(19)
(11)EP 2 716 284 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
05.11.2014 Bulletin 2014/45

(43)Date of publication A2:
09.04.2014 Bulletin 2014/15

(21)Application number: 13189513.8

(22)Date of filing:  28.05.2004
(51)International Patent Classification (IPC): 
A61K 9/00(2006.01)
A61K 47/38(2006.01)
C08L 71/02(2006.01)
A61K 47/34(2006.01)
C08J 5/18(2006.01)
(84)Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

(30)Priority: 28.05.2003 US 473902 P

(62)Application number of the earlier application in accordance with Art. 76 EPC:
04753818.6 / 1663178

(71)Applicant: MonoSol RX LLC
Portage IN 46368 (US)

(72)Inventors:
  • Yang, Robert K.
    Henderson, Nevada 89052 (US)
  • Fuisz, Richard C.
    Beverly Hills, CA California CA 90210 (US)
  • Myers, Gary L.
    Kingsport, TN Tennessee 37660-2936 (US)
  • Fuisz, Joseph M.
    Bay Harbor Island, FL Florida FL 33154-1204 (US)

(74)Representative: EP&C 
P.O. Box 3241
2280 GE Rijswijk
2280 GE Rijswijk (NL)

  


(54)Polyethylene oxide-based films and drug delivery systems made herefrom


(57) The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.





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