(19)
(11)EP 2 635 596 B8

(12)CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15)Correction information:
Corrected version no 1 (W1 B1)

(48)Corrigendum issued on:
11.03.2020 Bulletin 2020/11

(45)Mention of the grant of the patent:
04.09.2019 Bulletin 2019/36

(21)Application number: 11837324.0

(22)Date of filing:  01.11.2011
(51)International Patent Classification (IPC): 
C07K 14/435(2006.01)
A61K 38/17(2006.01)
(86)International application number:
PCT/AU2011/001402
(87)International publication number:
WO 2012/058715 (10.05.2012 Gazette  2012/19)

(54)

IMMUNE-MODULATING AGENTS AND USES THEREFOR

IMMUNMODULIERENDE MITTEL UND VERWENDUNGEN DAFÜR

AGENTS IMMUNO-MODULATEURS ET LEURS UTILISATIONS


(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)Priority: 01.11.2010 AU 2010904873

(43)Date of publication of application:
11.09.2013 Bulletin 2013/37

(73)Proprietor: University of Technology Sydney
Broadway, NSW 2007 (AU)

(72)Inventors:
  • DONNELLY, Sheila
    Rozelle New South Wales 2039 (AU)
  • ROBINSON, Mark, William
    Balmain East New South Wales 2041 (AU)
  • DALTON, John Pius
    Sainte Anne de Bellevue Quebec H9X 3V9 (CA)
  • TO, Joyce
    St Ives New South Wales 2075 (AU)

(74)Representative: CH Kilger Anwaltspartnerschaft mbB 
Fasanenstrasse 29
10719 Berlin
10719 Berlin (DE)


(56)References cited: : 
WO-A2-2005/023979
  
  • MARK W. ROBINSON ET AL: "A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides", PLOS PATHOGENS, vol. 7, no. 5, E1002042, 12 May 2011 (2011-05-12), pages 1-15, XP055090773, DOI: 10.1371/journal.ppat.1002042
  • DATABASE UniProtKB 8 July 2002 (2002-07-08), XP002723430, retrieved from EBI Database accession no. Q8MXC3 -& LEE HJ ET AL: "Purification and characterization of a 7-kDa protein from Clonorchis sinensis adult worms", THE JOURNAL OF PARASITOLOGY, vol. 88, no. 3, 1 January 2002 (2002-01-01), pages 499-504, XP009177586, AMERICAN SOCIETY OF PARASITOLOGISTS, US ISSN: 0022-3395
  • DATABASE EMBL [Online] 21 April 2010 (2010-04-21), "Fh_NGS2_25G08_f1 Liver fluke newly excysted juvenile Fasciola hepatica cDNA, mRNA sequence.", XP002723431, retrieved from EBI accession no. EMBL:GT741761 Database accession no. GT741761 -& CANCELA MARTÃN ET AL: "Survey of transcripts expressed by the invasive juvenile stage of the liver fluke Fasciola hepatica", BMC GENOMICS, vol. 11, no. 1, 7 April 2010 (2010-04-07), page 227, XP021072547, BIOMED CENTRAL LTD, LONDON, UK ISSN: 1471-2164, DOI: 10.1186/1471-2164-11-227
  • D. J. DOWLING ET AL: "Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses", INFECTION AND IMMUNITY, vol. 78, no. 2, 1 February 2010 (2010-02-01), pages 793-801, XP055113893, ISSN: 0019-9567, DOI: 10.1128/IAI.00573-09
  • TERRAZAS L I ET AL: "The schistosome oligosaccharide lacto-N-neotetraose expands Gr1(+) cells that secrete anti-inflammatory cytokines and inhibit proliferation of naive CD4(+) cells: a potential mechanism for immune polarization in helminth infections", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 9, 1 November 2001 (2001-11-01), pages 5294-5303, XP002430365, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US ISSN: 0022-1767
  • CATHERINE M. D. MILLER ET AL: "Immunological Interactions between 2 Common Pathogens, Th1-Inducing Protozoan Toxoplasma gondii and the Th2-Inducing Helminth Fasciola hepatica", PLOS ONE, vol. 4, no. 5, E5692, 25 May 2009 (2009-05-25), pages 1-10, XP055113901, DOI: 10.1371/journal.pone.0005692
  • DATABASE GENBANK [Online] 08 July 2002 XP003032737 Retrieved from NCBI Database accession no. AAM55183.1
  • DATABASE GENBANK [Online] 09 April 2009 XP003032738 Retrieved from NCBI Database accession no. CAX69999.1
  • DATABASE GENBANK [Online] 22 June 2006 XP003032739 Retrieved from NCBI Database accession no. AAW24619.1
  • ROBINSON M.W. ET AL.: 'A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides' PLOS PATHOGENS vol. 7, no. 5, May 2011, pages E1002042-1 - E1002042-15, XP055090773
  • NELL M J ET AL: "Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application", PEPTIDES, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 4, 1 April 2006 (2006-04-01), pages 649-660, XP027957714, ISSN: 0196-9781 [retrieved on 2006-04-01]
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).