(19)
(11)EP 0 267 723 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
06.12.1989 Bulletin 1989/49

(43)Date of publication A2:
18.05.1988 Bulletin 1988/20

(21)Application number: 87309688.7

(22)Date of filing:  02.11.1987
(51)International Patent Classification (IPC)4C07D 501/00, A61K 31/545
(84)Designated Contracting States:
AT BE CH DE ES FR GB GR IT LI LU NL SE

(30)Priority: 12.11.1986 US 930193

(71)Applicant: Merck & Co., Inc.
Rahway New Jersey 07065-0900 (US)

(72)Inventors:
  • Doherty, James B.
    New Milford New Jersey 07646 (US)
  • Finke, Paul E.
    Milltown New Jersey 08850 (US)
  • Firestone, Raymond A.
    Westfield New Jersey 07090 (US)
  • Hagmann, William K.
    Westfield New Jersey 07090 (US)
  • Thompson, Kevan R.
    Westfield New Jersey 07090 (US)
  • Shah, Shrenik K.
    Metuchen New Jersey 08840 (US)

(74)Representative: Cole, William Gwyn 
European Patent Department Merck & Co., Inc. Terlings Park Eastwick Road
Harlow Essex CM20 2QR
Harlow Essex CM20 2QR (GB)


(56)References cited: : 
  
      


    (54)New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents


    (57) New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.





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