(19)
(11)EP 0 577 699 A1

(12)

(43)Date of publication:
12.01.1994 Bulletin 1994/02

(21)Application number: 92908116.0

(22)Date of filing:  11.03.1992
(51)International Patent Classification (IPC): 
A61K 38/ 55( . )
C07K 7/ 06( . )
C07K 14/ 755( . )
C07K 16/ 40( . )
A61K 38/ 00( . )
A61P 7/ 02( . )
C07K 14/ 745( . )
C07K 16/ 00( . )
C12N 9/ 10( . )
A61K 39/ 00( . )
(86)International application number:
PCT/US1992/001926
(87)International publication number:
WO 1992/015609 (17.09.1992 Gazette  1992/24)
(84)Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

(30)Priority: 11.03.1991 US 19910667296

(71)Applicants:
  • THE GENERAL HOSPITAL CORPORATION
    Boston, MA 02114 (US)
  • BRISTOL-MYERS SQUIBB COMPANY
    Princeton, NJ 08543-4000 (US)

(72)Inventors:
  • REED, Guy, L.
    Winchester, MA 01890 (US)
  • MATSUEDA, Gary, R.
    Princeton, NJ 08540 (US)
  • HABER, Edgar
    Salisbury, NH 03268 (US)

(74)Representative: Roberts, Alison Christine, et al 
Kilburn & Strode, 30 John Street
London WC1N 2DD
London WC1N 2DD (GB)

  


(54)COMPOSITIONS AND METHODS TO INHIBIT THE ACTIVATION OF ACTIVE FACTOR XIII