(19)
(11)EP 4 196 583 A1

(12)

(43)Date of publication:
21.06.2023 Bulletin 2023/25

(21)Application number: 21856816.0

(22)Date of filing:  13.08.2021
(51)International Patent Classification (IPC): 
C12N 15/11(2006.01)
C12N 15/67(2006.01)
C12N 15/63(2006.01)
C12N 15/85(2006.01)
(52)Cooperative Patent Classification (CPC):
A61K 48/005; A61K 48/0058; A61K 48/0075; C12N 15/113; C12N 2310/14; C12N 2310/531; C12N 2750/14143
(86)International application number:
PCT/US2021/045995
(87)International publication number:
WO 2022/036255 (17.02.2022 Gazette  2022/07)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30)Priority: 14.08.2020 US 202063066008 P

(71)Applicant: Allen Institute
Seattle, Washington 98109 (US)

(72)Inventors:
  • DAIGLE, Tanya
    Seattle, Washington 98109 (US)
  • LEIN, Edward Sebastian
    Seattle, Washington 98109 (US)
  • LEVI, Boaz P.
    Seattle, Washington 98109 (US)
  • MICH, John K.
    Seattle, Washington 98109 (US)
  • TASIC, Bosiljka
    Seattle, Washington 98109 (US)
  • TING, Jonathan
    Seattle, Washington 98109 (US)
  • ZENG, Hongkui
    Seattle, Washington 98109 (US)

(74)Representative: Hobson, David James et al
Mathys & Squire The Shard 32 London Bridge Street
London SE1 9SG
London SE1 9SG (GB)

  


(54)ARTIFICIAL EXPRESSION CONSTRUCTS FOR MODULATING GENE EXPRESSION IN STRIATAL NEURONS