(19)
(11)EP 2 239 331 A1

(12)EUROPEAN PATENT APPLICATION

(43)Date of publication:
13.10.2010 Bulletin 2010/41

(21)Application number: 09157514.2

(22)Date of filing:  07.04.2009
(51)Int. Cl.: 
C12N 15/82  (2006.01)
C07D 231/06  (2006.01)
A01N 43/82  (2006.01)
(84)Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

(71)Applicant: Bayer CropScience AG
40789 Monheim (DE)

(72)Inventor:
  • Münks, Karl-Wilhelm
    40667 Meerbusch (DE)

  


(54)Method for improved utilization of the production potential of transgenic plants


(57) The Invention discloses novel uses and methods for a compound according to formula (I)

directed to increasing the production potential of transgenic plants as well as methods for controlling pests and/or phytopathogenic fungi and/or microorganisms and/or increasing plant health on transgenic plants by application of the compounds to the transgenic plants or to propagation material of these plants.


Description

Introduction



[0001] The invention relates to a method for improving the utilization of the production potential by controlling pests and/or phytopathogenic fungi and/or microorganisms and/or increasing plant health by treating transgenic plants with chemical agents.

[0002] In recent years, there has been a marked increase in the proportion of transgenic plants in agriculture, even if regional differences are still noticeable to date. Thus, for example, the proportion of transgenic maize in the USA has doubled from 26% to 52% since 2001, while transgenic maize has hardly been of any practical importance in Germany. However, in other European countries, for example in Spain, the proportion of transgenic maize is already about 12%.

[0003] Transgenic plants are employed mainly to utilize the production potential of respective plant varieties in the most favourable manner, at the lowest possible input of production means. The aim of the genetic modification of the plants is in particular the generation of resistance in the plants to certain pests or harmful organisms, in particular or else herbicides and also to abiotic stress (for example drought, heat or elevated salt levels). It is also possible to modify a plant genetically to increase certain quality or product features, such as, for example, the content of selected vitamins or oils, or to improve certain fibre properties.

[0004] Herbicide resistance or tolerance can be achieved, for example, by incorporating genes into the useful plant for expressing enzymes to detoxify certain herbicides, so that a relatively unimpeded growth of these plants is possible even in the presence of these herbicides for controlling broadleaved weeds and weed grasses. Examples which may be mentioned are cotton varieties or maize varieties which tolerate the herbicidally active compound glyphosate (Roundup®), (Roundup Ready®, Monsanto) or the herbicides glufosinate (LibertyLink®) or oxynil.

[0005] More recently, there has also been the development of useful plants comprising two or more genetic modifications ("stacked transgenic plants" or multiply transgenic crops). Thus, for example, Monsanto has developed multiply transgenic maize varieties which are resistant to the European corn borer (Ostrinia nubilalis) and the Western corn rootworm (Diabrotica virgifera). Also known are maize and cotton crops which are both resistant to the Western corn rootworm and the cotton bollworm and tolerant to the herbicide Roundup®.

Object of the present invention



[0006] It has now been found that the utilization of the production potential of transgenic useful plants can be improved even more by controlling pests and/or phytopathogenic fungi and/or microorganisms and/or increasing plant health by treating transgenic plants with
a compound according to formula (I)

wherein
A
is selected from nitrogen and C-Hal,
B
is selected from nitrogen and C-Hal,
R1
is selected from hydrogen, halogen, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, phenyl, C1-C6 alkyl substituted with Hal or cyano, C2-C6 alkenyl substituted with Hal or cyano, C3-C6 cycloalkyl substituted with Hal or cyano, phenyl which is substituted with one or more substituents selected from the group of halogen, cyano, and alkoxy,
R2
is selected from hydroxy, C1-C6 thioalkyl, C1-C6 aminoalkyl, C1-C6 alkoxy, phenoxy, aniline,
C1-C6 alkoxy which is substituted with one or more substituents selected from the group of halogen, cyano, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkylcarbonyl,
phenoxy which is substituted with one or more substituents selected from the group of with halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, formyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, C1-C6 alkylamino,
aniline which is substituted with one or more substituents selected from the group of halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylcarbonyl, C1-C6 alkylamino, C1-C6 dialkylamino,
Hal
is halogen.


[0007] Particular preference is given to a method for improving the utilization of the production potential by controlling pests by treating transgenic plants a compound according to formula (I).

[0008] Particular preference is given to a method for improving the utilization of the production potential by controlling phytopathogenic fungi and/or microorganisms by treating transgenic plants a compound according to formula (I).

[0009] Particular preference is given to a method for improving the utilization of the production potential by increasing plant health by treating transgenic plants a compound according to formula (I).

[0010] The compounds according to formula (I) and their plant-strengthening action are known from the prior art (cf. (WO 99/024 413, WO 2006/098128, JP 2007-84566, WO 96/29871US-A 5,240,951 und JP-A 06-009313). Therefore these compounds according to formula (I) are highly suitable for protecting plants against attack by undesirable phytopathogenic fungi and microorganisms.

[0011] From these documents, the person skilled in the art will be familiar with processes for preparing and methods for using compounds of the formula (I) and with the action of compounds of the formula (I).

[0012] Preference is given to a compound of the formula (I),

wherein
A
is selected from nitrogen and C-Hal,
B
is nitrogen,
R1
is selected from halogen, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl,
R2
is selected from hydroxy, C1-C6 thioalkyl, C1-C6 aminoalkyl,
C1-C6 alkoxy which is substituted with one or more substituents selected from the group of halogen, cyano, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkylcarbonyl,
phenoxy which is substituted with one or more substituents selected from the group of with halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, formyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, C1-C6 alkylamino,
aniline which is substituted with one or more substituents selected from the group of cyano, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylcarbonyl, C1-C6 alkylamino, C1-C6 dialkylamino,
Hal
is fluorine, chlorine, bromine.


[0013] Particular preference is given to compounds according to formula (I), wherein Hal is chlorine or bromine.

[0014] Particular preference is given to compounds according to formula (I), wherein Hal is chlorine.

[0015] Particular preference is given to to compounds according to formula (I), wherein A is C-Hal or nitrogen and B is nitrogen.

[0016] Particular preference is given to compounds according to formula (I), wherein A is C-Hal and B is nitrogen.

[0017] Particular preference is given to compounds according to formula (I), wherein A is nitrogen and B is nitrogen.

[0018] Particular preference is given to compounds according to formula (I), wherein A is C-Hal or nitrogen and B is nitrogen and R2 is aniline which is substituted with one or more substituents selected from the group of cyano, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylcarbonyl, C1-C6 alkylamino, C1-C6 dialkylamino.

[0019] Particular preference is given to compounds according to formula (I), wherein A is C-Hal or nitrogen and B is nitrogen and R2 is hydroxy.

[0020] Particular preference is given to compounds according to formula (I), wherein A is C-Hal and B is nitrogen and R2 is hydroxy.

[0021] Particular preference is given to compounds according to formula (I), wherein A is nitrogen and B is nitrogen and R2 is hydroxy.

[0022] Particular preference is given to compounds according to formula (I), wherein A is C-Hal or nitrogen and B is nitrogen and R2 is C1-C6 thioalkyl.

[0023] Particular preference is given to compounds according to formula (I) according to table 1:
Table 1
NoABR1R2Hal
I-1 N N CH3 3-chloro-4-methyl aniline -
I-2 N N CH3 OH -
I-3 N N CH3 methoxy -
I-4 N N CH3 thiomethyl -
I-5 N N CH3 2-Cyanoanilin -
I-6 N N Cyclopropyl 3-chloro-4-methyl aniline -
I-7 N N Cyclopropyl OH -
I-8 N N Cyclopropyl methoxy -
I-9 N N Cyclopropyl thiomethyl -
I-10 N N Cyclopropyl 2-cyano aniline -
I-11 C-Hal N Cl 3-chloro-4-methyl aniline Cl
I-12 C-Hal N Cl OH Cl
I-13 C-Hal N Cl methoxy Cl
I-14 C-Hal N Cl thiomethyl Cl
I-15 C-Hal N Cl 2-Cyanoanilin Cl
I-16 C-Hal N CH3 3-chloro-4-methyl aniline Cl
I-17 C-Hal N CH3 OH Cl
I-18 C-Hal N CH3 methoxy Cl
I-19 C-Hal N CH3 thiomethyl Cl
I-20 C-Hal N CH3 2-cyano aniline Cl


[0024] According to the invention, "alkyl" represents straight-chain or branched aliphatic hydrocarbons having 1 to 6, preferably 1 to 4 carbon atoms, most preferably having 1 to 3 carbon atoms. Suitable alkyl groups are, for example, methyl, ethyl, n-propyl, i-propyl, n-, iso-, sec- or tert-butyl, pentyl or hexyl. According to the invention, "alkenyl" represents straight-chain or branched hydrocarbons having at least one double bond. The double bond of the alkenyl group may be unconjugated or is conjugated to an unsaturated bond or group. Alkenyl groups having 2 to 6 or 3 to 6 carbon atoms are preferred. Suitable alkenyl groups are, for example, vinyl or allyl.

[0025] According to the invention, "halogen" represents fluorine, chlorine, bromine or iodine, preferably fluorine, chlorine or bromine, most preferably bromine and chlorine.

[0026] According to the invention, "cycloalkyl" represents cyclic hydrocarbons having 3 to 6 carbon atoms. Suitable cycloalkyl groups are, for example, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

[0027] According to the invention, "alkoxy" represents alkoxy groups having 1 to 6 carbon atoms, preferably having 1 to 4 carbon atoms, most preferably having 1 to 3 carbon atoms. Suitable alkoxy groups are, for example, methyloxy, ethyloxy, n-propyloxy, i-propyloxy, n-, iso-, sec- or tert-butyloxy, pentyloxy or hexyloxy.

[0028] According to the invention, "alkoxycarbonyl" represents alkoxycarbonyl groups having 1 to 6 carbon atoms, preferably having 1 to 4 carbon atoms, most preferably having 1 to 3 carbon atoms. Suitable alkoxycarbonyl groups are, for example, methyloxycarbonyl, ethyloxycarbonyl, n-propyloxycarbonyl, i-propyloxycarbonyl, n-, iso-, sec- or tert-butyloxycarbonyl, pentyloxycarbonyl or hexyloxycarbonyl.

[0029] According to the invention, "alkylcarbonyl" represents alkylcarbonyl groups having 1 to 6 carbon atoms, preferably having 1 to 4 carbon atoms, most preferably having 1 to 3 carbon atoms. Suitable alkyl groups are, for example, methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, i-propylcarbonyl, n-, iso-, sec- or tert-butylcarbonyl, pentylarbonyl or hexylcarbonyl.

[0030] The above-mentioned definitions either in the general description or in the preferred embodiments can be combined between the respective embodiments and preferred embodiments.

[0031] Here, the term "treatment" includes all measures resulting in a contact between the active compound and at least one plant part. "Plant parts" are to be understood as meaning all above-ground and below-ground parts and organs of plants, such as shoot, leaf, flower and root, by way of example leaves, needles, stalks, stems, flowers, fruit bodies, fruits and seed, and also roots, tubers and rhizomes. The plant parts also include harvested material and also vegetative and generative propagation material, for example cuttings, tubers, rhizomes, slips and seed.

[0032] According to the invention the expression "pathogen" stands for all organisms which cause damages on plants or any part of a plant.

[0033] According to the invention the expression "pesticidal" comprises all chemical agents with fungicidal and/or insecticidal and/or herbicidal and/or acaricidal and/or bactericidal and/or antiviral and/or nematicidal activity, in particular chemical agents with fungicidal and/or insecticidal and/or nematicidal and/or acaricidal activity.

[0034] According to the invention the expression "pesticide" comprises fungicides and/or insecticides and/or herbicides and/or acaricides and/or bactericides and/or antiviral agents and/or nematicides, in particular fungicides and/or insecticides and/or nematicides and/or acaricides.

[0035] According to the invention the expression "pests" stands for all aschelminthes and panarthropoda organisms which cause damages on plants or any part of a plant. Examples are Nematoda, Arthopoda, Hexapoda and Arachnida.

[0036] According to the invention the expression "insecticide" stands for the activity of a compound in combating unwanted insects, acari, or nematodes, or reducing the damage of plants or plant parts by pests.

[0037] According to the invention the expression "fungi" stands for all fungal and chromista organisms.

[0038] According to the invention the expression "phytopathogenic fungi" stands for all fungal and chromista organisms which cause damages on plants or any part of a plant. Examples for fungal taxonomic groups are Ascomycota, Basidiomycota, Chytridiomycota, Deuteromycota, Glomeromycota, Microsporidia, Zygomycota, and anamorphic fungi. Examples for Chromista are Oomycota.

[0039] According to the invention the expression "microorganisms" stands for all bacterial and protozoan organisms. Examples are Plasmodiophoromycetes.

[0040] According to the invention the expression "viruses" stands for all viruses which cause damages on plants or any part of a plant. Examples are DNA-, RNA, and DNA and RNA reverse transcribing viruses as well as subviral agents.

[0041] According to the invention the expression "pests" stands for all aschelminthes and panarthropoda organisms which cause damages on plants or any part of a plant. Examples are Nematoda, Arthopoda, Hexapoda and Arachnida.

[0042] According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant variety or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers or by bioengineering and genetic engineering methods methods or marker-assisted breeding methods, for example SMART breeding ("Selection with Markers and Advanced Reproductive Technologies"). By plant parts is meant all above ground and below ground parts and organs of plants such as shoot, leaf, blossom and root, whereby for example leaves, needles, stems, branches, blossoms, fruiting bodies, fruits and seed as well as roots, corms and rhizomes are listed. Crops and vegetative and generative propagating material, for example cuttings, corms, rhizomes, runners and seeds also belong to plant parts.

[0043] Among the plants that can be protected by the method according to the invention, mention may be made of major field crops like corn, soybean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugarbeet, sugarcane, oats, rye, barley, millet, triticale, flax, vine and various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit) ; Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp. (for instance lettuce, artichoke and chicory - including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber - including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans - such as climbing beans and broad beans), Chenopodiaceae sp. (for instance mangold, spinach beet, spinach, beetroots), Asteraceae sp. (for instance sunflower), Brassicaceae sp. (for instance white cabbage, red cabbage, brokkoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish as well as canola, rapeseed, mustard, horseradish, cress), (Cruciferae sp. (for instance colza), Fabacae sp. (for instance peanuts and beans), Papilionaceae sp. (for instance soybean), Solanaceae sp. (for instance potatoes), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants; as well as genetically modified homologues of these crops.

[0044] In particular embodiment plants selected from the group comprising of wheat, corn, oats, millet, triticale, barley, triticale, rice can be protected.

[0045] In particular embodiment rice can be protected.

[0046] The method of treatment according to the invention can be used in the treatment of genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into genome. The expression "heterologous gene" essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using for example, antisense technology, cosuppression technology or RNA interference - RNAi - technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

[0047] Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive ("synergistic") effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage stability and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.

[0048] At certain application rates, the active compound combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are also suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment. The period of time within which protection is effected generally extends from 1 to 10 days, preferably 1 to 7 days, after the treatment of the plants with the active compounds.

[0049] Plants and plant cultivars which are preferably to be treated according to the invention include all plants which have genetic material which impart particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means).

[0050] Plants and plant cultivars which are also preferably to be treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.

[0051] Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, shade avoidance.

[0052] Plants and plant cultivars which may also be treated according to the invention, are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.

Examples of plants with the above-mentioned traits are non-exhaustively listed in Table A and B.



[0053] Plants that may be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stresses). Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male sterile plants and sold to growers. Male sterile plants can sometimes (e.g. in corn) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described in Brassica species (W0 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and US 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/02069).

[0054] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.

[0055] Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., 1983, Science 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-145), the genes encoding a Petunia EPSPS (Shah et al., 1986, Science 233, 478-481), a Tomato EPSPS (Gasser et al., 1988, J. Biol. Chem. 263, 4280-4289), or an Eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS as described in for example EP 0837944, WO 00/66746, WO 00/66747 or WO02/26995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme as described in U.S. Patent Nos. 5,776,760 and 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in for example WO 02/36782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned genes, as described in for example WO 01/024615 or WO 03/013226.

[0056] Other herbicide resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition. One such efficient detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example described in U.S. Patent Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.

[0057] Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). Hydroxyphenylpyruvatedioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated HPPD enzyme as described in WO 96/38567, WO 99/24585 and WO 99/24586. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme prephenate deshydrogenase in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928.

[0058] Still further herbicide resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pryimidinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright (2002, Weed Science 50:700-712), but also, in U.S. Patent No. 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Patent Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; and international publication WO 96/33270. Other imidazolinone-tolerant plants are also described in for example WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351, and WO 2006/060634. Further sulfonylurea- and imidazolinone-tolerant plants are also described in for example WO 07/024782.

[0059] Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soybeans in U.S. Patent 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Patent 5,773,702 and WO 99/057965, for lettuce in U.S. Patent 5,198,599, or for sunflower in WO 01/065922.

[0060] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.

[0061] An "insect-resistant transgenic plant", as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:
  1. 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins listed by Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62: 807-813), updated by Crickmore et al. (2005) at the Bacillus thuringiensis toxin nomenclature, online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/). or insecticidal portions thereof, e.g., proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3Aa, or Cry3Bb or insecticidal portions thereof (e.g. EP 1999141 and WO 2007/107302); or
  2. 2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck et al. 2001, Nat. Biotechnol. 19: 668-72; Schnepf et al. 2006, Applied Environm. Microbiol. 71, 1765-1774) or the binary toxin made up of the Cry1A or Cry1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US Patent Appl. No. 12/214,022 and EP 08010791.5); or
  3. 3) a hybrid insecticidal protein comprising parts of different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g., the Cry1A.105 protein produced by corn event MON89034 (WO 2007/027777); or
  4. 4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in corn events MON863 or MON88017, or the Cry3A protein in corn event MIR604; or
  5. 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal (VIP) proteins listed at:

    http://www.lifesci.sussex.ac.uk/home/Neil Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa protein class; or

  6. 6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or
  7. 7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
  8. 8) a protein of any one of 5) to 7) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT102; or
  9. 9) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a crystal protein from Bacillus thuringiensis, such as the binary toxin made up of VIP3 and Cry1A or Cry1F (US Patent Appl. No. 61/126083 and 61/195019), or the binary toxin made up of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US Patent Appl. No. 12/214,022 and EP 08010791.5).
  10. 10) a protein of 9) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein)


[0062] Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.

[0063] An "insect-resistant transgenic plant", as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest, as described e.g. in WO 2007/080126.

[0064] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:
  1. 1) plants which contain a transgene capable of reducing the expression and/or the activity of poly(ADP-ribose) polymerase (PARP) gene in the plant cells or plants as described in WO 00/04173, WO 2006/045633, WO 2006/045633, or WO 2007/06009836.
  2. 2) plants which contain a stress tolerance enhancing transgene capable of reducing the expression and/or the activity of the PARG encoding genes of the plants or plants cells, as described e.g. in WO 2004/090140.
  3. 3) plants which contain a stress tolerance enhancing transgene coding for a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage synthesis pathway including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotine amide phosphorybosyltransferase as described e.g. in WO2006/032469, WO 2006/133827, EP 1999263, or WO 2007/107326.


[0065] Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention show altered quantity, quality and/or storage-stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as :
  1. 1) transgenic plants which synthesize a modified starch, which in its physical-chemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behaviour, the gelling strength, the starch grain size and/or the starch grain morphology, is changed in comparison with the synthesised starch in wild type plant cells or plants, so that this is better suited for special applications. Said transgenic plants synthesizing a modified starch are disclosed, for example, in EP 0571427, WO 95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, WO 2008/0175518, WO 2008/080630, WO 2008/080631, WO 2008/090008, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, US 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO 2005/002359, US 5,824,790, US 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936
  2. 2) transgenic plants which synthesize non starch carbohydrate polymers or which synthesize non starch carbohydrate polymers with altered properties in comparison to wild type plants without genetic modification. Examples are plants producing polyfructose, especially of the inulin and levan-type, as disclosed in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460, and WO 99/24593, plants producing alpha-1,4-glucans as disclosed in WO 95/31553, US 2002031826, US 6,284,479, US 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants producing alpha-1,6 branched alpha-1,4-glucans, as disclosed in WO 00/73422, plants producing alternan, as disclosed in e.g. WO 00/47727, WO 00/73422, WO 2008/098975, US 5,908,975 and EP 0728213,
  3. 3) transgenic plants which produce hyaluronan, as for example disclosed in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779, and WO 2005/012529.
  4. 4) transgenic plants or hybrid plants, such as onions with characteristics such as 'high soluble solids content', 'low pungency' (LP) and/or 'long storage' (LS), as described in US Patent Appl. No. 12/020,360 and 61/054,026.


[0066] Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as cotton plants, with altered fiber characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered fiber characteristics and include:
  1. a) Plants, such as cotton plants, containing an altered form of cellulose synthase genes as described in WO 98/00549
  2. b) Plants, such as cotton plants, containing an altered form of rsw2 or rsw3 homologous nucleic acids as described in WO 2004/053219
  3. c) Plants, such as cotton plants, with increased expression of sucrose phosphate synthase as described in WO 01/17333
  4. d) Plants, such as cotton plants, with increased expression of sucrose synthase as described in WO 02/45485
  5. e) Plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fiber cell is altered, e.g. through downregulation of fiber-selective β-1,3-glucanase as described in WO 2005/017157, or as described in EP 08075514.3 or US Patent Appl. No. 61/128,938
  6. f) Plants, such as cotton plants, having fibers with altered reactivity, e.g. through the expression of N-acetylglucosaminetransferase gene including nodC and chitin synthase genes as described in WO 2006/136351


[0067] Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation or by selection of plants which contain a mutation imparting such altered oil profile characteristics and include:
  1. a) Plants, such as oilseed rape plants, producing oil having a high oleic acid content as described e.g. in US 5,969,169, US 5,840,946 or US 6,323,392 or US 6,063,947
  2. b) Plants such as oilseed rape plants, producing oil having a low linolenic acid content as described in US 6,270,828, US 6,169,190 or US 5,965,755
  3. c) Plant such as oilseed rape plants, producing oil having a low level of saturated fatty acids as described e.g. in US Patent No. 5,434,283


[0068] Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants which contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering as described in US Patent Appl. No. 61/135,230 and EP 08075648.9.

[0069] Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combinations of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA) whether such petitions are granted or are still pending. At any time this information is readily available from APHIS (4700 River Road Riverdale, MD 20737, USA), for instance on its internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this application the petitions for nonregulated status that were pending with APHIS or granted by APHIS were those listed in table B which contains the following information:
  • Petition : the identification number of the petition. Technical descriptions of the transformation events can be found in the individual petition documents which are obtainable from APHIS, for example on the APHIS website, by reference to this petition number. These descriptions are herein incorporated by reference.
  • Extension of Petition : reference to a previous petition for which an extension is requested.
  • Institution : the name of the entity submitting the petition.
  • Regulated article : the plant species concerned.
  • Transgenic phenotype : the trait conferred to the plants by the transformation event.
  • Transformation event or line : the name of the event or events (sometimes also designated as lines or lines) for which nonregulated status is requested.
  • APHIS documents : various documents published by APHIS in relation to the Petition and which can be requested with APHIS.


[0070] Additional particularly useful plants containing single transformation events or combinations of transformation events are listed for example in the databases from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp browse.aspx and http://www.agbios.com/dbase.php).

[0071] Further particular transgenic plants include plants containing a transgene in an agronomically neutral or beneficial position as described in any of the patent publications listed in Table C.

[0072] In a particularly preferred variant, the process according to the invention is used for treating transgenic vegetable, maize, soya bean, cotton, tobacco, rice, potato and sugar beet varieties. These are preferably plants that comprise Bt toxins.

[0073] The vegetable plants or varieties are, for example, the following useful plants:

○ potatoes: preferably starch potatoes, sweet potatoes and table potatoes;

○ root vegetables: preferably carrots, turnips (swedes, stubble turnips (Brassica rapa var. rapa), spring turnips, autumn turnips (Brassica campestris ssp. rapifera), Brassica rapa L. ssp. rapa f. teltowiensis), scorzonera, Jerusalem artichoke, turnip-rooted parsley, parsnip, radish and horseradish;

○ tuber vegetables: preferably kohlrabi, beetroot, celeriac, garden radish;

○ bulb crops: preferably scallion, leek and onions (planting onions and seed onions);

○ brassica vegetables: preferably headed cabbage (white cabbage, red cabbage, kale, savoy cabbage), cauliflowers, broccoli, curly kale, marrow-stem kale, seakale and Brussels sprouts;

○ fruiting vegetables: preferably tomatoes (outdoor tomatoes, vine-ripened tomatoes, beef tomatoes, greenhouse tomatoes, cocktail tomatoes, industrial and fresh market tomatoes), melons, eggplants, aubergines, pepper (sweet pepper and hot pepper, Spanish pepper), chilli pepper, pumpkins, courgettes and cucumbers (outdoor cucumbers, greenhouse cucumbers snake gourds and gherkins);

○ vegetable pulses: preferably bush beans (as sword beans, string beans, flageolet beans, wax beans, corn beans of green- and yellow-podded cultivars), pole beans (as sword beans, string beans, flageolet beans, wax beans of green-, blue- and yellow-podded cultivars), broadbeans (field beans, Windsor beans, cultivars having white- and black-spotted flowers), peas (chickling vetch, chickpeas, marrow peas, shelling peas, sugar-peas, smooth peas, cultivars having light- and dark-green fresh fruits) and lentils;

○ green vegetables and stem vegetables: preferably Chinese cabbage, round-headed garden lettuce, curled lettuce, lamb's-lettuce, iceberg lettuce, romaine lettuce, oakleaf lettuce, endives, radicchio, lollo rossa, ruccola lettuce, chicory, spinach, chard (leaf chard and stem chard) and parsley;

○ other vegetables: preferably asparagus, rhubarb, chives, artichokes, mint varieties, sunflowers, Florence fennel, dill, garden cress, mustard, poppy seed, peanuts, sesame und salad chicory.



[0074] Preferred embodiments of the invention are those treatments with a compound according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0075] Preferred embodiments of the invention are those treatments with compound I-1 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0076] Preferred embodiments of the invention are those treatments with compound I-2 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0077] Preferred embodiments of the invention are those treatments with compound I-3 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0078] Preferred embodiments of the invention are those treatments with compound I-4 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0079] Preferred embodiments of the invention are those treatments with compound I-5 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0080] Preferred embodiments of the invention are those treatments with compound I-6 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0081] Preferred embodiments of the invention are those treatments with compound I-7 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0082] Preferred embodiments of the invention are those treatments with compound I-8 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0083] Preferred embodiments of the invention are those treatments with compound I-9 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0084] Preferred embodiments of the invention are those treatments with compound I-10 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0085] Preferred embodiments of the invention are those treatments with compound I-11 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0086] Preferred embodiments of the invention are those treatments with compound I-12 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0087] Preferred embodiments of the invention are those treatments with compound I-13 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0088] Preferred embodiments of the invention are those treatments with compound I-14 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0089] Preferred embodiments of the invention are those treatments with compound I-15 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0090] Preferred embodiments of the invention are those treatments with compound I-16 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0091] Preferred embodiments of the invention are those treatments with compound I-17 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0092] Preferred embodiments of the invention are those treatments with compound I-18 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0093] Preferred embodiments of the invention are those treatments with compound I-19 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0094] Preferred embodiments of the invention are those treatments with compound I-20 according to formula (I) wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0095] In a preferred embodiment of the invention, the transgenic plants are treated with a compound according to formula (I) to obtain a synergistic increase in
  1. (i) the pesticidal efficacy and/or
  2. (ii) the spectrum of activity against pests and/or phytopathogenic fungi and/or microorganisms and/or
  3. (iii) the control of pests and/or phytopathogenic fungi and/or microorganisms which display a partial or complete resistance or tolerance against a compound according to formula (I) or the plant to be engineered to be resistant against wildtype or sensitive strains of foresaid pest and/or phytopathogenic fungi and/or microorganisms.


[0096] In a preferred embodiment of the invention, the transgenic plants are treated with compound I-1 to obtain a synergistic increase in
  1. (i) the pesticidal efficacy and/or
  2. (ii) the spectrum of activity against pests and/or phytopathogenic fungi and/or microorganisms and/or
  3. (iii) the control of pests and/or phytopathogenic fungi and/or microorganisms which display a partial or complete resistance or tolerance compound I-1 or the plant to be engineered to be resistant against wildtype or sensitive strains of foresaid pest and/or phytopathogenic fungi and/or microorganisms.


[0097] In a preferred embodiment of the invention, the transgenic plants are treated with compound 1-2 to obtain a synergistic increase in
  1. (i) the pesticidal efficacy and/or
  2. (ii) the spectrum of activity against pests and/or phytopathogenic fungi and/or microorganisms and/or
  3. (iii) the control of pests and/or phytopathogenic fungi and/or microorganisms which display a partial or complete resistance or tolerance against compound I-2 or the plant to be engineered to be resistant against wildtype or sensitive strains of foresaid pest and/or phytopathogenic fungi and/or microorganisms.


[0098] In a preferred embodiment of the invention, the transgenic plants are treated with compound I-12 to obtain a synergistic increase in
  1. (i) the pesticidal efficacy and/or
  2. (ii) the spectrum of activity against pests and/or phytopathogenic fungi and/or microorganisms and/or
  3. (iii) the control of pests and/or phytopathogenic fungi and/or microorganisms which display a partial or complete resistance or tolerance against compound I-12 or the plant to be engineered to be resistant against wildtype or sensitive strains of foresaid pest and/or phytopathogenic fungi and/or microorganisms.


[0099] In a preferred embodiment of the invention, the transgenic plants are treated with compound I-15 to obtain a synergistic increase in
  1. (i) the pesticidal efficacy and/or
  2. (ii) the spectrum of activity against pests and/or phytopathogenic fungi and/or microorganisms and/or
  3. (iii) the control of pests and/or phytopathogenic fungi and/or microorganisms which display a partial or complete resistance or tolerance against compound I-12 or the plant to be engineered to be resistant against wildtype or sensitive strains of foresaid pest and/or phytopathogenic fungi and/or microorganisms.


[0100] The methods to determine the resistance of pests against active ingredients are well known to the person of ordinary skill in the art. Such methods can e.g. be found on the website of the "Insecticide Resistance Action Committee" under http://www.irac-online.org.

[0101] In a further preferred embodiment of the invention, the treatment of a transgenic plant with compound I-1 results in an increased health of the transgenic plant, wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises of one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0102] In a further preferred embodiment of the invention, the treatment of a transgenic plant with compound I-2 results in an increased health of the transgenic plant, wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises of one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0103] In a further preferred embodiment of the invention, the treatment of a transgenic plant with compound I-12 results in an increased health of the transgenic plant, wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises of one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0104] In a further preferred embodiment of the invention, the treatment of a transgenic plant with compound I-15 results in an increased health of the transgenic plant, wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises of one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0105] In a further preferred embodiment of the invention, the treatment of a transgenic plant with a compound according to formula (I) results in an increased health of the transgenic plant, wherein the transgenic plant:
  1. a.) is selected from the plants listed in Table A: A-1 to A-131 or Table B: B-1 to B-85, or
  2. b.) comprises of one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or
  3. c.) displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11, or
  4. d.) comprises a transgenic event selected from Table D from D-1 to D-48.


[0106] According to the invention the transgenic plants to be treated with a compound according to formula (I) can also contain combinations of transgenic events or traits that are disclosed in Tables A, B, C, and D.

[0107] According to the invention the transgenic plants to be treated with compound I-1 can also contain combinations of transgenic events or traits that are disclosed in Tables A, B, C, and D.

[0108] According to the invention the transgenic plants to be treated with compound I-2 can also contain combinations of transgenic events or traits that are disclosed in Tables A, B, C, and D.

[0109] According to the invention the transgenic plants to be treated with compound I-12 can also contain combinations of transgenic events or traits that are disclosed in Tables A, B, C, and D.

[0110] According to the invention the transgenic plants to be treated with compound I-15 can also contain combinations of transgenic events or traits that are disclosed in Tables A, B, C, and D.
Table A:
Non-exhaustive list of transgenic plants and events for working the invention. Source: AgBios database (AGBIOS, P.O. Box 475, 106 St. John St. Merrickville, Ontario K0G1N0, CANADA) which can be accessed under: http://www.agbios.com/dbase.php
No.Trans-genic eventCompanyDescriptionCrop
A-1 ASR368 Scotts Seeds Glyphosate tolerance derived by inserting a modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from Agrobacterium tumefaciens. Agrostis stolonifera Creeping Bentgrass
A-2 H7-1 Monsanto Company Glyphosate herbicide tolerant sugar beet produced by inserting a gene encoding the enzyme 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. Beta vulgaris
A-3 T120-7 Bayer CropScience (Aventis CropScience( AgrEvo)) Introduction of the PPT-acetyltransferase (PAT) encoding gene from Streptomyces viridochromogenes, an aerobic soil bacteria. PPT normally acts to inhibit glutamine synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. Beta vulgaris
A-4 GTSB77 Novartis Seeds; Monsanto Company Glyphosate herbicide tolerant sugar beet produced by inserting a gene encoding the enzyme 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. Beta vulgaris sugar Beet
A-5 23-18-17, 23-198 Monsanto Company (formerly Calgene) High laurate (12:0) and myristate (14:0) canola produced by inserting a thioesterase encoding gene from the California bay laurel (Umbellularia californica). Brassica napus (Argentine Canola)
A-6 45A37, 46A40 Pioneer Hi-Bred International Inc. High oleic acid and low linolenic acid canola produced through a combination of chemical mutagenesis to select for a fatty acid desaturase mutant with elevated oleic acid, and traditional back-crossing to introduce the low linolenic acid trait. Brassica napus (Argentine Canola)
A-7 46A12, 46A16 Pioneer Hi-Bred International Inc. Combination of chemical mutagenesis, to achieve the high oleic acid trait, and traditional breeding with registered canola varieties. Brassica napus (Argentine Canola)
A-8 GT200 Monsanto Company Glyphosate herbicide tolerant canola produced by inserting genes encoding the enzymes 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens and glyphosate oxidase from Ochrobactrum anthropi. Brassica napus (Argentine Canola)
A-9 GT73, RT73 Monsanto Company Glyphosate herbicide tolerant canola produced by inserting genes encoding the enzymes 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens and glyphosate oxidase from Ochrobactrum anthropi. Brassica napus (Argentine Canola)
A-10 HCN10 Aventis CropScience Introduction of the PPT-acetyltransferase (PAT) encoding gene from Streptomyces viridochromogenes, an aerobic soil bacteria. PPT normally acts to inhibit glutamine synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. Brassica napus (Argentine Canola)
A-11 HCN92 Bayer CropScience (Aventis CropScience( AgrEvo)) Introduction of the PPT-acetyltransferase (PAT) encoding gene from Streptomyces viridochromogenes, an aerobic soil bacteria. PPT normally acts to inhibit glutamine synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. Brassica napus (Argentine Canola)
A-12 MS1, RF1 =>PGS1 Aventis CropScience (formerly Plant Genetic Systems) Male-sterility, fertility restoration, pollination control system displaying glufosinate herbicide tolerance. MS lines contained the barnase gene from Bacillus amyloliquefaciens, RF lines contained the barstar gene from the same bacteria, and both lines contained the phosphinothricin N-acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus. Brassica napus (Argentine Canola)
A-13 MS1, RF2 =>PGS2 Aventis CropScience (formerly Plant Genetic Systems) Male-sterility, fertility restoration, pollination control system displaying glufosinate herbicide tolerance. MS lines contained the barnase gene from Bacillus amyloliquefaciens, RF lines contained the barstar gene from the same bacteria, and both lines contained the phosphinothricin N-acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus. Brassica napus (Argentine Canola)
A-14 MS8xRF3 Bayer CropScience (Aventis CropScience( AgrEvo)) Male-sterility, fertility restoration, pollination control system displaying glufosinate herbicide tolerance. MS lines contained the barnase gene from Bacillus amyloliquefaciens, RF lines contained the barstar gene from the same bacteria, and both lines contained the phosphinothricin N-acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus. Brassica napus (Argentine Canola)
A-15 NS738,
NS1471,
NS1473
Pioneer Hi-Bred
International Inc.
Selection of somaclonal variants with altered acetolactate synthase (ALS) enzymes, following chemical mutagenesis. Two lines (P1,P2) were initially selected with modifications at different unlinked loci. NS738 contains the P2 mutation only. Brassica
napus (Argentine Canola)
A-16 OXY-235 Aventis CropScience (formerly Rhône Poulenc Inc.) Tolerance to the herbicides bromoxynil and ioxynil by incorporation of the nitrilase gene from Klebsiella pneumoniae. Brassica napus (Argentine Canola)
A-17 PHY14,
PHY35
Aventis CropScience (formerly Plant Genetic Systems) Male sterility was via insertion of the barnase ribonuclease gene from Bacillus amyloliquefaciens; fertility restoration by insertion of the barstar RNase inhibitor; PPT resistance was via PPT-acetyltransferase (PAT) from Streptomyces hygroscopicus. Brassica napus (Argentine Canola)
A-18 PHY36 Aventis CropScience (formerly Plant Genetic Systems) Male sterility was via insertion of the barnase ribonuclease gene from Bacillus amyloliquefaciens; fertility restoration by insertion of the barstar RNase inhibitor; PPT resistance was via PPT-acetyltransferase (PAT) from Streptomyces hygroscopicus. Brassica napus (Argentine Canola)
A-19 T45 (HCN28) Bayer CropScience (Aventis CropScience( AgrEvo)) Introduction of the PPT-acetyltransferase (PAT) encoding gene from Streptomyces viridochromogenes, an aerobic soil bacteria. PPT normally acts to inhibit glutamine synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. Brassica napus (Argentine Canola)
A-20 HCR-1 Bayer CropScience (Aventis CropScience( AgrEvo)) Introduction of the glufosinate ammonium herbicide tolerance trait from transgenic B. napus line T45. This trait is mediated by the phosphinothricin acetyltransferase (PAT) encoding gene from S. viridochromogenes. Brassica rapa (Polish Canola)
A-21 ZSR500/502 Monsanto Company Introduction of a modified 5-enol-pyruvylshikimate-3-phosphate synthase (EPSPS) and a gene from Achromobacter sp that degrades glyphosate by conversion to aminomethylphosphonic acid (AMPA) and glyoxylate by interspecific crossing with GT73. Brassica rapa (Polish Canola)
A-22 55-1/63-1 Cornell University Papaya ringspot virus (PRSV) resistant papaya produced by inserting the coat protein (CP) encoding sequences from this plant potyvirus. Carica papaya (Papaya)
A-23 RM3-3,
RM3-4,
RM3-6
Bejo Zaden BV Male sterility was via insertion of the barnase ribonuclease gene from Bacillus amyloliquefaciens; PPT resistance was via the bar gene from S. hygroscopicus, which encodes the PAT enzyme. Cichorium intybus (Chicory )
A-24 A, B Agritope Inc. Reduced accumulation of Sadenosylmethionine (SAM), and consequently reduced ethylene synthesis, by introduction of the gene encoding S-adenosylmethionine hydrolase. Cucumis melo (Melon)
A-25 CZW-3 Asgrow (USA); Seminis Vegetable Inc. (Canada) Cucumber mosiac virus (CMV), zucchini yellows mosaic (ZYMV) and watermelon mosaic virus (WMV) 2 resistant squash ( Curcurbita pepo) produced by inserting the coat protein (CP) encoding sequences from each of these plant viruses into the host genome. Cucurbita pepo (Squash)
A-26 ZW20 Upjohn (USA); Seminis Vegetable Inc. (Canada) Zucchini yellows mosaic (ZYMV) and watermelon mosaic virus (WMV) 2 resistant squash ( Curcurbita pepo) produced by inserting the coat protein (CP) encoding sequences from each of these plant potyviruses into the host genome. Cucurbita pepo (Squash)
A-27 66 Florigene Pty Ltd. Delayed senescence and sulfonylurea herbicide tolerant carnations produced by inserting a truncated copy of the carnation aminocyclopropane cyclase (ACC) synthase encoding gene in order to suppress expression of the endogenous unmodified gene, which is required for normal ethylene biosynthesis. Tolerance to sulfonyl urea herbicides was via the introduction of a chlorsulfuron tolerant version of the acetolactate synthase (ALS) encoding gene from tobacco. Dianthus caryophyllus (Ca rnation)
A-28 4,11,15,16 Florigene Pty Ltd. Modified colour and sulfonylurea herbicide tolerant carnations produced by inserting two anthocyanin biosynthetic genes whose expression results in a violet/mauve colouration.Tolerance to sulfonyl urea herbicides was via the introduction of a chlorsulfuron tolerant version of the acetolactate synthase (ALS) encoding gene from tobacco. Dianthus caryophyllus (Ca rnation)
A-29 959A, 988A,
1226A,
1351A,
1363A,
1400A
Florigene Pty Ltd. Introduction of two anthocyanin biosynthetic genes to result in a violet/mauve colouration; Introduction of a variant form of acetolactate synthase (ALS). Dianthus caryophyllus (Ca rnation)
A-30 A2704-12,
A2704-21,
A5547-35
Aventis CropScience Glufosinate ammonium herbicide tolerant soybean produced by inserting a modified phosphinothricin acetyltransferase (PAT) encoding gene from the soil bacterium Streptomyces viridochromogenes. Glycine max
L. (Soybean)
A-31 A5547-127 Bayer CropScience (Aventis CropScience( AgrEvo)) Glufosinate ammonium herbicide tolerant soybean produced by inserting a modified phosphinothricin acetyltransferase (PAT) encoding gene from the soil bacterium Streptomyces viridochromogenes. Glycine max
L. (Soybean)
A-32 DP356043 Pioneer Hi-Bred International Inc. Soybean event with two herbicide tolerance genes: glyphosate N-acetlytransferase, which detoxifies glyphosate, and a modified acetolactate synthase (A Glycine max
L. (Soybean)
A-33 G94-1, G94-19, G168 DuPont Canada Agricultural Products High oleic acid soybean produced by inserting a second copy of the fatty acid desaturase (GmFad2-1) encoding gene from soybean, which resulted in "silencing" of the endogenous host gene. Glycine max
L. (Soybean)
A-34 GTS 40-3-2 Monsanto Company Glyphosate tolerant soybean variety produced by inserting a modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from the soil bacterium Agrobacterium tumefaciens. Glycine max
L. (Soybean)
A-35 GU262 Bayer CropScience (Aventis CropScience( AgrEvo)) Glufosinate ammonium herbicide tolerant soybean produced by inserting a modified phosphinothricin acetyltransferase (PAT) encoding gene from the soil bacterium Streptomyces viridochromogenes. Glycine max
L. (Soybean)
A-36 MON89788 Monsanto Company Glyphosate-tolerant soybean produced by inserting a modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding aroA (epsps) gene from Agrobacterium tumefaciens CP4. Glycine max
L. (Soybean)
A-37 OT96-15 Agriculture & Agri-Food Canada Low linolenic acid soybean produced through traditional cross-breeding to incorporate the novel trait from a naturally occurring fan1 gene mutant that was selected for low linolenic acid. Glycine max
L. (Soybean)
A-38 W62, W98 Bayer CropScience (Aventis CropScience( AgrEvo)) Glufosinate ammonium herbicide tolerant soybean produced by inserting a modified phosphinothricin acetyltransferase (PAT) encoding gene from the soil bacterium Streptomyces hygroscopicus. Glycine max
L. (Soybean)
A-39 15985 Monsanto Company Insect resistant cotton derived by transformation of the DP50B parent variety, which contained event 531 (expressing Cry1Ac protein), with purified plasmid DNA containing the cry2Ab gene from B. thuringiensis subsp. kurstaki. Gossypium hirsutum
L. (Cotton)
A-40 19-51A DuPont Canada Agricultural Products Introduction of a variant form of acetolactate synthase (ALS). Gossypium hirsutum
L. (Cotton)
A-41 281-24-236 DOW AgroSciences LLC Insect-resistant cotton produced by inserting the cry1F gene from Bacillus thuringiensisvar. aizawai. The PAT encoding gene from Streptomyces viridochromogenes was introduced as a selectable marker. Gossypium hirsutum
L. (Cotton)
A-42 3006-210-23 DOW AgroSciences LLC Insect-resistant cotton produced by inserting the cry1Ac gene from Bacillus thuringiensissubsp. kurstaki. The PAT encoding gene from Streptomyces viridochromogenes was introduced as a selectable marker. Gossypium hirsutum
L. (Cotton)
A-43 31807/31808 Calgene Inc. Insect-resistant and bromoxynil herbicide tolerant cotton produced by inserting the cry1Ac gene from Bacillus thuringiensis and a nitrilase encoding gene from Klebsiella pneumoniae. Gossypium hirsutum
L. (Cotton)
A-44 BXN Calgene Inc. Bromoxynil herbicide tolerant cotton produced by inserting a nitrilase encoding gene from Klebsiella pneumoniae. Gossypium hirsutum
L. (Cotton)
A-45 COT102 Syngenta Seeds, Inc. Insect-resistant cotton produced by inserting the vip3A(a) gene from Bacillus thuringiensisAB88. The APH4 encoding gene from E. coli was introduced as a selectable marker. Gossypium hirsutum
L. (Cotton)
A-46 DAS-21∅23-5 x DAS-24236-5 DOW AgroSciences LLC WideStrike™, a stacked insect-resistant cotton derived from conventional cross-breeding of parental lines 3006-210-23 (OECD identifier: DAS-21∅23-5) and 281-24-236 (OECD identifier: DAS-24236-5). Gossypium hirsutum
L. (Cotton)
A-47 DAS-21∅23-5 x DAS-24236-5 x MON88913 DOW AgroSciences LLC and Pioneer Hi-Bred International Inc. Stacked insect-resistant and glyphosate-tolerant cotton derived from conventional cross-breeding of WideStrike cotton (OECD identifier: DAS-21∅23-5 x DAS-24236-5) with MON88913, known as RoundupReady Flex (OECD identifier: MON-88913-8). Gossypium hirsutum
L. (Cotton)
A-48 DAS-21∅23-5 x DAS-24236-5 x MON-∅1445-2 DOW AgroSciences LLC WideStrike™/Roundup Ready® cotton, a stacked insect-resistant and glyphosate-tolerant cotton derived from conventional cross-breeding of WideStrike cotton (OECD identifier: DAS-21∅23-5 x DAS-24236-5) with MON1445 (OECD identifier: MON-∅1445-2). Gossypium hirsutum
L. (Cotton)
A-49 LLCotton25 Bayer CropScience (Aventis CropScience( AgrEvo)) Glufosinate ammonium herbicide tolerant cotton produced by inserting a modified phosphinothricin acetyltransferase (PAT) encoding gene from the soil bacterium Streptomyces hygroscopicus. Gossypium hirsutum
L. (Cotton)
A-50 LLCotton25 x MON15985 Bayer CropScience (Aventis CropScience( AgrEvo)) Stacked herbicide tolerant and insect resistant cotton combining tolerance to glufosinate ammonium herbicide from LLCotton25 (OECD identifier: ACS-GH∅∅1-3) with resistance to insects from MON15985 (OECD identifier: MON-15985-7) Gossypium hirsutum
L. (Cotton)
A-51 MON1445/16 98 Monsanto Company Glyphosate herbicide tolerant cotton produced by inserting a naturally glyphosate tolerant form of the enzyme 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) from A. tumefaciens strain CP4. Gossypium hirsutum L. (Cotton)
A-52 MON15985 x MON88913 Monsanto Company Stacked insect resistant and glyphosate tolerant cotton produced by conventional cross-breeding of the parental lines MON88913 (OECD identifier: MON-88913-8) and 15985 (OECD identifier: MON-15985-7). Glyphosate tolerance is derived from MON88913 which contains two genes encoding the enzyme 5-enolypyruvylshikimate-3 -phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. Insect resistance is derived MON15985 which was produced by transformation of the DP50B parent variety, which contained event 531 (expressing Cry1Ac protein), with purified plasmid DNA containing the cry2Ab gene from B. thuringiensis subsp. kurstaki. Gossypium hirsutum
L. (Cotton)
A-53 MON-15985-7 x MON-∅1445-2 Monsanto Company Stacked insect resistant and herbicide tolerant cotton derived from conventional cross-breeding of the parental lines 15985 (OECD identifier: MON-15985-7) and MON1445 (OECD identifier: MON-∅1445-2). Gossypium hirsutum
L. (Cotton)
A-54 MON531/757 /1076 Monsanto Company Insect-resistant cotton produced by inserting the cry1Ac gene from Bacillus thuringiensis subsp. kurstaki HD-73 (B.t.k.). Gossypium hirsutum
L. (Cotton)
A-55 MON88913 Monsanto Company Glyphosate herbicide tolerant cotton produced by inserting two genes encoding the enzyme 5-enolypyruvylshikimate-3 -phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. Gossypium hirsutum
L. (Cotton)
A-56 MON-∅∅531-6 x MON-∅1445-2 Monsanto Company Stacked insect resistant and herbicide tolerant cotton derived from conventional cross-breeding of the parental lines MON531 (OECD identifier: MON-∅∅531-6) and MON1445 (OECD identifier: MON-∅1445-2). Gossypium hirsutum L. (Cotton)
A-57 X81359 BASF Inc. Tolerance to imidazolinone herbicides by selection of a naturally occurring mutant. Helianthus annuus (Sunflow er)
A-58 RH44 BASF Inc. Selection for a mutagenized version of the enzyme acetohydroxyacid synthase (AHAS), also known as acetolactate synthase (ALS) or acetolactate pyruvate- lyase. Lens culinaris (Lentil)
A-59 FP967 University of Saskatchewan , Crop Dev. Centre A variant form of acetolactate synthase (ALS) was obtained from a chlorsulfuron tolerant line of A. thaliana and used to transform flax. Linum usitatissimum L. (Flax, Linseed)
A-60 5345 Monsanto Company Resistance to lepidopteran pests through the introduction of the cry1Ac gene from Bacillus thuringiensis subsp. Kurstaki. Lycopersicon esculentum (Tom ato)
A-61 8338 Monsanto Company Introduction of a gene sequence encoding the enzyme 1-amino-cyclopropane-1-carboxylic acid deaminase (ACCd) that metabolizes the precursor of the fruit ripening hormone ethylene. Lycopersicon esculentum (Tom ato)
A-62 1345-4 DNA Plant Technology Corporation Delayed ripening tomatoes produced by inserting an additional copy of a truncated gene encoding 1-aminocyclopropane-1-carboxyllic acid (ACC) synthase, which resulted in downregulation of the endogenous ACC synthase and reduced ethylene accumulation. Lycopersicon esculentum (Tom ato)
A-63 35 1 N Agritope Inc. Introduction of a gene sequence encoding the enzyme S-adenosylmethionine hydrolase that metabolizes the precursor of the fruit ripening hormone ethylene Lycopersicon esculentum (Tom ato)
A-64 B, Da, F Zeneca Seeds Delayed softening tomatoes produced by inserting a truncated version of the polygalacturonase (PG) encoding gene in the sense or anti-sense orientation in order to reduce expression of the endogenous PG gene, and thus reduce pectin degradation. Lycopersicon esculentum (Tom ato)
A-65 FLAVR SAVR Calgene Inc. Delayed softening tomatoes produced by inserting an additional copy of the polygalacturonase (PG) encoding gene in the anti-sense orientation in order to reduce expression of the endogenous PG gene and thus reduce pectin degradation. Lycopersicon esculentum (Tom ato)
A-66 J101, J163 Monsanto Company and Forage Genetics International Glyphosate herbicide tolerant alfalfa (lucerne) produced by inserting a gene encoding the enzyme 5-enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. Medicago sativa (Alfalfa)
A-67 C/F/93/08-02 Societe National d'Exploitation des Tabacs et Allumettes Tolerance to the herbicides bromoxynil and ioxynil by incorporation of the nitrilase gene from Klebsiella pneumoniae. Nicotiana tabacum L. (Tobacco)
A-68 Vector 21-41 Vector Tobacco Inc. Reduced nicotine content through introduction of a second copy of the tobacco quinolinic acid phosphoribosyltransferase (QTPase) in the antisense orientation. The NPTII encoding gene from E. coli was introduced as a selectable marker to identify transformants. Nicotiana tabacum L. (Tobacco)
A-69 CL121,
CL141,
CFX51
BASF Inc. Tolerance to the imidazolinone herbicide, imazethapyr, induced by chemical mutagenesis of the acetolactate synthase (ALS) enzyme using ethyl methanesulfonate (EMS). Oryza sativa (Rice)
A-70 IMINTA-1,
IMINTA-4 ,
BASF Inc. Tolerance to imidazolinone herbicides induced by chemical mutagenesis of the acetolactate synthase (ALS) enzyme using sodium azide. Oryza sativa (Rice)
A-71 LLRICE06
LLRICE62
Aventis CropScience Glufosinate ammonium herbicide tolerant rice produced by inserting a modified phosphinothricin acetyltransferase (PAT) encoding gene from the soil bacterium Streptomyces hygroscopicus). Oryza sativa (Rice)
A-72 LLRICE601 Bayer CropScience (Aventis CropScience( AgrEvo)) Glufosinate ammonium herbicide tolerant rice produced by inserting a modified phosphinothricin acetyltransferase (PAT) encoding gene from the soil bacterium Streptomyces hygroscopicus). Oryza sativa (Rice)
A-73 C5 United States Department of Agriculture - Agricultural Research Service Plum pox virus (PPV) resistant plum tree produced through Agrobacterium-mediated transformation with a coat protein (CP) gene from the virus. Prunus domestica (Plum)
A-74 PWC16 BASF Inc. Tolerance to the imidazolinone herbicide, imazethapyr, induced by chemical mutagenesis of the acetolactate synthase (ALS) enzyme using ethyl methanesulfonate (EMS). Oryza sativa (Rice)
A-75 ATBT04-6,
ATBT04-27,
ATBT04-30,
ATBT04-31,
ATBT04-36,
SPBT02-5,
SPBT02-7
Monsanto Company Colorado potato beetle resistant potatoes produced by inserting the cry3A gene from Bacillus thuringiensis (subsp. Tenebrionis). Solanum tuberosum L. (Potato)
A-76 BT6, BT10,
BT12, BT16,
BT17, BT18,
BT23
Monsanto Company Colorado potato beetle resistant potatoes produced by inserting the cry3A gene from Bacillus thuringiensis (subsp. Tenebrionis). Solanum tuberosum L. (Potato)
A-77 RBMT15-101,
SEMT15-02,
SEMT15-15
Monsanto Company Colorado potato beetle and potato virus Y (PVY) resistant potatoes produced by inserting the cry3A gene from Bacillus thuringiensis (subsp. Tenebrionis) and the coat protein encoding gene from PVY. Solanum tuberosum L. (Potato)
A-78 RBMT21-129,
RBMT21-350,
RBMT22-082
Monsanto Company Colorado potato beetle and potato leafroll virus (PLRV) resistant potatoes produced by inserting the cry3A gene from Bacillus thuringiensis (subsp. Tenebrionis) and the replicase encoding gene from PLRV. Solanum tuberosum L. (Potato)
A-79 AP205CL BASF Inc. Selection for a mutagenized version of the enzyme acetohydroxyacid synthase (AHAS), also known as acetolactate synthase (ALS) or acetolactate pyruvate- lyase. Triticum aestivum (Wheat )
A-80 AP602CL BASF Inc. Selection for a mutagenized version of the enzyme acetohydroxyacid synthase (AHAS), also known as acetolactate synthase (ALS) or acetolactate pyruvate- lyase. Triticum aestivum (Wheat )
A-81 BW255-2,
BW238-3
BASF Inc. Selection for a mutagenized version of the enzyme acetohydroxyacid synthase (AHAS), also known as acetolactate synthase (ALS) or acetolactate pyruvate- lyase. Triticum aestivum (Wheat )
A-82 BW7 BASF Inc. Tolerance to imidazolinone herbicides induced by chemical mutagenesis of the acetohydroxyacid synthase (AHAS) gene using sodium azide. Triticum aestivum (Wheat )
A-83 MON71800 Monsanto Company Glyphosate tolerant wheat variety produced by inserting a modified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from the soil bacterium Agrobacterium tumefaciens, strain CP4. Triticum aestivum (Wheat )
A-84 SWP965001 Cyanamid Crop Protection Selection for a mutagenized version of the enzyme acetohydroxyacid synthase (AHAS), also known as acetolactate synthase (ALS) or acetolactate pyruvate- lyase. Triticum aestivum (Wheat )
A-85 Teal 11A BASF Inc. Selection for a mutagenized version of the enzyme acetohydroxyacid synthase (AHAS), also known as acetolactate synthase (ALS) or acetolactate pyruvate- lyase. Triticum aestivum (Wheat )
A-86 176 Syngenta Seeds, Inc. Insect-resistant maize produced by inserting the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki. The genetic modification affords resistance to attack by the European corn borer (ECB). Zea mays
L. (Maize)
A-87 3751IR Pioneer Hi-Bred International Inc. Selection of somaclonal variants by culture of embryos on imidazolinone containing media. Zea mays
L. (Maize)
A-88 676,678,680 Pioneer Hi-Bred International Inc. Male-sterile and glufosinate ammonium herbicide tolerant maize produced by inserting genes encoding DNA adenine methylase and phosphinothricin acetyltransferase (PAT) from Escherichia coli and Streptomyces viridochromogenes, respectively. Zea mays
L. (Maize)
A-89 ACS-ZM∅∅3-2 x MON-∅∅81∅-6 Bayer CropScience (Aventis CropScience( AgrEvo)) Stacked insect resistant and herbicide tolerant corn hybrid derived from conventional cross-breeding of the parental lines T25 (OECD identifier: ACS-ZM∅∅3-2) and MON810 (OECD identifier:MON-∅∅81∅-6). Zea mays
L. (Maize)
A-90 B16 (DLL25) Dekalb Genetics Corporation Glufosinate ammonium herbicide tolerant maize produced by inserting the gene encoding phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus. Zea mays
L. (Maize)
A-91 BT11
(X4334CBR, X4734CBR)
Syngenta
Seeds, Inc.
Insect-resistant and herbicide tolerant maize produced by inserting the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S. viridochromogenes. Zea mays
L. (Maize)
A-92 BT11 x
MIR604
Syngenta
Seeds, Inc.
Stacked insect resistant and herbicide tolerant maize produced by conventional cross breeding of parental lines BT11 (OECD unique identifier: SYN-BT∅11-1) and MIR604 (OECD unique identifier: SYN-IR6∅5-5). Resistance to the European Corn Borer and tolerance to the herbicide glufosinate ammonium (Liberty) is derived from BT11, which contains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S. viridochromogenes. Corn rootworm-resistance is derived from MIR604 which contains the mcry3A gene from Bacillus thuringiensis. Zea mays
L. (Maize)
A-93 BT11 x
MIR604 x GA21
Syngenta
Seeds, Inc.
Stacked insect resistant and herbicide tolerant maize produced by conventional cross breeding of parental lines BT11 (OECD unique identifier: SYN-BT∅11-1), MIR604 (OECD unique identifier: SYN-IR6∅5-5) and GA21 (OECD unique identifier: MON-∅∅∅21-9). Resistance to the European Corn Borer and tolerance to the herbicide glufosinate ammonium (Liberty) is derived from BT11, which contains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S. viridochromogenes. Corn rootworm-resistance is derived from MIR604 which contains the mcry3A gene from Bacillus thuringiensis. Tolerance to glyphosate herbcicide is derived from GA21 which contains a modified EPSPS gene from maize. Zea mays
L. (Maize)
A-94 CBH-351 Aventis
CropScience
Insect-resistant and glufosinate ammonium herbicide tolerant maize developed by inserting genes encoding Cry9C protein from Bacillus thuringiensis subsp tolworthi and phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus. Zea mays
L. (Maize)
A-95 DAS-06275-8 DOW
AgroSciences LLC
Lepidopteran insect resistant and glufosinate ammonium herbicide-tolerant maize variety produced by inserting the cry1F gene from Bacillus thuringiensis var aizawai and the phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus. Zea mays
L. (Maize)
A-96 DAS-59122-7 DOW AgroSciences LLC and Pioneer Hi-Bred International Inc. Corn rootworm-resistant maize produced by inserting the cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1. The PAT encoding gene from Streptomyces viridochromogenes was introduced as a selectable marker. Zea mays
L. (Maize)
A-97 DAS-59122-7 x NK603 DOW AgroSciences LLC and Pioneer Hi-Bred International Inc. Stacked insect resistant and herbicide tolerant maize produced by conventional cross breeding of parental lines DAS-59122-7 (OECD unique identifier: DAS-59122-7) with NK603 (OECD unique identifier: MON-∅∅6∅3-6). Corn rootworm-resistance is derived from DAS-59122-7 which contains the cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1. Tolerance to glyphosate herbcicide is derived from NK603. Zea mays
L. (Maize)
A-98 DAS-59122-7 x TC1507 x NK603 DOW AgroSciences LLC and Pioneer Hi-Bred International Inc. Stacked insect resistant and herbicide tolerant maize produced by conventional cross breeding of parental lines DAS-59122-7 (OECD unique identifier: DAS-59122-7) and TC1507 (OECD unique identifier: DAS-∅15∅7-1) with NK603 (OECD unique identifier: MON-∅∅6∅3-6). Corn rootworm-resistance is derived from DAS-59122-7 which contains the cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1. Lepidopteran resistance and toleraance to glufosinate ammonium herbicide is derived from TC1507. Tolerance to glyphosate herbcicide is derived from NK603. Zea mays
L. (Maize)
A-99 DAS-∅15∅7-1 x MON-∅∅6∅3-6 DOW AgroSciences LLC Stacked insect resistant and herbicide tolerant corn hybrid derived from conventional cross-breeding of the parental lines 1507 (OECD identifier: DAS-∅15∅7-1) and NK603 (OECD identifier: MON-∅∅6∅∅-6). Zea mays
L. (Maize)
A-100 DBT418 Dekalb Genetics Corporation Insect-resistant and glufosinate ammonium herbicide tolerant maize developed by inserting genes encoding Cry1AC protein from Bacillus thuringiensis subsp kurstaki and phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus Zea mays
L. (Maize)
A-101 DK404SR BASF Inc. Somaclonal variants with a modified acetyl-CoA-carboxylase (ACCase) were selected by culture of embryos on sethoxydim enriched medium. Zea mays
L. (Maize)
A-102 Event 3272 Syngenta Seeds, Inc. Maize line expressing a heat stable alpha-amylase gene amy797E for use in the dry-grind ethanol process. The phosphomannose isomerase gene from E.coli was used as a selectable marker. Zea mays
L. (Maize)
A-103 EXP19101T Syngenta Seeds, Inc. (formerly Zeneca Seeds) Tolerance to the imidazolinone herbicide, imazethapyr, induced by chemical mutagenesis of the acetolactate synthase (ALS) enzyme using ethyl methanesulfonate (EMS). Zea mays
L. (Maize)
A-104 GA21 Monsanto Company Introduction, by particle bombardment, of a modified 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an enzyme involved in the shikimate biochemical pathway for the production of the aromatic amino acids. Zea mays
L. (Maize)
A-105 IT Pioneer Hi-Bred International Inc. Tolerance to the imidazolinone herbicide, imazethapyr, was obtained by in vitro selection of somaclonal variants. Zea mays
L. (Maize)
A-106 LY038 Monsanto Company Altered amino acid composition, specifically elevated levels of lysine, through the introduction of the cordapA gene, derived from Corynebacterium glutamicum, encoding the enzyme dihydrodipicolinate synthase (cDHDPS). Zea mays
L. (Maize)
A-107 MIR604 Syngenta Seeds, Inc. Corn rootworm resistant maize produced by transformation with a modified cry3A gene. The phosphomannose isomerase gene from E.coli was used as a selectable marker. Zea mays L. (Maize)
A-108 MIR604 x GA21 Syngenta Seeds, Inc. Stacked insect resistant and herbicide tolerant maize produced by conventional cross breeding of parental lines MIR604 (OECD unique identifier: SYN-IR6∅5-5) and GA21 (OECD unique identifier: MON-∅∅∅21-9). Corn rootworm-resistance is derived from MIR604 which contains the mcry3A gene from Bacillus thuringiensis. Tolerance to glyphosate herbcicide is derived from GA21. Zea mays
L. (Maize)
A-109 MON80100 Monsanto Company Insect-resistant maize produced by inserting the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki. The genetic modification affords resistance to attack by the European corn borer (ECB). Zea mays
L. (Maize)
A-110 MON802 Monsanto Company Insect-resistant and glyphosate herbicide tolerant maize produced by inserting the genes encoding the Cry1Ab protein from Bacillus thuringiensis and the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from A. tumefaciens strain CP4. Zea mays
L. (Maize)
A-111 MON809 Pioneer Hi-Bred International Inc. Resistance to European corn borer (Ostrinia nubilalis) by introduction of a synthetic cry1Ab gene. Glyphosate resistance via introduction of the bacterial version of a plant enzyme, 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS). Zea mays
L. (Maize)
A-112 MON810 Monsanto Company Insect-resistant maize produced by inserting a truncated form of the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki HD-1. The genetic modification affords resistance to attack by the European corn borer (ECB). Zea mays
L. (Maize)
A-113 MON810 x MON88017 Monsanto Company Stacked insect resistant and glyphosate tolerant maize derived from conventional cross-breeding of the parental lines MON810 (OECD identifier: MON-∅∅81-6) and MON88017 (OECD identifier:MON-88∅17-3). European corn borer (ECB) resistance is derived from a truncated form of the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki HD-1 present in MON810. Corn rootworm resistance is derived from the cry3Bb1 gene from Bacillus thuringiensis subspecies kumamotoensis strain EG4691 present in MON88017. Glyphosate tolerance is derived from a 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from Agrobacterium tumefaciens strain CP4 present in MON88017. Zea mays
L. (Maize)
A-114 MON832 Monsanto Company Introduction, by particle bombardment, of glyphosate oxidase (GOX) and a modified 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an enzyme involved in the shikimate biochemical pathway for the production of the aromatic amino acids. Zea mays
L. (Maize)
A-115 MON863 Monsanto Company Corn root worm resistant maize produced by inserting the cry3Bb1 gene from Bacillus thuringiensis subsp. kumamotoensis. Zea mays
L. (Maize)
A-116 MON88017 Monsanto Company Corn rootworm-resistant maize produced by inserting the cry3Bb1 gene from Bacillus thuringiensis subspecies kumamotoensis strain EG4691. Glyphosate tolerance derived by inserting a 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from Agrobacterium tumefaciens strain CP4. Zea mays
L. (Maize)
A-117 MON89034 Monsanto Company Maize event expressing two different insecticidal proteins from Bacillus thuringiensis providing resistance to number of lepidopteran pests. Zea mays
L. (Maize)
A-118 MON89034 x MON88017 Monsanto Company Stacked insect resistant and glyphosate tolerant maize derived from conventional cross-breeding of the parental lines MON89034 (OECD identifier: MON-89∅34-3) and MON88017 (OECD identifier:MON-88∅17-3). Resistance to Lepiopteran insects is derived from two crygenes present in MON89043. Corn rootworm resistance is derived from a single cry genes and glyphosate tolerance is derived from the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from Agrobacterium tumefaciens present in MON88017. Zea mays
L. (Maize)
A-119 MON-
∅∅ 6∅3-6 x
MON-∅∅81∅-6
Monsanto Company Stacked insect resistant and herbicide tolerant corn hybrid derived from conventional cross-breeding of the parental lines NK603 (OECD identifier: MON-∅∅6∅3-6) and MON810 (OECD identifier: MON-∅∅81∅-6). Zea mays
L. (Maize)
A-120 MON-∅∅81∅-6 x LY038 Monsanto Company Stacked insect resistant and enhanced lysine content maize derived from conventional cross-breeding of the parental lines MON810 (OECD identifier: MON-∅∅81∅-6) and LY038 (OECD identifier: REN-∅∅∅38-3). Zea mays
L. (Maize)
A-121 MON-∅∅863-5 x MON-∅∅6∅3-6 Monsanto Company Stacked insect resistant and herbicide tolerant corn hybrid derived from conventional cross-breeding of the parental lines MON863 (OECD identifier:MON-∅∅863-5) and NK603 (OECD identifier: MON-∅∅6∅3-6). Zea mays
L. (Maize)
A-122 MON-∅∅863-5 x MON-∅∅81∅-6 Monsanto Company Stacked insect resistant corn hybrid derived from conventional cross-breeding of the parental lines MON863 (OECD identifier: MON-∅∅863-5) and MON810 (OECD identifier: MON-∅∅81∅-6) Zea mays
L. (Maize)
A-123 MON-∅∅863-5 x MON-00810-6 x MON-00603-6 Monsanto Company Stacked insect resistant and herbicide tolerant corn hybrid derived from conventional cross-breeding of the stacked hybrid MON-∅∅863-5 x MON-∅∅81∅-6 and NK603 (OECD identifier:MON-∅∅6∅3-6). Zea mays
L. (Maize)
A-124 MON-∅∅∅21-9 x MON-∅∅81∅-6 Monsanto Company Stacked insect resistant and herbicide tolerant corn hybrid derived from conventional cross-breeding of the parental lines GA21 (OECD identifider: MON-∅∅∅21-9) and MON810 (OECD identifier: MON-∅∅81∅-6). Zea mays
L. (Maize)
A-125 MS3 Bayer CropScience (Aventis CropScience( AgrEvo)) Male sterility caused by expression of the barnase ribonuclease gene from Bacillus amyloliquefaciens; PPT resistance was via PPT-acetyltransferase (PAT). Zea mays
L. (Maize)
A-126 MS6 Bayer CropScience (Aventis CropScience( AgrEvo)) Male sterility caused by expression of the barnase ribonuclease gene from Bacillus amyloliquefaciens; PPT resistance was via PPT-acetyltransferase (PAT). Zea mays
L. (Maize)
A-127 NK603 Monsanto Company Introduction, by particle bombardment, of a modified 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an enzyme involved in the shikimate biochemical pathway for the production of the aromatic amino acids. Zea mays
L. (Maize)
A-128 SYN-BTØ11-1 x MON-ØØØ21-9 Syngenta Seeds, Inc. Stacked insect resistant and herbicide tolerant maize produced by conventional cross breeding of parental lines BT11 (OECD unique identifier: SYN-BTØ11-1) and GA21 (OECD unique identifier: MON-ØØØ21-9). Zea mays
L. (Maize)
A-129 T14, T25 Bayer CropScience (Aventis CropScience( AgrEvo)) Glufosinate herbicide tolerant maize produced by inserting the phosphinothricin N-acetyltransferase (PAT) encoding gene from the aerobic actinomycete Streptomyces viridochromogenes. Zea mays
L. (Maize)
A-130 TC1507 Mycogen (c/o Dow AgroSciences ); Pioneer (c/o Dupont) Insect-resistant and glufosinate ammonium herbicide tolerant maize produced by inserting the cry1f gene from Bacillus thuringiensis var. aizawai and the phosphinothricin N-acetyltransferase encoding gene from Streptomyces viridochromogenes. Zea mays
L. (Maize)
A-131 TC1507 x DAS-59122-7 DOW AgroSciences LLC and Pioneer Hi-Bred International Inc. Stacked insect resistant and herbicide tolerant maize produced by conventional cross breeding of parental lines TC1507 (OECD unique identifier: DAS-Ø15Ø7-1) with DAS-59122-7 (OECD unique identifier: DAS-59122-7). Resistance to lepidopteran insects is derived from TC1507 due the presence of the cry1F gene from Bacillus thuringiensis var. aizawai. Corn rootworm-resistance is derived from DAS-59122-7 which contains the cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1. Tolerance to glufosinate ammonium herbcicide is derived from TC1507 from the phosphinothricin N-acetyltransferase encoding gene from Streptomyces viridochromogenes. Zea mays
L. (Maize)


[0111] In one embodiment of the invention, the plants A-1 to A-131 of Table A, in total, or parts thereof, or propagation material of said plants are treated or contacted with a compound according to formula (I) alone, or in the form of compositions comprising a compound according to formula (I).

[0112] In one embodiment of the invention, the plants A-1 to A-131 of Table A, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-15 alone, or in the form of compositions comprising compound I-1.

[0113] In one embodiment of the invention, the plants A-1 to A-131 of Table A, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-15 alone, or in the form of compositions comprising compound I-2.

[0114] In one embodiment of the invention, the plants A-1 to A-131 of Table A, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-15 alone, or in the form of compositions comprising compound I-12.

[0115] In one embodiment of the invention, the plants A-1 to A-131 of Table A, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-15 alone, or in the form of compositions comprising compound I-15.

Table B



[0116] Non-exhaustive list of transgenic plants to work the invention from on APHIS database of the United States Department of Agriculture (USDA). The database can be found on : http://www.aphis.usda.gov/animal_welfare/efoia/index.shtml

Abbreviations used in this table:



[0117] 

CMV-cucumber mosaic virus

CPB-colorado potato beetle

PLRV- potato leafroll virus

PRSV-papaya ringspot virus

PVY-potato virus Y

WMV2- watermelon mosaic virus 2

ZYMV-zucchini yellow mosaic virus

No.PetitionExtension of Petition NumberInstitutionPlantTraitTrans- formation Event or LineFinal EA
&
Determination
B-1 08-315-01p   Florigene Rose Altered Flower Color Rosa X hybrida  
B-2 07-253-01p   Syngenta Corn Lepidopteran resistant MIR-162 Maize  
B-3 07-152-01p   Pioneer Corn glyphosate & Imidazolinone tolerant HT-98140  
B-4 07-108-01p   Syngenta Cotton Lepidopteran Resistant COT67B  
B-5 06-354-01p   Pioneer Soybean High Oleic Acid DP-3Ø5423-1  
B-6 06-332-01p   Bayer CropScience Cotton Glyphosate tolerant GHB614  
B-7 05-280-01p   Syngenta Corn Thermostable alpha-amylase 3272  
B-8 04-337-01p   University of Florida Papaya Papaya Ringspot Virus Resistant X17-2  
B-9 04-110-01p   Monsanto & Forage Genetics Alfalfa Glyphosate Tolerant J101, J163 04-110-01p_com
B-10 03-104-01p   Monsanto & Scotts Creeping bentgrass Glyphosate Tolerant ASR368  
B-11 06-298-01p   Monsanto Corn European Corn Borer resistant MON 89034 06-298-01p_com
B-12 06-271-01p   Pioneer Soybean Glyphosate & acetolactate synthase tolerant 356043 (DP-356Ø43-5) 06-271-01p_com
B-13 06-234-01p 98-329-01p Bayer CropScience Rice Phosphinothrici n tolerant LLRICE601 06-234-01p_com
B-14 06-178-01p   Monsanto Soybean Glyphosate tolerant MON 89788 06-178-01p_com
B-15 04-362-01p   Syngenta Corn Corn Rootworm Protected MIR604 04-362-01p_com
B-16 04-264-01p   ARS Plum Plum Pox Virus Resistant C5 04-264-01p_com
B-17 04-229-01p   Monsanto Corn High Lysine LY038 04-229-01p_com
B-18 04-125-01p   Monsanto Corn Corn Rootworm Resistant MON 88017 04-125-01p_com
B-19 04-086-01p   Monsanto Cotton Glyphosate Tolerant MON 88913 04-086-01p_com
B-20 03-353-01p   Dow Corn Corn Rootworm Resistant 59122 03-353-01p_com
B-21 03-323-01p   Monsanto Sugar Beet Glyphosate Tolerant H7-1 03-323-01p_com
B-22 03-181-01p 00-136-01p Dow Corn Lepidopteran Resistant & Phosphinothrici n tolerant TC-6275 03-181-01p_com
B-23 03-155-01p   Syngenta Cotton Lepidopteran Resistant COT 102 03-155-01p_com
B-24 03-036-01p   Mycogen/Do w Cotton Lepidopteran Resistant 281-24-236 03-036-01p_com
B-25 03-036-02p   Mycogen/Do w Cotton Lepidopteran Resistant 3006-210-23 03-036-02p com
B-26 02-042-01p   Aventis Cotton Phosphinotherici n tolerant LLCotton25 02-042-01p_com
B-27 01-324-01p 98-216-01p Monsanto Rapeseed Glyphosate tolerant RT200 01-324-01p_com
B-28 01-206-01p 98-278-01p Aventis Rapeseed Phosphinothrici n tolerant & pollination control MS1 & RF1/RF2 01-206-01p_com
B-29 01-206-02p 97-205-01p Aventis Rapeseed Phosphinothrici n tolerant Topas 19/2 01-206-02p_com
B-30 01-137-01p   Monsanto Corn Corn Rootworm Resistant MON 863 01-137-01p_com
B-31 01-121-01p   Vector Tobacco Reduced nicotine Vector 21-41 01-121-01p_com
B-32 00-342-01p   Monsanto Cotton Lepidopteran resistant Cotton Event 15985 00-342-01p_com
B-33 00-136-01p   Mycogen c/o Dow & Pioneer Corn Lepidopteran resistant phosphinothricin tolerant Line 1507 00-136-01p_com
B-34 00-011-01p 97-099-01p Monsanto Corn Glyphosate tolerant NK603 00-011-01p_com
B-35 99-173-01p 97-204-01p Monsanto Potato PLRV & CPB resistant RBMT22-82 99-173-01p_com
B-36 98-349-01p 95-228-01p AgrEvo Corn Phosphinothrici n tolerant and Male sterile MS6 98-349-01p_com
B-37 98-335-01p   U. of Saskatchewan Flax Tolerant to soil residues of sulfonyl urea herbicide CDC Triffid 98-335-01p_com
B-38 98-329-01p   AgrEvo Rice Phosphinothrici n tolerant LLRICE06, LLRICE62 98-329-01p_com
B-39 98-278-01p   AgrEvo Rapeseed Phosphinothrici n tolerant & Pollination control MS8 & RF3 98-278-01p_com
B-40 98-238-01p   AgrEvo Soybean Phosphinothrici n tolerant GU262 98-238-01p_com
B-41 98-216-01p   Monsanto Rapeseed Glyphosate tolerant RT73 98-216-01p_com
B-42 98-173-01p   Novartis Seeds & Monsanto Beet Glyphosate tolerant GTSB77 98-173-01p_com
B-43 98-014-01p 96-068-01p AgrEvo Soybean Phosphinothrici n tolerant A5547-127 98-014-01p_com
B-44 97-342-01p   Pioneer Corn Male sterile & Phosphinothrici n tolerant 676,678,680 97-342-01p_com
B-45 97-339-01p   Monsanto Potato CPB & PVY resistant RBMT15-101, SEMT15-02, SEMT15-15 97-339-01p_com
B-46 97-336-01p   AgrEvo Beet Phosphinothrici n tolerant T-120-7 97-336-01p_com
B-47 97-287-01p   Monsanto Tomato Lepidopteran resistant 5345 97-287-01p_com
B-48 97-265-01p   AgrEvo Corn Phosphinothrici n tolerant & Lep. resistant CBH-351 97-265-01p_com
B-49 97-205-01p   AgrEvo Rapeseed Phosphinothrici n tolerant T45 97-205-01p_com
B-50 97-204-01p   Monsanto Potato CPB & PLRV resistant RBMT21-129 & RBMT21-350 97-204-01p_com
B-51 97-148-01p   Bejo Cichorium intybus Male sterile RM3-3, RM3-4, RM3-6 97-148-01p_com
B-52 97-099-01p   Monsanto Corn Glyphosate tolerant GA21 97-099-01p_com
B-53 97-013-01p   Calgene Cotton Bromoxynil tolerant & Lepidopteran resistant Events 31807 & 31808 97-013-01p_com
B-54 97-008-01p   Du Pont Soybean Oil profile altered G94-1, G94-19, G-168 97-008-01p_com
B-55 96-317-01p   Monsanto Corn Glyphosate tolerant & ECB resistant MON802 96-317-01p_com
B-56 96-291-01p   DeKalb Corn European Corn Borer resistant DBT418 96-291-01p_com
B-57 96-248-01p 92-196-01p Calgene Tomato Fruit ripening altered 1 additional FLAVRSAV R line 96-248-01p_com
B-58 96-068-01p   AgrEvo Soybean Phosphinothrici n tolerant W62, W98, A2704- 12, A2704-21, A5547-35 96-068-01p_com
B-59 96-051-01p   Cornell U Papaya PRSV resistant 55-1,63-1 96-051-01p_com
B-60 96-017-01p 95-093-01p Monsanto Corn European Corn Borer resistant MON809 & MON810 96-017-01p_com
B-61 95-352-01p   Asgrow Squash CMV, ZYMV, WMV2 resistant CZW-3 95-352-01p_com
B-62 95-338-01p   Monsanto Potato CPB resistant SBT02-5 & -7, ATBT04-6 &-27, -30, -31, -36 95-338-01p_com
B-63 95-324-01p   Agritope Tomato Fruit ripening altered 35 1 N 95-324-01p_com
B-64 95-256-01p   Du Pont Cotton Sulfonylurea tolerant 19-51a 95-256-01p_com
B-65 95-228-01p   Plant Genetic Systems Corn Male sterile MS3 95-228-01p_com
B-66 95-195-01p   Northrup King Corn European Corn Borer resistant Bt11 95-195-01p_com
B-67 95-179-01p 92-196-01p Calgene Tomato Fruit ripening altered 2 additional FLAVRSAV R lines 95-179-01p_com
B-68 95-145-01p   DeKalb Corn Phosphinothrici n tolerant B16 95-145-01p_com
B-69 95-093-01p   Monsanto Corn Lepidopteran resistant MON 80100 95-093-01p_com
B-70 95-053-01p   Monsanto Tomato Fruit ripening altered 8338 95-053-01p_com
B-71 95-045-01p   Monsanto Cotton Glyphosate tolerant 1445,1698 95-045-01p_com
B-72 95-030-01p 92-196-01p Calgene Tomato Fruit ripening altered 20 additional FLAVRSAV R lines 95-030-01p_com
B-73 94-357-01p   AgrEvo Corn Phosphinothrici n tolerant T14, T25 94-357-01p_com
B-74 94-319-01p   Ciba Seeds Corn Lepidopteran resistant Event 176 94-319-01p_com
B-75 94-308-01p   Monsanto Cotton Lepidopteran resistant 531,757, 1076 94-308-01p_com
B-76 94-290-01p   Zeneca & Petoseed Tomato Fruit polygalacturona se level decreased B, Da, F 94-290-01p_com
B-77 94-257-01p   Monsanto Potato Coleopteran resistant BT6, BT10, BT12, BT16, BT17, BT18, BT23 94-257-01p_com
B-78 94-230-01p 92-196-01p Calgene Tomato Fruit ripening altered 9 additional FLAVRSAV R lines 94-230-01p_com
B-79 94-228-01p   DNA Plant Tech Tomato Fruit ripening altered 1345-4 94-228-01p_com
B-80 94-227-01p 92-196-01p Calgene Tomato Fruit ripening altered Line N73 1436-111 94-227-01p_com
B-81 94-090-01p   Calgene Rapeseed Oil profile altered pCGN3828-212/86- 18 & 23 94-090-01p_com
B-82 93-258-01p   Monsanto Soybean Glyphosate tolerant 40-3-2 93-258-01p_com
B-83 93-196-01p   Calgene Cotton Bromoxynil tolerant BXN 93-196-01p_com
B-84 92-204-01p   Upjohn Squash WMV2 & ZYMV resistant ZW-20 92-204-01p_com
B-85 92-196-01p   Calgene Tomato Fruit ripening altered FLAVR SAVR 92-196-01p_com


[0118] In one embodiment of the invention, the plants B-1 to B-85 of Table B, in total, or parts thereof, or propagation material of said plants are treated or contacted with a compound according to formula (I) alone, or in the form of compositions comprising a compound according to formula (I).

[0119] In one embodiment of the invention, the plants B-1 to B-85 of Table B, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-1 alone, or in the form of compositions comprising compound I-1.

[0120] In one embodiment of the invention, the plants B-1 to B-85 of Table B, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-2 alone, or in the form of compositions comprising compound I-2.

[0121] In one embodiment of the invention, the plants B-1 to B-85 of Table B, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-12 alone, or in the form of compositions comprising compound I-12.

[0122] In one embodiment of the invention, the plants B-1 to B-85 of Table B, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-15 alone, or in the form of compositions comprising compound I-15.
Table C
Non-exhaustive list of traits to work the invention with references to documents in which they are decribed.
No.TraitReference
C-1 Water use efficiency WO 2000/073475
  Nitrogen use efficiency WO 1995/009911
WO 1997/030163
WO 2007/092704
WO 2007/076115
WO 2005/103270
WO 2002/002776
C-2 Improved photosynthesis WO 2008/056915
WO 2004/101751
C-3 Nematode resistance WO 1995/020669
WO 2001/051627
WO 2008/139334
WO 2008/095972
WO 2006/085966
WO 2003/033651
WO 1999/060141
WO 1998/012335
WO 1996/030517
WO 1993/018170
C-4 Reduced pod dehiscence WO 2006/009649
WO 2004/113542
WO 1999/015680
WO 1999/000502
WO 1997/013865
WO 1996/030529
WO 1994/023043
C-5 Aphid resistance WO 2006/125065
WO 1997/046080
WO 2008/067043
WO 2004/072109
C-6 Sclerotinia resistance WO 2006/135717
WO 2006/055851
WO 2005/090578
WO 2005/000007
WO 2002/099385
WO 2002/061043
C-7 Botrytis resistance WO 2006/046861
WO 2002/085105
C-8 Bremia resistance US 20070022496
WO 2000/063432
WO 2004/049786
C-9 Erwinia resistance WO 2004/049786
C10 Closterovirus resistance WO 2007/073167
WO 2007/053015
WO 2002/022836
C-11 Tobamovirus resistance WO 2006/038794


[0123] In one embodiment of the invention, the plants comprising or expressing traits of C-1 to C-11 of Table C, in total, or parts thereof, or propagation material of said plants are treated or contacted with a compound according to formula (I) alone, or in the form of compositions comprising a compound according to formula (I).

[0124] In one embodiment of the invention, the plants comprising or expressing traits of C-1 to C-11 of Table C, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-1 alone, or in the form of compositions comprising compound I-1.

[0125] In one embodiment of the invention, the plants comprising or expressing traits of C-1 to C-11 of Table C, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-2 alone, or in the form of compositions comprising compound I-2.

[0126] In one embodiment of the invention, the plants comprising or expressing traits of C-1 to C-11 of Table C, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-12 alone, or in the form of compositions comprising compound I-12.

[0127] In one embodiment of the invention, the plants comprising or expressing traits of C-1 to C-11 of Table C, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-15 alone, or in the form of compositions comprising compound I-15.
Table D
Non-exhaustive list of transgenic events and traits the invention can be worked on with reference to patent applications.
No.Plant speciesTransgenic eventTraitPatent reference
D-1 Corn PV-ZMGT32 (NK603) Glyphosate tolerance US 2007-056056
D-2 Corn MIR604 Insect resistance (Cry3a055) EP 1 737 290
D-3 Corn LY038 High lysine content US 7,157,281
D-4 Corn 3272 Self processing corn (alpha-amylase) US 2006-230473
D-5 Corn PV-ZMIR13 (MON863) Insect resistance (Cry3Bb) US 2006-095986
D-6 Corn DAS-59122-7 Insect resistance (Cry34Ab1/Cry35Ab1) US 2006-070139
D-7 Corn TC1507 Insect resistance (Cry1F) US 7,435,807
D-8 Corn MON810 Insect resistance (Cry1Ab) US 2004-180373
D-9 Corn VIP1034 Insect resistance WO 03/052073
D-10 Corn B16 Glufosinate resistance US 2003-126634
D-11 Corn GA21 Glyphosate resistance US 6,040,497
D-12 Corn GG25 Glyphosate resistance US 6,040,497
D-13 Corn GJ11 Glyphosate resistance US 6,040,497
D-14 Corn FI117 Glyphosate resistance US 6,040,497
D-15 Corn GAT-ZM1 Glufosinate tolerance WO 01/51654
D-16 Corn DP-098140-6 Glyphosate tolerance / ALS inhibitor tolerance WO 2008/112019
D-17 Wheat Event 1 Fusarium resistance (trichothecene 3-O-acetyltransferase) CA 2561992
D-18 Sugar beet T227-1 Glyphosate tolerance US 2004-117870
D-19 Sugar beet H7-1 Glyphosate tolerance WO 2004-074492
D-20 Soybean MON89788 Glyphosate tolerance US 2006-282915
D-21 Soybean A2704-12 Glufosinate tolerance WO 2006/108674
D-22 Soybean A5547-35 Glufosinate tolerance WO 2006/108675
D-23 Soybean DP-305423-1 High oleic acid / ALS inhibitor tolerance WO 2008/054747
D-24 Rice GAT-OS2 Glufosinate tolerance WO 01/83818
D-25 Rice GAT-OS3 Glufosinate tolerance US 2008-289060
D-26 Rice PE-7 Insect resistance (Cry1Ac) WO 2008/114282
D-27 Oilseed rape MS-B2 Male sterility WO 01/31042
D-28 Oilseed rape MS-BN1/RF-BN1 Male sterility/restoration WO 01/41558
D-29 Oilseed rape RT73 Glyphosate resistance WO 02/36831
D-30 Cotton CE43-67B Insect resistance (Cry1Ab) WO 2006/128573
D-31 Cotton CE46-02A Insect resistance (Cry1Ab) WO 2006/128572
D-32 Cotton CE44-69D Insect resistance (Cry1Ab) WO 2006/128571
D-33 Cotton 1143-14A Insect resistance (Cry1Ab) WO 2006/128569
D-34 Cotton 1143-51B Insect resistance (Cry1Ab) WO 2006/128570
D-35 Cotton T342-142 Insect resistance (Cry1Ab) WO 2006/128568
D-36 Cotton event3006-210-23 Insect resistance (Cry1Ac) WO 2005/103266
D-37 Cotton PV-GHGT07 (1445) Glyphosate tolerance US 2004-148666
D-38 Cotton MON88913 Glyphosate tolerance WO 2004/072235
D-39 Cotton EE-GH3 Glyphosate tolerance WO 2007/017186
D-40 Cotton T304-40 Insect-resistance (Cry1Ab) WO2008/122406
D-41 Cotton Cot202 Insect resistance (VIP3) US 2007-067868
D-42 Cotton LLcotton25 Glufosinate resistance WO 2007/017186
D-43 Cotton EE-GH5 Insect resistance (Cry1Ab) WO 2008/122406
D-44 Cotton event 281-24-236 Insect resistance (Cry1F) WO 2005/103266
D-45 Cotton Cot102 Insect resistance (Vip3A) US 2006-130175
D-46 Cotton MON 15985 Insect resistance (Cry1A/Cry2Ab) US 2004-250317
D-47 Bent Grass Asr-368 Glyphosate tolerance US 2006-162007
D-48 Brinjal EE-1 Insect resistance (Cry1Ac) WO 2007/091277


[0128] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with a compound according to formula (I) alone, or in the form of compositions comprising a compound according to formula (I).

[0129] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-1 alone, or in the form of compositions comprising compound I-1.

[0130] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-2 alone, or in the form of compositions comprising compound I-2.

[0131] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-3 alone, or in the form of compositions comprising compound I-3.

[0132] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-4 alone, or in the form of compositions comprising compound I-4.

[0133] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-5 alone, or in the form of compositions comprising compound I-5.

[0134] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-6 alone, or in the form of compositions comprising compound I-6.

[0135] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-7 alone, or in the form of compositions comprising compound I-7.

[0136] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-8 alone, or in the form of compositions comprising compound I-8.

[0137] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-9 alone, or in the form of compositions comprising compound I-9.

[0138] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-10 alone, or in the form of compositions comprising compound I-10.

[0139] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-11 alone, or in the form of compositions comprising compound I-11.

[0140] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-12 alone, or in the form of compositions comprising compound I-12.

[0141] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-13 alone, or in the form of compositions comprising compound I-13.

[0142] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-14 alone, or in the form of compositions comprising compound I-14.

[0143] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-15 alone, or in the form of compositions comprising compound I-15.

[0144] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-16 alone, or in the form of compositions comprising compound I-16.

[0145] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-17 alone, or in the form of compositions comprising compound I-17.

[0146] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-18 alone, or in the form of compositions comprising compound I-18.

[0147] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-19 alone, or in the form of compositions comprising compound I-19.

[0148] In one embodiment of the invention, the plants comprising a transgenic event or expressing a trait of D-1 to D-48 of Table D, in total, or parts thereof, or propagation material of said plants are treated or contacted with compound I-20 alone, or in the form of compositions comprising compound I-20.

[0149] In one embodiment, the compositions comprising a compound according to formula (I), contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener.

[0150] Typically, the weight ratio between a compound according to formula (I) and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0151] In one embodiment, the compositions comprising compound I-1 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-1 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0152] In one embodiment, the compositions comprising compound I-2 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-2 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0153] In one embodiment, the compositions comprising compound I-3 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-3 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0154] In one embodiment, the compositions comprising compound I-4 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-4 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0155] In one embodiment, the compositions comprising compound I-5 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-5 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0156] In one embodiment, the compositions comprising compound I-6 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-6 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0157] In one embodiment, the compositions comprising compound I-7 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-7 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0158] In one embodiment, the compositions comprising compound I-8 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-8 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0159] In one embodiment, the compositions comprising compound I-9 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-9 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0160] In one embodiment, the compositions comprising compound I-10 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-10 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0161] In one embodiment, the compositions comprising compound I-11 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-11 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0162] In one embodiment, the compositions comprising compound I-12 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-12 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0163] In one embodiment, the compositions comprising compound I-13 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-13 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0164] In one embodiment, the compositions comprising compound I-14 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-14 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0165] In one embodiment, the compositions comprising compound I-15 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-15 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0166] In one embodiment, the compositions comprising compound I-16 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-16 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0167] In one embodiment, the compositions comprising compound I-17 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-17 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0168] In one embodiment, the compositions comprising compound I-18 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-18 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0169] In one embodiment, the compositions comprising compound I-19 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-19 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0170] In one embodiment, the compositions comprising compound I-20 contain another active ingredient. In particular this can be a fungicide or an acaricide, a nematicide, or an insecticide, or a herbicidal safener. Typically, the weight ratio between I-20 and another active ingredient is between 1000 to 1 and 1 to 125, preferably between 125 to 1 and 1 to 50 und particularly preferred between 25 to 1 and 1 to 5.

[0171] Preferred are the following fungicides selected from the group consisting of:

F1) a compound capable to inhibit the nucleic acid synthesis like benalaxyl, benalaxyl-M, bupirimate, clozylacon, dimethirimol, ethirimol, furalaxyl, hymexazol, mefenoxam, metalaxyl, metalaxyl-M, ofurace, oxadixyl, oxolinic acid ;

F2) a compound capable to inhibit the mitosis and cell division like benomyl, carbendazim, diethofencarb, ethaboxam, fuberidazole, pencycuron, thiabendazole, thiophanate-methyl, zoxamide;

F3) a compound capable to inhibit the respiration for example
an CI-respiration inhibitor like diflumetorim ;
an CII-respiration inhibitor like boscalid, carboxin, fenfuram, flutolanil, furametpyr, furmecyclox, mepronil, oxycarboxin, penthiopyrad, thifluzamide ;
an CIII-respiration inhibitor like amisulbrom, azoxystrobin, cyazofamid, dimoxystrobin, enestrobin, famoxadone, fenamidone, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, trifloxystrobin ;

F4) a compound capable of to act as an uncoupler like dinocap, fluazinam, meptyldinocap;

F5) a compound capable to inhibit ATP production like fentin acetate, fentin chloride, fentin hydroxide, silthiofam;

F6) a compound capable to inhibit AA and protein biosynthesis like andoprim, blasticidin-S, cyprodinil, kasugamycin, kasugamycin hydrochloride hydrate, mepanipyrim, pyrimethanil;

F7) a compound capable to inhibit the signal transduction like fenpiclonil, fludioxonil, quinoxyfen;

F8) a compound capable to inhibit lipid and membrane synthesis like biphenyl, chlozolinate, edifenphos, etridiazole, iodocarb, iprobenfos, iprodione, isoprothiolane, procymidone, propamocarb, propamocarb hydrochloride, pyrazophos, tolclofos-methyl, vinclozolin ;

F9) a compound capable to inhibit ergosterol biosynthesis like aldimorph, azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, dodemorph, dodemorph acetate, epoxiconazole, etaconazole, fenarimol, fenbuconazole, fenhexamid, fenpropidin, fenpropimorph, fluquinconazole, flurprimidol, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imazalil, imazalil sulfate, imibenconazole, ipconazole, metconazole, myclobutanil, naftifine, nuarimol, oxpoconazole, paclobutrazol, pefurazoate, penconazole, prochloraz, propiconazole, prothioconazole, pyributicarb, pyrifenox, simeconazole, spiroxamine, tebuconazole, terbinafine, tetraconazole, triadimefon, triadimenol, tridemorph, triflumizole, triforine, triticonazole, uniconazole, viniconazole, voriconazole ;

F10) a compound capable to inhibit cell wall synthesis like benthiavalicarb, dimethomorph, flumorph, iprovalicarb, mandipropamid, polyoxins, polyoxorim, validamycin A;

F11) a compound capable to inhibit melanine biosynthesis like carpropamid, diclocymet, fenoxanil, phthalide, pyroquilon, tricyclazole;

F12) a compound capable to induce a host defence like acibenzolar-S-methyl, probenazole, tiadinil;

F13) a compound capable to have a multisite action like Bordeaux mixture, captafol, captan, chlorothalonil, copper naphthenate, copper oxide, copper oxychloride, copper preparations such as copper hydroxide, copper sulphate, dichlofluanid, dithianon, dodine, dodine free base, ferbam, fluorofolpet, folpet, guazatine, guazatine acetate, iminoctadine, iminoctadine albesilate, iminoctadine triacetate, mancopper, mancozeb, maneb, metiram, metiram zinc, oxine-copper, propineb, sulphur and sulphur preparations including calcium polysulphide, thiram, tolylfluanid, zineb, ziram ;

F14) a compound selected in the following list: (2E)-2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylacetamide, (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylvinyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide, 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol, 1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl-1H-imidazole-1-carboxylate, 1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine, 2-butoxy-6-iodo-3-propyl-4H-chromen-4-one, 2-chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)nicotinamide, 2-phenylphenol and salts, 3-(difluoromethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazole-4-carboxamide, 3-(difluoromethyl)-N-[(9R)-9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1-methyl-1H-pyrazole-4-carboxamide, 3-(difluoromethyl)-N-[(9S)-9-isopropyl-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1-methyl-1H-pyrazole-4-carboxamide, 3-(difluoromethyl)-N-[4'-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide, 3,4,5-trichloropyridine-2,6-dicarbonitrile, 3-[5-(4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl]pyridine, 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine , 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine, 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine, 8-hydroxyquinoline sulfate, benthiazole, bethoxazin, capsimycin, carvone, chinomethionat, cufraneb, cyflufenamid, cymoxanil, dazomet, debacarb, dichlorophen, diclomezine, dicloran, difenzoquat, difenzoquat methylsulphate, diphenylamine, ecomate, ferimzone, flumetover, fluopicolide, fluoroimide, flusulfamide, fosetyl-aluminium, fosetyl-calcium, fosetyl-sodium, hexachlorobenzene, irumamycin, isotianil, methasulfocarb, methyl (2E)-2-{2-[({cyclopropyl[(4-methoxyphenyl)imino]methyl}thio)methyl]phenyl}-3-methoxyacrylate, methyl 1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate, methyl isothiocyanate, metrafenone, mildiomycin, N-(3',4'-dichloro-5-fluorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-(formylamino)-2-hydroxybenzamide, N-(4-chloro-2-nitrophenyl)-N-ethyl-4-methylbenzenesulfonamide, N-(4-chlorobenzyl)-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, N-[(4-chlorophenyl)(cyano)methyl]-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, N-[(5-bromo-3-chloropyridin-2-yl)methyl]-2,4-dichloronicotinamide, N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2,4-dichloronicotinamide, N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2-fluoro-4-iodonicotinamide, N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide, N-{2-[1,1'-bi(cyclopropyl)-2-yl]phenyl} -3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamide, natamycin, N-ethyl-N-methyl-N'-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}imido-formamide, N-ethyl-N-methyl-N'-{2-methyl-5-(difluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl} imidoformamide, nickel dimethyldithiocarbamate, nitrothal-isopropyl, O-{1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl}1H-imidazole-1-carbothioate, octhilinone, oxamocarb, oxyfenthiin, pentachlorophenol and salts, phosphorous acid and its salts, piperalin, propamocarb fosetylate, propanosine-sodium, proquinazid, pyribencarb, pyrrolnitrine, quintozene, S-allyl-5-amino-2-isopropyl-4-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-1-carbothioate, tecloftalam, tecnazene, triazoxide, trichlamide, valiphenal, zarilamid.



[0172] Particularly preferred fungicides as additional actives ingredients are the following fungicides selected from the group consisting of: azoxystrobin, dimoxystrobin, kresoxim-methyl, orysastrobin, pyraclostrobin, trifloxystrobin, bixafen, boscalid, isopyrazam, metalaxyl, penthiopyrad, 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide, N-(2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid amide, dimethomorph, fluopicolide, difenoconazole, ipconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, metconazol, myclobutanil, propiconazole, prothioconazole, tebuconazole, tetraconazole, triticonazole, prochloraz, carbendazim, fluazinam, cyprodinil, pyrimethanil, fludioxonil, dodemorph, fenpropimorph, tridemorph, fenpropidin, iprodione, vinclozolin, famoxadone, probenazole, captan, folpet, 5-ethyl-6-octyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-ylamine, mancozeb, maneb, metiram, thiram, dithianon, fosetyl, fosetyl-aluminium, chlorothalonil, thiophanate methyl, cymoxanil, metrafenone, spiroxamine, bixafen, N-(3',4',5'-trifluorobiphenyl-2-yl)- 3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-[2-(4'-trifluoromethylthio)-biphenyl]-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide,N-[2-(1,3-dimethylbutyl)-phenyl]-1,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide, N-(2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide,N-(cis-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-(trans-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxamide , N-[1,2,3,4-tetrahydro-9-(1 -methylethyl)-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1 -methyl-1 H-pyrazole-4-carboxamide.

[0173] Preferred are the following Insecticides/acaricides/nematicides selected from the group consisting of:
  1. (1) Acetylcholinesterase (AChE) inhibitors, for example
    carbamates, e.g. alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, bendiocarb, benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, cloethocarb, dimetilan, ethiofencarb, fenobucarb, fenothiocarb, formetanate, furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb, thiofanox, trimethacarb, XMC, and xylylcarb; or
    organophosphates, e.g. acephate, azamethiphos, azinphos (-methyl, -ethyl), bromophosethyl, bromfenvinfos (-methyl), butathiofos, cadusafos, carbophenothion, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl/-ethyl), coumaphos, cyanofenphos, cyanophos, chlorfenvinphos, demeton-S-methyl, demeton-S-methylsulphon, dialifos, diazinon, dichlofenthion, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, dioxabenzofos, disulfoton, EPN, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulfothion, fenthion, flupyrazofos, fonofos, formothion, fosmethilan, fosthiazate, heptenophos, iodofenphos, iprobenfos, isazofos, isofenphos, isopropyl, O-salicylate, isoxathion, malathion, mecarbam, methacrifos, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl/- ethyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phosphocarb, phoxim, pirimiphos (-methyl/ -ethyl), profenofos, propaphos, propetamphos, prothiofos, prothoate, pyraclofos, pyridaphenthion, pyridathion, quinalphos, sebufos, sulfotep, sulprofos, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon, vamidothion, and imicyafos.
  2. (2) GABA-gated chloride channel antagonists, for example
    organochlorines, e.g. camphechlor, chlordane, endosulfan, gamma-HCH, HCH, heptachlor, lindane, and methoxychlor; or
    fiproles (phenylpyrazoles), e.g. acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, and vaniliprole.
  3. (3) Sodium channel modulators/voltage-dependent sodium channel blockers, for example
    pyrethroids, e.g. acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentyl isomer, bioethanomethrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin (alpha-, beta-, theta-, zeta-), cyphenothrin, deltamethrin, empenthrin (1R isomer), esfenvalerate, etofenprox, fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinate, flucythrinate, flufenprox, flumethrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans-), phenothrin (1R-trans isomer), prallethrin, profluthrin, protrifenbute, pyresmethrin, resmethrin, RU 15525, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, tetramethrin (1R-isomer), tralomethrin, transfluthrin, ZXI 8901, pyrethrin (pyrethrum), eflusilanat;
    DDT; or methoxychlor.
  4. (4) Nicotinergic acetylcholine receptor agonists/antagonists, for example
    chloronicotinyls, e.g. acetamiprid, clothianidin, dinotefuran, imidacloprid, imidaclothiz, nitenpyram, nithiazine, thiacloprid, thiamethoxam, AKD-1022,
    nicotine, bensultap, cartap, thiosultap-sodium, and thiocylam.
  5. (5) Allosteric acetylcholine receptor modulators (agonists), for example
    spinosyns, e.g. spinosad and spinetoram.
  6. (6) Chloride channel activators, for example
    mectins/macrolides, e.g. abamectin, emamectin, emamectin benzoate, ivermectin, lepimectin, and milbemectin; or
    juvenile hormone analogues, e.g. hydroprene, kinoprene, methoprene, epofenonane, triprene, fenoxycarb, pyriproxifen, and diofenolan.
  7. (7) Active ingredients with unknown or non-specific mechanisms of action, for example
    gassing agents, e.g. methyl bromide, chloropicrin and sulfuryl fluoride;
    selective antifeedants, e.g. cryolite, pymetrozine, pyrifluquinazon and flonicamid; or
    mite growth inhibitors, e.g. clofentezine, hexythiazox, etoxazole.
  8. (8) Oxidative phosphorylation inhibitors, ATP disruptors, for example
    diafenthiuron;
    organotin compounds, e.g. azocyclotin, cyhexatin and fenbutatin oxide; or
    propargite, tetradifon.
  9. (9) Oxidative phoshorylation decouplers acting by interrupting the H proton gradient, for example chlorfenapyr, binapacryl, dinobuton, dinocap and DNOC.
  10. (10) Microbial disruptors of the insect gut membrane, for example Bacillus thuringiensis strains.
  11. (11) Chitin biosynthesis inhibitors, for example benzoylureas, e.g. bistrifluron, chlorfluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron or triflumuron.
  12. (12) Buprofezin.
  13. (13) Moulting disruptors, for example cyromazine.
  14. (14) Ecdysone agonists/disruptors, for example
    diacylhydrazines, e.g. chromafenozide, halofenozide, methoxyfenozide, tebufenozide, and
    Fufenozide (JS118); or
    azadirachtin.
  15. (15) Octopaminergic agonists, for example amitraz.
  16. (16) Site III electron transport inhibitors/site II electron transport inhibitors, for example hydramethylnon; acequinocyl; fluacrypyrim; or cyflumetofen and cyenopyrafen.
  17. (17) Electron transport inhibitors, for example
    Site I electron transport inhibitors, from the group of the METI acaricides, e.g. fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, and rotenone; or
    voltage-dependent sodium channel blockers, e.g. indoxacarb and metaflumizone.
  18. (18) Fatty acid biosynthesis inhibitors, for example tetronic acid derivatives, e.g. spirodiclofen and spiromesifen; or
    tetramic acid derivatives, e.g. spirotetramat.
  19. (19) Neuronal inhibitors with unknown mechanism of action, e.g. bifenazate.
  20. (20) Ryanodine receptor effectors, for example diamides, e.g. flubendiamide, (R),(S)-3-chloro-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}-N2-(1-methyl-2-methylsulphonylethyl)phthalamide, chlorantraniliprole (Rynaxypyr), or Cyantraniliprole (Cyazypyr).
  21. (21) Further active ingredients with unknown mechanism of action, for example amidoflumet, benclothiaz, benzoximate, bromopropylate, buprofezin, chinomethionat, chlordimeform, chlorobenzilate, clothiazoben, cycloprene, dicofol, dicyclanil, fenoxacrim, fentrifanil, flubenzimine, flufenerim, flutenzin, gossyplure, japonilure, metoxadiazone, petroleum, potassium oleate, pyridalyl, sulfluramid, tetrasul, triarathene or verbutine; or one of the following known active compounds
    4-{[(6-brompyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-fluorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(2-chlor-1,3-thiazol-5-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-chlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/ 115644), 4-{[(6-chlorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on known from WO 2007/115644), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from WO 2007/115643), 4-{[(5,6-dichlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115646), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-on (known from WO 2007/115643), 4-{[(6-chlorpyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), 4-{[(6-chlorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), [(6-chlorpyridin-3-yl)methyl](methyl)oxido-λ4-sulfanylidencyanamid (known from WO 2007/149134), [1-(6-chlorpyridin-3-yl)ethyl](methyl)oxido-λ4-sulfanylidencyanamid (known from WO 2007/149134) and its diastereomeres (A) and (B)

    (also known from WO 2007/149134), [(6-trifluormethylpyridin-3-yl)methyl](methyl)oxido-λ4sulfanylidencyanamid (known from WO 2007/095229), or [1-(6-trifluormethylpyridin-3-yl)ethyl](methyl)oxido-λ4-sulfanylidencyanamid (known from WO 2007/149134) and its diastereomeres (C) and (D), namely Sulfoxaflor



[0174] Particularly preferred acaricides, nematicides, or insecticides as additional active ingredients to a compound according to formula (I) are selected from the group consisting of acephate, chlorpyrifos, diazinon, dichlorvos, dimethoate, fenitrothion, methamidophos, methidathion, methyl-parathion, monocrotophos, phorate, profenofos, terbufos, aldicarb, carbaryl, carbofuran, carbosulfan, methomyl, thiodicarb, bifenthrin, cyfluthrin, cypermethrin, alpha-cypermethrin, zetacypermethrin, deltamethrin, esfenvalerate, lambda-cyhalothrin, permethrin, tefluthrin, diflubenzuron, flufenoxuron, lufenuron, teflubenzuron, spirotetramat; clothianidin, dinotefuran, imidacloprid, thiamethoxam, acetamiprid, thiacloprid; endosulfan, fipronil, abamectin, emamectin, spinosad, spinetoram, hydramethylnon; chlorfenapyr; fenbutatin oxide, indoxacarb, metaflumizone, flonicamid, flubendiamide, chlorantraniliprole, cyazypyr (HGW86), cyflumetofen.

[0175] Very particulary preferred acaricides, nematicides, or insecticides as additional active ingredients to a compound according to formula (I) are selected from the group consisting of thiodicarb, cyfluthrin, tefluthrin, clothianidin, imidacloprid, thiamethoxam, acetamiprid, thiacloprid; fipronil, abamectin, flubendiamide, chlorantraniliprole, cyazypyr

Foliar Fungicidal Treatment



[0176] Preferably, a compound according to formula (I) is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0177] Preferably, compound I-1 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0178] Preferably, compound I-2 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0179] Preferably, compound I-3 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0180] Preferably, compound I-4 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0181] Preferably, compound I-5 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0182] Preferably, compound I-6 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0183] Preferably, compound I-7 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0184] Preferably, compound I-8 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0185] Preferably, compound I-9 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0186] Preferably, compound I-10 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0187] Preferably, compound I-11 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0188] Preferably, compound I-12 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0189] Preferably, compound I-13 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0190] Preferably, compound I-14 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0191] Preferably, compound I-15 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0192] Preferably, compound I-16 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0193] Preferably, compound I-17 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0194] Preferably, compound I-18 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0195] Preferably, compound I-19 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0196] Preferably, compound I-20 is applied as a composition further comprising an agriculturally acceptable support, carrier or filler.

[0197] According to the invention, the term "support" denotes a natural or synthetic, organic or inorganic compound with which the active compound of formula (I) is combined or associated to make it easier to apply, notably to the parts of the plant. This support is thus generally inert and should be agriculturally acceptable. The support may be a solid or a liquid. Examples of suitable supports include clays, natural or synthetic silicates, silica, resins, waxes, solid fertilisers, water, alcohols, in particular butanol, organic solvents, mineral and plant oils and derivatives thereof. Mixtures of such supports may also be used.

[0198] The composition according to the invention may also comprise additional components. In particular, the composition may further comprise a surfactant. The surfactant can be an emulsifier, a dispersing agent or a wetting agent of ionic or non-ionic type or a mixture of such surfactants. Mention may be made, for example, of polyacrylic acid salts, lignosulphonic acid salts, phenolsulphonic or naphthalenesulphonic acid salts, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (in particular alkylphenols or arylphenols), salts of sulphosuccinic acid esters, taurine derivatives (in particular alkyl taurates), phosphoric esters of polyoxyethylated alcohols or phenols, fatty acid esters of polyols, and derivatives of the present compounds containing sulphate, sulphonate and phosphate functions. The presence of at least one surfactant is generally essential when the active compound and / or the inert support are water-insoluble and when the vector agent for the application is water. Preferably, surfactant content may be comprised from 5% to 40% by weight of the composition.

[0199] Colouring agents such as inorganic pigments, for example iron oxide, titanium oxide, ferrocyanblue, and organic dyestuffs such as alizarin, azo and metallophthalocyanine dyes, and trace elements such as iron, manganese, boron, copper, cobalt, molybdenum and zinc salts can be used.

[0200] Optionally, other additional components may also be included, e.g. protective colloids, adhesives, thickeners, thixotropic agents, penetration agents, stabilisers, sequestering agents. More generally, the active compounds can be combined with any solid or liquid additive, which complies with the usual formulation techniques.

[0201] In general, the composition according to the invention may contain from 0.05 to 99% by weight of active compounds, preferably from 10 to 70% by weight.

[0202] The combination or composition according to the invention can be used as such, in form of their formulations or as the use forms prepared therefrom, such as aerosol dispenser, capsule suspension, cold fogging concentrate, dustable powder, emulsifiable concentrate, emulsion of oil in water, emulsion water of in oil, encapsulated granule, fine granule, flowable concentrate for seed treatment, gas (under pressure), gas generating product, granule, hot fogging concentrate, macrogranule, microgranule, oil dispersible powder, oil miscible flowable concentrate, oil miscible liquid, paste, plant rodlet, powder for dry seed treatment, seed coated with a pesticide, soluble concentrate, soluble powder, solution for seed treatment, suspension concentrate (flowable concentrate), ultra low volume (ULV) liquid, ultra low volume (ULV) suspension, water dispersible granules or tablets, water dispersible powder for slurry treatment, water soluble granules or tablets, water soluble powder for seed treatment and wettable powder.

[0203] The treatment of plants and plant parts with the active compound combination according to the invention is carried out directly or by action on their environment, habitat or storage area by means of the normal treatment methods, for example by watering (drenching), drip irrigation, spraying, atomizing, broadcasting, dusting, foaming, spreading-on, and as a powder for dry seed treatment, a solution for seed treatment, a water-soluble powder for seed treatment, a water-soluble powder for slurry treatment, or by encrusting.

[0204] These compositions include not only compositions which are ready to be applied to the plant or seed to be treated by means of a suitable device, such as a spraying or dusting device, but also concentrated commercial compositions which must be diluted before application to the crop.

[0205] The active compounds within the composition according to the invention have potent microbicide activity and can be employed for controlling phytopathogenic fungi and/or micororoganisms, such as fungi or bacteria, in crop protection or in the protection of materials.

[0206] Within the composition according to the invention, fungicide compounds can be employed in crop protection for example for controlling Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes.

[0207] Within the composition according to the invention, bactericide compounds can be employed in crop protection for example for controlling Pseudomonadaceae, Rhizobiaceae, Enterobacteriaceae, Corynebacteriaceae and Streptomycetaceae.

[0208] The fungicide composition according to the invention can be used to curatively or preventively control phytopathogenic fungi and/or microorganisms of plants or crops. Thus, according to a further aspect of the invention, there is provided a method for curatively or preventively controlling phytopathogenic fungi and/or microorganisms of plants or crops comprising the use of a fungicide composition according to the invention by application to the seed, the plant or to the fruit of the plant or to the soil in which the plant is growing or in which it is desired to grow.

Foliar Treatment



[0209] The methods and compositions according to the invention can be used to control the following animal pests.

[0210] From the order of the Anoplura (Phthiraptera), for example, Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Trichodectes spp.

[0211] From the class of the Arachnida, for example, Acarus siro, Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp., Epitrimerus pyri, Eutetranychus spp., Eriophyes spp., Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranychus spp., Oligonychus spp., Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp., Vasates lycopersici.

[0212] From the class of the Bivalva, for example, Dreissena spp.

[0213] From the order of the Chilopoda, for example, Geophilus spp., Scutigera spp.

[0214] From the order of the Coleoptera, for example, Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apogonia spp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus spp., Ceuthorhynchus spp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica, Curculio spp., Cryptorhynchus lapathi, Dermestes spp., Diabrotica spp., Epilachna spp., Faustinus cubae, Gibbium psylloides, Heteronychus arator, Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Leptinotarsa decemlineata, Lissorhoptrus oryzophilus, Lixus spp., Lyctus spp., Meligethes aeneus, Melolontha melolontha, Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Otiorrhynchus sulcatus, Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Popillia japonica, Premnotrypes spp., Psylliodes chrysocephala, Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Sternechus spp., Symphyletes spp., Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp.

[0215] From the order of the Collembola, for example, Onychiurus armatus.

[0216] From the order of the Dermaptera, for example, Forficula auricularia.

[0217] From the order of the Diplopoda, for example, Blaniulus guttulatus.

[0218] From the order of the Diptera, for example, Aedes spp., Anopheles spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chrysomyia spp., Cochliomyia spp., Cordylobia anthropophaga, Culex spp., Cuterebra spp., Dacus oleae, Dermatobia hominis, Drosophila spp., Fannia spp., Gastrophilus spp., Hylemyia spp., Hyppobosca spp., Hypoderma spp., Liriomyza spp., Lucilia spp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp., Stomoxys spp., Tabanus spp., Tannia spp., Tipula paludosa, Wohlfahrtia spp.

[0219] From the class of the Gastropoda, for example, Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Succinea spp.

[0220] From the class of the helminths, for example, Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp, Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp., Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereria bancrofti.

[0221] It is furthermore possible to control protozoa, such as Eimeria.

[0222] From the order of the Heteroptera, for example, Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus seriatus, Pseudacysta persea, Rhodnius spp., Sahlbergella singularis, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.

[0223] From the order of the Homoptera, for example, Acyrthosipon spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma piri, Aphis spp., Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp., Diaphorina spp., Diaspis spp., Doralis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelis bilobatus, Geococcus coffeae, Homalodisca coagulata, Hyalopterus arundinis, Icerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva fimbriolata, Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoides titanus, Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes vaporariorum, Trioza spp., Typhlocyba spp., Unaspis spp., Viteus vitifolii.

[0224] From the order of the Hymenoptera, for example, Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.

[0225] From the order of the Isopoda, for example, Armadillidium vulgare, Oniscus asellus, Porcellio scaber.

[0226] From the order of the Isoptera, for example, Reticulitermes spp., Odontotermes spp.

[0227] From the order of the Lepidoptera, for example, Acronicta major, Aedia leucomelas, Agrotis spp., Alabama argillacea, Anticarsia spp., Barathra brassicae, Bucculatrix thurberiella, Bupalus piniarius, Cacoecia podana, Capua reticulana, Carpocapsa pomonella, Cheimatobia brumata, Chilo spp., Choristoneura fumiferana, Clysia ambiguella, Cnaphalocerus spp., Earias insulana, Ephestia kuehniella, Euproctis chrysorrhoea, Euxoa spp., Feltia spp., Galleria mellonella, Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homona magnanima, Hyponomeuta padella, Laphygma spp., Lithocolletis blancardella, Lithophane antennata, Loxagrotis albicosta, Lymantria spp., Malacosoma neustria, Mamestra brassicae, Mocis repanda, Mythimna separata, Oria spp., Oulema oryzae, Panolis flammea, Pectinophora gossypiella, Phyllocnistis citrella, Pieris spp., Plutella xylostella, Prodenia spp., Pseudaletia spp., Pseudoplusia includens, Pyrausta nubilalis, Spodoptera spp., Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix viridana, Trichoplusia spp.

[0228] From the order of the Orthoptera, for example, Acheta domesticus, Blatta orientalis, Blattella germanica, Gryllotalpa spp., Leucophaea maderae, Locusta spp., Melanoplus spp., Periplaneta americana, Schistocerca gregaria.

[0229] From the order of the Siphonaptera, for example, Ceratophyllus spp., Xenopsylla cheopis.

[0230] From the order of the Symphyla, for example, Scutigerella immaculata.

[0231] From the order of the Thysanoptera, for example, Baliothrips biformis, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Kakothrips spp., Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamoni, Thrips spp.

[0232] From the order of the Thysanura, for example, Lepisma saccharina.

[0233] The phytoparasitic nematodes include, for example, Anguina spp., Aphelenchoides spp., Belonoaimus spp., Bursaphelenchus spp., Ditylenchus dipsaci, Globodera spp., Heliocotylenchus spp., Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radopholus similis, Rotylenchus spp., Trichodorus spp., Tylenchorhynchus spp., Tylenchulus spp., Tylenchulus semipenetrans, Xiphinema spp.

[0234] If appropriate, the compounds according to the invention can, at certain concentrations or application rates, also be used as herbicides, safeners, growth regulators or agents to improve plant properties, or as microbicides, for example as fungicides, antimycotics, bactericides, viricides (including agents against viroids) or as agents against MLO (Mycoplasma-like organisms) and RLO (Rickettsia-like organisms). If appropriate, they can also be employed as intermediates or precursors for the synthesis of other active compounds.

[0235] Among the diseases of plants or crops that can be controlled by the method according to the invention, mention may be made of :

Powdery Mildew Diseases such as

Blumeria diseases caused for example by Blumeria graminis

Podosphaera diseases caused for example by Podosphaera leucotricha

Sphaerotheca diseases caused for example by Sphaerotheca fuliginea

Uncinula diseases caused for example by Uncinula necator

Rust Diseases such as

Gymnosporangium diseases caused for example by Gymnosporangium sabinae

Hemileia diseases caused for example by Hemileia vastatrix

Phakopsora diseases caused for example by Phakopsora pachyrhizi and Phakopsora meibomiae

Puccinia diseases caused for example by Puccinia recondite, and Puccinia triticina;

Uromyces diseases caused for example by Uromyces appendiculatus

Oomycete Diseases such as

Bremia diseases caused for example by Bremia lactucae

Peronospora diseases caused for example by Peronospora pisi and Peronospora brassicae

Phytophthora diseases caused for example by Phytophthora infestans

Plasmopara diseases caused for example by Plasmopara viticola

Pseudoperonospora diseases caused for example by Pseudoperonospora humuli and Pseudoperonospora cubensis

Pythium diseases caused for example by Pythium ultimum

Leafspot, Leaf blotch and Leaf Blight Diseases such as

Alternaria diseases caused for example by Alternaria solani

Cercospora diseases caused for example by Cercospora beticola

Cladiosporium diseases caused for example by Cladiosporium cucumerinum

Cochliobolus diseases caused for example by Cochliobolus sativus

(Conidiaform: Drechslera, Syn: Helminthosporium);

Colletotrichum diseases caused for example by Colletotrichum lindemuthianum

Cycloconium diseases caused for example by Cycloconium oleaginum

Diaporthe diseases caused for example by Diaporthe citri

Elsinoe diseases caused for example by Elsinoe fawcettii

Gloeosporium diseases caused for example by Gloeosporium laeticolor

Glomerella diseases caused for example by Glomerella cingulata

Guignardia diseases caused for example by Guignardia bidwellii

Leptosphaeria diseases caused for example by Leptosphaeria maculans

Magnaporthe diseases caused for example by Magnaporthe grisea

Mycosphaerella diseases caused for example by Mycosphaerella graminicola and Mycosphaerella fijiensis

Phaeosphaeria diseases caused for example by Phaeosphaeria nodorum

Pyrenophora diseases caused for example by Pyrenophora teres

Ramularia diseases caused for example by Ramularia collo-cygni

Rhynchosporium diseases caused for example by Rhynchosporium secalis

Septoria diseases caused for example by Septoria apii;

Typhula diseases caused for example by Thyphula incarnata

Venturia diseases caused for example by Venturia inaequalis

Root- and Stem Diseases such as

Corticium diseases caused for example by Corticium graminearum

Fusarium diseases caused for example by Fusarium oxysporum

Gaeumannomyces diseases caused for example by Gaeumannomyces graminis

Rhizoctonia diseases caused for example by Rhizoctonia solani

Oculimacula (Tapesia) diseases caused for example by Oculimacula Tapesia acuformis

Thielaviopsis diseases caused for example by Thielaviopsis basicola

Ear and Panicle Diseases including Maize cob such as

Alternaria diseases caused for example by Alternaria spp.


Aspergillus diseases caused for example by Aspergillus flavus



[0236] Cladosporium diseases caused for example by Cladiosporium cladosporioides
Claviceps diseases caused for example by Claviceps purpurea
Fusarium diseases caused for example by Fusarium culmorum
Gibberella diseases caused for example by Gibberella zeae
Monographella diseases caused for example by Monographella nivalis
Smut- and Bunt Diseases such as
Sphacelotheca diseases caused for example by Sphacelotheca reiliana
Tilletia diseases caused for example by Tilletia caries
Urocystis diseases Urocystis occulta
Ustilago diseases caused for example by Ustilago nuda;
Fruit Rot and Mould Diseases such as
Aspergillus diseases caused for example by Aspergillus flavus
Botrytis diseases caused for example by Botrytis cinerea
Penicillium diseases caused for example by Penicillium expansum and Penicillium purpurogenum
Sclerotinia diseases caused for example by Sclerotinia sclerotiorum;
Verticillium diseases caused for example by Verticillium alboatrum
Seed- and Soilborne Decay, Mould, Wilt, Rot and Damping-off diseases
Fusarium diseases caused for example by Fusarium culmorum
Phytophthora diseases caused for example by Phytophthora cactorum
Pythium diseases caused for example by Pythium ultimum
Rhizoctonia diseases caused for example by Rhizoctonia solani
Sclerotium diseases caused for example by Sclerotium rolfsii
Canker, Broom and Dieback Diseases such as
Nectria diseases caused for example by Nectria galligena
Blight Diseases such as
Monilinia diseases caused for example by Monilinia laxa
Leaf Blister or Leaf Curl Diseases including deformation of blooms and fruits such as
Taphrina diseases caused for example by Taphrina deformans
Decline Diseases of Wooden Plants such as
Esca disease caused for example by Phaeomoniella clamydospora and Phaeoacremonium aleophilum and Fomitiporia mediterranea
Diseases of Flowers and Seeds such as
Botrytis diseases caused for example by Botrytis cinerea
Diseases of Tubers such as
Rhizoctonia diseases caused for example by Rhizoctonia solani
Helminthosporium diseases caused for example by Helminthosporium solani
Diseases caused by Bacterial Organisms such as
Xanthomanas species for example Xanthomonas campestris pv. Oryzae
Pseudomonas species for example Pseudomonas syringae pv. Lachrymans
Erwinia species for example Erwinia amylovora.

[0237] The compounds releated to this invention are preferably used to control the following soybean diseases:

Fungal Diseases of the Foliage, Upper Stems, Pods and Seeds for example

Alternaria leaf spot (Alternaria spec. atrans tenuissima), Anthracnose (Colletotrichum gloeosporoides dematium var. truncatum), Brown spot (Septoria glycines), Cercospora leaf spot and blight (Cercospora kikuchii), Choanephora leaf blight (Choanephora infundibulifera trispora (Syn.)), Dactuliophora leaf spot (Dactuliophora glycines), Downy Mildew (Peronospora manshurica), Drechslera blight (Drechslera glycini), Frogeye Leaf spot (Cercospora sojina), Leptosphaerulina Leaf Spot (Leptosphaerulina trifolii), Phyllostica Leaf Spot (Phyllosticta sojaecola), Pod and Stem Blight (Phomopsis sojae), Powdery Mildew (Microsphaera diffusa), Pyrenochaeta Leaf Spot (Pyrenochaeta glycines), Rhizoctonia Aerial, Foliage, and Web Blight (Rhizoctonia solani), Rust (Phakopsora pachyrhizi, Phakopsora meibomiae), Scab (Sphaceloma glycines), Stemphylium Leaf Blight (Stemphylium botryosum), Target Spot (Corynespora cassiicola)

Fungal Disease of the Roots and Lower Stems for example

Black Root Rot (Calonectria crotalariae), Charcoal Rot (Macrophomina phaseolina), Fusarium Blight or Wilt, Root Rot, and Pod and Collar Rot (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), Mycoleptodiscus Root Rot (Mycoleptodiscus terrestris), Neocosmospora (Neocosmopspora vasinfecta), Pod and Stem Blight (Diaporthe phaseolorum), Stem Canker (Diaporthe phaseolorum var. caulivora), Phytophthora Rot (Phytophthora megasperma), Brown Stem Rot (Phialophora gregata), Pythium Rot (Pythium aphanidermatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), Rhizoctonia Root Rot, Stem Decay, and Damping-Off (Rhizoctonia solani), Sclerotinia Stem Decay (Sclerotinia sclerotiorum), Sclerotinia Southern Blight (Sclerotinia rolfsii), Thielaviopsis Root Rot (Thielaviopsis basicola)


Formulations



[0238] The active compounds can be converted to the customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, granules for broadcasting, suspension-emulsion concentrates, natural materials impregnated with active compound, synthetic materials impregnated with active compound, fertilizers and microencapsulations in polymeric substances.

[0239] These formulations are produced in a known manner, for example by mixing the active compounds with extenders, that is liquid solvents and/or solid carriers, optionally with the use of surfactants, that is emulsifiers and/or dispersants and/or foam-formers. The formulations are prepared either in suitable plants or else before or during the application.

[0240] Suitable for use as auxiliaries are substances which are suitable for imparting to the composition itself and/or to preparations derived therefrom (for example spray liquors, seed dressings) particular properties such as certain technical properties and/or also particular biological properties. Typical suitable auxiliaries are: extenders, solvents and carriers.

[0241] Suitable extenders are, for example, water, polar and non-polar organic chemical liquids, for example from the classes of the aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which, if appropriate, may also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).

[0242] If the extender used is water, it is also possible to employ, for example, organic solvents as auxiliary solvents. Essentially, suitable liquid solvents are: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulphoxide, and also water.

Suitable solid carriers are:



[0243] for example, ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as finely divided silica, alumina and silicates; suitable solid carriers for granules are: for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, and also synthetic granules of inorganic and organic meals, and granules of organic material such as paper, sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam-formers are: for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates and also protein hydrolysates; suitable dispersants are nonionic and/or ionic substances, for example from the classes of the alcohol-POE and/or -POP ethers, acid and/or POP-POE esters, alkyl aryl and/or POP-POE ethers, fat and/or POP-POE adducts, POE- and/or POP-polyol derivatives, POE- and/or POP-sorbitan- or -sugar adducts, alkyl or aryl sulphates, alkyl- or arylsulphonates and alkyl or aryl phosphates or the corresponding PO-ether adducts. Furthermore, suitable oligo- or polymers, for example those derived from vinylic monomers, from acrylic acid, from EO and/or PO alone or in combination with, for example, (poly)alcohols or (poly)amines. It is also possible to employ lignin and its sulphonic acid derivatives, unmodified and modified celluloses, aromatic and/or aliphatic sulphonic acids and their adducts with formaldehyde.

[0244] Tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations.

[0245] It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and metal phthalocyanine dyestuffs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

[0246] Other possible additives are perfumes, mineral or vegetable, optionally modified oils, waxes and nutrients (including trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

[0247] Stabilizers, such as low-temperature stabilizers, preservatives, antioxidants, light stabilizers or other agents which improve chemical and/or physical stability may also be present.

[0248] The formulations generally comprise between 0.01 and 98% by weight of active compound, preferably between 0.5 and 90%.

[0249] One skilled in the art will, of course, recognize that the formulation and mode of application of a toxicant may affect the activity of the material in a given application. Thus, for agricultural and general household pest use the present insecticidal compounds may be formulated as a granular of relatively large particle size (for example, 8/16 or 4/8 US Mesh), as water-soluble or water-dispersible granules, as powdery dusts, as wettable powders, as emulsifiable concentrates, as aqueous emulsions, as solutions, or as any of other known types of useful formulations, depending on the desired mode of application. It is to be understood that the amounts specified in this specification are intended to be approximate only, as if the word "about" were placed in front of the amounts specified.

[0250] These insecticidal compositions may be applied either as water-diluted sprays, or dusts, or granules to the areas in which suppression of insects is desired. These formulations may contain as little as 0.1%, 0.2% or 0.5% to as much as 95% or more by weight of active ingredient.

[0251] Dusts are free flowing admixtures of the active ingredient with finely divided solids such as talc, natural clays, kieselguhr, flours such as walnut shell and cottonseed flours, and other organic and inorganic solids which act as dispersants and carriers for the toxicant; these finely divided solids have an average particle size of less than about 50 microns. A typical dust formulation useful herein is one containing 1.0 part or less of the insecticidal compound and 99.0 parts of talc.

[0252] Wettable powders, also useful formulations for insecticides, are in the form of finely divided particles that disperse readily in water or other dispersant. The wettable powder is ultimately applied to the locus where insect control is needed either as a dry dust or as an emulsion in water or other liquid. Typical carriers for wettable powders include Fuller's earth, kaolin clays, silicas, and other highly absorbent, readily wet inorganic diluents. Wettable powders normally are prepared to contain about 5-80% of active ingredient, depending on the absorbency of the carrier, and usually also contain a small amount of a wetting, dispersing or emulsifying agent to facilitate dispersion. For example, a useful wettable powder formulation contains 80.0 parts of the insecticidal compound, 17.9 parts of Palmetto clay, and 1.0 part of sodium lignosulfonate and 0.3 part of sulfonated aliphatic polyester as wetting agents. Additional wetting agents and/or oils will frequently be added to a tank mix for to facilitate dispersion on the foliage of the plant.

[0253] Other useful formulations for insecticidal applications are emulsifiable concentrates (ECs) which are homogeneous liquid compositions dispersible in water or other dispersant, and may consist entirely of the insecticidal compound and a liquid or solid emulsifying agent, or may also contain a liquid carrier, such as xylene, heavy aromatic naphthas, isophorone, or other non-volatile organic solvents. For insecticidal application these concentrates are dispersed in water or other liquid carrier and normally applied as a spray to the area to be treated. The percentage by weight of the essential active ingredient may vary according to the manner in which the composition is to be applied, but in general comprises 0.5 to 95% of active ingredient by weight of the insecticidal composition.

[0254] Flowable formulations are similar to ECs, except that the active ingredient is suspended in a liquid carrier, generally water. Flowables, like ECs, may include a small amount of a surfactant, and will typically contain active ingredients in the range of 0.5 to 95%, frequently from 10 to 50%, by weight of the composition. For application, flowables may be diluted in water or other liquid vehicle, and are normally applied as a spray to the area to be treated.

[0255] Typical wetting, dispersing or emulsifying agents used in agricultural formulations include, but are not limited to, the alkyl and alkylaryl sulfonates and sulfates and their sodium salts; alkylaryl polyether alcohols; sulfated higher alcohols; polyethylene oxides; sulfonated animal and vegetable oils; sulfonated petroleum oils; fatty acid esters of polyhydric alcohols and the ethylene oxide addition products of such esters; and the addition product of long-chain mercaptans and ethylene oxide. Many other types of useful surface-active agents are available in commerce. Surface-active agents, when used, normally comprise 1 to 15% by weight of the composition.

[0256] Other useful formulations include suspensions of the active ingredient in a relatively non-volatile solvent such as water, corn oil, kerosene, propylene glycol, or other suitable solvents.

[0257] Still other useful formulations for insecticidal applications include simple solutions of the active ingredient in a solvent in which it is completely soluble at the desired concentration, such as acetone, alkylated naphthalenes, xylene, or other organic solvents. Granular formulations, wherein the toxicant is carried on relative coarse particles, are of particular utility for aerial distribution or for penetration of cover crop canopy. Pressurized sprays, typically aerosols wherein the active ingredient is dispersed in finely divided form as a result of vaporization of a low-boiling dispersant solvent carrier may also be used. Water-soluble or water-dispersible granules are free flowing, non-dusty, and readily water-soluble or water-miscible. In use by the farmer on the field, the granular formulations, emulsifiable concentrates, flowable concentrates, aqueous emulsions, solutions, etc., may be diluted with water to give a concentration of active ingredient in the range of say 0.1 % or 0.2% to 1.5% or 2%.

[0258] The active compound according to the invention can be used in its commercially available formulations and in the use forms, prepared from these formulations, as a mixture with other active compounds, such as insecticides, attractants, sterilizing agents, bactericides, acaricides, nematicides, fungicides, growth-regulating substances, herbicides, safeners, fertilizers or semiochemicals.

[0259] When used as insecticides, the active compounds according to the invention can furthermore be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with synergists. Synergists are compounds which increase the action of the active compounds, without it being necessary for the synergistic agent added to be active itself.

[0260] When used as insecticides, the active compounds according to the invention can furthermore be present in their commercially available formulations and in the use forms, prepared from these formulations, as a mixture with inhibitors which reduce degradation of the active compound after use in the environment of the plant, on the surface of parts of plants or in plant tissues.

[0261] The active compound content of the use forms prepared from the commercially available formulations can vary within wide limits. The active compound concentration of the use forms can be from 0.00000001 to 95% by weight of active compound, preferably between 0.00001 and 1% by weight, most preferably between 0.01 and 0,1 %.

[0262] The compounds are employed in a customary manner appropriate for the use forms.

[0263] All plants and plant parts can be treated in accordance with the invention. Plants are to be understood as meaning in the present context all plants and plant populations such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants can be plants which can be obtained by conventional plant breeding and optimization methods or by biotechnological and genetic engineering methods or by combinations of these methods, including the transgenic plants and including the plant cultivars protectable or not protectable by plant breeders' rights. Plant parts are to be understood as meaning all parts and organs of plants above and below the ground, such as shoot, leaf, flower and root, examples which may be mentioned being leaves, needles, stalks, stems, flowers, fruit bodies, fruits, seeds, roots, tubers and rhizomes. The plant parts also include harvested material, and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, offshoots and seeds.

[0264] Treatment according to the invention of the plants and plant parts with the active compounds is carried out directly or by allowing the compounds to act on the surroundings, habitat or storage space by the customary treatment methods, for example by immersion, spraying, evaporation, fogging, scattering, painting on, injection and, in the case of propagation material, in particular in the case of seeds, also by applying one or more coats.

[0265] Treatment according to the invention of the plants and plant parts with the active compound combinations is carried out directly or by allowing the compounds to act on the surroundings, habitat or storage space by the customary treatment methods, for example by immersion, spraying, evaporation, fogging, scattering, painting on, and, in the case of propagation material, in particular in the case of seeds, also by applying one or more coats.

[0266] Besides the treatment of plants or plant parts other than seeds, the methods and compositions of the invention are particularly suitable for the treatment of seeds. A large part of the damage caused by pests and pathogens on cultigens occurs by infestation of the seed during storage and after sowing the seed in the ground as well as during and immediately after germination of the plants. This phase is especially critical since the roots and shoots of the growing plant are particularly sensitive and even a small amount of damage can lead to withering of the whole plant. There is therefore considerable interest in protecting the seed and the germinating plant by the use of suitable agents.

[0267] The control of pests and phytopathogenic fungi and/or microorganisms by treatment of the seeds of plants has been known for a considerable time and is the object of continuous improvement. However, there are a number of problems in the treatment of seed that cannot always be satisfactorily solved. Therefore it is worthwhile to develop methods for the protection of seeds and germinating plants which makes the additional application of plant protection agents after seeding or after germination of the plants superfluous. It is further worthwhile to optimize the amount of the applied active material such that the seed and the germinating plants are protected against infestation by pests as best as possible without the plants themselves being damaged by the active compound applied. In particular, methods for the treatment seed should also take into account the intrinsic insecticidal and fungicidal properties of transgenic plants in order to achieve optimal protection of the seed and germinating plants with a minimal expenditure of plant protection agents.

[0268] The present invention relates therefore especially to a method for the protection of seed and germinating plants from infestation with pests and pathogens in that the seed is treated with a combination of the invention.

[0269] The invention comprises a procedure in which the seed the treated at the same time with components a compound according to formula (I) and optionally furher active ingredients. It further comprises a method in which the seed is treated with a compound according to formula (I) and optional further active ingredients separately.

[0270] The invention comprises a procedure in which the seed the treated at the same time with components a compound according to formula (I) and optionally furher active ingredients. It further comprises a method in which the seed is treated with compound according I-1 and optional further active ingredients separately.

[0271] The invention comprises a procedure in which the seed the treated at the same time with components a compound according to formula (I) and optionally furher active ingredients. It further comprises a method in which the seed is treated with compound according I-2 and optional further active ingredients separately.

[0272] The invention comprises a procedure in which the seed the treated at the same time with components a compound according to formula (I) and optionally furher active ingredients. It further comprises a method in which the seed is treated with compound according I-12 and optional further active ingredients separately.

[0273] The invention comprises a procedure in which the seed the treated at the same time with components a compound according to formula (I) and optionally furher active ingredients. It further comprises a method in which the seed is treated with compound according I-15 and optional further active ingredients separately.

[0274] The invention also comprises a seed, which has been treated with a compound according to formula (I) and optional further active ingredients at the same time or separately, and which still contains an effective amount of these active ingredients.

[0275] The invention also comprises a seed, which has been treated with compound I-1 and optional further active ingredients at the same time or separately, and which still contains an effective amount of these active ingredients.

[0276] The invention also comprises a seed, which has been treated with compound I-2 and optional further active ingredients at the same time or separately, and which still contains an effective amount of these active ingredients.

[0277] The invention also comprises a seed, which has been treated with compound I-12 and optional further active ingredients at the same time or separately, and which still contains an effective amount of these active ingredients.

[0278] The invention also comprises a seed, which has been treated with compound I-15 and optional further active ingredients at the same time or separately, and which still contains an effective amount of these active ingredients.

[0279] For the latter seed, the active ingredients can be applied in separate layers. These layers can optionally be separated by an additional layer that may or may not contain an active ingredient.

[0280] The time interval between the application of different layers of the style compounds is in general not critical.

[0281] In addition the invention relates also to the use of the combination of the invention for the treatment of seeds for protection of the seed and the germinating plants from pests. Furthermore the invention relates to seed which was treated with an agent of the invention for protection from pests.

[0282] One of the advantages of the invention is because of the special systemic properties of the agents of the invention treatment with these agents protects not only the seed itself from pests but also the plants emerging after sprouting. In this way the direct treatment of the culture at the time of sowing or shortly thereafter can be omitted.

[0283] The agents of the invention are suitable for the protection of seed of plant varieties of all types as already described which are used in agriculture, in greenhouses, in forestry, in horticulture or in vineyards. In particular, this concerns seed of maize, peanut, canola, rape, poppy, olive, coconut, cacao, soy cotton, beet, (e.g. sugar beet and feed beet), rice, millet, wheat, barley, oats, rye, sunflower, bananas, sugar cane or tobacco. The agents of the invention are also suitable for the treatment of the seed of fruit plants and vegetables as previously described. Particular importance is attached to the treatment of the seed of rice, maize, soy, cotton, wheat and canola or rape. Thus, for example, the combination of number (1) is particularly suitable for the treatment of rice seed.

[0284] As already described, the treatment of transgenic seed with an agent of the invention is of particular importance. This concerns the seeds of plants which generally contain at least one heterologous gene that controls the expression of a polypeptide with special insecticidal properties. The heterologous gene in transgenic seed can originate from microorganisms such as Bacillus, Rhizobium, Pseudomonas, Serratia, Trichoderma, Clavibacter, Glomus or Gliocladium. The present invention is particularly suitable for the treatment of transgenic seed that contains at least one heterologous gene that originates from Bacillus sp. and whose gene product exhibits activity against the European corn borer and/or western corn rootworm. Particularly preferred is a heterologous gene that originates from Bacillus thuringiensis.

[0285] Within the context of the present invention the agent of the invention is applied to the seed alone or in a suitable formulation. Preferably the seed is treated in a state in which it is so stable, that no damage occurs during treatment. In general treatment of the seed can be carried out at any time between harvest and sowing. Normally seed is used that was separated from the plant and has been freed of spadix, husks, stalks, pods, wool or fruit flesh. Use of seed that was harvested, cleaned, and dried to moisture content of below 15 % w/w. Alternatively, seed treated with water after drying and then dried again can also be used.

[0286] In general care must be taken during the treatment of the seed that the amount of the agent of the invention and/or further additive applied to the seed is so chosen that the germination of the seed is not impaired and the emerging plant is not damaged. This is to be noted above all with active compounds which can show phytotoxic effects when applied in certain amounts.

[0287] The compositions of the invention can be applied directly, that is without containing additional components and without being diluted. It is normally preferred to apply the agent to the seed in the form of a suitable formulation. Suitable formulations and methods for seed treatment are known to the person skilled in the art and are described, for example, in the following documents: US 4,272,417 A, US 4,245,432 A, US 4,808,430 A, US 5,876,739 A, US 2003/0176428 A1, WO 2002/080675 A1, WO 2002/028186 A2.

[0288] Compositions, which are especially useful for seed treatment, are e.g.:
A
Soluble concentrates (SL, LS)
D
Emulsions (EW, EO, ES)
E
Suspensions (SC, OD, FS)
F
Water-dispersible granules and water-soluble granules (WG, SG)
G
Water-dispersible powders and water-soluble powders (WP, SP, WS)
H
Gel-Formulations (GF)
I
Dustable powders (DP, DS)


[0289] Conventional seed treatment formulations include for example flowable concentrates FS, solutions LS, powders for dry treatment DS, water dispersible powders for slurry treatment WS, water-soluble powders SS and emulsion ES and EC and gel formulation GF. These formulations can be applied to the seed diluted or undiluted. Application to the seeds is carried out before sowing, either directly on the seeds or after having pregerminated the latter. Preferred are FS formulations.

[0290] In the treatment of seed, the application rates of the inventive combination are generally from 0.1 to 10 kg per 100 kg of seed. The separate or joint application of the compounds I and II or of the combinations of the compounds I and II is carried out by spraying or dusting the seeds, the seedlings, the plants or the soils before or after sowing of the plants or before or after emergence of the plants.

[0291] The invention also relates to the propagation products of plants, and especially the seed comprising, that is, coated with and/or containing, a combination as defined above or a composition containing the combination of two or more active ingredients or a combination of two or more compositions each providing one of the active ingredients. The seed comprises the inventive combinations in an amount of from 0.1 g to 10 kg per 100 kg of seed.

[0292] The composition comprising a combination of pesticides 45 can be applied "neat",that is, without any diluting or additional components present. However, the composition is typically applied to the seeds in the form of a pesticide formulation. This formulation may contain one or more other desirable components including but not limited to liquid diluents, binders to serve as a matrix for the pesticide, fillers for protecting the seeds during stress conditions, and plasticizers to improve flexibility, adhesion and/or spreadability of the coating. In addition, for oily pesticide formulations containing little or no filler, it may be desirable to add to the formulation drying agents such as calcium carbonate, kaolin or bentonite clay, perlite, diatomaceous earth or any other adsorbent material. Use of such components in seed treatments is known in the art. See, e.g., U.S. Pat. No. 5,876,739. The skilled artisan can readily select desirable components to use in the pesticide formulation depending on the seed type to be treated and the particular pesticide that is selected. In addition, readily available commercial formulations of known pesticides may be used, as demonstrated in the examples below.

[0293] The seeds may also be treated with one or more of the following ingredients: other pesticides, including compounds which act only below the ground; fungicides, such as captan, thiram, metalxyl, fhidioxonil, oxadixyl, and isomers of each of those materials, and the like; herbicides, including compounds selected from acetamides, triazines, dinitroanilines, glycerol ethers, pyridazinones, uracils, phenoxys, ureas, and benzoic acids; herbicidal safeners such as benzoxazine, benzhydryl derivatives, N,N-diallyl dichloroacetamide, various dihaloacyl, oxazolidinyl and thiazolidinyl compounds, ethanone, naphthalic anhydride compounds, and oxime derivatives; fertilizers; and biocontrol agents such as naturally-occurring or recombinant bacteria and fungi from the genera Rhizobium, Bacillus, Pseudomonas, Serratia, Trichoderma, Glomus, Gliocladium and mycorrhizal fungi. These ingredients may be added as a separate layer on the seed or alternatively may be added as part of the pesticide composition.

[0294] Preferably, the amount of the novel composition or other ingredients used in the seed treatment should not inhibit germination of the seed, or cause phytotoxic damage to the seed.

[0295] The composition of the present invention can be in the form of a suspension; emulsion; slurry of particles in an aqueous medium (e.g., water); wettable powder; wettable granules (dry flowable); and dry granules. If formulated as a suspension or slurry, the concentration of the active ingredient in the formulation is preferably about 0.5% to about 99% by weight (w/w), preferably 5-40%.

[0296] As mentioned above, other conventional inactive or inert ingredients can be incorporated into the formulation. Such inert ingredients include but are not limited to: conventional sticking agents, dispersing agents such as mefhylcellulose (Methocel A15LV or Methocel A15C, for example, serve as combined dispersant/sticking agents for use in seed treatments), polyvinyl alcohol (e.g., Elvanol 51-05), lecithin (e.g., Yelkinol P), polymeric dispersants (e.g., polyvinylpyrrolidone/vinyl acetate PVP/VA S-630), thickeners (e.g., clay thickeners such as Van Gel B to improve viscosity and reduce settling of particle suspensions), emulsion stabilizers, surfactants, antifreeze compounds (e.g., urea), dyes, colorants, and the like. Further inert ingredients useful in the present invention can be found in McCutcheon's, vol. 1, "Emulsifiers and Detergents" MC Publishing Company, Glen Rock, N.J., U.S.A., 1996. Additional inert ingredients useful in the present invention can be found in McCutcheon's, vol.2, "FunctionalMaterials," MC Publishing Company, Glen Rock, N.J., U.S.A., 1996.

[0297] The pesticides, compositions of pesticide combinations, and formulations of the present invention can be applied to seeds by any standard seed treatment methodology, including but not limited to mixing in a container (e.g., a bottle or bag), mechanical application, tumbling, spraying, and immersion. Any conventional active or inert material can be used for contacting seeds with pesticides according to the present invention, such as conventional film-coating materials including but not limited to water-based film coating materials such as Sepiret (Seppic, Inc., Fairfield, N.J.) and Opacoat (Berwind Pharm. Services, Westpoint, Pa.).

[0298] Seed coating: The subject combination of pesticides can be applied to a seed as a component of a seed coating. Seed coating methods and compositions that are known in the art are useful when they are modified by the addition of one of the embodiments of the combination of pesticides of the present invention. Such coating methods and apparatus for their application are disclosed in, for example, U.S. Pat. Nos. 5,918,413, 5,891,246, 5,554,445, 5,389,399, 5,107,787, 5,080,925, 4,759,945 and 4,465,017. Seed coating compositions are disclosed, for example, in U.S. Pat. Nos. 5,939,356, 5,882,713, 5,876,739, 5,849,320, 5,834,447, 5,791,084, 5,661,103, 5,622,003, 5,580,544, 5,328,942, 5,300,127, 4,735,015, 4,634,587, 4,383,391, 4,372,080, 4,339,456, 4,272,417 and 4,245,432, among others. Useful seed coatings contain one or more binders and at least one of the subject combinations of pesticides.

[0299] Binders that are useful in the present invention preferably comprise an adhesive polymer that may be natural or synthetic and is without phytotoxic effect on the seed to be coated. The binder may be selected from polyvinyl acetates; polyvinyl acetate copolymers; polyvinyl alcohols; polyvinyl alcohol copolymers; celluloses, including ethylcelluloses, methylcelluloses, hydroxymethylcelluloses, hydroxypropy-lcelluloses and carboxymethylcellulose; polyvinylpyrolidones; polysaccharides, including starch, modified starch, dextrins, maltodextrins, alginate and chitosans; fats; oils; proteins, including gelatin and zeins; gum arabics; shellacs; vinylidene chloride and vinylidene chloride copolymers; calcium lignosulfonates; acrylic copolymers; polyvinylacrylates; polyethylene oxide; acrylamide polymers and copolymers; polyhydroxyethyl acrylate, methylacrylamide monomers; and polychloroprene.

[0300] It is preferred that the binder be selected so that it can serve as a matrix for the subject combination of pesticides. While the binders disclosed above may all be useful as a matrix, the specific binder will depend upon the properties of the combination of pesticides. The term "matrix", as used herein, means a continuous solid phase of one or more binder compounds throughout which is distributed as a discontinuous phase one or more of the subject combinations of pesticides. Optionally, a filler and/or other components can also be present in the matrix. The term matrix is to be understood to include what may be viewed as a matrix system, a reservoir system or a microencapsulated system. In general, a matrix system consists of a combination of pesticides of the present invention and filler uniformly dispersed within a polymer, while a reservoir system consists of a separate phase comprising the subject combination of pesticides that is physically dispersed within a surrounding, rate-limiting, polymeric phase. Microencapsulation includes the coating of small particles or droplets of liquid, but also dispersions in a solid matrix.

[0301] The amount of binder in the coating can vary, but will be in the range of about 0.01 to about 25% of the weight of the seed, more preferably from about 0.05 to about 15%, and even more preferably from about 0.1% to about 10%.

[0302] As mentioned above, the matrix can optionally include filler. The filler can be an absorbent or inert filler, such as are known in the art, and may include wood flours, clays, activated carbon, sugars, diatomaceous earth, cereal flours, fine-grain inorganic solids, calcium carbonate, and the like. Clays and inorganic solids which may be used include calcium bentonite, kaolin, china clay, talc, perlite, mica, vermiculite, silicas, quartz powder, montmorillonite and mixtures thereof. Sugars which may be useful include dextrin and maltodextrin. Cereal flours include wheat flour, oat flour and barley flour.

[0303] The filler is selected so that it will provide a proper microclimate for the seed, for example the filler is used to increase the loading rate of the active ingredients and to adjust the control-release of the active ingredients. The filler can aid in the production or process of coating the seed. The amount of filler can vary, but generally the weight of the filler components will be in the range of about 0.05 to about 75% of the seed weight, more preferably about 0.1 to about 50%, and even more preferably about 0.5% to 15%.

[0304] The pesticides that are useful in the coating are those combinations of pesticides that are described herein. The amount of pesticide that is included in the coating will vary depending upon the type of seed and the type of active ingredients, but the coating will contain an amount of the combination of pesticides that is pesticidally effective. When insects are the target pest, that amount will be an amount of the combination of insecticides that is insecticidally effective. As used herein, an insecticidally effective amount means that amount of insecticide that will kill insect pests in the larvae or pupal state of growth, or will consistently reduce or retard the amount of damage produced by insect pests. In general, the amount of pesticide in the coating will range from about 0.005 to about 50% of the weight of the seed. A more preferred range for the pesticide is from about 0.01 to about 40%; more preferred is from about 0.05 to about 20%.

[0305] The exact amount of the combination of pesticides that is included in the coating is easily determined by one of skill in the art and will vary depending upon the size of the seed to be coated. The pesticides of the coating must not inhibit germination of the seed and should be efficacious in protecting the seed and/or the plant during that time in the target pests and phytopathogenic fungi and/or microorganisms life cycle in which it causes injury to the seed or plant. In general, the coating will be efficacious for approximately 0 to 120 days after sowing.

[0306] The coating is particularly effective in accommodating high fungicidal and/or insecticidal loads, as can be required to treat typically refractory pests, such as corn root worm, while at the same time preventing unacceptable phytotoxicity due to the increased fungicidal and/or insecticidal load.

[0307] Optionally, a plasticizer can be used in the coating formulation. Plasticizers are typically used to make the film that is formed by the coating layer more flexible, to improve adhesion and spreadability, and to improve the speed of processing. Improved film flexibility is important to minimize chipping, breakage or flaking during storage, handling or sowing processes. Many plasticizers may be used. However, useful plasticizers include polyethylene glycol, glycerol, butylbenzylphthalate, glycol benzoates and related compounds. The amount of plasticizer in the coating layer will be in the range of from bout 0.1 to about 20% by weight.

[0308] When the combination of pesticides used in the coating is an oily type formulation and little or no filler is present, it may be useful to hasten the drying process by drying the formulation. This optional step may be accomplished by means will known in the art and can include the addition of calcium carbonate, kaolin or bentonite clay, perlite, diatomaceous earth, or any absorbent material that is added preferably concurrently with the pesticidal coating layer to absorb the oil or excess moisture. The amount of calcium carbonate or related compounds necessary to effectively provide a dry coating will be in the range of about 0.5 to about 10% of the weight of the seed.

[0309] The coatings formed with the combination of pesticides are capable of effecting a slow rate of release of the pesticide by diffusion or movement through the matrix to the surrounding medium.

[0310] The coating can be applied to almost any crop seed that is described herein, including cereals, vegetables, ornamentals and fruits.

[0311] In addition to the coating layer, the seed may be treated with one or more of the following ingredients: other pesticides including fungicides and herbicides; herbicidal safeners; fertilizers and/or biocontrol agents. These ingredients may be added as a separate layer or alternatively may be added in the pesticidal coating layer.

[0312] The pesticide formulation may be applied to the seeds using conventional coating techniques and machines, such as fluidized bed techniques, the roller mill method, rotostatic seed treaters, and drum coaters. Other methods, such as spouted beds may also be useful. The seeds may be presized before coating. After coating, the seeds are typically dried and then transferred to a sizing machine for sizing. Such procedures are known in the art.

[0313] The pesticide-treated seeds may also be enveloped with a film overcoating to protect the pesticide coating. Such overcoatings are known in the art and may be applied using conventional fluidized bed and drum film coating techniques.

[0314] In another embodiment of the present invention, a pesticide can be introduced onto or into a seed by use of solid matrix priming. For example, a quantity of the pesticide can be mixed with a solid matrix material and then the seed can be placed into contact with the solid matrix material for a period to allow the pesticide to enter to the seed. The seed can then optionally be separated from the solid matrix material and stored or used, or the mixture of solid matrix material plus seed can be stored or planted directly. Solid matrix materials which are useful in the present invention include polyacrylamide, starch, clay, silica, alumina, soil, sand, polyurea, polyacrylate, or any other material capable of absorbing or adsorbing the pesticide for a time and releasing that pesticide into or onto the seed. It is useful to make sure that the pesticide and the solid matrix material are compatible with each other. For example, the solid matrix material should be chosen so that it can release the pesticide at a reasonable rate, for example over a period of minutes, hours, or days.

[0315] The present invention further embodies inhibition as another method of treating seed with the pesticide. For example, plant seed can be combined for a period of time with a solution comprising from about 1% by weight to about 75% by weight of the pesticide in a solvent such as water. Preferably the concentration of the solution is from about 5% by weight to about 50% by weight, more preferably from about 10% by weight to about 25% by weight. During the period that the seed is combined with the solution, the seed takes up (imbibition) a portion of the pesticide. Optionally, the mixture of plant seed and solution can be agitated, for example by shaking, rolling, tumbling, or other means. After inhibition, the seed can be separated from the solution and optionally dried, for example by patting or air drying.

[0316] In yet another embodiment, a powdered pesticide can be mixed directly with seed. Optionally, a sticking agent can be used to adhere the powder to the seed surface. For example, a quantity of seed can be mixed with a sticking agent and optionally agitated to encourage uniform coating of the seed with the sticking agent. The seed coated with the sticking agent can then be mixed with the powdered pesticide. The mixture can be agitated, for example by tumbling, to encourage contact of the sticking agent with the powdered pesticide, thereby causing the powdered pesticide to stick to the seed.

[0317] The present invention also provides a seed that has been treated by the method described above. The treated seeds of the present invention can be used for the propagation of plants in the same manner as conventional treated seed. The treated seeds can be stored, handled, sowed and tilled in the same manner as any other pesticide treated seed. Appropriate safety measures should be taken to limit contact of the treated seed with humans, food or feed materials, water and birds and wild or domestic animals.


Claims

1. Method for improving the utilization of the production potential of a transgenic plant by controlling pests and/or phytopathogenic fungi and/or microorganisms and/or increasing plant health, comprising treating the transgenic plant with an effective amount of a compound according to formula (I)

wherein

A is selected from nitrogen and C-Hal,

B is selected from nitrogen and C-Hal,

R1 is selected from hydrogen, halogen, C1-C6 alkyl, C2-C6 alkenyl, C3-C6 cycloalkyl, phenyl, C1-C6 alkyl substituted with Hal or cyano, C2-C6 alkenyl substituted with Hal or cyano, C3-C6 cycloalkyl substituted with Hal or cyano, phenyl which is substituted with one or more substituents selected from the group of halogen, cyano, and alkoxy,

R2 is selected from hydroxy, C1-C6 thioalkyl, C1-C6 aminoalkyl, C1-C6 alkoxy, phenoxy, aniline,

C1-C6 alkoxy which is substituted with one or more substituents selected from the group of halogen, cyano, C1-C6 alkoxy, C1-C6 alkyl, C1-C6 alkylcarbonyl,
phenoxy which is substituted with one or more substituents selected from the group of with halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, formyl, C1-C6 alkylcarbonyl, C1-C6 alkoxycarbonyl, C1-C6 alkylamino,
aniline which is substituted with one or more substituents selected from the group of halogen, cyano, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylcarbonyl, C1-C6 alkylamino, C1-C6 dialkylamino,

Hal is halogen.


 
2. The method of claim 1, wherein the transgenic plant

a. is selected from the plants listed in Table A: A-1 to A-131 or

b. is selected from the plants listed in Table B: B-1 to B-85, or

c. comprises one or more transgenic events selected from the transgenic events listed in Table A from A-1 to A-131 or in Table B from B-1 to B-85, or

d. displays a trait based one or several transgenic events as listed in Table C from C-1 to C-11.


 
3. The method of claim 1 or 2 wherein the transgenic plant with an effective amount of a compound I-15 of table 1
 
4. The method of any of the claims 1 to 4, wherein the plants are selected from maize, soybean, cotton, rice, potato, canola, rapeseed, wheat and sugar beet.
 
5. The method of any one of the claims 1 to 4, wherein an additional active ingredient is used with the compound according to formula (I), wherein this active ingredient is selected from the group consisting of azoxystrobin, dimoxystrobin, kresoxim-methyl, orysastrobin, pyraclostrobin, trifloxystrobin, bixafen, boscalid, isopyrazam, metalaxyl, penthiopyrad, 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide, N-(2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid amide, dimethomorph, fluopicolide, difenoconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, metconazol, myclobutanil, propiconazole, prothioconazole, tebuconazole, tetraconazole, triticonazole, prochloraz, carbendazim, fluazinam, cyprodinil, pyrimethanil, fludioxonil, dodemorph, fenpropimorph, tridemorph, fenpropidin,
iprodione, vinclozolin, famoxadone, probenazole, captan, folpet, 5-ethyl-6-octyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-ylamine, mancozeb, maneb, metiram, thiram, dithianon, fosetyl, fosetyl-aluminium, chlorothalonil, thiophanate methyl, cymoxanil, metrafenone, spiroxamine, bixafen, N-(3',4',5'-trifluorobiphenyl-2-yl)- 3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-[2-(4'-trifluoromethylthio)-biphenyl]-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide,N-[2-(1,3-dimethylbutyl)-phenyl]-1,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide, N-(2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide,N-(cis-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-(trans-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxamide , N-[1,2,3,4-tetrahydro-9-(1 -methylethyl)-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1 - methyl-1 H-pyrazole-4-carboxamide.
 
6. The method to any of the claims 1 to 5, wherein a seed is treated.
 
7. The method to any of the claims 1 to 5, for increasing the health of the plant.
 
8. The method to any of the claims 1 to 5, for controlling pests and/or phytopathogenic fungi and/or microorganisms.
 























REFERENCES CITED IN THE DESCRIPTION



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Patent documents cited in the description




Non-patent literature cited in the description