(19)
(11)EP 1 911 767 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
10.09.2008 Bulletin 2008/37

(43)Date of publication A2:
16.04.2008 Bulletin 2008/16

(21)Application number: 07113307.8

(22)Date of filing:  27.12.1995
(51)Int. Cl.: 
C12N 15/12  (2006.01)
C12N 15/82  (2006.01)
A01H 5/00  (2006.01)
C12N 15/13  (2006.01)
C07K 16/00  (2006.01)
C07K 14/705  (2006.01)
(84)Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30)Priority: 30.12.1994 US 367395
04.05.1995 US 434000

(62)Application number of the earlier application in accordance with Art. 76 EPC:
95944237.7 / 0807173

(71)Applicants:
  • PLANET BIOTECHNOLOGY, INC.
    San Diego, CA 92121 (US)
  • KINGS COLLEGE LONDON
    London SE1 8WA (GB)
  • The Regents of the University of California
    Oakland, CA 94607-5200 (US)

(72)Inventors:
  • Hiatt, Andrew C.
    San Diego, CA 92103 (US)
  • Ma, Julian K.-C.
    London SE11 5PN (GB)
  • Lehner, Thomas
    Barnet Hertfordshire EN4 0LL (GB)
  • Mostov, Keith E.
    San Francisco, CA 94116 (US)

(74)Representative: Williams, Richard Andrew Norman 
Harrison Goddard Foote 40- 43 Chancery Lane
London WC2A 1JA
London WC2A 1JA (GB)

  


(54)Methods for producing immunoglobulins containing protection proteins in plants and their use


(57) The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protective protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.