current value.

    [0021] The image acquisition unit 29 sequentially loads the X-ray image data output from the X-ray detection unit 22, and stores each as a two-dimensional image data into the image storage unit 33.

    [0022] The mechanism control unit 30 controls the operation of the drive unit 25 rotating the C arm 20. Accordingly, the X-ray generation unit 21 and the X-ray detection unit 22 rotate around the sample 1 as a rotation center.

    [0023] The imaging control unit 31 gives a command to the mechanism control unit 30 to at least twice rotate the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center. At the same time, the imaging control unit 31 gives each command to the X-ray generation control unit 28 and the imaging acquisition unit 29 at every time rotating the X-ray generation unit 21 and the X-ray detection unit 22 for the at least twice rotations. Accordingly, the imaging control unit 31 allows the imaging of the sample 1 at a plurality of rotation angles where angles are deviated to one another.

    [0024] FIG. 3 is a functional block diagram illustrating an image acquisition. The imaging control unit 31 allows the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center twice without a contrast (contrast agent is not injected to the sample 1) and with a contrast (contrast agent is injected to the sample 1) in the sample 1.

    [0025] The imaging control unit 31 gives a command to the mechanism control unit 30 to, without a contrast, start the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center where start rotating from the rotation start angle position S to the rotation end angle position e within the imaging range of θ. At the same time, the imaging control unit 31 gives a command to the X-ray generation control unit 28 and the image acquisition unit 29 to perform imaging at every predetermined φ stepped angles of equal distance, for example, at imaging angle positions f1, f2, ..., fn, which are stepped by angles φ = 1°. The imaging angle direction is, for example, in 200 directions.

    [0026] The imaging control unit 31 gives a command to the mechanism control unit 30, in the presence of a contrast, to start the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center where start rotating from the rotation start angle position sa, which is the position deviated by angle φ/2 e.g., deviated by 0.5° angle with respect to the rotation start angle position S, to the rotation end angle position en within the imaging range of θ. The deviated angle φ/2 is set to, for example, a half of the stepped angle φ of imaging angle positions f1, f2, ..., fn. At the same time, the imaging control unit 31 gives a command to the X-ray generation control unit 28 and the image acquisition unit 29 to perform imaging from the rotation start angle position sa by every predetermined stepped angles of equal distance, for example, at imaging angle positions g1, g2, ..., gn, which are stepped every by 1° angle. The imaging angle direction in the case of with a contrast is also 200 directions as in the case of without a contrast.

    [0027] When the X-ray generation unit 21 and the X-ray detection unit 22 are rotated under two conditions of without a contrast and with a contrast, the rotation start angle position S for the case of without a contrast and the rotation start angle position sa for the case of with a contrast differ from each other in response to the deviated angle φ/2. In addition, the rotation end angle position e for the case of without a contrast and the rotation end angle position en for the case of with a contrast also differ in response to the deviated angle φ/2.

    [0028] The imaging control unit 31 may set the stepped angle for giving equal distant imaging angle positions f1, f2, ..., fn in the case of without a contrast, and the stepped angle for giving equal distant imaging angle positions g1, g2, ..., gn in the case of with a contrast, to an equal angle of, for example, 1° angle. Accordingly, the imaging control unit 31 deviates the imaging angle positions f1, f2, ..., fn for the case of without a contrast to the imaging angle positions g1, g2, ..., gn for the case of with a contrast.

    [0029] The above-mentioned angle φ/2 is set to, for example, a half of the stepped angle φ of imaging angle positions f1, f2, ..., fn. Accordingly, when imaging angle positions g1, g2, ..., gn, and imaging angle positions f1, f2, ..., fn are combined, imaging angle positions f1, g1, f2, g2, ..., fn, gn give an equal angle interval.

    [0030] The imaging control unit 31 performs the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 in the same plane for rotations of without a contrast and with a contrast.

    [0031] The X-ray generation unit 21 in FIG. 3 indicates the position at the time of starting the rotation when initiating the X-ray imaging, and the symbol "(21)" in the same figure indicates the position of the X-ray generation unit 21 when terminating the X-ray imaging.

    [0032] The image calculation unit 32 performs a calculation process such as a reconstruction process and an addition/subtraction process against a plurality of two-dimensional image data acquired by the imaging of with and without a contrast during the rotation of the X-ray generation unit 21 and the X-ray detection unit 22. That is, the image calculation unit 32 subjects the plurality of two-dimensional image data stored in the image storage unit 33 to the calculation process such as a reconstruction process and an addition/subtraction process, and thus acquires a three-dimensional soft tissue image data 3, a three-dimensional blood vessel image data 5, and a three-dimensional soft tissue/blood vessel image data 34, of the sample 1.

    [0033] In specific, the image calculation unit 32 is provided with a first reconstruction unit 35, a second reconstruction unit 36, and an inter-image calculation unit 37. The first reconstruction unit 35 reads out a plurality of two-dimensional image data, which is acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35 allows the reconstruction with the use of the plurality of two-dimensional image data by applying the reconstruction theory such as Feldkamp method, or the like, and acquires a three-dimensional tissue image data 38 of the sample 1. The first reconstruction unit 35 employs, as for the reconstruction filter, a filter such as Shepp & Logan and Ramachandran, which emphasizes a relatively high-frequency component.

    [0034] The second reconstruction unit 36 allows the reconstruction with the use of the plurality of two-dimensional image data, which is acquired by giving a contrast to the sample 1, by applying the reconstruction theory such as Feldkamp method, or the like, and acquires a three-dimensional soft tissue/blood vessel image data 39 including soft tissues and blood vessels of the sample 1. The second reconstruction unit 36 as in the first reconstruction unit 35 employs, as for the reconstruction filter, a filter such as Shepp & Logan and Ramachandran, which emphasizes a relatively high-frequency component.

    [0035] The inter-image calculation unit 37 carries out an inter-calculation between the tissue image data 38 reconstructed by the first reconstruction unit 35 and the tissue/blood vessel image data 39 reconstructed by the second reconstruction unit 36, and thus acquires the three-dimensional soft tissue image data 3, the three-dimensional soft tissue/blood vessel image data 34, and the three-dimensional blood vessel image data 5, of the sample 1. In specific, the inter-image calculation unit 37 is provided with an adder 40 and two subtracters 41 and 42. The inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 with the subtracter (first calculation unit) 41, and thus acquires the three-dimensional blood vessel image data 5. Next, the inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the blood vessel image data 5 with the subtracter (second calculation unit) 42, and adds the found difference and the tissue image data 38 with the adder (third calculation unit) 40, such to acquire the three-dimensional soft tissue image data 3. Then, the inter-image calculation unit (fourth calculation unit) 37 performs adding the blood vessel image data 5 and the soft tissue image data 3 to acquire the three-dimensional soft tissue/blood vessel image data 34.

    [0036] Hereinbelow, the imaging operation with the device constructed in the above manner will be explained.

    [0037] The sample 1 is positioned such to be the rotation center (isocenter) for the X-ray generation unit 21 and the X-ray detection unit 22.

    [0038] The imaging control unit 31 allows performing the first rotary imaging with the X-ray generation unit 21 and the X-ray detection unit 22 under a condition of without a contrast. That is, the imaging control unit 31 gives a command to the mechanism control unit 30 to start the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center where start rotating from the rotation start angle position S to the rotation end angle position e within the imaging range of 6. Accordingly, the C arm 20 rotates, for example, in the arrowed W direction. The X-ray generation unit 21 and the X-ray detection unit 22 rotate around the sample 1 as a rotation center. The rotation angle of the imaging range θ is obtained by adding 180° with a Fan angle F. When the performance of the C arm 20 is 50 deg/sec, the C arm 20 requires, for example, about 5 seconds to rotate the imaging range θ.

    [0039] In addition, the imaging control unit 31 gives a command to the X-ray generation control unit 28 and the image acquisition unit 29 to perform imaging at every predetermined stepped angles of equal distance, for example, at imaging angle positions f1, f2, ..., fn, which are stepped by 1° angle.

    [0040] The X-ray generation unit 21 and the X-ray detection unit 22 rotate around the sample 1 as the rotation center where start rotating from the rotation start angle position S to the rotation end angle position e within the imaging range θ. During this rotation, the X-ray generation unit 21 generates an X-ray beam at every predetermined stepped angles of equal distance, for example, at imaging angle positions f1, f2, ..., fn, which are stepped by 1° angle, which is controlled by the X-ray generation control unit 28. In this case, the imaging angle positions f1, f2, ..., fn are, for example, 200 directions.

    [0041] The X-ray detection unit 22 detects the amount of X-rays passing through the sample 1 at imaging angle positions f1, f2, ..., fn, and outputs its X-ray image data. The rotation angle of the imaging range θ is obtained by adding 180° with a Fan angle F.

    [0042] As a result, the image acquisition unit 29 sequentially loads the X-ray image data output from the X-ray detection unit 22, and stores in the image storage unit 33, for example, as 200 frames of two-dimensional image data (Mask image data) A1 without a contrast.

    [0043] When the first rotary imaging is finished, the C arm 20 returns back to its original position.

    [0044] Next, the imaging control unit 31 allows performing the second rotary imaging with the X-ray generation unit 21 and the X-ray detection unit 22 under a condition of with a contrast. That is, the imaging control unit 31 gives a command to the mechanism control unit 30 to start the rotation from the rotation start angle position sa, which is the position deviated by angle φ/2, half of the stepped angle φ (= 1°) of imaging angle positions f1, f2, ..., fn, e.g., deviated by φ = 0.5° with respect to the rotation start angle position S for the case of without a contrast, to the rotation end angle position en within the imaging range of θ.

    [0045] Accordingly, the C arm 20 rotates, for example, in the arrowed W direction. The X-ray generation unit 21 and the X-ray detection unit 22 rotate around the sample 1 as a rotation center (isocenter). The rotations of with and without a contrast with the X-ray generation unit 21 and the X-ray detection unit 22 are performed in the same plane.

    [0046] In addition, the imaging control unit 31 gives a command to the X-ray generation control unit 28 and the image acquisition unit 29 to perform imaging from the rotation start angle position sa by every predetermined stepped angles of equal distance, for example, at imaging angle positions g1, g2, ..., gn, which are stepped by 1° angle as in the case of without a contrast. The imaging angle direction in the presence of a contrast is also 200 directions as in the case of without a contrast.

    [0047] The X-ray generation unit 21 and the X-ray detection unit 22 rotate around the sample 1 as the rotation center where start rotating from the rotation start angle position sa to the rotation end angle position en within the imaging range θ. During this rotation of the X-ray generation unit 21 and the X-ray detection unit 22, the X-ray generation unit 21 generates an X-ray beam at every predetermined stepped angles of equal distance, for example, at imaging angle positions g1, g2, ..., gn, which are stepped by 1° angle, which is controlled by the X-ray generation control unit 28. The imaging angle positions g1, g2, ..., gn are, for example, 200 directions. The X-ray detection unit 22 detects the amount of X-rays passing through the sample 1 at imaging angle positions g1, g2, ..., gn, and outputs its X-ray image data. As a.result, the image acquisition unit 29 sequentially loads the X-ray image data outputted from the X-ray detection unit 22. Then, the image acquisition unit 29 stores in the image storage unit 33, for example, as 200 frames of two-dimensional image data (Contrast image data) A2 with a contrast.

    [0048] The image storage unit 33 stores 400 frames of two-dimensional image data in total obtained from 200 frames of the two-dimensional image data A1 without a contrast and 200 frames of the two-dimensional image data A2 with a contrast. Each of two dimensional image data A1 without a contrast and A2 with a contrast, is obtained by performing imaging at imaging angle positions f1, f2, ..., fn and at imaging angle positions g1, g2, ..., gn, respectively, which are deviated by angle φ e.g., deviated by 0.5° angle.

    [0049] Accordingly, 400 frames of the two-dimensional image data A1 and A2 in total are same to the images acquired at imaging angle positions f1, g1, f2, g2, ..., fn, gn, of equal interval. The two-dimensional image data A1 and A2 have the same information as the ones obtained by taking the image of organs in the sample 1 at imaging angles of 400 directions. When there are two-dimensional image data of 400 imaging directions, the soft tissue image of the sample 1 can be obtained. When there are two-dimensional image data of 200 imaging directions, the blood vessel image of the sample 1 can be obtained.

    [0050] The first reconstruction unit 35 reads out, for example, 200 frames of the two-dimensional image data A1 stored in the image storage unit 33. The first reconstruction unit 35 allows the reconstruction with the use of two-dimensional image data A1, and acquires the three-dimensional tissue image data 38 of the sample 1. The first reconstruction unit 35 may conduct the reconstruction at the same time of acquiring the two-dimensional image data A2 with a contrast without waiting for the acquisition of the two-dimensional image data A2 with a contrast to end.

    [0051] The second reconstruction unit 36 allows the reconstruction with the use of, for example, 200 frames of the two-dimensional image data A2 acquired by giving a contrast to the sample 1, and acquires the three-dimensional tissue/blood vessel image data 39 including soft tissues and blood vessels of the sample 1.

    [0052] The inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 with the subtracter 41, and thus acquires the three-dimensional blood vessel image data 5. The three-dimensional blood vessel image data 5 only shows blood vessels.

    [0053] Next, the inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the blood vessel image data 5 with the subtracter 42, and adds the found difference and the tissue image data 38 with the adder 40, such to acquire the three-dimensional soft tissue image data 3.

    [0054] Subsequently, the inter-image calculation unit 37 performs adding the blood vessel image data 5 and the soft tissue image data 3 to acquire the three-dimensional soft tissue/blood vessel image data 34.

    [0055] As a result, the blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34 of the sample 1 are displayed on the monitor 23.

    [0056] According to the first embodiment as above, the X-ray generation unit 21 and the X-ray detection unit 22 are rotated under a condition of without a contrast from the rotation start angle position S and the imaging is performed at imaging angle positions f1, f2, ..., fn, respectively, thereby acquiring, for example, 200 frames of the two-dimensional image data A1 without a contrast. In addition, the X-ray generation unit 21 and the X-ray detection unit 22 are rotated under a condition of with a contrast from the rotation start angle position sa, which is the position deviated by angle φ e.g., deviated by 0.5° angle with respect to the rotation start angle position S, and the imaging is performed at imaging angle positions g1, g2, ..., gn, respectively, thereby acquiring, for example, 200 frames of the two-dimensional image data A2 with a contrast. The total 400 frames of the two-dimensional image data A1 without a contrast and A2 with a contrast have the same information as the ones obtained by taking the image of organs in the sample 1 at imaging angles of 400 directions. When there are two-dimensional image data of 400 imaging directions, the soft tissue image of the sample 1 can be obtained. When there are two-dimensional image data of 200 imaging directions, the blood vessel image of the sample 1 can be obtained. Accordingly, from the reconstruction with the use of each 200 frames of the two-dimensional image data A1 without a contrast and A2 with a contrast and the addition/subtraction calculation, the three-dimensional blood vessel image data 5, the three-dimensional soft tissue image data 3, and the three-dimensional soft tissue/blood vessel image data 34, of the sample 1 are acquired.

    [0057] As a result, only by performing the imaging of total 400 frames of 200 imaging without a contrast and 200 imaging with a contrast, the three-dimensional soft tissue image data 3, the blood vessel image data 5, and the soft tissue/blood vessel image data 34, of the sample 1 can be acquired. In this manner, the amount of X-ray exposure against the sample 1 can be reduced.

    [0058] Reduced number of frames of imaging can also reduce the imaging time. Thus, the technique can be more swiftly done. In addition, the risk of obtaining a low quality image due to the move of the sample 1 e.g., patient during perform imaging can be reduced by half when the imaging time is shortened.

    [0059] While subjecting the sample 1 to an operation, the three-dimensional soft tissue image of the sample 1 acquired by the X-ray imaging device is displayed on the monitor 23. When there is confirmed, for example, a bleeding in the sample 1 while observing the soft tissue image displayed on the monitor 23, a treatment to stop the bleeding is carried out. In this case, the operator may give a request to identify a bleeding blood vessel in the sample 1 and display the soft tissue/blood vessel image data 34 obtained by superimposing the blood vessel image data 5 and the soft tissue image data 3 on the monitor 23. The present device allows the display of the soft tissue/blood vessel image data 34 on the monitor 23, thereby meeting the request from the operator.

    [0060] Next, the second embodiment of the invention will be described with reference to the accompanying drawings. Since the device shown in FIG. 1 and FIG. 2 has a same configuration, a description thereof will be omitted.

    [0061] FIG. 4 is a functional block diagram illustrating an image acquisition of an X-ray imaging device, and particularly shows a specific configuration of the inter-image calculation unit 37. The inter-calculation unit 37 is provided with a noise reduction filter 43 and a low-frequency emphasis filter 44. The noise reduction filter 43 reduces a noise included in the blood vessel image 5. The noise reduction filter 43, for example, employs a median filter. The noise reduction filter 43 is not limited by the median filter, and various noise reduction filters can also be employed.

    [0062] The low-frequency emphasis filter 44 emphasizes a low-frequency component included in the three-dimensional soft tissue image data 3 outputted from the adder 40. In specific, the low-frequency emphasis filter 44 emphasizes a low-frequency component with the use of a relatively strong low-frequency emphasis filter for the body axis direction, and emphasizes a low-frequency component with the use of a relatively weak low-frequency emphasis filter for the Axial direction (cross section which is perpendicular to the body axis), in the soft tissue image data 3.

    [0063] Hereinbelow, the imaging operation with the device constructed in the above manner will be explained.

    [0064] As above, the imaging is performed at imaging angle positions f1, f2, ..., fn. Accordingly, 200 frames of the two-dimensional image data A1 without a contrast are acquired. Each imaging is performed at imaging angle positions g1, g2, ..., gn. Accordingly, 200 frames of the two-dimensional image data A2 with a contrast are acquired.

    [0065] The first reconstruction unit 35 reads out, for example, 200 frames of the two-dimensional image data A1 stored in the image storage unit 33, and allows the reconstruction with the use of two-dimensional image data A1, thereby acquiring the three-dimensional tissue image data 38 of the sample 1.

    [0066] The second reconstruction unit 36 allows the reconstruction with the use of, for example, 200 frames of the two-dimensional image data A2 acquired by giving a contrast to the sample 1, and acquires the three-dimensional tissue/blood vessel image data 39 including soft tissues and blood vessels of the sample 1.

    [0067] The inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 with the subtracter 41, and thus acquires the three-dimensional blood vessel image data 5. The blood vessel image data 5 has many noise components in the region other than the blood vessels. Thus, the noise reduction filter 43 reduces the noise component included in the blood vessel image data 5.

    [0068] Next, the inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the blood vessel image data 5 which has been subjected to the noise component reduction, with the subtracter 42, and acquires the tissue image data 47 showing tissues in the sample 1. The tissue image data 38 and the tissue image data 47 have information obtained from different imaging directions of imaging angle directions f1, f2, ..., fn, and imaging angle positions g1, g2, ..., gn, respectively. When the tissue image data 38 and the tissue image data 45 are added, a density resolution which can express soft tissues can be obtained.

    [0069] The inter-image calculation unit 37 adds the tissue image data 38 and the tissue image data 47 with the adder 40, and thus acquires the three-dimensional soft tissue image data 3. In addition, the low-frequency emphasis filter 44 emphasizes a low-frequency component with the use of a relatively strong low-frequency emphasis filter for the body axis direction, and emphasizes a low-frequency component with the use of a relatively weak low-frequency emphasis filter for the Axial direction, in the soft tissue image data 3.

    [0070] The inter-image calculation unit 37 adds the blood vessel image data 5 and the soft tissue image data 3 to acquire the three-dimensional soft tissue/blood vessel image data 34. These blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34, of the sample 1, are displayed on the monitor 23.

    [0071] According to the above-mentioned second embodiment, the blood vessel image data 5 for which the noise component is reduced, the soft tissue image data 3, and the soft tissue/blood vessel image data 34 can be acquired as well as achieving the same effect as in the first embodiment.

    [0072] The first and the second embodiments may also be modified as follows.

    [0073] In the first and the second embodiments, the imaging in the presence of a contrast is performed after performing the imaging without a contrast, but the imaging in the presence of a contrast may be performed before performing the imaging without a contrast. The contrast may be given by intra arterial injection or intravenous injection. After performing the imaging without a contrast, the imaging without a contrast may be re-performed.

    [0074] The number of imaging frames is mentioned as 200 frames without a contrast and 200 frames with a contrast, but may not be limited by this and may be changed to the number necessary for the examination, for example, 210 frames without a contrast and 210 frames with a contrast.

    [0075] The imaging is performed twice by performing the first rotary imaging without a contrast and the second rotary imaging with a contrast, but ,three or more rotary imaging may be performed in combination.

    [0076] FIG. 5A to FIG. 5C show one example of first to third rotary imaging. For the first rotary imaging shown in FIG. 5A, the imaging control unit 31 allows the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center under a condition of without a contrast, where start rotating from the rotation start angle position S to the rotation end angle position e within the imaging range of θ, and allows performing the imaging at every predetermined α stepped angles of equal distance such as at imaging angle positions k1, k2, ..., km. In this case, the imaging angle positions k1, k2, ..., km, for example, are 130 directions.

    [0077] For the second rotary imaging shown in FIG. 5B, the imaging control unit 31 allows performing the imaging without a contrast at imaging angle positions l1, l2, ..., ln, which are the position deviated by 1/3 of the angle α, angle (α/3), with respect to the rotation start angle position S for the case of without a contrast. In this case, the imaging angle positions l1, l2, ..., lm, for example, are 130 directions.

    [0078] For the third rotary imaging shown in FIG. 5C, the imaging control unit 31 allows performing the imaging with a contrast at imaging angle positions n1, n2, ..., nn, which are the position deviated by 2/3 of the angle α, angle (2α/3), with respect to the rotation start angle position S for the case of without a contrast. In this case, the imaging angle positions n1, n2, ..., nm, for example, are 130 directions.

    [0079] As a result, 260 frames without a contrast and 130 frames with a contrast can be acquired. A plurality of two-dimensional image data acquired by the first to third rotary imaging is obtained at equal distant imaging angle positions k1, l1, n1, k2, l2, n2, ..., km, lm, nm.

    [0080] FIG. 6A and FIG. 6B show rotary imaging which is performed by combining the first and the second rotary imaging shown in FIG. 5A and FIG. 5B. For the first rotary imaging shown in FIG. 6A, the imaging control unit 31 allows the rotation of the X-ray generation unit 21 and the X-ray detection unit 22 around the sample 1 as a rotation center under a condition of without a contrast, where start rotating from the rotation start angle position S to the rotation end angle position e within the imaging range of θ. The imaging control unit 31 allows performing the imaging at imaging angle positions k1, l1, k2, l2, ..., km, lm, which are at angle of irregular distance, during the rotation of the X-ray generation unit 21 and the X-ray detection unit 22. The imaging angle positions k1, l1, k2, l2, ..., km, lm, for example, are 260 directions. The imaging angle positions k1, l1, k2, l2, ..., km, lm are distant at irregular interval but the imaging angle positions k1 and l1, k2 and l2, ..., km and lm, are deviated by angle (α/3), respectively. The imaging angle positions l1 and k2, l2 and k3, ..., lm-1 and km, are deviated by angle (2α/3), respectively.

    [0081] FIG. 6B shows a second rotary imaging. For the second rotary imaging, the imaging control unit 31 allows performing the imaging with a contrast at imaging angle positions n1, n2, ..., nm, which are the position deviated by 2/3 of the angle α, angle (2α/3), with respect to the rotation start angle position S for the case of without a contrast. The imaging angle positions n1, n2, ..., nm, for example, are 130 directions.

    [0082] As a result, 260 frames of the two-dimensional image data without a contrast can be acquired. Also, 130 frames of the two-dimensional image data with a contrast can be acquired. A plurality of two-dimensional image data acquired by the first and second rotary imaging is obtained at equal distant imaging angle positions k1, l1, n1, k2, l2, n2, ..., km, lm, nm.

    [0083] Hereat, the first reconstruction unit 35 allows the reconstruction with the use of, for example, 260 frames of the two-dimensional image data obtained from the imaging at imaging angle positions k1, l1, k2, l2, ..., km, lm, of irregular interval so as to acquire the three-dimensional tissue image data of the sample 1. In the reconstruction, a correction is conducted to prevent the generation of an artifact.

    [0084] FIG. 7 shows a method of acquiring a two-dimensional image data. Herein, same symbols are given to the same parts as in FIG. 6A and FIG. 6B, and a detailed description thereof will be omitted. For the first rotary imaging, the imaging is performed under a condition of without a contrast at imaging angle positions k1, l1, k2, l2, ..., km, lm. Accordingly, 260 frames of the two-dimensional image data A3 without a contrast are acquired. From the first rotary imaging, without being limited to acquiring 260 frames of the two-dimensional image data A3, many of two-dimensional image data may also be acquired by performing the imaging at many imaging angle positions of narrower interval than the imaging interval of imaging angle positions k1, l2, k2, l2, ..., km, lm.

    [0085] For the second rotary imaging, the imaging is performed under a condition of with a contrast at imaging angle positions n1, n2, ..., nm. Accordingly, 130 frames of the two-dimensional image data A4 with a contrast are acquired.

    [0086] The first reconstruction unit 35 extracts a two-dimensional image data A3-1, for example, from 260 frames of the two-dimensional image data A3 without a contrast. The extracted two-dimensional image data A3-1 is combined with, for example, 130 frames of the two-dimensional image data A4 with a contrast, and as a result, an image data with imaging angle positions of equal interval is obtained.

    [0087] The first reconstruction unit 35 allows the reconstruction with the use of the extracted two-dimensional image data A3-1, and acquires the three-dimensional tissue image data 38 of the sample 1. The second reconstruction unit 36 allows the reconstruction with the use of, for example, 130 frames of the two-dimensional image data A4 acquired by giving a contrast to the sample 1, and acquires the three-dimensional tissue/blood vessel image data 39 including tissues and blood vessels of the sample 1. The subtracter 41 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38, and acquires the three-dimensional blood vessel image data 5. The calculation process of the image calculation unit 32 is same as above, thus the description thereof will be omitted.

    [0088] According to the first and the second embodiments, the X-ray generation unit 21 and the X-ray detection unit 22 rotated by the C arm 20 are all rotated in the arrowed W direction for the first to third rotary imaging. In this manner, it is easy to mechanically determine the position for the X-ray generation unit 21 and the X-ray detection unit 22 by the C arm 20, etc.

    [0089] The rotation of the X-ray generation unit 21 and the X-ray detection unit 22 may be a reciprocal movement of, for example, rotating in the arrowed W direction for the first rotary imaging and rotating in the Wa direction which is opposite to the arrowed W direction for the second rotary imaging, as shown in FIG. 8. In this manner, a total time taken for rotating the X-ray generation unit 21 and the X-ray detection unit 22 by the C arm 20 in the first and the second rotary imaging can be reduced.

    [0090] The rotation of the X-ray generation unit 21 and the X-ray detection unit 22 may be, for example, performed in the arrowed Wb direction by 200° for the first rotary imaging and in the arrowed Wc direction by 200° for the second rotary imaging, as shown in FIG. 9. Herein, the first rotary imaging is in the condition of without a contrast and the second rotary imaging is in the condition of with a contrast. The rotations are performed in the same axial plane. It is possible to extract a two-dimensional image data without a contrast from the plurality of two-dimensional image data acquired by the first rotary imaging and to extract a two-dimensional image data with a contrast which according to the invention are deviated by an angle from the plurality of two-dimensional image data acquired by the second rotary imaging, for example, deviated by 0.5° angle.

    [0091] The first rotary imaging and the second rotary imaging can be performed with the use of a floor-suspended arm and a ceiling-suspended arm in a biplane imaging device. For example, the first rotary imaging is performed by rotating the floor-suspended arm, and the second rotary imaging is performed by rotating the ceiling-suspended arm. For the X-ray imaging device shown in FIG. 1, the first rotary imaging is performed by rotating the second X-ray generation unit 21 and the second X-ray detection unit 22 due to the rotation of the C arm 20. The second rotary imaging is performed by rotating the first X-ray generation unit and the first X-ray detection unit due to the rotation of an Ω arm.

    [0092] The rotation of the C arm 20 for the first rotary imaging and the second rotary imaging may be performed by successively twice rotating in either an arrowed W direction or an arrowed Wa direction, as shown in FIG. 8.

    [0093] As shown in FIG. 10, a first rotation J1 of the X-ray generation unit 21 and the X-ray detection unit 22 in the first rotary imaging and a second rotation J2 of the X-ray generation unit 21 and the X-ray detection unit 22 in the second rotary imaging are performed in a same plane H1. Without being limited by this, as shown in FIG. 11, while the first rotation J1 is performed in the plane H1, the second rotation J2 may be performed in the plane H2 different from the plane H1. For the plane H1 and plane H2, the distance between the plane H1 and the plane H2 is known, and they are distanced only by the range capable of aligning two-dimensional image data acquired by the first rotation J1 with two-dimensional image data acquired by the second rotation J2.

    [0094] For displaying the blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34, of the sample 1 on the monitor 23, any one of the images may be displayed or all of the images may be displayed at the same time. The monitor 23 may display a desired image selected by the operator among the blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34. The monitor 23 may switch the display of the blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34 at every predetermined period.

    [0095] Next, the third embodiment of the invention will be described with reference to the accompanying drawings. Since the device shown in FIG. 1 and FIG. 2 has a same configuration, a description thereof will be omitted.

    [0096] FIG. 12 is a functional block diagram illustrating an image acquisition of an X-ray imaging device. The first reconstruction unit 35 reads out the plurality of two-dimensional image data A1 acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35 allows the reconstruction with the use of two-dimensional image data A1 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 38 of the sample 1. The first reconstruction unit 35 employs, as for the reconstruction filter, a filter such as Shepp & Logan and Ramachandran, which emphasizes a relatively high-frequency component.

    [0097] The second reconstruction unit 36 allows the reconstruction with the use of the plurality of two-dimensional image data A2 acquired by giving a contrast to the sample 1, by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue/blood vessel image data 39 including tissues and blood vessels of the sample 1. The second reconstruction unit 36 as in the first reconstruction unit 35 employs, as for the reconstruction filter, a filter such as Shepp & Logan and Ramachandran, which emphasizes a relatively high-frequency component.

    [0098] The subtracter (first calculation unit) 41 of the inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 to acquire the three-dimensional blood vessel image data 5.

    [0099] The blood vessel region-extraction unit (second calculation unit) 45 extracts the blood vessel region from the three-dimensional blood vessel image data 5 acquired with the subtracter 41. The blood vessel region-extraction unit 45 extracts the blood vessel region from the three-dimensional blood vessel mage data 5, for example, by binarization. The blood vessel image data 5 has a level difference between blood vessels and other tissues. Thus, for the blood vessel image data 5, only the blood vessels can be extracted on the basis of a preliminarily set threshold value.

    [0100] The blood vessel region-removal unit (second calculation unit) 46 removes the blood vessel region extracted by the blood vessel region-extraction unit 45 from the tissue/blood vessel image data 39 to acquire an incomplete tissue image data 47. The incomplete tissue image data 47 has information on the tissue region, but has no information on the blood vessel region.

    [0101] The addition/compensation unit (third calculation unit) 48 acquires information on the blood vessel region missed in the incomplete tissue image data 47 from the tissue image data 38, and compensates the acquired information on the blood vessel region to the incomplete tissue image data 47, to obtain a complete tissue image. The addition/compensation unit 48 adds the complete tissue image data 47 obtained by compensation and the tissue image data 38, and acquires the soft tissue image data 3.

    [0102] Hereinbelow, the reconstruction operation with the device constructed in the above manner will be explained.

    [0103] As in the above embodiment, the imaging is performed at imaging angle positions f1, f2, ..., fn. Accordingly, 200 frames of the two-dimensional image data A1 without a contrast are acquired. The imaging is also performed at imaging angle positions g1, g2, ..., gn. Accordingly, 200 frames of the two-dimensional image data A2 with a contrast are acquired.

    [0104] The first reconstruction unit 35 reads out the plurality of two-dimensional image data A1 acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35 allows the reconstruction with the use of two-dimensional image data A1 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 38 of the sample 1.

    [0105] The second reconstruction unit 36 allows the reconstruction with the use of the plurality of two-dimensional image data A2 acquired by giving a contrast to the sample 1, by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue/blood vessel image data 39 including tissues and blood vessels of the sample 1.

    [0106] The subtracter 41 of the inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 to acquire the three-dimensional blood vessel image data 5. Next, the blood vessel region-extraction unit 45 extracts the blood vessel region from the three-dimensional blood vessel image data 5 acquired with the subtracter 41, for example, by binarization. The blood vessel region-removal unit 46 removes the blood vessel region extracted by the blood vessel region-extraction unit 45 from the tissue/blood vessel image data 39 to acquire the incomplete tissue image data 47. Then, the addition/compensation unit 48 acquires information on the blood vessel region missed in the incomplete tissue image data 47 from the tissue image data 38. The addition/compensation unit 48 compensates the acquired information on the blood vessel region to the incomplete tissue image data 47, to obtain a complete tissue image. The addition/compensation unit 48 adds the complete tissue image data 47 obtained by compensation and the tissue image data 38, and acquires the soft tissue image data 3.

    [0107] The low-frequency emphasis filter 44 emphasizes a low-frequency component with the use of a relatively strong low-frequency emphasis filter for the body axis direction, and emphasizes a low-frequency component with the use of a relatively weak low-frequency emphasis filter for the Axial direction, in the soft tissue image data 3.

    [0108] The inter-image calculation unit 37 adds the blood vessel image data 5 and the soft tissue image data 3 to acquire the three-dimensional soft tissue/blood vessel image data 34. These blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34, of the sample 1, are displayed on the monitor 23.

    [0109] According to the above-mentioned third embodiment, there is no doubt about achieving the same effect as in the first embodiment. According to the third embodiment, since the blood vessel region-extraction unit 45 extracts the blood vessel region from the three-dimensional blood image data 5, for example, by binarization and the blood vessel region-removal unit 46 removes the extracted blood vessel region from the tissue/blood vessel image.data 39, the artifact effect in the blood vessel image data 5 can be reduced.

    [0110] Next, an example will be described with reference to the accompanying drawings. Since the device shown in FIG. 1 and FIG. 2 has a same configuration, a description thereof will be omitted.

    [0111] FIG. 13 is a functional block diagram illustrating an image acquisition of an X-ray imaging device. A noise reduction filter 49 reduces the noise in the three-dimensional blood vessel image data 5. The noise reduction filter 49, for example, employs a median filter. The noise reduction filter 49 is not limited by the median filter, and various noise reduction filters can also be employed.

    [0112] A projection unit 50 projects the three-dimensional blood vessel image data 5 to give a plurality of two-dimensional image data of blood vessels, i.e., 200 frames of the two-dimensional image data A5. The two-dimensional image data A5 of blood vessels is acquired by projecting at angles corresponding to imaging angle positions g1, g2, ..., gn for 200 frames of two-dimensional image data A2 which are imaged under a condition of with a contrast. That is, the two-dimensional image data A5 of blood vessels is acquired by projecting at imaging angle positions g1, g2, ..., gn, which are stepped by φ angle (= 1°), during the rotation performed within the imaging range of θ and start rotating from the rotation start angle position sa, which is the position deviated by φ/2 angle e.g., 0.5° angle with respect to the rotation start angle position S, to the rotation end angle position en.

    [0113] The subtracted (second calculation unit) 51 subtracts 200 frames of the two-dimensional image data A5 of blood vessels from the 200 frames of two-dimensional image data A2 which are imaged under a condition of with a contrast, and acquires 200 frames of a tissue image data A6.

    [0114] The third reconstruction unit 52 allows the reconstruction with the use of 200 frames of the tissue image data A6 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires a three-dimensional tissue image data 53 including tissues of the sample 1. The third reconstruction unit 52 as in the first reconstruction unit 35 employs, as for the reconstruction filter, a filter such as Shepp & Logan and Ramachandran, which emphasizes a relatively high-frequency component.

    [0115] The adder (third calculation unit) 54 adds the three-dimensional tissue image data 53 acquired by the third reconstruction unit 52 and the three-dimensional tissue image data 38 acquired by the first reconstruction unit 35, to acquire the three-dimensional soft tissue image data 3.

    [0116] Hereinbelow, the reconstruction operation with the device constructed in the above manner will be explained.

    [0117] As in the above example, the imaging is performed at imaging angle positions f1, f2, ..., fn. Accordingly, 200 frames of the two-dimensional image data A1 without a contrast are acquired. The imaging is also performed at imaging angle positions g1, g2, ..., gn. Accordingly, 200 frames of the two-dimensional image data A2 with a contrast are acquired.

    [0118] The first reconstruction unit 35 reads out the plurality of two-dimensional image data A1 acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35 allows the reconstruction with the use of two-dimensional image data A1 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 38 of the sample 1.

    [0119] The second reconstruction unit 36 allows the reconstruction with the use of the plurality of two-dimensional image data A2 acquired by giving a contrast to the sample 1, by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue/blood vessel image data 39 including tissues and blood vessels of the sample 1.

    [0120] The subtracter 41 of the inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 to acquire the three-dimensional blood vessel image data 5. Next, the noise reduction filter 49 reduces the noise in the three-dimensional blood vessel image data 5, and then sends to the projection unit 50.

    [0121] The projection unit 50 inputs the noise reduced three-dimensional blood vessel image data 5, and projects the three-dimensional blood vessel image data 5 to give a plurality of two-dimensional image data of blood vessels, i.e., 200 frames of the two-dimensional image data A5. The two-dimensional image data A5 of blood vessels is acquired in the same manner as above such as by projecting at angles corresponding to imaging angle positions g1, g2, ..., gn for 200 frames of two-dimensional image data A2 which are imaged under a condition of with a contrast.

    [0122] The subtracter 51 subtracts 200 frames of the two-dimensional image data A5 of blood vessels from the 200 frames of two-dimensional image data A2 which are imaged under a condition of with a contrast, and acquires 200 frames of the tissue image data A6.

    [0123] The third reconstruction unit 52 allows the reconstruction with the use of 200 frames of the tissue image data A6 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 53 including tissues of the sample 1.

    [0124] The adder 54 adds the three-dimensional tissue image data 53 acquired by the third reconstruction unit 52 and the three-dimensional tissue image data 38 acquired by the first reconstruction unit 35, to acquire the three-dimensional soft tissue image data 3.

    [0125] The low-frequency emphasis filter 44 emphasizes a low-frequency component with the use of a relatively strong low-frequency emphasis filter for the body axis direction, and emphasizes a low-frequency component with the use of a relatively weak low-frequency emphasis filter for the Axial direction, in the three-dimensional soft tissue image data 3.

    [0126] Next, the inter-image calculation unit 37 adds the blood vessel image data 5 and the soft tissue image data 3 to acquire the three-dimensional soft tissue/blood vessel image data 34. These blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34, of the sample 1, are displayed on the monitor 23.

    [0127] According to the above, a plurality of the two-dimentional image data A5 of blood vessels is acquired by projecting the three-dimensional blood vessel image data 5, the tissue image data A6 is acquired from the difference between the two-dimensional image data A5 of blood vessels and two-dimensional image data A2 imaged under a contrast, and then the three-dimensional tissue image data 53 is acquired by performing the reconstruction with the use of the tissue image data A6. In this manner, the artifact effect in the blood vessel image data 5 can be reduced as the addition from many directions is achieved at the time of the reconstruction.

    [0128] Next, an example will be described with reference to the accompanying drawings. Since the device shown in FIG. 1 and FIG. 2 has a same configuration, a description thereof will be omitted.

    [0129] FIG. 14 is a functional block diagram illustrating an image acquisition of an X-ray imaging device. The first reconstruction unit 35 is provided with a first reconstruction unit 35a and a first reconstruction unit 35b. The first reconstruction unit 35a reads out the plurality of two-dimensional image data A1 acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35a allows the reconstruction with the use of two-dimensional image data A1 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 38 of the sample 1.

    [0130] The first reconstruction unit 35b employs, as for the reconstruction filter, a filter such as Shepp & Logan and Ramachandran, which emphasizes a relatively high-frequency component, and a low-frequency emphasis filter which emphasizes a low-frequency component.

    [0131] The third reconstruction unit 52 allows the reconstruction with the use of 200 frames of the tissue image data A6 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 53 including tissues of the sample 1. The third reconstruction unit 52 as in the first reconstruction unit 35 employs, as for the reconstruction filter, a low-frequency component filter emphasizing a low-frequency component.

    [0132] Hereinbelow, the reconstruction operation with the device constructed in the above manner will be explained.

    [0133] As in the above example, the imaging is performed at imaging angle positions f1, f2, ..., fn. Accordingly, 200 frames of the two-dimensional image data A1 without a contrast are acquired. The imaging is also performed at imaging angle positions g1, g2, ..., gn. Accordingly, 200 frames of the two-dimensional image data A2 with a contrast are acquired.

    [0134] The first reconstruction unit 35a reads out the plurality of two-dimensional image data A1 acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35a allows the reconstruction with the use of two-dimensional image data A1 and a filter emphasizing a high-frequency component, and the three-dimensional tissue image data 38 of the sample 1 is acquired.

    [0135] In addition, the first reconstruction unit 35b reads out the plurality of two-dimensional image data A1 acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35b allows the reconstruction with the use of two-dimensional image data A1 and a filter emphasizing a low-frequency component, and the three-dimensional tissue image data 55 of the sample 1 is acquired.

    [0136] The second reconstruction unit 36 allows the reconstruction with the use of the plurality of two-dimensional image data A2 acquired by giving a contrast to the sample 1, and acquires the three-dimensional tissue/blood vessel image data 39 including tissues and blood vessels of the sample 1.

    [0137] The subtracter 41 of the inter-image calculation unit 37 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 to acquire the three-dimensional blood vessel image data 5. Next, the noise reduction filter 49 reduces the noise in the three-dimensional blood vessel image data 5, and then sends to the projection unit 50. The projection unit 50 projects the three-dimensional blood vessel image data 5 to give a plurality of two-dimensional image data of blood vessels, i.e., 200 frames of the two-dimensional image data A5. The subtracter 51 subtracts 200 frames of the two-dimensional image data A5 of blood vessels from the 200 frames of two-dimensional image data A2 which are imaged under a condition of with a contrast, and acquires 200 frames of the tissue image data A6.

    [0138] The third reconstruction unit 52 allows the reconstruction with the use of 200 frames of the tissue image data A6 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 53 including tissues of the sample 1.

    [0139] The adder 54 adds the three-dimensional tissue image data 53 acquired by the third reconstruction unit 52 and the three-dimensional tissue image data 55 reconstructed by the first reconstruction unit 35, to acquire the three-dimensional soft tissue image data 3.

    [0140] The inter-image calculation unit 37 adds the blood vessel image data 5 and the soft tissue image data 3 to acquire the three-dimensional soft tissue/blood vessel image data 34. These blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34, of the sample 1, are displayed on the monitor 23.

    [0141] According to the above, the first reconstruction unit 35 allows the reconstruction with the use of the two-dimensional image data A1 and a filter emphasizing a low-frequency component to acquire the three-dimensional tissue image data 55 of the sample 1. Accordingly, there is no need for the low-frequency emphasis filter 44 to be provided for after the reconstruction.

    [0142] Next, an example will be described with reference to the accompanying drawings. Since the device shown in FIG. 1 and FIG. 2 has a same configuration, a description thereof will be omitted.

    [0143] FIG. 15 is a functional block diagram illustrating an image acquisition of an X-ray imaging device. An integrator 55 is connected on the output side of the subtracter 51. The integrator 55 inputs 200 frames of the tissue image data A6 outputted from the subtracter 51, which is the difference between 200 frames of two-dimensional image data A2 imaged with a contrast and 200 frames of the two-dimensional image A5 of blood vessels. The integrator 55 combines the tissue image data A6 and the two-dimensional image data A1 to acquire 400 frames of a two-dimensional tissue image data A7.

    [0144] The third reconstruction unit 52 allows the reconstruction with the use of 400 frames of the tissue image data A7 by applying the reconstruction theory such as Feldkamp method, or the like, and acquires the three-dimensional tissue image data 3 including tissues of the sample 1. The third reconstruction unit 52 employs, as for the reconstruction filter, a low-frequency filter which emphasizes a low-frequency component.

    [0145] Hereinbelow, the reconstruction operation with the device constructed in the above manner will be explained.

    [0146] As in the above embodiment, the imaging is performed at imaging angle positions f1, f2, ..., fn. Accordingly, 200 frames of the two-dimensional image data A1 without a contrast are acquired. The imaging is also performed at imaging angle positions g1, g2, ..., gn. Accordingly, 200 frames of the two-dimensional image data A2 with a contrast are acquired.

    [0147] The first reconstruction unit 35 reads out the plurality of two-dimensional image data A1 acquired by giving no contrast to the sample 1, from the image storage unit 33. The first reconstruction unit 35 allows the reconstruction with the use of two-dimensional image data A1 and a filter emphasizing a high-frequency component, and acquires the three-dimensional tissue image data 38 of the sample 1.

    [0148] The second reconstruction unit 36 allows the reconstruction with the use of the plurality of two-dimensional image data A2 acquired by giving a contrast to the sample 1 and a filter emphasizing a high-frequency component, and acquires the three-dimensional tissue/blood vessel image data 39 including tissues and blood vessels of the sample 1.

    [0149] The subtracter 41 calculates the difference between the tissue/blood vessel image data 39 and the tissue image data 38 to acquire the three-dimensional blood vessel image data 5. Next, the noise reduction filter 49 reduces the noise in the three-dimensional blood vessel image data 5, and then sends to the projection unit 50. The projection unit 50 projects the three-dimensional blood vessel image data 5 to give a plurality of two-dimensional image data of blood vessels, i.e., 200 frames of the two-dimensional image data A5. The subtracter 51 subtracts 200 frames of the two-dimensional image data A5 of blood vessels from the 200 frames of two-dimensional image data A2 which are imaged under a condition of with a contrast, and acquires 200 frames of the tissue image data A6.

    [0150] The integrator 55 inputs 200 frames of the tissue image data A6 outputted from the subtracter 51, which is the difference between 200 frames of two-dimensional image data A2 imaged with a contrast and 200 frames of the two-dimensional image A5 of blood vessels. The integrator 55 combines the tissue image data A6 and the two-dimensional image data A1 to acquire 400 frames of the two-dimensional tissue image data A7.

    [0151] The third reconstruction unit 52 allows the reconstruction with the use of 400 frames of the two-dimensional tissue image data A7 and a low-frequency filter emphasizing a low-frequency component, and acquires the three-dimensional image data 3 including tissues of the sample 1.

    [0152] The inter-image calculation unit 37 adds the blood vessel image data 5 and the soft tissue image data 3 to acquire the three-dimensional soft tissue/blood vessel image data 34. These blood vessel image data 5, the soft tissue image data 3, and the soft tissue/blood vessel image data 34, of the sample 1, are displayed on the monitor 23.

    [0153] According to the above-mentioned example, there is no doubt about achieving the same effect as in the first embodiment. According to the example, before performing the reconstruction, 200 frames of the tissue image data A6, which is the difference between two-dimensional image data A2 imaged with a contrast and the two-dimensional image A5 of blood vessels, are inputted, and the two-dimensional tissue image data A7 is acquired by combining the tissue image data A6 and the two-dimensional image data A1. The reconstruction is performed with the use of the two-dimensional tissue image data A7 and a low-frequency filter emphasizing a low-frequency component to acquire the three-dimensional tissue image data 3. In this manner, the same effect as in the first embodiment is achieved without a doubt, and the low-frequency emphasis filter 44 is not necessarily provided for after the reconstruction.

    [0154] Next, an example will be described with reference to the accompanying drawings. Since the device shown in FIG. 1 and FIG. 2 has a same configuration, a description thereof will be omitted.

    [0155] FIG. 16 is a flow diagram illustrating an application of an image acquisition for a navigation surgery. For an X-ray imaging device, any of X-ray imaging devices described in the first to third embodiment can be employed. Herein, a display example of a surgical instrument 56 for approaching a soft tissue lesion G such as cancer in the sample 1 will be described.

    [0156] In a state that the surgical instrument 56 is not inserted into the sample 1 and a contrast agent is not injected into the sample 1, the imaging at imaging angle positions (first angle) f1; f2, ..., fn is performed as in the above manner. Accordingly, 200 frames of the two-dimensional image data without a contrast are acquired. The first reconstruction unit 35 allows the reconstruction with the use of the plurality of two-dimensional image data acquired by giving no contrast to the sample 1, and acquires a three-dimensional tissue image data (first reconstruction image) 57 of the sample 1. The tissue image data 57 shows the soft tissue lesion G. The tissue image data 57 is, for example, stored in the image storage unit 33.

    [0157] Next, in a state that the surgical instrument 56 is inserted into the sample 1 and still the contrast agent is not injected into the sample 1, the imaging at imaging angle positions (second angle which is deviated from the first angle) g1, g2, ..., gn is performed. Accordingly, 200 frames of a two-dimensional image data without a contrast are acquired. The second reconstruction unit 36 allows the reconstruction with the use of 200 frames of two-dimensional image data acquired by giving no contrast to the sample 1, and acquires a three-dimensional soft tissue/instrument image data (second reconstruction image) 56 of the sample 1. On the soft tissue/instrument image data 58, the surgical instrument 56 for approaching the soft tissue lesion G is imaged.

    [0158] The inter-image calculation unit 37 carries out an inter-calculation between the tissue image data 57 reconstructed by the first reconstruction unit 35 and the soft tissue/instrument image data 58 reconstructed by the second reconstruction unit 36, and thus acquires a three-dimensional soft tissue image data 59 and a three-dimensional soft tissue/instrument image data 60.

    [0159] The approach of the surgical instrument 56 in the sample 1 is further processed, and the contrast agent is not injected into the sample 1. In this state, the imaging at imaging angle positions g1, g2, ..., gn is again performed. Accordingly, 200 frames of a two-dimensional image data without a contrast are acquired. The second reconstruction unit 36 allows the reconstruction with the use of 200 frames of the two-dimensional image data acquired by giving no contrast to the sample 1, and acquires a three-dimensional soft tissue/instrument image data (second reconstruction image) 61 of the sample 1. On the soft tissue/instrument image data 61, the surgical instrument 56 which is further inserted to the sample 1 is imaged.

    [0160] The inter-calculation unit 37 reads out the tissue image data 57 stored in the image storage unit 33. The inter-image calculation unit 37 carries out an inter-calculation between the tissue image data 57 and the soft tissue/instrument image data 61 reconstructed by the second reconstruction unit 36, and thus acquires a three-dimensional soft tissue image data 62 and a three-dimensional soft tissue/instrument image data 63.

    [0161] The approach of the surgical instrument 56 in the sample 1 is further processed, and the contrast agent is not injected into the sample 1. In this state, the imaging at imaging angle positions g1, g2, ..., gn is again performed. Accordingly, 200 frames of a two-dimensional image data without a contrast are acquired. The second reconstruction unit 36 allows the reconstruction with the use of 200 frames of the two-dimensional image data acquired by giving no contrast to the sample 1, and acquires a three-dimensional soft tissue/instrument image data (second reconstruction image) 64 of the sample 1. On the soft tissue/instrument image data 64, the surgical instrument 56 which is further inserted to the sample 1 is imaged.

    [0162] The inter-image calculation unit 37 again reads out the tissue image data 57 stored in the image storage unit 33. The inter-image calculation unit 37 carries out an inter-calculation between the tissue image data 57 and the soft tissue/instrument image data 64 reconstructed by the second reconstruction unit 36, and thus acquires a three-dimensional soft tissue image data 65 and a three-dimensional soft tissue/instrument image data 66.

    [0163] The approach of the surgical instrument 56 into the sample 1 and the imaging at imaging angle positions g1, g2, ···, gn are repeatedly carried out. Accordingly, the three-dimensional soft tissue image data 59, 62, and 65, and the three-dimensional soft tissue/instrument image data 60, 63, and 66 imaging the surgical instrument 56 inserted into the sample 1, are acquired.

    [0164] According to the example, the tissue image data 57 showing the soft tissue lesion G, which is acquired by imaging at imaging angle positions f1, f2, ..., fn under conditions of not introducing the surgical instrument 56 and not injecting a contrast agent into the sample 1, is stored in the image storage unit 33. Thereafter, soft tissue/instrument image data 58, 61, and 64 are acquired by several times performing the imaging at imaging angle positions g1, g2, ..., gn, with a time interval. The reconstruction of each of the soft tissue/instrument image data 58, 61, and 64 with the tissue image data 57 is performed, respectively. Accordingly, three-dimensional soft tissue image data 59, 62, and 65 and three-dimensional soft tissue/instrument image data 60, 63, and 66, are acquired.

    [0165] As a result, a positional relationship between the surgical instrument 56 for approaching the sample 1 and soft tissues can be confirmed in three dimensions. The tissue image data 57 showing the soft tissue lesion G is acquired by performing the initial imaging at imaging angle positions f1, f2, ..., fn, and then stored in the image storage unit 33. In this manner, the imaging at imaging angle positions f1, f2, ..., fn can be omitted from the second round performance. Therefore, the imaging can be carried out only at imaging angle positions g1, g2, ..., gn. The time required for acquiring each of three-dimensional soft tissue/instrument image data 60, 63, and 66 can be reduced.

    [0166] It is explicitly stated that all features disclosed in the description and/or the claims are intended to be disclosed separately and independently from each other for the purpose of original disclosure as well as for the purpose of restricting the claimed invention independent of the compositions of the features in the embodiments and/or the claims. It is explicitly stated that all value ranges or indications of groups of entities disclose every possible intermediate value or intermediate entity for the purpose of original disclosure as well as for the purpose of restricting the claimed invention, in particular as limits of value ranges.


    Claims

    1. An X-ray imaging device comprising:

    an X-ray generation unit (21) adapted to emit X-rays to a sample;

    an X-ray detection unit (22) adapted to detect the amount of X-rays passing through the sample;

    an imaging control unit (31) which two or more times rotates the X-ray generation unit (21) and the X-ray detection unit (22) around the sample as a rotation center and imaging the sample at a plurality of rotation angles different from each other during the rotations; and

    an image calculation unit (32) adapted to acquire a three-dimensional image of the sample by performing a calculation process including at least a reconstruction based on the plurality of two-dimensional images which are acquired by performing imaging during the rotations of the X-ray generation unit (21) and the X-ray detection unit (22),

    the image calculation unit (32) includes:

    a first reconstruction unit (35) adapted to acquire a three-dimensional tissue image (38) of the sample by performing a reconstruction based on the two-dimensional images acquired from the sample without a contrast agent,a second reconstruction unit (36) adapted to acquire a three-dimensional tissue/blood vessel image 39 including tissues and blood vessels of the sample by performing a reconstruction based on the two-dimensional images acquired from the sample with a contrast agent, and

    an inter-image calculation unit (37) adapted to acquire a three-dimensional soft tissue image (3), a three-dimensional soft tissue/blood vessel image (34), and a three-dimensional blood vessel image (5), by performing an inter-calculation between the three-dimensional tissue image and the three-dimensional tissue/blood vessel image,

    wherein the inter-image calculation unit (37) includes:

    a first calculation unit (41) adapted to acquire the three-dimensional blood vessel image (5) from the difference between the three-dimensional tissue image (38) and the three-dimensional tissue/blood vessel image (39);

    a second calculation unit (42) adapted to acquire a three-dimensional tissue image (47) from the difference between the three-dimensional blood vessel image (5) acquired by the first calculation unit (41) and the three-dimensional tissue/blood vessel (39) image acquired by the second reconstruction unit (36);

    a third calculation unit (40) adapted to acquire the three-dimensional soft tissue image (3) by adding the three-dimensional tissue image (47) acquired by the second calculation unit (42) and the three-dimensional tissue image (38) acquired by the first reconstruction unit (35); and

    a fourth calculation unit (37) adapted to acquire the three-dimensional soft tissue/blood vessel image (34) by adding the three-dimensional blood vessel image (5) acquired by the first calculation unit (41) and the three-dimensional soft tissue image (3) acquired by the third calculation unit (40).


     
    2. The X-ray imaging device of claim 1, wherein the imaging control unit (31) is adapted to control rotation of the X-ray generation unit (21) and the X-ray detection unit (22) to different imaging angles during the two-dimensional imaging, and wherein the image calculation unit (32) is adapted to acquire the three-dimensional image of the sample on the basis of a plurality of two-dimensional images without a contrast agent and a plurality of two-dimensional images with a contrast agent acquired under the control of the imaging control unit (31).
     
    3. The X-ray imaging device according to claim 2, wherein the imaging control unit (31) is adapted to control the X-ray generation unit (21) and the X-ray detection unit (22) to set angle steps of the two-dimensional images without a contrast agent and the two-dimensional images with a contrast agent to be different from each other.
     
    4. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) sets rotation start angles and rotation end angles to be different in the two or more rotations of the X-ray generation unit (21) and the X-ray detection unit (22).


     
    5. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) images the sample by constant rotation angles during the two or more rotations.


     
    6. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) sets the number of imaging copies of the sample to be constant during the two or more rotations.


     
    7. The X-ray imaging device according to claim 1,
    characterized in that the imaging control unit (31) images while two or more times rotating the X-ray generation unit (21) and the X-ray detection unit (22), and sets the imaging angles for performing the imaging to be constant.
     
    8. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) two or more times rotates the X-ray generation unit (21) and the X-ray detection unit (22) in the same rotation direction.


     
    9. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) two or more times rotates the X-ray generation unit (21) and the X-ray detection unit (22) in planes different from each other in the acceptable range.


     
    10. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) several times rotates the X-ray generation unit (21) and the X-ray detection unit (22) and performs imaging at rotation angles of irregular interval, and sets the final imaging angles to be constant.


     
    11. The X-ray imaging device according to claim 1, characterized in that: ,

    the imaging control unit (31) performs imaging by at least twice rotating the X-ray, generation unit (21) and the X-ray detection unit (22), and

    wherein the image calculation unit (32) extracts the two-dimensional images giving constant imaging angles, from a plurality of two-dimensional images acquired by performing the imaging.


     
    12. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) at least once rotates the X-ray generation unit (21) and the X-ray detection unit (22) in each case of the sample with a contrast agent and without a contrast agent.


     
    13. The X-ray imaging device according to claim 1, characterized in that:

    the imaging control unit (31) several times rotates the X-ray generation unit (21) and the X-ray detection unit (22), where at least one rotation is performed under a sample with a contrast agent.


     
    14. The X-ray imaging device according to claim 1, characterized by further comprising a C arm provided with the X-ray generation unit (21) and the X-ray detection unit (22) facing to each other,
    wherein the imaging control unit (31) at least twice rotates the C arm.
     
    15. The X-ray imaging unit according to claim 1, characterized in that:

    the imaging control unit (31) at least twice rotates the X-ray generation unit (21) and the X-ray detection unit (22) in each case of the sample without a contrast agent and the sample inserted with an instrument.


     
    16. The X-ray imaging device according to claim 1, characterized by further comprising a low-frequency component emphasis filter adapted to emphasize a low-frequency component of the soft tissue image acquired by the third calculation unit.
     
    17. An X-ray imaging method comprising the steps of:

    at least twice rotating an X-ray generation unit (21) and an X-ray detection unit (22) around a sample as a rotation center by a computer processing;

    imaging the sample at a plurality of rotation angles different from each other during the rotations;

    acquiring a plurality of two-dimensional images by performing the imaging during the rotations; and

    acquiring at least a three-dimensional image of the sample by conducting a calculation process which at least includes performing a first reconstruction based on the plurality of two-dimensional images,

    acquiring the three-dimensional tissue image (38) of the sample by performing a first reconstruction based on the two-dimensional images acquired from the sample without a contrast agent,

    acquiring a three-dimensional tissue/blood vessel image (39) including tissues and blood vessels of the sample by performing a second reconstruction based on the two-dimensional images acquired from the sample with a contrast agent, and

    acquiring a three-dimensional soft tissue image (3), a three-dimensional blood vessel image (5) and a three-dimensional soft tissue/blood vessel image (34) by performing an inter-calculation between the three-dimensional tissue image (38) and the three-dimensional tissue/blood vessel image (39), wherein performing the inter-calculation comprises:

    acquiring the three-dimensional blood vessel image (5) from the difference between the three-dimensional tissue image (38) and the three-dimensional tissue/blood vessel image (39) by a first calculation;

    acquiring a three-dimensional tissue image (47) from the difference between the three-dimensional blood vessel image (5) being calculated by the first calculation and the three-dimensional tissue/blood vessel image (39) being acquired by the second reconstruction, by a second calculation;

    acquiring the three-dimensional soft tissue image (3) by adding the three-dimensional tissue image (47) being acquired by the second calculation and the three-dimensional tissue image (38) acquired by the first reconstruction, by a third calculation; and

    acquiring the three-dimensional soft tissue/blood vessel image (34) by adding the three-dimensional blood vessel image (5) being acquired by the first calculation and the three-dimensional soft tissue image (3) acquired by the third calculation.


     
    18. The X-ray imaging method according to claim 17, characterized in that:

    the two or more rotations of the X-ray generation unit (21) and the X-ray detection unit (22) are performed in the same plane.


     
    19. The X-ray imaging method according to claim 17, characterized in that:

    the two or more rotations set rotation start angles and rotation end angles to be different.


     
    20. The X-ray imaging method according to claim 17, characterized in that:

    the imaging of the sample during the two or more rotations is performed by constant rotation angles.


     
    21. The X-ray imaging method according to claim 17, characterized in that:

    the number of imaging copies of the sample during the two or more rotations is constant.


     
    22. The X-ray imaging method according to claim 17, characterized in that:

    the imaging angles for performing the imaging while two or more times rotating the X-ray generation unit (21) and the X-ray detection unit (22) are set to be constant.


     
    23. The X-ray imaging method according to claim 17, characterized in that:

    the two or more rotations of the X-ray generation unit (21) and the X-ray detection unit (22) are performed in the same rotation direction.


     
    24. The X-ray imaging method according to claim 17, characterized in that:

    for the X-ray generation unit (21) and the X-ray detection unit (22), rotation start angles for the two or more rotations are set to be different from each other.


     
    25. The X-ray imaging method according to claim 17, characterized in that:

    the two or more rotations of the X-ray generation unit (21) and the X-ray detection unit (22) are performed in planes different from each other in the acceptable range.


     
    26. The X-ray imaging method according to claim 17, characterized in that:

    the X-ray generation unit (21) and the X-ray detection unit (22) are several times rotated and the imaging by rotation at every stepped angles of irregular interval is performed, and the final imaging angles are set to be constant.


     
    27. The X-ray imaging method according to claim 17, characterized in that:

    the X-ray generation unit (21) and the X-ray detection unit (22) are at least once rotated in each case of the sample with a contrast agent and without a contrast agent.


     
    28. The X-ray imaging method according to claim 17, characterized in that:

    the rotation of the X-ray generation unit (21) and the X-ray detection unit (22) is performed several times, where at least one rotation is performed under a sample with a contrast agent.


     


    Ansprüche

    1. Röntgenstrahlenbildgebungsvorrichtung mit:

    einer Röntgenstrahlenerzeugungseinheit (21), die dazu ausgebildet ist, Röntgenstrahlung auf eine Probe einzustrahlen,

    einer Röntgenstrahlenerkennungseinheit (22), die dazu ausgebildet ist, die Menge an Röntgenstrahlen, die durch die Probe treten, zu detektieren,

    einer Bildgebungssteuerungseinheit (31), die zweimal oder mehrmals die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) um die Probe als ein Rotationszentrum rotiert und die Probe von einer Mehrzahl von Rotationswinkeln abbildet, die sich voneinander während der Rotationen unterscheiden, und

    einer Bildberechnungseinheit (32), die dazu ausgebildet ist, ein dreidimensionales Bild der Probe durch Durchführen eines Berechnungsvorgangs mit mindestens einer Rekonstruktion basierend auf der Mehrzahl von zweidimensionalen Bildern, die durch das Durchführen des Bildgebens während den Rotationen der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) gewonnen wurden, zu gewinnen,

    die Bildberechnungseinheit (32) weist auf

    eine erste Rekonstruktionseinheit (35), die dazu ausgebildet ist, ein dreidimensionales Gewebebild (38) der Probe durch Durchführen einer Rekonstruktion basierend auf den zweidimensionalen Bildern, die von der Probe ohne Kontrastmittel gewonnen wurden, zu gewinnen, einer zweiten Rekonstruktion Einheit (36), die dazu ausgebildet ist, ein dreidimensionales GewebeBlutgefäßbild (39) mit Gewebe und Blutgefäßen der Probe durch Durchführen einer Rekonstruktion basierend auf den zweidimensionalen Bildern, die von der Probe mit einem Kontrastmittel gewonnen wurden, zu gewinnen, und

    eine Zwischenbildberechnungseinheit (37), die dazu ausgebildet ist, ein dreidimensionales Weichgewebebild (3), ein dreidimensionales WeichgewebeBlutgefäßbild (34) und ein dreidimensionales Blutgefäßbild (5) durch Durchführen einer Zwischenberechnung zwischen dem dreidimensionalen Gewebebild und dem dreidimensionalen GewebeBlutgefäßbild zu gewinnen,

    wobei die Zwischenbildberechnungseinheit (37) aufweist

    eine erste Berechnungseinheit (41), die dazu ausgebildet ist, das dreidimensionale Blutgefäßbild (5) aus der Differenz zwischen dem dreidimensionalen Gewebebild (38) und dem dreidimensionalen GewebeBlutgefäßbild (39) zu gewinnen,

    eine zweite Berechnungseinheit (42), die dazu ausgebildet ist, ein dreidimensionales Gewebebild (47) aus der Differenz zwischen dem dreidimensionalen Blutgefäßbild (5), welches von der ersten Berechnungseinheit (41) gewonnen wurde, und dem dreidimensionalen Gewebe/Blutgefäßbild (39), welches von der zweiten Rekonstruktionseinheit (36) gewonnen wurde, zu gewinnen,

    eine dritte Berechnungseinheit (40), die dazu ausgebildet ist, das dreidimensionale Weichgewebebild (3) durch Zusammenzählen des dreidimensionalen Gewebebildes (47), welches von der zweiten Berechnungseinheit (42) gewonnen wurde, und des dreidimensionalen Gewebebildes (38), welches von der ersten Rekonstruktionseinheit (35) gewonnen wurde, zu gewinnen, und

    eine vierte Berechnungseinheit (37), die dazu ausgebildet ist, das dreidimensionale Weichgewebe/Blutgefäßbild (34) durch Zusammenzählen des dreidimensionalen Blutgefäßbildes (5), welches von der ersten Berechnungseinheit (41) gewonnen wurde, und des dreidimensionalen Weichgewebebildes (3), welches von der dritten Berechnungseinheit (40) gewonnen wurde, zu gewinnen.


     
    2. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, wobei die Bildgebungssteuerungseinheit (31) dazu ausgebildet ist, die Rotation der Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) zu unterschiedlichen Bildgebungswinkeln während der zweidimensionalen Bildgebung anzusteuern, und wobei die Bildberechnungseinheit (32) dazu ausgebildet ist, das dreidimensionale Bild der Probe auf Basis einer Mehrzahl von zweidimensionalen Bildern ohne Kontrastmittel und einer Mehrzahl von zweidimensionalen Bildern mit Kontrastmittel, die unter der Steuerung der Bildgebungssteuerungseinheit (31) gewonnen wurden, zu gewinnen.
     
    3. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 2, wobei die Bildgebungssteuerungseinheit (31) dazu ausgebildet ist, die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlendetektionseinheit (22) zum Einstellen von Winkelschritten der zweidimensionalen Bilder ohne Kontrastmittel und der zweidimensionalen Bilder mit Kontrastmittel derart anzusteuern, dass diese sich unterscheiden.
     
    4. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) die Rotationsstartwinkel und die Rotationsendwinkel derart einstellt, dass diese sich in zwei oder mehreren Rotationen der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) unterscheiden.
     
    5. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) die Probe mit konstanten Rotationswinkeln während der zwei oder mehreren Rotationen abbildet.
     
    6. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) einstellt, dass die Anzahl der Bildgebungskopien der Probe während den zwei oder mehreren Rotationen konstant sind.
     
    7. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) eine Bildgegung durchführt, während die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) zweimal oder mehrmals rotieren, und die Bildgebungswinkel zum Durchführen der Bildgebung konstant einstellt.
     
    8. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) zweimal oder mehrmals die Röntgenstrahlenzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) in die gleiche Rotationsrichtung rotiert.
     
    9. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) zweimal oder mehrmals die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) in voneinander unterschiedlichen Ebenen in dem akzeptierten Bereich rotiert.
     
    10. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) mehrere Male die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) rotiert und Bildgebung bei Rotationswinkeln von irregulärem Interval durchführt und die finalen Bildgebungswinkel konstant einstellt.
     
    11. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) Bildgebung durch mindestens zweimaliges Rotieren der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) durchführt und
    wobei die Bildberechnungseinheit (32) die zweidimensionalen Bilder bei konstant gegebenen Bildgebungswinkeln extrahiert aus einer Mehrzahl von zweidimensionalen Bildern, die durch Durchführen der Bildgebung gewonnen wurden.
     
    12. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) mindestens einmal die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) in jedem Fall der Probe mit einem Kontrastmittel und ohne einem Kontrastmittel rotiert.
     
    13. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Bildgebungssteuerungseinheit (31) mehrmals die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) rotiert, wobei mindestens eine Rotation für eine Probe mit einem Kontrastmittel durchgeführt wird.
     
    14. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Röntgenstrahlenbildgebungsvorrichtung ferner einen C-Arm mit der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) aufweist, die aufeinander gerichtet sind,
    wobei die Bildgebungssteuerungseinheit (31) den C-Arm mindestens zweimal rotiert.
     
    15. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass
    die Bildgebungssteuerungseinheit (31) mindestens zweimal die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) in jedem Fall der Probe ohne einem Kontrastmittel und der mit einem Instrument eingeführten Probe rotiert.
     
    16. Röntgenstrahlenbildgebungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Röntgenstrahlenbildgebungsvorrichtung ferner
    einen Niederfrequenzkomponentenbetonungsfilter aufweist, der dazu ausgebildet ist, eine Niederfrequenzkomponente des Weichgewebebildes, welches mit der dritten Berechnungseinheit gewonnen wurde, zu betonen.
     
    17. Röntgenstrahlenbildgebungsverfahren mit den Schritten
    mindestens zweimal Rotieren einer Röntgenstrahlenerzeugungseinheit (21) und einer Röntgenstrahlenerkennungseinheiten (22) um eine Probe als ein Rotationszentrum durch einen Computervorgang,
    Bildgeben der Probe bei einer Mehrzahl von Rotationswinkeln, die sich voneinander während der Rotationen unterscheiden,
    Gewinnen eine Mehrzahl von zweidimensionalen Bildern durch Durchführung des Bildgebens während der Rotationen und
    Gewinnen von mindestens einem dreidimensionalen Bild der Probe durch Durchführen eines Berechnungsvorgangs, der mindestens ein Durchführen einer ersten Rekonstruktion basierend auf der Mehrzahl von zweidimensionalen Bildern umfasst,
    Gewinnen des dreidimensionalen Gewebebildes (38) der Probe durch Durchführen einer ersten Rekonstruktion basierend auf den zweidimensionalen Bildern, welche von der Probe ohne Kontrastmittel gewonnen wurden,
    Gewinnen eines dreidimensionalen Gewebe/Blutgefäßbildes (39) mit Gewebe und Blutgefäßen der Probe durch Durchführen einer zweiten Rekonstruktion basierend auf den zweidimensionalen Bildern, welche von der Probe mit einem Kontrastmittel gewonnen wurden, und
    Gewinnen eines dreidimensionalen Weichgewebebildes (3), eines dreidimensionalen Blutgefäßbildes (5) und eines dreidimensionalen Weichgewebe/Blutgefäßbildes (34) durch Durchführen einer Zwischenberechnung zwischen dem dreidimensionalen Gewebebild (38) und dem dreidimensionalen Gewebe/Blutgefäßbild (39), wobei das Durchführen der Zwischenberechnung umfasst:

    Gewinnen des dreidimensionalen Blutgefäßbildes (5) aus der Differenz zwischen dem dreidimensionalen Gewebebild (38) und dem dreidimensionalen Gewebe/Blutgefäßbild (39) mit einer ersten Berechnung,

    Gewinnen eines dreidimensionalen Gewebebildes (47) aus der Differenz zwischen dem dreidimensionalen Blutgefäßbild (5), welches von der ersten Berechnung berechnet wurde, und dem dreidimensionalen Gewebe/Blutgefäßbild (39), welches durch die zweite Rekonstruktion gewonnen wurde, mit einer zweiten Berechnung,

    Gewinnen des dreidimensionalen Weichgewebebildes (3) durch Zusammenzählen des dreidimensionalen Gewebebildes (47), welches von der zweiten Berechnung gewonnen wurde, und des dreidimensionalen Bildes (38), welches durch die erste Rekonstruktion gewonnen wurde, mit einer dritten Berechnung und

    Gewinnen des dreidimensionalen Weichgewebe/Blutgefäßbildes (34) durch Zusammenzählen des dreidimensionalen Blutgefäßbildes (5), welches mit der ersten Rechnung gewonnen wurde, und des dreidimensionalen Weichgewebebildes (3), welches mit der dritten Berechnung gewonnen wurde.


     
    18. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die zwei oder mehr Rotationen der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) in der gleichen Ebenen durchgeführt werden.
     
    19. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die zwei oder mehr Rotationen Rotationsstartwinkel und Rotationsendwinkel unterschiedlich festlegen.
     
    20. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die Bildgebung der Probe während der zwei oder mehr Rotationen bei konstanten Rotationswinkeln durchgeführt wird.
     
    21. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die Anzahl der Bildgebungskopien der Probe während der zwei oder mehr Rotationen konstant ist.
     
    22. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die Bildgebundswinkel für die Durchführung der Bildgebung, während die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) zweimal der mehrmals rotiert werden, konstant festgelegt ist.
     
    23. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die zwei oder mehr Rotationen der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) in der gleichen Rotationsrichtung durchgeführt werden.
     
    24. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    für die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) die Rotationsstartwinkel für die die zwei oder mehr Rotationen unterschiedlich festgelegt sind.
     
    25. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die zwei oder mehr Rotationen der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) in der gleichen Rotationsrichtung in voneinander unterschiedlichen Ebenen in dem akzeptierten Bereich durchgeführt werden.
     
    26. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) mehrere Male rotiert werden und die Bildgebung durch Rotation bei jedem abgesetzten Winkel von irregulärem Interval durchgeführt wird und die finalen Bildgebungswinkel konstant eingestellt sind.
     
    27. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die Röntgenstrahlenerzeugungseinheit (21) und die Röntgenstrahlenerkennungseinheit (22) mindestens einmal in jedem Fall der Probe mit einem Kontrastmittel und ohne einem Kontrastmittel rotiert werden.
     
    28. Röntgenstrahlenbildgebungsverfahren nach Anspruch 17, dadurch gekennzeichnet, dass
    die Rotation der Röntgenstrahlenerzeugungseinheit (21) und der Röntgenstrahlenerkennungseinheit (22) mehrmals durchgeführt wird, wobei mindestens eine Rotation für eine Probe mit einem Kontrastmittel durchgeführt wird.
     


    Revendications

    1. Dispositif d'imagerie par rayons X comprenant :

    une unité de génération de rayons X (21) adaptée pour émettre des rayons X sur un échantillon ;

    une unité de détection de rayons X (22) adaptée pour détecter la quantité de rayons X passant par l'échantillon ;

    une unité de commande d'imagerie (31) qui met en rotation deux fois ou plus l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) autour de l'échantillon en tant que centre de rotation et image l'échantillon à une pluralité d'angles de rotation différents les uns des autres pendant les rotations ; et

    une unité de calcul d'image (32) adaptée pour acquérir une image tridimensionnelle de l'échantillon en réalisant un processus de calcul incluant au moins une reconstruction d'après la pluralité d'images bidimensionnelles qui sont acquises en réalisant une imagerie pendant les rotations de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22),

    l'unité de calcul d'image (32) comporte :

    une première unité de reconstruction (35) adaptée pour acquérir une image de tissu tridimensionnelle (38) de l'échantillon en réalisant une reconstruction d'après les images bidimensionnelles acquises à partir de l'échantillon sans agent de contraste, une seconde unité de reconstruction (36) adaptée pour acquérir une image de tissu/vaisseau sanguin tridimensionnelle (39) incluant des tissus et des vaisseaux sanguins de l'échantillon en réalisant une reconstruction d'après les images bidimensionnelles acquises à partir de l'échantillon avec agent de contraste, et

    une unité de calcul interimage (37) adaptée pour acquérir une image de tissu mou tridimensionnelle (3), une image de tissu mou/vaisseau sanguin tridimensionnelle (34), une image de vaisseau sanguin tridimensionnelle (5), en réalisant un intercalcul entre l'image de tissu tridimensionnelle et l'image de tissu/vaisseau sanguin tridimensionnelle,

    dans lequel l'unité de calcul interimage (37) comporte :

    une première unité de calcul (41) adaptée pour acquérir l'image de vaisseau sanguin tridimensionnelle (5) à partir de la différence entre l'image de tissu tridimensionnelle (38) et l'image de tissu/vaisseau sanguin tridimensionnelle (39) ;

    une deuxième unité de calcul (42) adaptée pour acquérir une image de tissu tridimensionnelle (47) à partir de la différence entre l'image de vaisseau sanguin tridimensionnelle (5) acquise par la première unité de calcul (41) et l'image de tissu/vaisseau sanguin tridimensionnelle (39) acquise par la seconde unité de reconstruction (36) ;

    une troisième unité de calcul (40) adaptée pour acquérir l'image de tissu mou tridimensionnelle (3) en ajoutant l'image de tissu tridimensionnelle (47) acquise par la deuxième unité de calcul (42) et l'image de tissu tridimensionnelle (38) acquise par la première unité de reconstruction (35) ; et

    une quatrième unité de calcul (37) adaptée pour acquérir l'image de tissu mou/vaisseau sanguin tridimensionnelle (34) en ajoutant l'image de vaisseau sanguin tridimensionnelle (5) acquise par la première unité de calcul (41) et l'image de tissu mou tridimensionnelle (3) acquise par la troisième unité de calcul (40).


     
    2. Dispositif d'imagerie par rayons X selon la revendication 1, dans lequel l'unité de commande d'imagerie (31) est adaptée pour commander une rotation de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22) à des angles d'imagerie différents pendant l'imagerie bidimensionnelle, et dans lequel l'unité de calcul d'image (32) est adaptée pour acquérir l'image tridimensionnelle de l'échantillon sur la base d'une pluralité d'images bidimensionnelles sans agent de contraste et d'une pluralité d'images bidimensionnelles avec agent de contraste acquises sous la commande de l'unité de commande d'imagerie (31).
     
    3. Dispositif d'imagerie par rayons X selon la revendication 2, dans lequel l'unité de commande d'imagerie (31) est adaptée pour commander l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) pour régler des paliers d'angles des images bidimensionnelles sans agent de contraste et des images bidimensionnelles avec agent de contraste pour qu'ils soient différents les uns des autres.
     
    4. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) règle des angles de début de rotation et des angles de fin de rotation pour qu'ils soient différents dans les deux rotations ou plus de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22).


     
    5. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) image l'échantillon par des angles de rotation constants pendant les deux rotations ou plus.


     
    6. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) règle le nombre de copies d'imagerie de l'échantillon pour qu'il soit constant pendant les deux rotations ou plus.


     
    7. Dispositif d'imagerie par rayons X selon la revendication 1,
    caractérisé en ce que l'unité de commande d'imagerie (31) image tout en mettant en rotation deux fois ou plus l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22), et règle les angles d'imagerie pour que la réalisation de l'imagerie soit constante.
     
    8. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) met en rotation deux fois ou plus l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) dans la même direction de rotation.


     
    9. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) met en rotation deux fois ou plus l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) dans des plans différents les uns des autres dans la plage acceptable.


     
    10. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) met en rotation plusieurs fois l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) et réalise une imagerie à des angles de rotation d'intervalle irrégulier, et règle les derniers angles d'imagerie pour qu'ils soient constants.


     
    11. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) réalise une imagerie en mettant en rotation au moins deux fois l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22), et

    dans lequel l'unité de calcul d'image (32) extrait les images bidimensionnelles donnant des angles d'imagerie constants, à partir d'une pluralité d'images bidimensionnelles acquises en réalisant l'imagerie.


     
    12. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) met en rotation au moins une fois l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) dans chaque cas de l'échantillon avec agent de contraste et sans agent de contraste.


     
    13. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce que :

    l'unité de commande d'imagerie (31) met en rotation plusieurs fois l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22), où au moins une rotation est réalisée sous un échantillon avec agent de contraste.


     
    14. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce qu'il comprend en outre un arceau pourvu de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22) en regard l'une de l'autre,
    dans lequel l'unité de commande d'imagerie (31) met en rotation au moins deux fois l'arceau.
     
    15. Unité d'imagerie par rayons X selon la revendication 1, caractérisée en ce que :

    l'unité de commande d'imagerie (31) met en rotation au moins deux fois l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) dans chaque cas de l'échantillon sans agent de contraste et de l'échantillon inséré avec un instrument.


     
    16. Dispositif d'imagerie par rayons X selon la revendication 1, caractérisé en ce qu'il comprend en outre un filtre d'accentuation de composante basse fréquence adapté pour accentuer une composante basse fréquence de l'image de tissu mou acquise par la troisième unité de calcul.
     
    17. Procédé d'imagerie par rayons X comprenant les étapes de :

    mise en rotation au moins deux fois d'une unité de génération de rayons X (21) et d'une unité de détection de rayons X (22) autour d'un échantillon en tant que centre de rotation par un traitement d'ordinateur ;

    imagerie de l'échantillon à une pluralité d'angles de rotation différents les uns des autres pendant les rotations ;

    acquisition d'une pluralité d'images bidimensionnelles en réalisant l'imagerie pendant les rotations ; et

    acquisition d'au moins une image tridimensionnelle de l'échantillon en effectuant un processus de calcul qui comporte au moins la réalisation d'une première reconstruction d'après la pluralité d'images bidimensionnelles,

    acquisition de l'image de tissu tridimensionnelle (38) de l'échantillon en réalisant une première reconstruction d'après les images bidimensionnelles acquises à partir de l'échantillon sans agent de contraste,

    acquisition d'une image de tissu/vaisseau sanguin tridimensionnelle (39) comportant des tissus et des vaisseaux sanguins de l'échantillon en réalisant une deuxième reconstruction d'après les images bidimensionnelles acquises à partir de l'échantillon avec agent de contraste, et

    acquisition d'une image de tissu mou tridimensionnelle (3), d'une image de vaisseau sanguin tridimensionnelle (5) et d'une image de tissu mou/vaisseau sanguin tridimensionnelle (34), en réalisant un intercalcul entre l'image de tissu tridimensionnelle (38) et l'image de tissu/vaisseau sanguin tridimensionnelle (39), dans lequel la réalisation de l'intercalcul comprend :

    l'acquisition de l'image de vaisseau sanguin tridimensionnelle (5) à partir de la différence entre l'image de tissu tridimensionnelle (38) et l'image de tissu/vaisseau sanguin tridimensionnelle (39) par un premier calcul ;

    l'acquisition d'une image de tissu tridimensionnelle (47) à partir de la différence entre l'image de vaisseau sanguin tridimensionnelle (5) calculée par le premier calcul et l'image de tissu/vaisseau sanguin tridimensionnelle (39) acquise par la seconde unité de reconstruction, par un second calcul ;

    l'acquisition d'une image de tissu mou tridimensionnelle (3) en ajoutant l'image de tissu tridimensionnelle (47) acquise par le deuxième calcul et l'image de tissu tridimensionnelle (38) acquise par la première reconstruction, par un troisième calcul ; et

    l'acquisition d'une image de tissu mou/vaisseau sanguin tridimensionnelle (34) en ajoutant l'image de vaisseau sanguin tridimensionnelle (5) acquise par le premier calcul et l'image de tissu mou tridimensionnelle (3) acquise par le troisième calcul.


     
    18. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    les deux rotations ou plus de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22) sont réalisées dans le même plan.


     
    19. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    les deux rotations ou plus règlent des angles de début de rotation et des angles de fin de rotation pour qu'ils soient différents.


     
    20. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    l'imagerie de l'échantillon pendant les deux rotations ou plus est réalisée par des angles de rotation constants.


     
    21. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    le nombre de copies d'imagerie de l'échantillon pendant les deux rotations ou plus est constant.


     
    22. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    les angles d'imagerie pour réaliser l'imagerie tout en mettant en rotation deux fois ou plus l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) sont réglés pour être constants.


     
    23. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    les deux rotations ou plus de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22) sont réalisées dans la même direction de rotation.


     
    24. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    pour l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22), des angles de début de rotation pour les deux rotations ou plus sont réglés pour être différents les uns des autres.


     
    25. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    les deux rotations ou plus de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22) sont réalisées dans des plans différents les uns des autres dans la plage acceptable.


     
    26. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) sont mises en rotation plusieurs fois et l'imagerie par rotation à chaque angle à palier d'intervalle irrégulier est réalisée, et les derniers angles d'imagerie sont réglés pour être constants.


     
    27. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    l'unité de génération de rayons X (21) et l'unité de détection de rayons X (22) sont mises en rotation au moins une fois dans chaque cas de l'échantillon avec agent de contraste et sans agent de contraste.


     
    28. Procédé d'imagerie par rayons X selon la revendication 17, caractérisé en ce que :

    la rotation de l'unité de génération de rayons X (21) et de l'unité de détection de rayons X (22) est réalisée plusieurs fois, où au moins une rotation est réalisée sous un échantillon avec agent de contraste.


     




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    REFERENCES CITED IN THE DESCRIPTION



    This list of references cited by the applicant is for the reader's convenience only. It does not form part of the European patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be excluded and the EPO disclaims all liability in this regard.

    Patent documents cited in the description