(19)
(11)EP 2 392 597 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
07.03.2012 Bulletin 2012/10

(43)Date of publication A2:
07.12.2011 Bulletin 2011/49

(21)Application number: 11168730.7

(22)Date of filing:  28.04.2008
(51)International Patent Classification (IPC): 
C07K 16/24(2006.01)
C07K 16/46(2006.01)
A61K 39/395(2006.01)
A61P 37/06(2006.01)
(84)Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA MK RS

(30)Priority: 27.04.2007 US 914681 P
27.04.2007 US 914663 P
27.04.2007 US 741189
13.06.2007 US 762738

(62)Application number of the earlier application in accordance with Art. 76 EPC:
08754949.9 / 2150564

(71)Applicant: ZymoGenetics, Inc.
Seattle, Washington 98102 (US)

(72)Inventors:
  • Lewis, Katherine E.
    Lake Forest Park, WA Washington 98155 (US)
  • Presnell, Scott R.
    Tacoma, WA Washington 98407 (US)
  • Levin, Steven D.
    Seattle, WA Washington 98177 (US)

(74)Representative: Griffin, Philippa Jane 
Mathys & Squire LLP 120 Holborn
London EC1N 2SQ
London EC1N 2SQ (GB)

  


(54)Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use


(57) There is provided an antagonist of IL-23 and of IL-17A or IL-17F comprising: (i) an antibody or antibody fragment that binds the p19 subunit of IL-23 as shown in SEQ ID NO: 4; and (ii) an antibody or antibody fragment that binds IL-17A as shown in SEQ ID NO: 2 or that binds IL-17F as shown in SEQ ID NO: 6; wherein the antibody or antibody fragment that binds IL-17A or IL-17F comprises a HCDR1 amino acid sequence, a HCDR2 amino acid sequence, and a HCDR3 amino acid sequence of the variable heavy region selected from the group consisting of the variable heavy region of the hybridoma of ATCC Patent Deposit Designation PTA-7988; and wherein the variable light region comprises a LCDR1 amino acid sequence, a LCDR2 amino acid sequence, and a LCDR3 amino acid sequence of the variable light region of the hybridoma of ATCC Patent Deposit Designation PTA-7988.





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