(19)
(11)EP 2 319 528 B8

(12)CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15)Correction information:
Corrected version no 1 (W1 B1)

(48)Corrigendum issued on:
04.03.2020 Bulletin 2020/10

(45)Mention of the grant of the patent:
22.01.2020 Bulletin 2020/04

(21)Application number: 10184898.4

(22)Date of filing:  18.09.2003
(51)Int. Cl.: 
A61K 38/18  (2006.01)

(54)

METHODS OF INCREASING PLATELET AND HEMATOPOIETIC STEM CELL PRODUCTION

METHODE ZUR PRODUKTIONSSTEIGERUNG VON BLUTPLÄTTCHEN UND HÄMATOPOETISCHEN STAMMZELLEN

METHODE POUR AUGMENTER LA PRODUCTION DE PLAQUETTES ET DE CELLULES SOUCHES HEMATOPOIETIQUES


(84)Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
LT LV

(30)Priority: 18.09.2002 US 411700 P
18.09.2002 US 411779 P

(43)Date of publication of application:
11.05.2011 Bulletin 2011/19

(62)Application number of the earlier application in accordance with Art. 76 EPC:
03759345.6 / 1542714

(73)Proprietor: Janssen Pharmaceuticals, Inc.
Titusville, NJ 08560 (US)

(72)Inventors:
  • Kaushansky, Kenneth
    Del Mar, CA 92014 (US)
  • MacDonald, Brian R.
    Newton Square, PA 19073 (US)

(74)Representative: Goodfellow, Hugh Robin 
Carpmaels & Ransford LLP One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)


(56)References cited: : 
WO-A-01/21180
WO-A2-2005/023834
WO-A-02/078612
US-A- 6 060 052
  
  • DE SERRES M ET AL: "Pharmacokinetics and hematological effects of the PEGylated thrombopoietin peptide mimetic GW395058 in rats and monkeys after intravenous or subcutaneous administration", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 17, no. 6, 1 January 1999 (1999-01-01), pages 316-326, XP002421200, ISSN: 1066-5099
  • GOODNOUGH LAWRENCE T ET AL: "Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 98, no. 5, 1 September 2001 (2001-09-01), pages 1346-1351, XP009150233, ISSN: 0006-4971, DOI: DOI:10.1182/BLOOD.V98.5.1346
  • FOX NORMA ET AL: "Thrombopoietin expands hematopoietic stem cells after transplantation", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, vol. 110, no. 3, 1 August 2002 (2002-08-01), pages 389-394, XP002583509, ISSN: 0021-9738, DOI: DOI:10.1172/JCI200215430
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).