(19)
(11)EP 2 471 512 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
11.07.2012 Bulletin 2012/28

(43)Date of publication A2:
04.07.2012 Bulletin 2012/27

(21)Application number: 12161556.1

(22)Date of filing:  23.06.2004
(51)Int. Cl.: 
A61K 9/127  (2006.01)
A61K 41/00  (2006.01)
(84)Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

(30)Priority: 26.08.2003 US 648168

(62)Application number of the earlier application in accordance with Art. 76 EPC:
04776989.8 / 1660041

(71)Applicant: CeramOptec GmbH
53121 Bonn (DE)

(72)Inventors:
  • Albrecht, Volker
    07749 Jena (DE)
  • Fahr, Alfred
    35091 Cölbe/Marburg (DE)
  • Scheglmann, Dietrich
    07751 Heba (DE)
  • Gräfe, Susanna
    07745 Jena (DE)
  • Neuberger, Wolfgang
    87000 F.T. Labuan (MY)

(74)Representative: Horner, Martin Grenville 
Marks & Clerk LLP Aurora 120 Bothwell Street
Glasgow G2 7JS
Glasgow G2 7JS (GB)

  


(54)Non-polar photosensitizer formulations for photodynamic therapy


(57) A pharmaceutical liposomal formulation for photodynamic therapy comprising a non-polar porphyrin photosensitizer and one or more phospholipids, which are stable in storage without requiring freeze-drying is described. The liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. The phospholipids may be modified by pegylation, i.e. they contain poly ethylene glycol as an integral part of the phospholipids. The formed liposomes contain the non-polar photosensitizer within the membrane and are useful for the combined targeting of a nonpolar photosensitizer and a second polar substance. The invention also relates to the liposome composition formed upon reconstitution with an aqueous vehicle. The freeze-dried formulation upon reconstitution with a suitable aqueous vehicle forms liposomes that are also useful for intravenous administration.