(19)
(11)EP 2 900 205 B1

(12)EUROPEAN PATENT SPECIFICATION

(45)Mention of the grant of the patent:
26.06.2019 Bulletin 2019/26

(21)Application number: 13805544.7

(22)Date of filing:  27.09.2013
(51)International Patent Classification (IPC): 
A23L 33/15(2016.01)
A61Q 3/00(2006.01)
A23L 33/105(2016.01)
A61K 8/27(2006.01)
A61K 8/97(2017.01)
A23L 33/175(2016.01)
A61K 8/67(2006.01)
A23L 33/16(2016.01)
A61K 8/46(2006.01)
(86)International application number:
PCT/IB2013/058932
(87)International publication number:
WO 2014/049563 (03.04.2014 Gazette  2014/14)

(54)

USE OF A COMBINATION OF TAURINE OR A DERIVATE THEREOF AND A GRAPE EXTRACT FOR IMPROVING THE QUALITY OF THE NAILS

VERWENDUNG EINER KOMBINATION VON TAURIN ODER DESSEN DERIVAT UND EINEM TRAUBENEXTRAKT ZUR VERBESSERUNG DER QUALITÄT DER NÄGEL .

UTILISATION D'UNE COMBINAISON DE TAURINE OU D'UN DÉRIVÉ DE CELLE-CI ET D'UN EXTRAIT DE RAISIN POUR AMÉLIORER LA QUALITÉ DES ONGLES


(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)Priority: 28.09.2012 FR 1259223

(43)Date of publication of application:
05.08.2015 Bulletin 2015/32

(73)Proprietor: NUTRICOS Technologies
92117 Clichy Cedex (FR)

(72)Inventors:
  • PICCARDI, Nathalie
    F-21310 Arceau (FR)
  • MAHE, Yann
    F-91700 Sainte Genevieve Des Bois (FR)
  • BRU, Carole
    F-92400 Courbevoie (FR)

(74)Representative: Nony 
11 rue Saint-Georges
75009 Paris
75009 Paris (FR)


(56)References cited: : 
WO-A1-2006/104730
WO-A1-2009/115769
  
  • DATABASE GNPD [Online] MINTEL; September 2011 (2011-09), "Night Multivitamin for Women", XP002700119, Database accession no. 1640776
  • parapharma3000: "Inneov Masse capillaire cheveux colorés-Boite 2X60 comprimés", , 14 May 2012 (2012-05-14), XP002700120, Retrieved from the Internet: URL:http://wayback.archive.org/web/2012051 4195041/http://www.parapharma3000.com/chev eux/2957-inneov-fermete-duo-boite-2x40-cap s-2607189.html [retrieved on 2013-07-02] -& Parapharma3000: "Phyto Citrus Masque Restructurant 200 mL", , 14 May 2012 (2012-05-14), XP002700121, Retrieved from the Internet: URL:http://wayback.archive.org/web/2012051 4195411/http://www.parapharma3000.com/chev eux/2573-phyto-citrus-masque-restructurant -200ml-7573319.html [retrieved on 2013-07-02]
  • Nutra News: "Beauté et santé des cheveux et des ongles", , June 2008 (2008-06), pages 13-15, XP002700122, Retrieved from the Internet: URL:http://www.nutranews.org/data/pdf/nume ros/fr/nutranews200806.pdf [retrieved on 2013-07-02]
  • COLOMBO V E ET AL: "Treatment of brittle fingernails and onychoschizia with biotin: Scanning electron microscopy", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, C.V. MOSBY, ST. LOUIS, MO, US, vol. 23, no. 6, 1 December 1990 (1990-12-01), pages 1127-1132, XP025616321, ISSN: 0190-9622, DOI: 10.1016/0190-9622(90)70345-I [retrieved on 1990-12-01]
  
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).


Description


[0001] The present invention relates to the field of cosmetic products and food supplements for improving the quality of the nails.

[0002] More particularly, the present invention proposes the use of a novel combination of active agents for reducing and/or preventing aesthetic defects, and/or for improving the solidity or hardness of the nails. The invention is also directed towards the use of a combination of active agents in accordance with the invention for reducing and/or preventing splitting of the nails.

[0003] The present invention also relates to a cosmetic process for reducing and/or preventing brittle, fragile, soft, split or cracked nails, preferably split nails, in an individual in need thereof, characterized in that it comprises at least the oral administration, to the said individual, of a combination or of a composition in accordance with the invention.

[0004] A nail or ungual plaque is a flexible, sleek and translucent horny blade which forms a surface excrescence of the skin, consisting of keratinocytes and a very dense and homogeneous keratin matrix. This matrix keeps the cells welded together and gives the nail its strength, hardness, solidity and flexibility. The nail is enveloped by an epidermal sheath, or matrix.

[0005] From a morphological viewpoint, a nail consists of a dorsal part, an intermediate part, a ventral part, a proximal matrix, an intermediate matrix, a lunula and the nail bed. 80% of the thickness of a nail is produced by the proximal matrix, and 20% of its thickness is produced by the intermediate matrix and the nail bed. The dorsal part consists of hard keratin, the intermediate part is the thickest and is formed of moderately hard keratin, and the ventral part consists of soft keratin.

[0006] As regards its chemical constitution, a nail contains water, lipids, mucopolysaccharides and minerals, such as sodium, potassium, iron, calcium, zinc or silicon.

[0007] The hardness and flexibility of nails depend especially on the orientation of the keratin fibres, the arrangement of the keratinocytes and their cohesion and chemical constitution, in particular the content of water, lipids and phospholipids.

[0008] Many factors may impair the chemical constitution of the nails, and as a result their hardness or shape.

[0009] Among the extrinsic factors that are liable to affect the nails, mention may be made of exposure to sunlight, exposure to temperature and/or humidity variations, and exposure to pollutants or to cigarette smoke. Among the intrinsic factors affecting the nails, mention may be made of stress, fatigue, hormonal changes, dehydration, a metabolic deficit, ageing or certain pathologies.

[0010] These various factors are prone to make the nails fragile or brittle, affect their shape, make them split, and thus greatly reduce their aesthetic appeal.

[0011] At the present time, the main solutions proposed in the field of nail quality are based on the use of nail varnishes, of moisturizing active agents in handcare products, or of chemical reinforcement of the nail. The latter solution is based on the use of nail-hardening agents, such as formaldehyde at 1-2%, which generate crossbonds in the keratin. However, frequent use of these products may give rise to too many crossbonds, paradoxically promoting embrittlement of the nails.

[0012] Temporary implants, such as false nails, have also been proposed in the field of nail quality, but the main aim thereof is to hide the poor quality of the nails rather than to prevent and/or restore their quality.

[0013] From a cosmetic viewpoint, there is thus a need to be able to reduce or prevent the various aesthetic impairments that may affect the nails, irrespective of the origin of these impairments.

[0014] There is also a need for novel active agents or for a combination of active agents that can exert efficient and beneficial action on the quality of the nails, and in particular on their hardness, their solidity, their resistance to impacts or to external attacking factors, their resistance to splitting, their smooth appearance, their sheen and consequently their general aesthetic appearance.

[0015] There is more particularly a need for novel active agents or a combination of active agents that are capable of exerting efficient action on the solidity of the nails and of reducing and/or preventing their splitting.

[0016] The object of the present invention is to satisfy these needs.

[0017] Thus, according to a first aspect, the present invention relates to the oral cosmetic use of a combination of active agents comprising at least taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine and at least one grape seed extract, as cosmetic active agents for reducing and/or preventing brittle, fragile, soft, split or cracked nails, preferably split nails.

[0018] Taurine has already been described in the prior art, either as a cell activator for regulating hair cells, proposed as a hair stimulator for topical application (WO 02/24189), or as an agent that is useful for improving hair density, via oral administration
(WO 2004/000 293).

[0019] To the inventors' knowledge, it has never been proposed or suggested hitherto that the oral administration, to an individual in need thereof, of a combination of taurine, a derivative thereof and/or an acceptable salt thereof, and of at least one grape extract, as active agents, could prove to be particularly effective for improving the quality of the nails.

[0020] More particularly, the oral administration of a cosmetic combination in accordance with the invention makes it possible to make the nails more solid, and thus to reduce and/or prevent the nails from breaking and/or splitting.

[0021] More particularly, the oral administration of a cosmetic combination in accordance with the invention makes it possible to reduce and/or prevent lamellar and/or transverse separations of the nails, and especially their splitting.

[0022] More particularly, the oral administration of a cosmetic combination in accordance with the invention makes it possible to improve the hardness of the nails, and thus to reduce and/or prevent soft or overly flexible nails.

[0023] More particularly, the oral administration of a cosmetic combination in accordance with the invention makes it possible to improve the general aesthetic appearance of the nails, and especially to reduce and/or prevent striated and/or damaged nails.

[0024] More particularly, the oral administration of a combination in accordance with the invention makes it possible to improve the sheen and/or transparency of the nails.

[0025] Furthermore, due to the improvement in the quality of the nails associated with the oral administration of a cosmetic combination in accordance with the invention, such an administration also advantageously makes it possible to have longer nails. This also makes it possible to facilitate the staying power of nail varnishes.

[0026] More particularly, the oral administration of a cosmetic combination of active agents in accordance with the invention makes it possible to improve the aesthetic appearance of the cuticle of the nails.

[0027] The administration of a combination in accordance with the invention also enables the nails more quickly to regain a sleek and shiny appearance after the removal of false nails and/or to be protected in the event of the application of false nails.

[0028] Thus, and as demonstrated in the examples, an administration for 3 months of a combination in accordance with the invention makes it possible to reinforce the quality of the nails. In particular, it enables the nails to become harder, less brittle, more resistant to impacts, less prone to splitting and to have a sleek, homogeneous and translucent appearance, and also an improved general aesthetic appearance, especially with less damaged and less striated, or even unstriated, nails.

[0029] According to a preferred embodiment, the combination in accordance with the invention also comprises, as additional active agent, zinc or a salt thereof, and preferably zinc gluconate.

[0030] The combination in accordance with the invention also comprises, as additional active agents, zinc or a salt thereof, vitamin B8 and vitamin C.

[0031] The combination in accordance with the invention is used in a cosmetic composition that is suitable for oral administration.

[0032] A cosmetic composition in accordance with the invention gives the same advantages as those afforded by the combination in accordance with the invention, as indicated previously.

[0033] According to yet another of its aspects, the subject of the present invention is a cosmetic treatment process for improving the quality of the nails, in an individual in need thereof, characterized in that it comprises at least the oral administration, to the said individual, of a combination or of a composition in accordance with the invention.

[0034] The use of a combination of active agents in accordance with the invention is necessarily performed in an effective amount, i.e. an amount that enables the active agents to manifest their properties with regard to the improvement to be afforded to the quality of the nails.

[0035] For the purposes of the present invention, the term "prevent" means reducing to a lesser extent the risk or probability of manifestation of a given phenomenon, i.e. in the present invention impairment of the quality or aesthetic appearance of the nails.

[0036] The present invention describes a combination of active agents comprising, or even consisting of, at least taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N- diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or an acceptable salt thereof, at least one extract of grape seeds, zinc or a salt thereof, vitamin B8 and vitamin C.

[0037] According to yet another of its aspects, the present invention relates to a cosmetic composition that is suitable for oral administration, comprising at least taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine at least one extract of grape seeds, zinc or a salt thereof, vitamin B8 and vitamin C, wherein taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine is used in a content of between 1% and 30% by weight relative to the total weight of the composition, expressed as taurine equivalent.

[0038] For the purposes of the present invention, the term "splitting of the nail" means both lamellar splitting (or onychoschizia) and longitudinal separation of the nail (or onychorrhexis). Preferably, for the purposes of the present invention, the term "splitting of the nail" means lamellar splitting (or onychoschizia).

[0039] The term "onychoschizia" means the deterioration of the intracellular adhesion factors of the nails, which is characterized by lamellar cracking of the end of the nail and also of its distal portion. [Van de Kerkhof et al., 2005; Kechijian, 1985].

[0040] The term "onychorrhexis" means a state characterized by vertical cracking or ridges on the nails.

[0041] According to yet another of its aspects, the present invention relates to a packaging kit or assembly comprising:
  1. (i) a combination in accordance with the invention intended for oral administration, and
  2. (ii) an antifungal agent intended for topical application,
the combination (i) and the antifungal agent (ii) being intended to be administered independently of each other, separately, simultaneously or consecutively over time, the antifungal agent (ii) advantageously being administered before the combination (i).

[0042] According to yet another of its aspects, the present invention relates to a packaging kit or assembly comprising:
  1. (i) a combination in accordance with the invention intended for oral administration, and
  2. (ii) a moisturizer and/or a hardener intended for topical application,
the combination (i) and the moisturizer and/or hardener (ii) being intended to be administered independently of each other, separately, simultaneously or consecutively over time.

[0043] Taurine, derivatives thereof and acceptable salts thereof

[0044] As active agents that are present in a combination in accordance with the invention, use is made of taurine and/or a derivative thereof and/or an acceptable salt thereof.

[0045] Taurine, or 2-aminoethanesulfonic acid, is an amino acid derivative. It is naturally present ubiquitously in the human body.

[0046] It is involved, for example, in the mechanism of fat digestion since it is present in the structure of bile acids (taurocholic and taurochenodeoxycholic acids), precursors of emulsifier-charged bile salts (in the form of micelles) of food lipids (especially including cholesterol) arriving in the duodenum after a meal.

[0047] However, the physiological/physiopathological action and the role of taurine remains disputable (Huxtable et al., 1992, Physiol. Research, 72: 101-103; Hansen et al. 2001, Metab. Res. Rev., 2001, 17: 330-346).

[0048] For the purposes of the present invention, the term "taurine derivatives" means structural analogues of taurine, metabolites thereof or acceptable salts thereof.

[0049] Such structural analogues are, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof as described in Taurine analogues; a new class of therapeutics: retrospect and prospects, Gupta et al., S. Curr. Med. Chem. 2005; 12(17): 2021-39.

[0050] A taurine metabolite is hypotaurine.

[0051] The term "acceptable salts" means salts chosen for their total harmlessness, insofar as the compositions in accordance with the invention are intended to be administered to an individual. In this respect, alkali metal or alkaline-earth metal salts, in particular the magnesium, manganese, iron(II) or zinc salts, are most particularly suitable for use in the invention.

[0052] Taurine derivatives may also be natural extracts that are rich in taurine (2-aminoethanesulfonic acid) or derivatives thereof.

[0053] According to the invention, taurine or an acceptable salt thereof will preferably be used.

[0054] According to a preferred embodiment, taurine and/or hypotaurine will be used.

[0055] The taurine in accordance with the invention may be, for example, the product sold by the company Quimdis.

[0056] According to the invention, taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine are used at daily doses ranging from 1 to 3000 mg per day, advantageously from 5 to 2000 mg per day and preferably from 10 to 300 mg per day.

[0057] According to a preferred embodiment, the daily dose is from about 50 to 150 mg per day.

[0058] The indicated doses of taurine derivatives or of a salt thereof in the present description are doses of taurine equivalent.

Grape extract



[0059] A grape extract is naturally rich in polyphenols.

[0060] Polyphenols from the grape extracts in accordance with the invention may be in the form of monomers and/or oligomers. The polyphenols more particularly present in the grape extracts, especially in grape seed extracts, are polyphenols of the stilbenoid or tannin family, more particularly condensed tannins. They are more particularly oligo-proanthocyanidin (OPC) polyphenols.

[0061] A grape extract in accordance with the invention consists of a grape seed extract.

[0062] It may be, for example, the product sold under the name Vitoflavan 50 by the company DRT.

[0063] A grape extract in accordance with the invention is used so as to afford daily doses of polyphenols ranging from 0.1 to 2000 mg per day, advantageously from 10 to 1000 mg per day and preferably from 50 to 500 mg per day.

[0064] According to a preferred embodiment, the daily dose is from about 50 to 300 mg per day.

[0065] Thus, a combination of active agents in accordance with the invention advantageously comprises taurine or hypotaurine and a grape seed extract.

[0066] In the context of the present invention, the doses of grape extract represent the doses of polyphenols.

[0067] According to the present invention, taurine, a derivative thereof and/or an acceptable salt thereof and a grape extract in accordance with the invention are used in a ratio of taurine, a derivative thereof and/or an acceptable salt thereof/grape extract as described previously of between 1/5 and 5/1, preferably between 1/4 and 4/1 and even more preferably between 1/3 and 3/1.

Additional active agent(s)



[0068] A combination in accordance with the invention may also comprise one or more additional cosmetic active agents.

[0069] Advantageously, such an additional cosmetic active agent may be intended to reinforce the desired cosmetic effect as described previously.

[0070] As additional active agents that may be used, mention may be made of:
  • vitamins, such as vitamin A, B5, B6, B8 or PP (vitamin B3 or niacin),
  • antioxidants, such as curcuminoids; carotenoids, especially a carotenoid chosen from β-carotene, astaxanthin, zeaxanthin and lutein or compounds containing the same, such as wolfberry or lactowolfberry; polyphenol compounds, flavonoids such as catechins; proanthocyanidins, anthocyanins, PCOs (procyanidol oligomers); ubiquinones; coffee extracts containing polyphenols and/or diterpenes; chicory extracts; Ginkgo biloba extracts; grape extracts rich in proanthocyanidins; pimento extracts; soybean extracts; cocoa or coconut milk; pomegranate; Emblica,
  • minerals, such as zinc, calcium, magnesium, copper, iron, iodine, manganese, selenium and chromium(III),
  • sugars,
  • amino acids, especially sulfur amino acids such as glutathione precursors, selenium amino acids and citrulline,
  • prebiotics, chosen especially from oligosaccharides, produced from glucose, galactose, xylose, maltose, sucrose, lactose, starch, xylan, hemicellulose, inulin, gums of acacia type, for example, or a mixture thereof. More particularly, the oligosaccharide comprises at least one fructo-oligosaccharide. More particularly, this prebiotic may comprise a mixture of fructo-oligosaccharide and of inulin,
  • phytosterols, such as resveratrol,
  • hesperidin and neohesperidin,
  • orthosilicic acid and monomethylsilanetriol,
  • arterial pressure modulators, and
  • mixtures thereof.


[0071] A combination in accordance with the invention comprises zinc or a salt thereof as active agent, preferably zinc gluconate.

[0072] It may be, for example, the product sold under the name Gluconal Zn-P by the company Arnaud.

[0073] A combination in accordance with the invention also comprises vitamin B8 and vitamin C.

[0074] A combination in accordance with the invention comprises, besides taurine, a derivative thereof and/or an acceptable salt thereof and a grape seed extract as defined previously, zinc or a salt thereof, and vitamin C and vitamin B8.

[0075] A combination of the invention may contain, besides the additional active agents indicated previously, one or more divalent mineral cations in various forms.

[0076] A divalent mineral cation may thus be in the form of an anhydrous or hydrated mineral or organic salt or a chelated complex. These salts may be, for example, carbonates, bicarbonates, sulfates, glycerophosphates, chlorides, nitrates, acetates, hydroxides, oxides, α-hydroxy acid salts (citrates, tartrates, lactates, malates) or fruit acid salts, or alternatively amino acid salts (aspartate, arginate, fumarate) or fatty acid salts (palmitate, oleate, caseinate, behenate).

[0077] A divalent mineral cation may be chosen from manganese, copper and/or zinc or from alkaline-earth metals. As alkaline-earth metals that may be used in the invention, mention may be made of barium, calcium, magnesium, strontium and/or beryllium.

[0078] Advantageously, a divalent mineral cation, and especially an alkaline-earth metal, is used in the present invention in salt form. In particular, the salt may be chosen from nitrate, citrate, chloride, gluconate, sulfate, lactate and/or acetate salts.

[0079] A divalent mineral cation may also be used in the form of a chelated complex, especially chelated to crystalline or ionized proteins.

[0080] A divalent mineral cation may also be in a specific form stored by a microorganism, for example such as a yeast, like selenium yeasts.

[0081] According to another embodiment, a composition of the invention may contain non-photosynthetic, non-fructifying filamentous bacteria or bacterial extracts derived from non-photosynthetic, non-fructifying filamentous bacteria as defined according to the classification in Bergey's Manual of Systemic Bacteriology, volume 3, section 23, 9th edition, 1989.

[0082] Mention may be made in particular of bacteria belonging to the order of Beggiatoales, and especially bacteria belonging to the genus Beggiatoa. Mention may moreover be made of bacteria belonging to the genus Vitreoscilla, which is similar to the genus Beggiatoa. Among the bacteria that may be used, mention may be made, for example, of Vitreoscilla beggiatoides (ATCC 43181) and Beggiatoa alba (ATCC33555), and preferentially the use of the extract of Vitreoscilla filiformis, in particular with the strain ATCC 15551, metabolites thereof and fractions thereof may be used.

[0083] As indicated previously, a combination of active agents in accordance with the invention may further comprise at least one arterial pressure modulator.

[0084] Arterial pressure biological modulators are known to those skilled in the art.

[0085] An arterial pressure modulator in accordance with the invention may be chosen from vitamin D, cysteine, arginine, citrulline, glutamate, tryptophan, leucine, a tripeptide chosen from Val-Pro-Pro (VPP) and isoleucine-proline-proline (IPP), adenosine, flavonoids from berries, onions, pomegranate, red wine, tea, cocoa and dark chocolate, coenzyme Q10 (CoQ), acetyl-L-carnitine, α-lipoic acid, soybean proteins, spirulina; a microorganism such as Lactobacillus helveticus, Bifidobacterium longum, Lactobacillus acidophilus, L. casei, L. acidophilus, Saccharomyces cerevisiae, Streptococcus thermophilic prebiotic agents, chosen especially from oligosaccharides produced from glucose, galactose, xylose, maltose, sucrose, lactose, starch, xylan, hemicellulose and inulin; glutathione, soybean isoflavones (genistin, genistein, daidzin, daidzein, glycitin, glycitein, estradiol, estrone), soybean lecithin and Fruitflow™, or mixtures thereof.

[0086] More particularly, the oligosaccharide comprises at least one fructo-oligosaccharide.

[0087] More particularly, a prebiotic that is suitable for use in the invention may comprise a mixture of fructo-oligosaccharide and of inulin.

[0088] Such an arterial pressure modulator may be present in a combination of active agents in accordance with the invention in a content of between 0.1% and 50% by weight, preferably between 1% and 40% by weight and preferentially between 2% and 30% by weight relative to the total weight of the combination.

[0089] According to a particular embodiment, a composition of the invention may also comprise at least one probiotic microorganism, a prebiotic agent or a mixture of probiotic microorganisms and a mixture of prebiotic agents.

[0090] Specific examples of probiotic microorganisms that are suitable for use in the invention are Bifidobacterium adolescentis, Bifidobacterium animalis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium infantis, Bifidobacterium pseudocatenulatum, Lactobacillus acidophilus (LC1, NCFB 1748); Lactobacillus amylovorus, Lactobacillus casei (Shirota), Lactobacillus rhamnosus (strain GG), Lactobacillus brevis, Lactobacillus crispatus, Lactobacillus delbruckii (subsp. bulgaricus, lactis), Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus gallinarum, Lactobacillus gasseri, Lactobacillus johnsonii, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus alimentarius, Lactobacillus curvatus, Lactobacillus casei subsp. casei, Lactobacillus sake, Lactococcus lactis, Enterococcus faecalis or faecium, Lactococcus lactis subsp. lactis or cremoris, Leuconostoc mesenteroides subsp. dextranicum, Pediococcus acidilactici, Sporolactobacillus inulinus, Streptococcus salvarius subsp. thermophilus, Streptococcus thermophilus, Staphylococcus carnosus, Staphylococcus xylosus, Saccharomyces (cerevisiae or boulardii), Bacillus (cereus var. toyo or subtilis), Bacillus coagulans, Bacillus licheniformis, Escherichia coli strain nissle, Propionibacterium freudenreichii, and mixtures thereof.

[0091] The microorganisms may be formulated in the form of powders, i.e. in a dry form, or in the form of suspensions or solutions.

[0092] More particularly, they may be probiotic microorganisms chosen from microorganisms of the genus Lactobacillus sp. and/or Bifidobacterium sp., a fraction thereof and/or a metabolite thereof. As illustrations of these microorganisms, mention may be made more particularly of Lactobacillus johnsonii, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium animalis, Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium adolescentis and Bifidobacterium pseudocatenulatum, and mixtures thereof.

[0093] The species that are most particularly suitable are Lactobacillus johnsonii, Lactobacillus paracasei, Bifidobacterium adolescentis, Bifidobacterium longum and Bifidobacterium lactis NCC 2818 (also known as Bb12 ATCC 27536), which were deposited, respectively, according to the Treaty of Budapest, at the Institut Pasteur (28, rue du Docteur Roux, F-75024 Paris cedex 15) on 30/06/92, 12/01/99, 15/04/99, 15/04/99 and 07/06/05 under the following designations CNCM 1-1225, CNCM 1-2116, CNCM 1-2168 and CNCM 1-2170 and CNCM 1-3446, and the genus Bifidobacterium longum (BB536). The strain of Bifidobacterium lactis CNCM 1-3446 may be obtained from Hansen (Chr. Hansen A/S, 10-12 Boege Alle, P.O. Box 407, DK-2970 Hoersholm, Denmark).

[0094] According to one particular embodiment of the invention, the composition comprises at least two different microorganisms, which are especially probiotic, and/or metabolites and/or fractions thereof. These microorganisms may differ by their nature, for example bacterium and fungus, or alternatively by their family, their genus or their species, or only by their strain.

[0095] The prebiotic agents that are suitable for the invention may be chosen from oligosaccharides, produced from glucose, galactose, xylose, maltose, sucrose, lactose, starch, xylan, hemicellulose, inulin, gums of acacia type, for example, or a mixture thereof. More particularly, the oligosaccharide comprises at least one fructo-oligosaccharide. More particularly, this prebiotic may comprise a mixture of fructo-oligosaccharide and of inulin.

[0096] According to one embodiment, a combination of the invention may comprise additional hydrophilic active agents. Hydrophilic active agents that may be used include proteins or protein hydrolysates, amino acids, polyols, especially of C2 to C10, for instance glycerol, sorbitol, butylene glycol or polyethylene glycol, urea, allantoin, sugars and sugar derivatives, water-soluble vitamins, starch, and bacterial or plant extracts, for instance those from Aloe vera.

[0097] According to another embodiment, a combination of the invention may also comprise a lipophilic active agent. Lipophilic active agents that may be used include retinol (vitamin A) and derivatives thereof, ceramides and essential oils.

Composition and kits



[0098] According to one aspect of the invention, a combination of active agents in accordance with the invention is used in a cosmetic composition that is suitable for oral administration.

[0099] A composition in accordance with the invention comprises a physiologically or pharmaceutically acceptable medium.

[0100] Needless to say, a person skilled in the art will take care to select the additional active agents and the amount thereof such that the advantageous properties of the composition in accordance with the invention are not, or are not substantially, adversely affected by the envisaged addition.

[0101] A cosmetic composition in accordance with the invention may comprise taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine in a content of between 1% and 30% by weight relative to the total weight of the composition, expressed as taurine equivalent.

[0102] Preferably, taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine is present in a content of between 5% and 20% by weight and preferentially between 10% and 15% by weight relative to the total weight of the composition, expressed as taurine equivalent.

[0103] In addition, a cosmetic composition in accordance with the invention comprises a grape seed extract, as defined previously, in a content of between 1% and 80% by weight relative to the total weight of the composition.

[0104] Preferably, the grape extract is present in a content of between 5% and 70% by weight and preferably between 10% and 60% by weight relative to the total weight of the composition.

[0105] A composition in accordance with the invention may also comprise the additional cosmetic active agents indicated previously. They may be present in a composition in accordance with the invention in an amount of between 0.0001% and 20% by weight relative to the total weight of the composition.

[0106] More particularly, zinc or a salt thereof may be used in a composition in accordance with the invention in an amount of between 0.1% and 30% by weight relative to the total weight of the composition. Preferably, zinc or a salt thereof may be used in a content of between 0.5% and 20% by weight and preferentially between 1% and 10% by weight relative to the total weight of the composition.

[0107] Vitamin B8 in accordance with the invention may be used in a composition in accordance with the invention in a content of between 0.0001% and 1% by weight relative to the total weight of the composition. Preferably, vitamin B8 may be used in a content of between 0.0005% and 0.5% by weight and preferentially between 0.001% and 0.1% by weight relative to the total weight of the composition.

[0108] Furthermore, vitamin C in accordance with the invention may be used in a composition in accordance with the invention in a content of between 0.5% and 25% by weight relative to the total weight of the composition. Preferably, vitamin C may be used in a content of between 1% and 20% by weight and preferentially between 2% and 10% by weight relative to the total weight of the composition.

[0109] A combination of active agents and a composition in accordance with the invention make it possible, via their oral administration, to improve, reinforce or restore an aesthetic state of a nail.

[0110] As indicated previously, various intrinsic or extrinsic factors may be the cause of an aesthetically degraded state of the nails. The object of the present invention is to restore this state without treating it or preventing its cause, and is thus limited to the cosmetic field. The invention does not relate to the therapeutic field.

[0111] According to one embodiment, the invention is directed towards reducing and/or preventing an impairment in the structure of the nails, in particular to reduce and/or prevent brittle, fragile, soft, split or cracked nails, preferably split nails.

[0112] For the purposes of the invention, the expression "impairment in the structure of the nails" means an impairment in the organization of the keratin fibres or in their chemical composition constituting the nails with regard to an organization or a composition observed in nails of good aesthetic quality.

[0113] More particularly, the impairments in the structure of the nails may lead to the presence of striations on the surface of the nails. Thus, the invention is also directed towards reducing and/or preventing striated nails.

[0114] According to one embodiment, the combination of active agents under consideration in the invention promotes and/or improves the flexibility and/or hardness of the nails. Following the use of the combination in accordance with the invention, the nails are found to be less brittle, harder, more flexible, and/or more resistant to impacts, and have less of a tendency to split.

[0115] According to one embodiment, the combination of active agents in accordance with the invention also makes it possible to make the nails sleek, shiny and/or translucent.

[0116] In particular, the combination of active agents in accordance with the invention makes it possible to increase the transparency and/or whiteness and/or sheen of the nails, as indicated in the tests presented hereinbelow.

[0117] The present invention further describes that the combination of active agents in accordance with the invention also makes it possible to improve the general aesthetic appearance of the nails.

[0118] According to the present invention, it is considered that the general aesthetic appearance of a nail is improved when at least one of the parameters chosen from the hardness, the solidity, the resistance to impacts or to external attacking factors, the resistance to splitting, the sleek appearance and/or the sheen is improved. This improvement in the general aesthetic appearance is illustrated in the table of Example 2.3.

[0119] The combination of active agents in accordance with the invention or the composition in accordance with the invention is administered orally.

[0120] The combinations and compositions in accordance with the invention, intended for oral administration, may especially comprise all or only part of the daily dose.

[0121] The required daily dose may thus be divided up so as to be taken, for example, 1 to 3 times in the day.

[0122] Typically, the duration of this cosmetic treatment may be longer than 4 weeks, especially from 4 to 15 weeks, with, where appropriate, one or more periods of stoppage.

[0123] The oral route has the advantage of acting in a more overall manner on the whole of the structure of the nails.

[0124] The expression "oral cosmetic composition" means, for example, nutritional, nutraceutical or cosmeceutical compositions, comprising at least a combination according to the invention.

[0125] In the case of compositions that are suitable for oral administration, the use of an ingestible support is preferred. The ingestible support may be of diverse nature according to the type of composition under consideration.

[0126] For ingestion, numerous embodiments of oral compositions and especially of food supplements are possible.

[0127] Such compositions may be formulated via any common process known to those skilled in the art.

[0128] Thus, a composition in accordance with the invention may preferably take the form of a coated tablet, a gel capsule, a suspension, a gel, an emulsion, a drinkable solution, a tablet to be swallowed or chewed, a capsule, especially a soft or hard capsule, a granule to be dissolved, a syrup, a lozenge or a food supplement.

[0129] In particular, a combination of active agents in accordance with the invention may be incorporated into any form of food supplement or enriched food, for example food bars or compacted or loose powders. The powders may be diluted with water, in soda, dairy products or soybean derivatives, or may be incorporated into food bars.

[0130] According to one preferred embodiment, a composition in accordance with the invention administered orally may be formulated in the form of coated tablets, gel capsules, gels, emulsions, tablets, capsules, hydrogels, food bars, compact or loose powders, liquid suspensions or solutions, confectionery products, fermented milks, fermented cheeses, chewing gums, toothpastes or spray solutions.

[0131] Milk, yoghurt, cheese, fermented milks, milk-based fermented products, ice creams, fermented or non-fermented cereal-based products, milk-based powders, infant and baby formulas, animal feed in particular for pets, tablets or lozenges, liquid bacterial suspensions, oral supplements in dry form and oral supplements in liquid form are, for example, suitable as food supports.

[0132] The oral compositions may be either in anhydrous form or in aqueous form.

[0133] A combination of active agents in accordance with the invention may be formulated with the usual excipients and components for such oral compositions or food supplements, i.e. especially fatty and/or aqueous components, humectants, thickeners, preserving agents, texture agents, taste agents and/or coating agents, antioxidants, preserving agents and dyes that are common in the food sector.

[0134] The formulating agents and excipients for oral compositions, and especially for food supplements, are known in this field and are not the subject of a detailed description herein.

[0135] In particular, a composition in accordance with the invention may be a food composition for human consumption. This may be, in particular, nutritional complete foods, drinks, mineral waters, soups, dietary supplements and replacement or substitute foods, nutritional bars, confectionery, milk-based products or fermented milk-based products, yoghurts, milk-based powders, enteral nutritional products, infant and/or baby compositions, fermented or non-fermented cereal-based products, ice creams, chocolate, coffee, "culinary" products such as mayonnaise, tomato puree or salad dressings.

[0136] According to one embodiment, a kit according to the invention uses an antifungal agent. Such an agent may be chosen from the families of imidazoles, morpholines or pyridones.

[0137] According to another embodiment, a kit according to the invention uses a moisturizer and/or a hardener.

[0138] A moisturizer in accordance with the invention may be chosen from vitamins and oils. As examples of oils that are suitable for use as moisturizers, mention may be made especially of argan oil, sesame seed oil and sunflower oil.

[0139] A hardener in accordance with the invention may be chosen from hydrolysed wheat proteins, calcium pantothenate or vitamin B5, iron, epoxy resins and polyesters, and nitrocellulose.

Process



[0140] According to another of its aspects, the present invention relates to a cosmetic process for reducing and/or preventing brittle, fragile, soft, split or cracked nails, preferably split nails, in an individual in need thereof, characterized in that it comprises at least the oral administration, to the said individual, of a combination or of a composition in accordance with the invention.

[0141] A process according to the invention may comprise a step that consists in observing a reduction in, or even disappearance of, the impairment in the quality of the nails.

[0142] Advantageously, the application of a process of the invention gives the advantages indicated previously as being associated with the use of a combination or of a composition in accordance with the invention, and may especially improve, or even restore, the hardness, the resistance to impacts, a physiological form, a sleek appearance or a translucent appearance.

[0143] A cosmetic process according to the invention may be performed especially by administering a food composition as defined above.

[0144] A process of the invention may be performed on a daily basis, for example, for instance at a rate of one single administration per day or one administration twice a day, for example once in the morning and once in the evening, or three times a day, in particular at each meal.

[0145] A cosmetic process according to the invention may be performed, for example, by daily administration of a composition formulated, for example, in the form of gel capsules, coated tablets, emulsions, tablets, capsules or drinkable vials, in appropriate amount and number, depending on their form.

[0146] An effective amount of a combination in accordance with the invention may be administered in a single dose per day or in divided doses over the day, for example two to three times a day.

[0147] A process according to the invention may advantageously comprise a single administration.

[0148] A cosmetic process may be performed over a time period ranging from one week to several weeks, or even several months, this period moreover possibly being repeated after periods without treatment, for several months or even several years.

[0149] By way of example, the administration of a combination of active agents in accordance with the invention may be performed at a rate, for example, of three times a day, generally over a prolonged period of at least 4 weeks, or even 4 to 15 weeks, optionally comprising one or more periods of stoppage or being repeated after a period of stoppage.

[0150] In the description and the examples that follow, unless otherwise mentioned, the percentages are weight percentages and the ranges of values written in the form "between ... and ..." include the stated lower and upper limits. The ingredients are mixed, before being formed, in the order and under conditions that are easily determined by those skilled in the art.

[0151] The examples hereinafter are presented as nonlimiting illustrations of the field of the invention.

EXAMPLES


Example 1



[0152] 
Oral composition in tablet form
Ingredients(mg/tablet)(% by weight relative to the total weight of the composition)
Taurine(1) 75 10.641
Zinc gluconate(2) 25.74 3.652
Grape seed extract(3) 93.5 13.266
Vitamin B8(4) 0.016 0.002
Vitamin C(5) 18.34 2.602
     
Excipients for the core  
Dibasic calcium phosphate dihydrate 218 30.931
Microcrystalline cellulose 214 30.363
Croscarmellose sodium 20 2.838
Silicon dioxide 7 0.993
Magnesium stearate 6 0.851
     
Film-coating agents  
Hydroxypropylmethylcellulose 9.18 1.303
Hydroxypropylcellulo se 9.18 1.303
Talc 5.44 0.772
Titanium dioxide 3.21 0.455
Yellow iron oxide 0.12 0.017
Red iron oxide 0.07 0.010
(1) sold under the name Taurine by the company Quimdis
(2) sold under the name Gluconal Zn-P by the company Arnaud
(3) sold under the name Vitaflavan 50 by the company DRT
(4) sold under the name D-Biotin by the company DSM
(5) sold under the name Ascorbic acid 90% granulation by the company DSM


[0153] One to three of these tablets may be taken per day.

[0154] This composition may be prepared according to the process described below:
The D-biotin and the excipients are first mixed together. Next, the taurine, the zinc gluconate, the grape seed extract and the vitamin C are added to this mixture.

[0155] The mixture thus obtained is then lubricated and compressed, before being coated with the film-coating agents and purified water.

Example 2



[0156] A single-blind study was performed, on the basis of the composition of Example 1, under dermatological control, on 50 healthy women from 18 to 50 years old, having brittle/split nails.

[0157] These women were supplemented for 3 months with the composition of Example 1, at a rate of two tablets per day. The efficacy of the supplementation was then validated by clinical scoring and self-evaluation.

[0158] The results obtained are presented in the tables below.

1. Onychoschizia clinical scores



[0159] 
Table 1
 Mean
T0T1 monthT2 monthsT3 months
Lamellar separation (1) 1.47 1.06 0.76 0.71
Longitudinal separation (2) 0.20 0.08 0.00 0.02
Onychoschizia score (1+2) 1.67 1.14 0.76 0.73


[0160] The onychoschizia score decreases in a significant manner from 1 month of supplementation with the combination according to the invention, demonstrating the efficacy of the formulation on splitting of the nails.

2. Overall clinical efficacy score



[0161] The overall clinical score measures the change between times T0 and T1 month, T0 and T2 months and T0 and T3 months in the embrittled nature of the nail.

[0162] This score is evaluated by means of a 5-point scale as indicated in the table below. The results are presented in terms of number and frequency.
Table 2
 T1 monthT2 monthsT3 months
0 Deterioration 4% 2% 0%
1 No improvement 38% 21% 30%
2 Moderate 27% 42% 39%
3 Good 31% 35% 29%
4 Excellent 0% 0% 2%


[0163] From 1 month of supplementation with the combination in accordance with the invention, the clinician notes a marked improvement in the embrittled nature of the nail for 58% of the individuals.

[0164] The improvement concerns 77% and 70% of the women after, respectively, 2 and 3 months of supplementation.

3. Self-evaluation of the Quality of the nails by the individuals of the study



[0165] 
Table 3
PopulationT1 monthT2 MonthsT3 months
%%%
With the supplementation, my nails split less Entirely in agreement 4.1 24.5 24.5
Quite in agreement 40.8 38.8 53
Remotely in agreement 36.7 24.5 14.3
Not at all in agreement 18.4 12.2 8.2
No opinion 0 0 0
With the supplementation, my nails crack less Entirely in agreement 2.0 8.2 16.3
Quite in agreement 44.9 46.9 53.1
Remotely in agreement 38.8 34.7 30.6
Not at all in agreement 0 6.1 14.3
No opinion 0 4.1 0
With the supplementation, my nails appear to be less damaged Entirely in agreement 6.1 18.4 26.5
Quite in agreement 42.9 42.9 49.0
Remotely in agreement 32.7 26.5 20.4
Not at all in agreement 18.4 8.2 4.1
No opinion 0 4.1 0
With the supplementation, my nails are less brittle Entirely in agreement 4.1 10.2 10.2
Quite in agreement 40.8 44.9 55.1
Remotely in agreement 28.6 38.8 30.6
Not at all in agreement 16.3 16.3 4.1
No opinion 0 0 0
With the supplementation, my nails are less striated Entirely in agreement 4.1 12.2 14.3
Quite in agreement 32.7 38.8 49.0
Remotely in agreement 40.8 30.6 28.6
Not at all in agreement 16.3 12.2 6.1
No opinion 6.1 6.1 2.0
With the supplementation, my nails are more solid Entirely in agreement 10.2 20.4 22.4
Quite in agreement 32.7 34.7 44.9
Remotely in agreement 34.7 32.7 28.6
Not at all in agreement 20.4 10.2 4.1
No opinion 2.0 2.0 0
The food supplement makes my nails shinier Entirely in agreement 4.1 8.2 16.3
Quite in agreement 20.4 34.7 51.0
Remotely in agreement 32.7 34.7 30.6
Not at all in agreement 22.4 14.3 2.0
No opinion 20.4 8.2 0
The food supplement makes my nails more beautiful Entirely in agreement 2.0 14.3 22.4
Quite in agreement 26.5 32.7 40.8
Remotely in agreement 34.7 38.8 32.7
Not at all in agreement 18.4 14.3 2.0
No opinion 18.4 0 2.0


[0166] The majority of the women participating in the study noted the efficacy of the combination in accordance with the invention.


Claims

1. Oral cosmetic use of a combination of active agents comprising at least taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine and at least one grape seed extract, as cosmetic active agents for reducing and/or preventing brittle, fragile, soft, split or cracked nails, preferably split nails, characterized in that the combination also comprises, as additional active agent, zinc or a salt thereof, and also comprises vitamin C and vitamin B8, in which the combination of active agents is used in a cosmetic composition that is suitable for oral administration, and further characterized in that taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine is used in a content of between 1% and 30% by weight, relative to the total weight of the composition, expressed as taurine equivalent.
 
2. Use according to any one of the preceding claims, for reducing and/or preventing striated nails.
 
3. Use according to any one of the preceding claims, for making the nails sleek, shiny and/or translucent, in particular for increasing the transparency and/or whiteness and/or sheen of the nails.
 
4. Use according to any one of the preceding claims, for improving the general aesthetic appearance of the nails.
 
5. Use according to any one of the preceding claims, characterized in that the salt of zinc is zinc gluconate.
 
6. Use according to any one of the preceding claims, in which the said composition is in the form of a coated tablet, a gel capsule, a suspension, a gel, an emulsion, a drinkable solution, a tablet to be swallowed or chewed, a capsule, especially a soft or hard capsule, a granule to be dissolved, a syrup, a lozenge or a food supplement.
 
7. Use according to claim 6, in which taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine is used in a content of between 5% and 20% by weight and preferentially between 10% and 15% by weight relative to the total weight of the composition, expressed as taurine equivalent.
 
8. Use according to claim 6 or 7, in which the grape extract is used in a content of between 1% and 80% by weight, preferably between 5% and 70% by weight and preferentially between 10% and 60% by weight relative to the total weight of the composition, expressed as polyphenol dose.
 
9. Use according to any one of claims 6 to 8, in which zinc is used in a content of between 0.1% and 30% by weight, preferably between 0.5% and 20% by weight and preferentially between 1% and 10% by weight relative to the total weight of the composition.
 
10. Cosmetic process for reducing and/or preventing brittle, fragile, soft, split or cracked nails, preferably split nails, in an individual in need thereof, characterized in that it comprises at least the oral administration, to the said individual, of a composition as defined in any one of claims 1 to 9.
 
11. Cosmetic composition suitable for oral administration, comprising at least taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine at least one extract of grape seeds, zinc or a salt thereof, vitamin B8 and vitamin C, wherein taurine, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, N-acyltaurine, acetylhomotaurine, N,N-diacetylsalicyloxyethyltaurine, acylmethyltaurine, homotaurine or salts thereof or hypotaurine is used in a content of between 1% and 30% by weight relative to the total weight of the composition, expressed as taurine equivalent, preferably in a content of between 5% and 20% by weight and preferentially between 10% and 15% by weight.
 
12. Cosmetic composition suitable for oral administration according to claim 11, wherein grape extract is used in a content of between 1% and 80% by weight, preferably between 5% and 70% by weight and preferentially between 10% and 60% by weight relative to the total weight of the composition, expressed as polyphenol dose, wherein zinc is used in a content of between 0.1% and 30% by weight, preferably between 0.5% and 20% by weight and preferentially between 1% and 10% by weight relative to the total weight of the composition, wherein vitamin B8 is present in a content of between 0.0001% and 1% by weight relative to the total weight of the composition, preferably between 00005% and 0.5% by weight and preferentially between 0.001% and 0.1% by weight relative to the total weight of the composition, and wherein vitamin C is present in a content of between 0.5% and 25% by weight relative to the total weight of the composition, preferably between 1% and 20% by weight and preferentially between 2% and 10% by weight, relative to the total weight of the composition.
 
13. Packaging kit or assembly comprising:

(i) a combination as defined in any one of claims 1 to 9, which is intended for oral administration, and

(ii) an antifungal agent intended for topical application,

the combination (i) and the antifungal agent (ii) being intended to be administered independently of each other, separately, simultaneously or consecutively over time, the antifungal agent (ii) advantageously being administered before the combination (i).
 
14. Packaging kit or assembly comprising:

(i) a combination as defined in any one of claims 1 to 9, which is intended for oral administration, and

(ii) a moisturizer and/or a hardener intended for topical application,

the combination (i) and the moisturizer and/or hardener (ii) being intended to be administered independently of each other, separately, simultaneously or consecutively over time.
 


Ansprüche

1. Orale kosmetische Verwendung einer Kombination von Wirkstoffen, umfassend wenigstens Taurin, 4-(2-Hydroxyethyl)-1-piperazinethansulfonsäure, N-Acetyltaurin, Acetylhomotaurin, N,N-Diacetylsalicyloxyethyltaurin, Acylmethyltaurin, Homotaurin oder Salze davon oder Hypotaurin und wenigstens einen Traubenkernextrakt als kosmetische Wirkstoffe, zum Verringern und/oder Verhindern von spröden, brüchigen, weichen, gespalteten oder gebrochenen Nägeln, vorzugsweise gespalteten Nägeln, dadurch gekennzeichnet, dass die Kombination ferner als zusätzlichen Wirkstoff Zink oder ein Salz davon umfasst und auch Vitamin C und Vitamin B8 umfasst, wobei die Kombination von Wirkstoffen in einer kosmetischen Zusammensetzung verwendet wird, die zur oralen Verabreichung geeignet ist, und ferner dadurch gekennzeichnet, dass Taurin, 4-(2-Hydroxyethyl)-1-piperazinethansulfonsäure, N-Acetyltaurin, Acetylhomotaurin, N,N-Diacetylsalicyloxyethyltaurin, Acylmethyltaurin, Homotaurin oder Salze davon oder Hypotaurin in einem Gehalt von zwischen 1 Gew.-% und 30 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, ausgedrückt als Taurin-Äquivalent, verwendet wird.
 
2. Verwendung gemäß einem der vorstehenden Ansprüche zum Verringern und/oder Verhindern von geriffelten Nägeln.
 
3. Verwendung gemäß einem der vorstehenden Ansprüche, um die Nägel geschmeidig, glänzend und/oder durchscheinend zu machen, insbesondere zum Erhöhen der Transparenz und/oder der Weiße und/oder des Glanzes der Nägel.
 
4. Verwendung gemäß einem der vorstehenden Ansprüche zum Verbessern des allgemeinen ästhetischen Aussehens der Nägel.
 
5. Verwendung gemäß einem der vorstehenden Ansprüche, dadurch gekennzeichnet, dass das Zinksalz Zinkgluconat ist.
 
6. Verwendung gemäß einem der vorstehenden Ansprüche, wobei die Zusammensetzung in der Form einer beschichteten Tablette, einer Gelkapsel, einer Suspension, eines Gels, einer Emulsion, einer trinkbaren Lösung, einer zu schluckenden oder zu kauenden Tablette, einer Kapsel, insbesondere einer weichen oder harten Kapsel, eines aufzulösenden Granulats, eines Sirups, einer Lutschtablette oder eines Nahrungsergänzungsmittels vorliegt.
 
7. Verwendung gemäß Anspruch 6, wobei Taurin, 4-(2-Hydroxyethyl)-1-piperazinethansulfonsäure, N-Acetyltaurin, Acetylhomotaurin, N,N-Diacetylsalicyloxyethyltaurin, Acylmethyltaurin, Homotaurin oder Salze davon oder Hypotaurin in einem Gehalt von zwischen 5 Gew.-% und 20 Gew.-% und vorzugsweise zwischen 10 Gew.-% und 15 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, ausgedrückt als Taurin-Äquivalent, verwendet wird.
 
8. Verwendung gemäß Anspruch 6 oder 7, wobei der Traubenextrakt in einem Gehalt von zwischen 1 Gew.-% und 80 Gew.-%, vorzugsweise zwischen 5 Gew.-% und 70 Gew.-% und bevorzugt zwischen 10 Gew.-% und 60 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, ausgedrückt als Polyphenoldosis, verwendet wird.
 
9. Verwendung gemäß einem der Ansprüche 6 bis 8, wobei Zink in einem Gehalt von zwischen 0,1 Gew.-% und 30 Gew.-%, vorzugsweise zwischen 0,5 Gew.-% und 20 Gew.-% und bevorzugt zwischen 1 Gew.-% und 10 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, verwendet wird.
 
10. Kosmetisches Verfahren zum Verringern und/oder Verhindern von spröden, brüchigen, weichen, gespalteten oder gebrochenen Nägeln, vorzugsweise gespalteten Nägeln, bei einem Individuum mit Bedarf daran, dadurch gekennzeichnet, dass es wenigstens die orale Verabreichung einer Zusammensetzung gemäß einem der Ansprüche 1 bis 9 an das Individuum umfasst.
 
11. Kosmetische Zusammensetzung, die zur oralen Verabreichung geeignet ist, umfassend wenigstens Taurin, 4-(2-Hydroxyethyl)-1-piperazinethansulfonsäure, N-Acetyltaurin, Acetylhomotaurin, N,N-Diacetylsalicyloxyethyltaurin, Acylmethyltaurin, Homotaurin oder Salze davon oder Hypotaurin und wenigstens einen Extrakt von Traubenkernen, Zink oder ein Salz davon, Vitamin B8 und Vitamin C, wobei Taurin, 4-(2-Hydroxyethyl)-1-piperazinethansulfonsäure, N-Acetyltaurin, Acetylhomotaurin, N,N-Diacetylsalicyloxyethyltaurin, Acylmethyltaurin, Homotaurin oder Salze davon oder Hypotaurin in einem Gehalt von zwischen 1 Gew.-% und 30 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, ausgedrückt als Taurin-Äquivalent, vorzugsweise in einem Gehalt von zwischen 5 Gew.-% und 20 Gew.-% und bevorzugt zwischen 10 Gew.-% und 15 Gew.-%, verwendet wird.
 
12. Kosmetische Zusammensetzung, die zur oralen Verabreichung geeignet ist, gemäß Anspruch 11, wobei Traubenextrakt in einem Gehalt von zwischen 1 Gew.-% und 80 Gew.-%, vorzugsweise zwischen 5 Gew.-% und 70 Gew.-% und bevorzugt zwischen 10 Gew.-% und 60 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, ausgedrückt als Polyphenoldosis, verwendet wird, wobei Zink in einem Gehalt von zwischen 0,1 Gew.-% und 30 Gew.-%, vorzugsweise zwischen 0,5 Gew.-% und 20 Gew.-% und bevorzugt zwischen 1 Gew.-% und 10 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, verwendet wird, wobei Vitamin B8 in einem Gehalt von zwischen 0,0001 Gew.-% und 1 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, vorzugsweise zwischen 0,0005 Gew.-% und 0,5 Gew.-% und bevorzugt zwischen 0,001 Gew.-% und 0,1 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, vorhanden ist, und wobei Vitamin C in einem Gehalt von zwischen 0,5 Gew.-% und 25 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, vorzugsweise zwischen 1 Gew.-% und 20 Gew.-% und bevorzugt zwischen 2 Gew.-% und 10 Gew.-%, bezogen auf das Gesamtgewicht der Zusammensetzung, vorhanden ist.
 
13. Packungs-Kit oder -Gruppe, umfassend:

(i) eine Kombination gemäß einem der Ansprüche 1 bis 9, die zur oralen Verabreichung vorgesehen ist, und

(ii) ein antifungielles Mittel, das zur topischen Anwendung vorgesehen ist,

wobei die Kombination (i) und das antifungielle Mittel (ii) zur voneinander unabhängigen, getrennten, gleichzeitigen oder zeitlich aufeinanderfolgenden Verabreichung vorgesehen sind, wobei das antifungielle Mittel (ii) vorzugsweise vor der Kombination (i) verabreicht wird.
 
14. Packungs-Kit oder -Gruppe, umfassend:

(i) eine Kombination gemäß einem der Ansprüche 1 bis 9, die zur oralen Verabreichung vorgesehen ist, und

(ii) ein Feuchthaltemittel und/oder einen Härter, das/der zur topischen Anwendung vorgesehen ist,

wobei die Kombination (i) und das Feuchthaltemittel und/oder der Härter (ii) zur voneinander unabhängigen, getrennten, gleichzeitigen oder zeitlich aufeinanderfolgenden Verabreichung vorgesehen sind.
 


Revendications

1. Utilisation cosmétique orale d'une combinaison d'agents actifs comprenant au moins de la taurine, de l'acide 4-(2-hydroxyéthyl)-1-pipérazineéthanesulfonique, de la N-acyltaurine, de l'acétylhomotaurine, de la N,N-diacétylsalicyloxyéthyltaurine, de l'acylméthyltaurine, de l'homotaurine ou des sels de ceux-ci, ou de l'hypotaurine et d'au moins un extrait de pépins de raisin, comme agents actifs cosmétiques destinés à la réduction et/ou la prévention d'ongles cassants, fragiles, mous, dédoublés ou fendillés, préférablement d'ongles dédoublés, caractérisée en ce que la combinaison comprend également, comme agent actif supplémentaire, du zinc ou un sel de celui-ci, et comprend également de la vitamine C et de la vitamine B8, où la combinaison d'agents actifs est utilisée dans une composition cosmétique qui est convenable pour une administration orale, et caractérisée en outre en ce que la taurine, l'acide 4-(2-hydroxyéthyl)-1-pipérazineéthanesulfonique, la N-acyltaurine, l'acétylhomotaurine, la N,N-diacétylsalicyloxyéthyltaurine, l'acylméthyltaurine, l'homotaurine ou des sels de ceux-ci, ou l'hypotaurine est utilisé(e) selon une teneur comprise entre 1% et 30% en poids, par rapport au poids total de la composition, exprimée en équivalent de taurine.
 
2. Utilisation selon l'une quelconque des revendications précédentes, destinée à la réduction et/ou la prévention d'ongles striés.
 
3. Utilisation selon l'une quelconque des revendications précédentes, destinée à rendre les ongles lisses, brillants et/ou translucides, en particulier pour augmenter la transparence et/ou la blancheur et/ou le brillant des ongles.
 
4. Utilisation selon l'une quelconque des revendications précédentes, destinée à améliorer l'aspect esthétique général des ongles.
 
5. Utilisation selon l'une quelconque des revendications précédentes, caractérisée en ce que le sel de zinc est le gluconate de zinc.
 
6. Utilisation selon l'une quelconque des revendications précédentes, dans laquelle ladite composition se trouve sous la forme d'un comprimé enrobé, d'une capsule de gel, d'une suspension, d'un gel, d'une émulsion, d'une solution buvable, d'un comprimé à avaler ou mâcher, d'une capsule, notamment une capsule molle ou dure, d'un granulé à dissoudre, d'un sirop, d'une tablette ou d'un complément alimentaire.
 
7. Utilisation selon la revendication 6, dans laquelle la taurine, l'acide 4-(2-hydroxyéthyl)-1-pipérazineéthanesulfonique, la N-acyltaurine, l'acétylhomotaurine, la N,N-diacétylsalicyloxyéthyltaurine, l'acylméthyltaurine, l'homotaurine ou des sels de ceux-ci, ou l'hypotaurine est utilisé (e) selon une teneur comprise entre 5% et 20% en poids, et préférentiellement entre 10% et 15% en poids, par rapport au poids total de la composition, exprimée en équivalent de taurine.
 
8. Utilisation selon la revendication 6 ou 7, dans laquelle l'extrait de raisin est utilisé selon une teneur comprise entre 1% et 80% en poids, préférablement entre 5% et 70% en poids, et préférentiellement entre 10% et 60% en poids, par rapport au poids total de la composition, exprimée en dose de polyphénol.
 
9. Utilisation selon l'une quelconque des revendications 6 à 8, dans laquelle le zinc est utilisé selon une teneur comprise entre 0,1% et 30% en poids, préférablement entre 0,5% et 20% en poids, et préférentiellement entre 1% et 10% en poids, par rapport au poids total de la composition.
 
10. Procédé cosmétique destiné à la réduction et/ou la prévention d'ongles cassants, fragiles, mous, dédoublés ou fendillés, préférablement d'ongles dédoublés, chez un individu en ayant besoin, caractérisé en ce qu'il comprend au moins l'administration orale, audit individu, d'une composition telle que définie selon l'une quelconque des revendications 1 à 9.
 
11. Composition cosmétique convenable pour une administration orale, comprenant au moins de la taurine, de l'acide 4-(2-hydroxyéthyl)-1-pipérazineéthanesulfonique, de la N-acyltaurine, de l'acétylhomotaurine, de la N,N-diacétylsalicyloxyéthyltaurine, de l'acylméthyltaurine, de l'homotaurine ou des sels de ceux-ci, ou de l'hypotaurine, au moins un extrait de pépins de raisin, du zinc ou un sel de celui-ci, de la vitamine B8 et de la vitamine C, dans laquelle la taurine, l'acide 4-(2-hydroxyéthyl)-1-pipérazineéthanesulfonique, la N-acyltaurine, l'acétylhomotaurine, la N,N-diacétylsalicyloxyéthyltaurine, l'acylméthyltaurine, l'homotaurine ou des sels de ceux-ci, ou l'hypotaurine est utilisé(e) selon une teneur comprise entre 1% et 30% en poids, par rapport au poids total de la composition, exprimée en équivalent de taurine, préférablement selon une teneur comprise entre 5% et 20% en poids et préférentiellement entre 10% et 15% en poids.
 
12. Composition cosmétique convenable pour une administration orale selon la revendication 11, dans laquelle l'extrait de raisin est utilisé selon une teneur comprise entre 1% et 80% en poids, préférablement entre 5% et 70% en poids, et préférentiellement entre 10% et 60% en poids, par rapport au poids total de la composition, exprimée en dose de polyphénol, où le zinc est utilisé selon une teneur comprise entre 0,1% et 30% en poids, préférablement entre 0,5% et 20% en poids, et préférentiellement entre 1% et 10% en poids, par rapport au poids total de la composition, où la vitamine B8 est présente selon une teneur comprise entre 0,0001% et 1% en poids, par rapport au poids total de la composition, préférablement entre 0,0005% et 0,5% en poids et préférentiellement entre 0,001% et 0,1% en poids, par rapport au poids total de la composition, et où la vitamine C est présente selon une teneur comprise entre 0,5% et 25% en poids, par rapport au poids total de la composition, préférablement entre 1% et 20% en poids et préférentiellement entre 2% et 10% en poids, par rapport au poids total de la composition.
 
13. Kit d'emballage ou assemblage, comprenant :

(i) une combinaison telle que définie selon l'une quelconque des revendications 1 à 9, qui est prévue pour une administration orale, et

(ii) un agent antifongique prévu pour une application topique,

la combinaison (i) et l'agent antifongique (ii) étant prévus pour être administrés indépendamment l'un de l'autre, séparément, simultanément ou consécutivement au cours du temps, l'agent antifongique (ii) étant administré de manière avantageuse avant la combinaison (i).
 
14. Kit d'emballage ou assemblage, comprenant :

(i) une combinaison telle que définie selon l'une quelconque des revendications 1 à 9, qui est prévue pour une administration orale, et

(ii) un hydratant et/ou un durcisseur prévu pour une application topique,

la combinaison (i) et l'hydratant et/ou le durcisseur (ii) étant prévus pour être administrés indépendamment l'un de l'autre, séparément, simultanément ou consécutivement au cours du temps.
 






Cited references

REFERENCES CITED IN THE DESCRIPTION



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Patent documents cited in the description




Non-patent literature cited in the description