(19)
(11)EP 3 091 024 A1

(12)EUROPEAN PATENT APPLICATION

(43)Date of publication:
09.11.2016 Bulletin 2016/45

(21)Application number: 16001000.5

(22)Date of filing:  04.05.2016
(51)International Patent Classification (IPC): 
C07F 15/00(2006.01)
C07F 19/00(2006.01)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(30)Priority: 05.11.2015 US 201514933684
05.05.2015 WO PCT/US2015/029269

(71)Applicant: Universal Display Corporation
Ewing, NJ 08618 (US)

(72)Inventors:
  • Brooks, Jason
    Ewing, New Jersey 08618 (US)
  • Szigethy, Geza
    Ewing, New Jersey 08618 (US)
  • Morello, Glenn
    Ewing, New Jersey 08618 (US)
  • Deng, Jun
    Ewing, New Jersey 08618 (US)
  • Djurovich, Peter I.
    Ewing, New Jersey 08618 (US)
  • Chen, Hsiao-Fan
    Ewing, New Jersey 08618 (US)

(74)Representative: Maiwald Patentanwalts GmbH 
Elisenhof Elisenstrasse 3
80335 München
80335 München (DE)

  


(54)ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES


(57) Imidazophenanthridine ligands and metal complexes are provided. The compounds exhibit improved stability through a linking substitution that links a nitrogen bonded carbon of an imidizole ring to a carbon on the adjacent fused aryl ring. The compounds may be used in organic light emitting devices, particularly as emissive dopants, providing devices with improved efficiency, stability, and manufacturing. In particular, the compounds provided herein may be used in blue devices having high efficiency.




Description

CROSS-REFERENCE TO RELATED APPLICATIONS



[0001] This application is a continuation-in-part of PCT application Serial No. PCT/US15/29269, filed on May 5, 2015, which claims priority to U.S. Provisional Application Serial No. 61/990,239, filed on May 08, 2014, and to U.S. Provisional Application Serial No. 62/082,970, filed on November 21, 2014, the entire contents of which are incorporated herein by reference.

FIELD OF THE INVENTION



[0002] The present invention generally relates to novel compounds, compositions comprising the same, and applications of the compounds and compositions, including organic electroluminescent devices comprising the compounds and/or compositions.

JOINT RESEARCH AGREEMENT



[0003] The claimed inventions were made by, on behalf of, and/or in connection with one or more of the following parties to a joint university corporation research agreement: University of Southern California, and the Universal Display Corporation. The agreement was in effect on and before the date the claimed inventions were made, and the claimed inventions were made as a result of activities undertaken within the scope of the agreement.

BACKGROUND OF THE INVENTION



[0004] Generally, an OLED comprises at least one organic layer disposed between and electrically connected to an anode and a cathode. When a current is applied, the anode injects holes and the cathode injects electrons into the organic layer(s). The injected holes and electrons each migrate toward the oppositely charged electrode. When an electron and hole localize on the same molecule, an "exciton," which is a localized electron-hole pair having an excited energy state, is formed. Light is emitted when the exciton relaxes via a photoemissive mechanism. In some cases, the exciton may be localized on an excimer or an exciplex. Non-radiative mechanisms, such as thermal relaxation, may also occur, but are generally considered undesirable.

[0005] The initial OLEDs used emissive molecules that emitted light from their singlet states ("fluorescence") as disclosed, for example, in U.S. Pat. No. 4,769,292, which is incorporated by reference in its entirety. Fluorescent emission generally occurs in a time frame of less than 10 nanoseconds.

[0006] More recently, OLEDs having emissive materials that emit light from triplet states ("phosphorescence") have been demonstrated. Baldo et al., "Highly Efficient Phosphorescent Emission from Organic Electroluminescent Devices," Nature, vol. 395, 151-154, 1998; ("Baldo-I") and Baldo et al., "Very high-efficiency green organic light-emitting devices based on electrophosphorescence," Appl. Phys. Lett., vol. 75, No. 3, 4-6 (1999) ("Baldo-II"), which are incorporated by reference in their entireties. Phosphorescence may be referred to as a "forbidden" transition because the transition requires a change in spin states, and quantum mechanics indicates that such a transition is not favored. As a result, phosphorescence generally occurs in a time frame exceeding at least 10 nanoseconds, and typically greater than 100 nanoseconds. If the natural radiative lifetime of phosphorescence is too long, triplets may decay by a non-radiative mechanism, such that no light is emitted. Organic phosphorescence is also often observed in molecules containing heteroatoms with unshared pairs of electrons at very low temperatures. 2,2'-bipyridine is such a molecule. Non-radiative decay mechanisms are typically temperature dependent, such that an organic material that exhibits phosphorescence at liquid nitrogen temperatures typically does not exhibit phosphorescence at room temperature. But, as demonstrated by Baldo, this problem may be addressed by selecting phosphorescent compounds that do phosphoresce at room temperature. Representative emissive layers include doped or undoped phosphorescent organometallic materials such as disclosed in U.S. Pat. Nos. 6,303,238; 6,310,360; 6,830,828 and 6,835,469; U.S. Patent Application Publication No. 2002-0182441; and WO 2002/074015.

[0007] Phosphorescence may be preceded by a transition from a triplet excited state to an intermediate non-triplet state from which the emissive decay occurs. For example, organic molecules coordinated to lanthanide elements often phosphoresce from excited states localized on the lanthanide metal. However, such materials do not phosphoresce directly from a triplet excited state but instead emit from an atomic excited state centered on the lanthanide metal ion. The europium diketonate complexes illustrate one group of these types of species.

[0008] Phosphorescence from triplets can be enhanced over fluorescence by confining, preferably through bonding, the organic molecule in close proximity to an atom of high atomic number. This phenomenon, called the heavy atom effect, is created by a mechanism known as spin-orbit coupling. Such a phosphorescent transition may be observed from an excited metal-to-ligand charge transfer (MLCT) state of an organometallic molecule such as tris(2-phenylpyridine)iridium(III).

[0009] Opto-electronic devices that make use of organic materials are becoming increasingly desirable for a number of reasons. Many of the materials used to make such devices are relatively inexpensive, so organic opto-electronic devices have the potential for cost advantages over inorganic devices. In addition, the inherent properties of organic materials, such as their flexibility, may make them well suited for particular applications such as fabrication on a flexible substrate. Examples of organic opto-electronic devices include organic light emitting devices (OLEDs), organic phototransistors, organic photovoltaic cells, and organic photodetectors. For OLEDs, the organic materials may have performance advantages over conventional materials. For example, the wavelength at which an organic emissive layer emits light may generally be readily tuned with appropriate dopants.

[0010] OLEDs make use of thin organic films that emit light when voltage is applied across the device. OLEDs are becoming an increasingly interesting technology for use in applications such as flat panel displays, illumination, and backlighting. Several OLED materials and configurations are described in U.S. Pat. Nos. 5,844,363, 6,303,238, and 5,707,745, which are incorporated herein by reference in their entirety.

[0011] One application for phosphorescent emissive molecules is a full color display. Industry standards for such a display call for pixels adapted to emit particular colors, referred to as "saturated" colors. In particular, these standards call for saturated red, green, and blue pixels. Alternatively, the OLED can be designed to emit white light. In conventional liquid crystal displays, emission from a white backlight is filtered using absorption filters to produce red, green and blue emission. The same technique can also be used with OLEDs.The white OLED can be either a single EML device or a stacked structure. Color may be measured using CIE coordinates, which are well known to the art.

[0012] One example of a green emissive molecule is tris(2-phenylpyridine) iridium, denoted Ir(ppy)3, which has the following structure:



[0013] In this, and later figures herein, we depict the dative bond from nitrogen to metal (here, Ir) as a straight line.

[0014] As used herein, the term "organic" includes polymeric materials as well as small molecule organic materials that may be used to fabricate organic opto-electronic devices. "Small molecule" refers to any organic material that is not a polymer, and "small molecules" may actually be quite large. Small molecules may include repeat units in some circumstances. For example, using a long chain alkyl group as a substituent does not remove a molecule from the "small molecule" class. Small molecules may also be incorporated into polymers, for example as a pendent group on a polymer backbone or as a part of the backbone. Small molecules may also serve as the core moiety of a dendrimer, which consists of a series of chemical shells built on the core moiety. The core moiety of a dendrimer may be a fluorescent or phosphorescent small molecule emitter. A dendrimer may be a "small molecule," and it is believed that all dendrimers currently used in the field of OLEDs are small molecules.

[0015] As used herein, "top" means furthest away from the substrate, while "bottom" means closest to the substrate. Where a first layer is described as "disposed over" a second layer, the first layer is disposed further away from substrate. There may be other layers between the first and second layer, unless it is specified that the first layer is "in contact with" the second layer. For example, a cathode may be described as "disposed over" an anode, even though there are various organic layers in between.

[0016] As used herein, "solution processible" means capable of being dissolved, dispersed, or transported in and/or deposited from a liquid medium, either in solution or suspension form.

[0017] A ligand may be referred to as "photoactive" when it is believed that the ligand directly contributes to the photoactive properties of an emissive material. A ligand may be referred to as "ancillary" when it is believed that the ligand does not contribute to the photoactive properties of an emissive material, although an ancillary ligand may alter the properties of a photoactive ligand.

[0018] As used herein, and as would be generally understood by one skilled in the art, a first "Highest Occupied Molecular Orbital" (HOMO) or "Lowest Unoccupied Molecular Orbital" (LUMO) energy level is "greater than" or "higher than" a second HOMO or LUMO energy level if the first energy level is closer to the vacuum energy level. Since ionization potentials (IP) are measured as a negative energy relative to a vacuum level, a higher HOMO energy level corresponds to an IP having a smaller absolute value (an IP that is less negative). Similarly, a higher LUMO energy level corresponds to an electron affinity (EA) having a smaller absolute value (an EA that is less negative). On a conventional energy level diagram, with the vacuum level at the top, the LUMO energy level of a material is higher than the HOMO energy level of the same material. A "higher" HOMO or LUMO energy level appears closer to the top of such a diagram than a "lower" HOMO or LUMO energy level.

[0019] As used herein, and as would be generally understood by one skilled in the art, a first work function is "greater than" or "higher than" a second work function if the first work function has a higher absolute value. Because work functions are generally measured as negative numbers relative to vacuum level, this means that a "higher" work function is more negative. On a conventional energy level diagram, with the vacuum level at the top, a "higher" work function is illustrated as further away from the vacuum level in the downward direction. Thus, the definitions of HOMO and LUMO energy levels follow a different convention than work functions.

[0020] More details on OLEDs, and the definitions described above, can be found in US Pat. No. 7,279,704, which is incorporated herein by reference in its entirety.

SUMMARY OF THE INVENTION



[0021] According to an aspect of the present disclosure, a compound having a structure (LA)nMLm according to the following Formula 1 is disclosed:



[0022] In Formula 1,

M is a metal having an atomic weight greater than 40, n has a value of at least 1 and m+n is the maximum number of ligands that may be attached to the metal M;

wherein A is a linking group having two to three linking atoms, wherein the linking atoms are each independently selected from the group consisting of C, Si, O, S, N, B or combinations thereof; wherein the linking atoms form at least one single bond between two linking atoms;

wherein R1a - R1g are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF3, CO2R, C(O)R, C(O)NR2, NR2, NO2, OR, SR, SO2, SOR, SO3R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;

wherein each R is independently selected from the group consisting of hydrogen, deuterium, halo, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, aryl, heteroaryl, and combinations thereof;

wherein any one of the ring atoms to which R1b to R1g are attached may be replaced with a nitrogen atom,

wherein when the ring atom is replaced with a nitrogen atom the corresponding R group is not present; and wherein L is a substituted or unsubstituted cyclometallated ligand.



[0023] According to another aspect of the present disclosure, an organic light emitting device is disclosed. The OLED comprises an anode; a cathode; and an organic layer disposed between the anode and the cathode, wherein the organic layer comprises the compound having the structure according to Formula 1.

[0024] According to another aspect of the present disclosure, a formulation comprising the compound having the structure according to Formula 1 is also disclosed.

[0025] According to another aspect of the present disclosure, a compound having a structure according to Formula (1a) shown below is disclosed.



[0026] In Formula (1a),

A is a linking group having two to three linking atoms, wherein the linking atoms are each independently selected from the group consisting of C, Si, O, S, N, B or combinations thereof;

wherein Rab, Rga, R1b - R1f are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF3, CO2R, C(O)R, C(O)NR2, NR2, NO2, OR, SR, SO2, SOR, SO3R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;

wherein each R is independently selected from the group consisting of hydrogen, deuterium, halo, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl; alkynyl, aralkyl, aryl, heteroaryl, and combinations thereof; and

wherein any one of the ring atoms to which Rab, Rga, R1b - R1f are attached may be replaced with a nitrogen atom, wherein when the ring atom is replaced with a nitrogen atom the corresponding R group is not present.



[0027] According to another aspect of the present disclosure, the compound of Formula (1a) can be a compound having a structure represented by structural formulas, Formula (2a) and Formula (2b) tethered together as defined below:

wherein A1 and A2 are each a first linking group having two to three linking atoms, wherein the linking atoms are each independently selected from the group consisting of C, Si, O, S, N, B and combinations thereof, and

wherein Rac, Rgb, and R2b - R2f are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF3, CO2R, C(O)R, C(O)NR2, NR2, NO2, OR, SR, SO2, SOR, SO3R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;

wherein the compound is tethered together via at least one second linking group formed between Rab and Rac and/or Rga and Rgb, wherein at least one second linking group has one to three linking atoms and each linking atom is independently selected from the group consisting of B, N, P, O, S, Se, C, Si, Ge and combinations thereof; and any one of the ring atoms to which R1b - R1f and R2b - R2f are attached may be replaced with a nitrogen atom, wherein when the ring atom is replaced with a nitrogen atom the corresponding R group is not present.



[0028] According to another aspect of the present disclosure, the compound of Formula (1a) can be a compound having a structure represented by Formula (3a) shown below:

wherein L2 and L3 are each independently selected from the group consisting of a single bond, BR1, NR1, PR1, O, S, Se, C=O, S=O, SO2, CR1R2, SiR1R2, and GeR1R2;

wherein R3a - R3f, are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF3, CO2R, C(O)R, C(O)NR2, NR2, NO2, OR, SR, SO2, SOR, SO3R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;

wherein each R1 and R2 is independently selected from the group consisting of hydrogen, deuterium, halo, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, aryl, heteroaryl, and combinations thereof;

wherein any two adjacent R1f, R3a, R3c, R3d, R1 and R2 are optionally joined to form a ring;

wherein L2 and R1f, L2 and R3a, or L2 and both R1f and R3a are optionally joined to form one or more rings; and wherein L3 and R3c, L3 and R3d, or L3 and both R3c and R3d are optionally joined to form one or more rings.


BRIEF DESCRIPTION OF THE DRAWINGS



[0029] The foregoing summary, as well as the following detailed description of exemplary embodiments of the compounds, compositions and devices in accordance with the present invention, will be better understood when read in conjunction with the appended drawings of exemplary embodiments. It should be understood, however, that the invention is not limited to the precise arrangements and instrumentalities shown.

[0030] In the drawings:

FIG. 1 shows an exemplary organic light emitting device 100; and

FIG. 2 illustrates an exemplary organic light emitting device 200 according to the present disclosure.

FIGS. 3 a and 3b illustrate a computational model of minimized bond-broken geometry (top) and minimized non-bond broken geometry (bottom) for comparative example 1.

FIG. 4 illustrates a MALDI negative mode mass spectrum for comparative compound 4. The highest intensity peak corresponds to fragmentation of the imidazole ring.

FIG. 5 illustrates the x-ray crystal structure of 3,4-dihydrodibenzo[b,ij]imidazo[2,1,5-de]quinolizine.

FIG. 6 illustrates the x-ray crystal structure of 3,3-dimethyl-3,4-dihydro-1,2a1-diaza-3-silabenzo[fg]aceanthrylene.

FIG. 7 depicts Emission spectrum of Compound 49 in 77 K and room temperature 2-methyl THF solvent and solid state PMMA matrix.


DETAILED DESCRIPTION



[0031] Generally, an OLED comprises at least one organic layer disposed between and electrically connected to an anode and a cathode. When a current is applied, the anode injects holes and the cathode injects electrons into the organic layer(s). The injected holes and electrons each migrate toward the oppositely charged electrode. When an electron and hole localize on the same molecule, an "exciton," which is a localized electron-hole pair having an excited energy state, is formed. Light is emitted when the exciton relaxes via a photoemissive mechanism. In some cases, the exciton may be localized on an excimer or an exciplex. Non-radiative mechanisms, such as thermal relaxation, may also occur, but are generally considered undesirable.

[0032] The initial OLEDs used emissive molecules that emitted light from their singlet states ("fluorescence") as disclosed, for example, in U.S. Pat. No. 4,769,292, which is incorporated by reference in its entirety. Fluorescent emission generally occurs in a time frame of less than 10 nanoseconds.

[0033] More recently, OLEDs having emissive materials that emit light from triplet states ("phosphorescence") have been demonstrated. Baldo et al., "Highly Efficient Phosphorescent Emission from Organic Electroluminescent Devices," Nature, vol. 395, 151-154, 1998; ("Baldo-I") and Baldo et al., "Very high-efficiency green organic light-emitting devices based on electrophosphorescence," Appl. Phys. Lett., vol. 75, No. 3, 4-6 (1999) ("Baldo-II"), which are incorporated by reference in their entireties. Phosphorescence is described in more detail in US Pat. No. 7,279,704 at cols. 5-6, which are incorporated by reference.

[0034] Imidazophenanthridines are useful ligands that can provide 460 nm emission when ligated to both platinum and iridium metals. Phosphorescent imidazophenanthridine complexes can provide deep blue emission with tunable photoluminescent quantum yield ranging from nearly zero to unity. Unfortunately, the device lifetime is limited for both iridium and platinum based blue-emitting complexes. We provide a strategy herein to improve the stability of the imidazophenanthridine ligand by addressing a bond on the ligand that is shown by computational theory, mass spec fragmentation analysis, and photooxidative studies to be a weak bond due to polycyclic ring strain and electronic structure.

[0035] FIG. 1 shows an organic light emitting device 100. The figures are not necessarily drawn to scale. Device 100 may include a substrate 110, an anode 115, a hole injection layer 120, a hole transport layer 125, an electron blocking layer 130, an emissive layer 135, a hole blocking layer 140, an electron transport layer 145, an electron injection layer 150, a protective layer 155, a cathode 160, and a barrier layer 170. Cathode 160 is a compound cathode having a first conductive layer 162 and a second conductive layer 164. Device 100 may be fabricated by depositing the layers described, in order. The properties and functions of these various layers, as well as example materials, are described in more detail in US 7,279,704 at cols. 6-10, which are incorporated by reference.

[0036] More examples for each of these layers are available. For example, a flexible and transparent substrate-anode combination is disclosed in U.S. Pat. No. 5,844,363, which is incorporated by reference in its entirety. An example of a p-doped hole transport layer is m-MTDATA doped with F4-TCNQ at a molar ratio of 50:1, as disclosed in U.S. Patent Application Publication No. 2003/0230980, which is incorporated by reference in its entirety. Examples of emissive and host materials are disclosed in U.S. Pat. No. 6,303,238 to Thompson et al., which is incorporated by reference in its entirety. An example of an n-doped electron transport layer is BPhen doped with Li at a molar ratio of 1:1, as disclosed in U.S. Patent Application Publication No. 2003/0230980, which is incorporated by reference in its entirety. U.S. Pat. Nos. 5,703,436 and 5,707,745, which are incorporated by reference in their entireties, disclose examples of cathodes including compound cathodes having a thin layer of metal such as Mg:Ag with an overlying transparent, electrically-conductive, sputter-deposited ITO layer. The theory and use of blocking layers is described in more detail in U.S. Pat. No. 6,097,147 and U.S. Patent Application Publication No. 2003/0230980, which are incorporated by reference in their entireties. Examples of injection layers are provided in U.S. Patent Application Publication No. 2004/0174116, which is incorporated by reference in its entirety. A description of protective layers may be found in U.S. Patent Application Publication No. 2004/0174116, which is incorporated by reference in its entirety.

[0037] FIG. 2 shows an inverted OLED 200. The device includes a substrate 210, a cathode 215, an emissive layer 220, a hole transport layer 225, and an anode 230. Device 200 may be fabricated by depositing the layers described, in order. Because the most common OLED configuration has a cathode disposed over the anode, and device 200 has cathode 215 disposed under anode 230, device 200 may be referred to as an "inverted" OLED. Materials similar to those described with respect to device 100 may be used in the corresponding layers of device 200. FIG. 2 provides one example of how some layers may be omitted from the structure of device 100.

[0038] The simple layered structure illustrated in FIGS. 1 and 2 is provided by way of nonlimiting example, and it is understood that embodiments of the invention may be used in connection with a wide variety of other structures. The specific materials and structures described are exemplary in nature, and other materials and structures may be used. Functional OLEDs may be achieved by combining the various layers described in different ways, or layers may be omitted entirely, based on design, performance, and cost factors. Other layers not specifically described may also be included. Materials other than those specifically described may be used. Although many of the examples provided herein describe various layers as comprising a single material, it is understood that combinations of materials, such as a mixture of host and dopant, or more generally a mixture, may be used. Also, the layers may have various sublayers. The names given to the various layers herein are not intended to be strictly limiting. For example, in device 200, hole transport layer 225 transports holes and injects holes into emissive layer 220, and may be described as a hole transport layer or a hole injection layer. In one embodiment, an OLED may be described as having an "organic layer" disposed between a cathode and an anode. This organic layer may comprise a single layer, or may further comprise multiple layers of different organic materials as described, for example, with respect to FIGS. 1 and 2.

[0039] Structures and materials not specifically described may also be used, such as OLEDs comprised of polymeric materials (PLEDs) such as disclosed in U.S. Pat. No. 5,247,190 to Friend et al., which is incorporated by reference in its entirety. By way of further example, OLEDs having a single organic layer may be used. OLEDs may be stacked, for example as described in U.S. Pat. No. 5,707,745 to Forrest et al, which is incorporated by reference in its entirety. The OLED structure may deviate from the simple layered structure illustrated in FIGS. 1 and 2. For example, the substrate may include an angled reflective surface to improve out-coupling, such as a mesa structure as described in U.S. Pat. No. 6,091,195 to Forrest et al., and/or a pit structure as described in U.S. Pat. No. 5,834,893 to Bulovic et al., which are incorporated by reference in their entireties.

[0040] Unless otherwise specified, any of the layers of the various embodiments may be deposited by any suitable method. For the organic layers, preferred methods include thermal evaporation, ink-jet, such as described in U.S. Pat. Nos. 6,013,982 and 6,087,196, which are incorporated by reference in their entireties, organic vapor phase deposition (OVPD), such as described in U.S. Pat. No. 6,337,102 to Forrest et al., which is incorporated by reference in its entirety, and deposition by organic vapor jet printing (OVJP), such as described in U.S. Pat. No. 7,431,968, which is incorporated by reference in its entirety. Other suitable deposition methods include spin coating and other solution based processes. Solution based processes are preferably carried out in nitrogen or an inert atmosphere. For the other layers, preferred methods include thermal evaporation. Preferred patterning methods include deposition through a mask, cold welding such as described in U.S. Pat. Nos. 6,294,398 and 6,468,819, which are incorporated by reference in their entireties, and patterning associated with some of the deposition methods such as ink-jet and OVJD. Other methods may also be used. The materials to be deposited may be modified to make them compatible with a particular deposition method. For example, substituents such as alkyl and aryl groups, branched or unbranched, and preferably containing at least 3 carbons, may be used in small molecules to enhance their ability to undergo solution processing. Substituents having 20 carbons or more may be used, and 3-20 carbons is a preferred range. Materials with asymmetric structures may have better solution processibility than those having symmetric structures, because asymmetric materials may have a lower tendency to recrystallize. Dendrimer substituents may be used to enhance the ability of small molecules to undergo solution processing.

[0041] Devices fabricated in accordance with embodiments of the present invention may further optionally comprise a barrier layer. One purpose of the barrier layer is to protect the electrodes and organic layers from damaging exposure to harmful species in the environment including moisture, vapor and/or gases, etc. The barrier layer may be deposited over, under or next to a substrate, an electrode, or over any other parts of a device including an edge. The barrier layer may comprise a single layer, or multiple layers. The barrier layer may be formed by various known chemical vapor deposition techniques and may include compositions having a single phase as well as compositions having multiple phases. Any suitable material or combination of materials may be used for the barrier layer. The barrier layer may incorporate an inorganic or an organic compound or both. The preferred barrier layer comprises a mixture of a polymeric material and a non-polymeric material as described in U.S. Pat. No. 7,968,146, PCT Pat. Application Nos. PCT/US2007/023098 and PCT/US2009/042829, which are herein incorporated by reference in their entireties. To be considered a "mixture", the aforesaid polymeric and non-polymeric materials comprising the barrier layer should be deposited under the same reaction conditions and/or at the same time. The weight ratio of polymeric to non-polymeric material may be in the range of 95:5 to 5:95. The polymeric material and the non-polymeric material may be created from the same precursor material. In one example, the mixture of a polymeric material and a non-polymeric material consists essentially of polymeric silicon and inorganic silicon.

[0042] Devices fabricated in accordance with embodiments of the invention can be incorporated into a wide variety of electronic component modules (or units) that can be incorporated into a variety of electronic products or intermediate components. Examples of such electronic products or intermediate components include display screens, lighting devices such as discrete light source devices or lighting panels, etc. that can be utilized by the end-user product manufacturers. Such electronic component modules can optionally include the driving electronics and/or power source(s). Devices fabricated in accordance with embodiments of the invention can be incorporated into a wide variety of consumer products that have one or more of the electronic component modules (or units) incorporated therein. Such consumer products would include any kind of products that include one or more light source(s) and/or one or more of some type of visual displays. Some examples of such consumer products include flat panel displays, computer monitors, medical monitors, televisions, billboards, lights for interior or exterior illumination and/or signaling, heads-up displays, fully or partially transparent displays, flexible displays, laser printers, telephones, cell phones, tablets, phablets, personal digital assistants (PDAs), wearable devices, laptop computers, digital cameras, camcorders, viewfinders, micro-displays, 3-D displays, vehicles, a large area wall, theater or stadium screen, or a sign. Various control mechanisms may be used to control devices fabricated in accordance with the present invention, including passive matrix and active matrix. Many of the devices are intended for use in a temperature range comfortable to humans, such as 18 degrees C. to 30 degrees C., and more preferably at room temperature (20-25 degrees C), but could be used outside this temperature range, for example, from -40 degree C to + 80 degree C.

[0043] The materials and structures described herein may have applications in devices other than OLEDs. For example, other optoelectronic devices such as organic solar cells and organic photodetectors may employ the materials and structures. More generally, organic devices, such as organic transistors, may employ the materials and structures.

[0044] The term "halo," "halogen," or "halide" as used herein includes fluorine, chlorine, bromine, and iodine.

[0045] The term "alkyl" as used herein means a straight or branched chain saturated acyclic hydrocarbon radical, which may optionally be substituted with any suitable substituent. Accordingly, an alkyl radical in accordance with the present invention can comprise any combination of primary, secondary, tertiary and quaternary carbon atoms. Exemplary alkyl radicals include, but are not limited to, C1-C20-alkyl, C1-C18-alkyl, C1-C16-alkyl, C1-C14-alkyl, C1-C12-alkyl, C1-C10-alkyl, C1-C8-alkyl, C1-C6-alkyl, C1-C4-alkyl, C1-C3-alkyl, and C2-alkyl. Specific examples include methyl, ethyl, 1-propyl, 2-propyl, 2-methyl-1-propyl, 1-butyl, 2-butyl, t-butyl, n-octyl, n-decyl, and n-hexadecyl.

[0046] As used herein, the term "heteroalkyl" refers to an alkyl group as described herein in which one or more carbon atoms is replaced by a heteroatom. Suitable heteroatoms include oxygen, sulfur, nitrogen, phosphorus, and the like. Examples of heteroalkyl groups include, but are not limited to, alkoxy, amino, thioester, poly(ethylene glycol), and alkyl-substituted amino.

[0047] The term "cycloalkyl" as used herein contemplates cyclic alkyl radicals. Preferred cycloalkyl groups are those containing 3 to 7 carbon atoms and includes cyclopropyl, cyclopentyl, cyclohexyl, and the like. Additionally, the cycloalkyl group may be optionally substituted.

[0048] As used herein, the term "alkenyl" means acyclic branched or unbranched hydrocarbon radical having one or more carbon-carbon double bonds. Exemplary alkenyl radicals include, but are not limited to, C1-C20-alkenyl radical, C2-C18-alkenyl radical, C2-C16-alkenyl radical, C2-C14-alkenyl radical, C2-C12-alkenyl radical, C2-C10-alkenyl radical, C2-C8-alkenyl radical, C2-C6-alkenyl radical, C2-C4-alkenyl radical, C2-C3-alkenyl radical, and C2-alkenyl radical. Specific examples include, but are not limited to, ethylenyl, propylenyl, 1-butenyl, 2-butenyl, isobutylenyl, 1-pentenyl, 2-pentenyl, 3-methyl-1-butenyl, 2-methyl-2-butenyl, and 2,3-dimethyl-2-butenyl.

[0049] As used herein, the term "alkylene" means an optionally substituted saturated straight or branched chain hydrocarbon radical. Exemplary alkylene radicals include, but are not limited to, C1-C20-alkylene, C2-C18-alkylene, C2-C16-alkylene, C2-C14-alkylene, C2-C12-alkylene, C2-C10-alkylene, C2-C8-alkylene, C2-C6-alkylene, C2-C4-alkylene, C2-C3-alkylene, and C2-alkylene. Specific examples of alkylene include, but are not limited to, methylene, dimethylene, and trimethylene.

[0050] As used herein, the term "alkynyl" means an acyclic branched or unbranched hydrocarbon having at least one carbon-carbon triple bond. Exemplary alkylene radicals include, but are not limited to, C1-C20-alkynyl radical, C2-C18-alkynyl radical, C2-C16-alkynyl radical, C2-C14-alkynyl radical, C2-C12-alkynyl radical, C2-C10-alkynyl radical, C2-C8-alkynyl radical, C2-C6-alkynyl radical, C2-C4-alkynyl radical, C2-C3-alkynyl radical, and C2-alkynyl radical. Specific examples of alkynyl include, but are not limited to, propargyl, and 3-pentynyl, acetylenyl, propynyl, 1-butynyl, 2-butynyl, 1-pentynyl, 2-pentynyl, and 3-methyl-1-butynyl.

[0051] As used herein, the term "aralkyl" means one or more aryl radicals as defined herein attached through an alkyl bridge (e.g., -alkyl-(aryl)j, wherein j is 1, 2 or 3). Specific examples of aralkyl include, but are not limited to, benzyl (-CH2-phenyl, i.e., Bn), diphenyl methyl (-CH2- (phenyl)2) and trityl (-C-(phenyl)3). Additionally, the aralkyl group may be optionally substituted.

[0052] Unless stated otherwise, as used herein, the term "heterocycle" and variants of the term, including "heterocyclic group" and "heterocyclyl," means an optionally substituted monocyclic or polycyclic ring system having as ring members atoms of at least two different elements and wherein the monocyclic or polycyclic ring system is either saturated, unsaturated or aromatic. In some embodiments, heterocyle comprises carbon atoms and at least one heteroatom. In some embodiments, heterocyle comprises carbon atoms and at least one heteroatom selected from nitrogen, oxygen, silicon, selenium, and sulfur, and wherein the nitrogen, oxygen, silicon, selenium, and sulfur heteroatoms may be optionally oxidized, and the nitrogen heteroatom may be optionally quaternized. Examples of heterocycle include, but are not limited to, furyl, benzofuranyl, thiophenyl, benzothiophenyl, pyrrolyl, indolyl, isoindolyl, azaindolyl, pyridyl, quinolinyl, isoquinolinyl, oxazolyl, isooxazolyl, benzoxazolyl, pyrazolyl, imidazolyl, benzimidazolyl, thiazolyl, benzothiazolyl, isothiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, cinnolinyl, phthalazinyl, and quinazolinyl. Thus, in addition to the aromatic heteroaryls listed above, heterocycles also include (but are not limited to) morpholinyl, pyrrolidinonyl, pyrrolidinyl, piperizinyl, piperidinyl, hydantoinyl, valerolactamyl, oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydropyridinyl, tetrahydroprimidinyl, tetrahydrothiophenyl, tetrahydrothiopyranyl, tetrahydropyrimidinyl, tetrahydrothiophenyl, and tetrahydrothiopyranyl.

[0053] As used herein, the term "aryl" means an optionally substitued monocyclic or polycyclic aromatic hydrocarbon. Specific examples of aryl include, but are not limited to, phenyl, phenyl, 4-methylphenyl, 2,6-dimethylphenyl, naphthyl,anthracenyl, and phenanthrenyl. The term "aryl" or "aromatic group" as used herein contemplates single-ring groups and polycyclic ring systems. The polycyclic rings may have two or more rings in which two carbons are common to two adjoining rings (the rings are "fused") wherein at least one of the rings is aromatic, e.g., the other rings can be cycloalkyls, cycloalkenyls, aryl, heterocycles, and/or heteroaryls. Additionally, the aryl group may be optionally substituted.

[0054] As used herein, the term "heteroaryl" means an optionally substituted monoyclic or polycyclic aromatic hydrocarbon having at least one heteroatom and at least one carbon atom. In some embodiments, the at least one heteroatom is selected from nitrogen, oxygen, silicon, selenium, and sulfur. Specific examples of heteroaryl include, but are not limited to, furyl, benzofuranyl, thiophenyl, benzothiophenyl, pyrrolyl, indolyl, isoindolyl, azaindolyl, pyridyl, quinolinyl, isoquinolinyl, oxazolyl, isooxazolyl, benzoxazolyl, pyrazolyl, imidazolyl, benzimidazolyl, thiazolyl, benzothiazolyl, isothiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, cinnolinyl, phthalazinyl, and quinazolinyl.

[0055] The alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, heterocyclic group, aryl, and heteroaryl may be optionally substituted with one or more substituents selected from the group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, cyclic amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.

[0056] As used herein, "substituted" indicates that a substituent other than H is bonded to the relevant position, such as carbon. Thus, for example, where R1 is mono-substituted, then one R1 must be other than H. Similarly, where R1 is di-substituted, then two of R1 must be other than H. Similarly, where R1 is unsubstituted, R1 is hydrogen for all available positions.

[0057] The "aza" designation in the fragments described herein, i.e. aza-dibenzofuran, aza-dibenzothiophene, etc. means that one or more of the C-H groups in the respective fragment can be replaced by a nitrogen atom, for example, and without any limitation, azatriphenylene encompasses both dibenzo[f,h]quinoxaline and dibenzo[f,h]quinoline. One of ordinary skill in the art can readily envision other nitrogen analogs of the aza-derivatives described above, and all such analogs are intended to be encompassed by the terms as set forth herein.

[0058] It is to be understood that when a molecular fragment is described as being a substituent or otherwise attached to another moiety, its name may be written as if it were a fragment (e.g. phenyl, phenylene, naphthyl, dibenzofuryl) or as if it were the whole molecule (e.g. benzene, naphthalene, dibenzofuran). As used herein, these different ways of designating a substituent or attached fragment are considered to be equivalent.

[0059] As used herein, and as would be generally understood by one skilled in the art, a first "Highest Occupied Molecular Orbital" (HOMO) or "Lowest Unoccupied Molecular Orbital" (LUMO) energy level is "greater than" or "higher than" a second HOMO or LUMO energy level if the first energy level is closer to the vacuum energy level. Since ionization potentials (IP) are measured as a negative energy relative to a vacuum level, a higher HOMO energy level corresponds to an IP having a smaller absolute value (an IP that is less negative). Similarly, a higher LUMO energy level corresponds to an electron affinity (EA) having a smaller absolute value (an EA that is less negative). On a conventional energy level diagram, with the vacuum level at the top, the LUMO energy level of a material is higher than the HOMO energy level of the same material. A "higher" HOMO or LUMO energy level appears closer to the top of such a diagram than a "lower" HOMO or LUMO energy level.

[0060] As used herein, the term "triplet energy" refers to an energy corresponding to the highest energy feature discernable in the phosphorescence spectrum of a given material. The highest energy feature is not necessarily the peak having the greatest intensity in the phosphorescence spectrum, and could, for example, be a local maximum of a clear shoulder on the high energy side of such a peak.

[0061] According to an aspect of the present disclosure, a compound having a structure (LA)nMLm according to Formula 1 shown below is disclosed.



[0062] In Formula

I, M is a metal having an atomic weight greater than 40, n has a value of at least 1 and m+n is the maximum number of ligands that may be attached to the metal;

wherein A is a linking group having two to three linking atoms, wherein the linking atoms are each independently selected from the group consisting of C, Si, O, S, N, B or combinations thereof;

wherein the linking atoms form at least one single bond between two linking atoms;

wherein R1a to R1g are each independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, CN, CF3, CO2R, C(O)R, C(O)NR2, NR2, NO2, OR, SR, SO2, SOR, SO3R, halo, aryl, heteroaryl, a heterocyclic group, and combinations thereof;

wherein each R is independently selected from the group consisting of hydrogen, deuterium, halo, alkyl, cycloalkyl, heteroalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aralkyl, aryl, heteroaryl, and combinations thereof;

wherein any one of the ring atoms to which R1b to R1g are attached may be replaced with a nitrogen atom, wherein when the ring atom is replaced with a nitrogen atom the corresponding R group is not present; and

wherein L is a substituted or unsubstituted cyclometallated ligand.



[0063] In some embodiments of the compound of Formula 1, one of the ring atoms to which R1b to R1g are attached is a nitrogen atom. In some embodiments, the ring atom to which R1e is attached a nitrogen atom.

[0064] In one embodiment, the compound has a triplet excited state and wherein the linking group A stabilizes the bond between N2 and C1b from cleavage when the compound is in the triplet excited state.

[0065] In one embodiment, the compound has a peak emissive wavelength less than 500 nm. In another embodiment, the compound has a peak emissive wavelength less than 480 nm. In yet another embodiment, the compound has a peak emissive wavelength ranging from 400 nm to 500 nm.

[0066] In some embodiments of the compound of Formula 1, the linking group A is a saturated group.

[0067] In one embodiment of the compound of Formula 1, the linking group A is independently selected from the group consisting of -CR1R2-CR3R4-, -CR1R2-CR3R4-CR5R6-, -CR1R2-NR3-, -CR1=CR2-CR3R4-, -O-SiR1R2-, -CR1R2-S-, -CR1R2-O-, and -C-SiR1R2-, wherein the substituents R1 to R6 can be same or different, and are independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof; wherein any adjacent R1 to R6 are optionally connected to form a saturated five membered ring or a saturated six membered ring. Any adjacent substituents refers to any two of substituents that are possible to form the ring. The two adjacent substituents can be on the same atom, or on different atoms. The linking group A can be selected from the group consisting of:























[0068] In some embodiments where the linking group A is independently selected from the group consisting of -CR1R2-CR3R4-, -CR1R2-CR3R4-CR5R6-, -CR1R2-NR3-, -CR1=CR2-CR3R4-, -O-SiR1R2-, -CR1R2-S-, -CR1R2-O-, and -C-SiR1R2-, wherein the substituents R1 to R6 can be same or different, and are independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof; at least one adjacent R1 to R6 are connected to form a saturated five membered ring or a saturated six membered ring. In some embodiments, at least two adjacent R1 to R6, if present, are connected to form a saturated five membered ring or a saturated six membered ring. In some embodiments, each R1 to R6 are independently selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, partially or fully deuterated variants thereof, and combinations thereof; wherein any adjacent R1 to R6 are optionally connected to form a saturated five membered ring or a saturated six membered ring.

[0069] In some embodiments where the linking group A is independently selected from the group consisting of -CR1R2-CR3R4-, -CR1R2-CR3R4-CR5R6-, -CR1R2-NR3-, -CR1=CR2-CR3R4-, -O-SiR1R2-, -CR1R2-S-, -CR1R2-O-, and -C-SiR1R2-, wherein the substituents R1 to R6 can be same or different, and are independently selected from the group consisting of hydrogen, deuterium, alkyl, cycloalkyl, aryl, heteroaryl, and combinations thereof; each R1 to R6 are independently selected from the group consisting of methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl, cyclopentyl, cyclohexyl, phenyl, 2,6-dimethylphenyl, 2,4,6-trimethylphenyl, 2,6-diisopropylphenyl, partially or fully deuterated variants thereof and combinations thereof. In some embodiments, each R1 to R6 are independently selected from the group consisting of alkyl, partially or fully deuterated variants thereof, and combinations thereof; wherein any adjacent R1 to R6 are optionally connected to form a saturated five membered ring or a saturated six membered ring.

[0070] In some embodiments of the compound of Formula 1, at least one of R1a to R1g is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, partially or fully deuterated variants thereof, and combinations thereof. In other embodiments, at least one of R1b, R1d and R1e is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, partially or fully deuterated variants thereof, and combinations thereof. In other embodiments, R1d is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, partially or fully deuterated variants thereof, and combinations thereof. In other embodiments, R1a is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, partially or fully deuterated variants thereof, and combinations thereof.

[0071] In some embodiments of the compound of Formula 1, the metal M is selected from the group consisting of Re, Ru, Os, Rh, Ir, Pd, Pt, and Au. In some embodiments, the metal M is selected from the group consisting of Ir and Pt.

[0072] In some embodiments of the compound of Formula 1, the ligand LA is selected from the group consisting of:
LALinker AR1aR1bR1cR1dR1eR1fR1g
LA1   H H H H H H H
LA2   Me H H H H H H
LA3   H Me H H H H H
LA4   H H Me H H H H
LA5   H H H Me H H H
LA6   H H H H Me H H
LA7   CD3 H H H H H H
LA8   H CD3 H H H H H
LA9   H H CD3 H H H H
LA10   H H H CD3 H H H
LA11   H H H H CD3 H H
LA12   iPr H H H H H H
LA13   H iPr H H H H H
LA14   H H iPr H H H H
LA15   H H H iPr H H H
LA16   H H H H iPr H H
LA17   Ph H H H H H H
LA18   H Ph H H H H H
LA19   H H Ph H H H H
LA20   H H H Ph H H H
LA21

H H H H Ph H H
LA22 Me Me H H H H H
LA23 Me H Me H H H H
LA24 Me H H Me H H H
LA25 Me H H H Me H H
LA26 Me CD3 H H H H H
LA27 Me H CD3 H H H H
LA28 Me H H CD3 H H H
LA29   Me H H H CD3 H H
LA30   Me iPr H H H H H
LA31   Me H iPr H H H H
LA32   Me H H iPr H H H
LA33   Me H H H iPr H H
LA34   Me Ph H H H H H
LA35   Me H Ph H H H H
LA36   Me H H Ph H H H
LA37   Me H H H Ph H H
LA38   CD3 Me H H H H H
LA39   CD3 H Me H H H H
LA40   CD3 H H Me H H H
LA41   CD3 H H H Me H H
LA42   CD3 CD3 H H H H H
LA43   CD3 H CD3 H H H H
LA44   CD3 H H CD3 H H H
LA45   CD3 H H H CD3 H H
LA46   CD3 iPr H H H H H
LA47   CD3 H iPr H H H H
LA48   CD3 H H iPr H H H
LA49   CD3 H H H iPr H H
LA50   CD3 Ph H H H H H
LA51   CD3 H Ph H H H H
LA52   CD3 H H Ph H H H
LA53   CD3 H H H Ph H H
LA54   iPr Me H H H H H
LA55   iPr H Me H H H H
LA56   iPr H H Me H H H
LA57   iPr H H H Me H H
LA58   iPr CD3 H H H H H
LA59   iPr H CD3 H H H H
LA60   iPr H H CD3 H H H
LA61   iPr H H H CD3 H H
LA62   iPr iPr H H H H H
LA63   iPr H iPr H H H H
LA64   iPr H H iPr H H H
LA65   iPr H H H iPr H H
LA66   iPr Ph H H H H H
LA67   iPr H Ph H H H H
LA68   iPr H H Ph H H H
LA69   iPr H H H Ph H H
LA70   Ph Me H H H H H
LA71   Ph H Me H H H H
LA72   Ph H H Me H H H
LA73   Ph H H H Me H H
LA74

Ph CD3 H H H H H
LA75 Ph H CD3 H H H H
LA76 Ph H H CD3 H H H
LA77 Ph H H H CD3 H H
LA78 Ph iPr H H H H H
LA79 Ph H iPr H H H H
LA80   Ph H H iPr H H H
LA81   Ph H H H iPr H H
LA82   Ph Ph H H H H H
LA83   Ph H Ph H H H H
LA84   Ph H H Ph H H H
LA85   Ph H H H Ph H H
LA86   H Me Me H H H H
LA87   H Me H Me H H H
LA88   H Me H H Me H H
LA89   H Me CD3 H H H H
LA90   H Me H CD3 H H H
LA91   H Me H H CD3 H H
LA92   H Me iPr H H H H
LA93   H Me H iPr H H H
LA94   H Me H H iPr H H
LA95   H Me Ph H H H H
LA96   H Me H Ph H H H
LA97   H Me H H Ph H H
LA98   H CD3 Me H H H H
LA99   H CD3 H Me H H H
LA100   H CD3 H H Me H H
LA101   H CD3 CD3 H H H H
LA102   H CD3 H CD3 H H H
LA103   H CD3 H H CD3 H H
LA104   H CD3 iPr H H H H
LA105   H CD3 H iPr H H H
LA106   H CD3 H H iPr H H
LA107   H CD3 Ph H H H H
LA108   H CD3 H Ph H H H
LA109   H CD3 H H Ph H H
LA110   H iPr Me H H H H
LA111   H iPr H Me H H H
LA112   H iPr H H Me H H
LA113   H iPr CD3 H H H H
LA114   H iPr H CD3 H H H
LA115   H iPr H H CD3 H H
LA116   H iPr iPr H H H H
LA117   H iPr H iPr H H H
LA118   H iPr H H iPr H H
LA119   H iPr Ph H H H H
LA120   H iPr H Ph H H H
LA121   H iPr H H Ph H H
LA122   H Ph Me H H H H
LA123   H Ph H Me H H H
LA124   H Ph H H Me H H
LA125

H Ph CD3 H H H H
LA126 H Ph H CD3 H H H
LA127 H Ph H H CD3 H H
LA128 H Ph iPr H H H H
LA129 H Ph H iPr H H H
LA130 H Ph H H iPr H H
LA131 H Ph Ph H H H H
LA132   H Ph H Ph H H H
LA133   H Ph H H Ph H H
LA134   H H Me Me H H H
LA135   H H CD3 Me H H H
LA136   H H iPr Me H H H
LA137   H H Ph Me H H H
LA138   H H Me CD3 H H H
LA139   H H CD3 CD3 H H H
LA140   H H iPr CD3 H H H
LA141   H H Ph CD3 H H H
LA142   H H Me iPr H H H
LA143   H H CD3 iPr H H H
LA144   H H iPr iPr H H H
LA145   H H Ph iPr H H H
LA146   H H Me Ph H H H
LA147   H H CD3 Ph H H H
LA148   H H iPr Ph H H H
LA149   H H Ph Ph H H H
LA150   H H Me H Me H H
LA151   H H CD3 H Me H H
LA152   H H iPr H Me H H
LA153   H H Ph H Me H H
LA154   H H Me H CD3 H H
LA155   H H CD3 H CD3 H H
LA156   H H iPr H CD3 H H
LA157   H H Ph H CD3 H H
LA158   H H Me H iPr H H
LA159   H H CD3 H iPr H H
LA160   H H iPr H iPr H H
LA161   H H Ph H iPr H H
LA162   H H Me H Ph H H
LA163   H H CD3 H Ph H H
LA164   H H iPr H Ph H H
LA165   H H Ph H Ph H H
LA166   Me Me H Me H H H
LA167   H Me Me Me H H H
LA168   CD3 Me H Me H H H
LA169   H Me CD3 Me H H H
LA170   iPr Me H Me H H H
LA171   H Me iPr Me H H H
LA172   Ph Me H Me H H H
LA173   H Me Ph Me H H H
LA174

Me CD3 H CD3 H H H
LA175 H CD3 Me CD3 H H H
LA176 CD3 CD3 H CD3 H H H
LA177 H CD3 CD3 CD3 H H H
LA178 iPr CD3 H CD3 H H H
LA179 H CD3 iPr CD3 H H H
LA180 Ph CD3 H CD3 H H H
LA181 H CD3 Ph CD3 H H H
LA182   Me iPr H iPr H H H
LA183   H iPr Me iPr H H H
LA184   CD3 iPr H iPr H H H
LA185   H iPr CD3 iPr H H H
LA186   iPr iPr H iPr H H H
LA187   H iPr iPr iPr H H H
LA188   Ph iPr H iPr H H H
LA189   H iPr Ph iPr H H H
LA190   Me Ph H Ph H H H
LA191   H Ph Me Ph H H H
LA192   CD3 Ph H Ph H H H
LA193   H Ph CD3 Ph H H H
LA194   iPr Ph H Ph H H H
LA195   H Ph iPr Ph H H H
LA196   Ph Ph H Ph H H H
LA197   H Ph Ph Ph H H H
LA198

H H H H H H H
LA199 Me H H H H H H
LA200 H Me H H H H H
LA201 H H Me H H H H
LA202 H H H Me H H H
LA203 H H H H Me H H
LA204 CD3 H H H H H H
LA205 H CD3 H H H H H
LA206   H H CD3 H H H H
LA207   H H H CD3 H H H
LA208   H H H H CD3 H H
LA209   iPr H H H H H H
LA210   H iPr H H H H H
LA211   H H iPr H H H H
LA212   H H H iPr H H H
LA213   H H H H iPr H H
LA214   Ph H H H H H H
LA215   H Ph H H H H H
LA216   H H Ph H H H H
LA217   H H H Ph H H H
LA218   H H H H Ph H H
LA219   Me Me H H H H H
LA220   Me H Me H H H H
LA221   Me H H Me H H H
LA222   Me H H H Me H H
LA223   Me CD3 H H H H H
LA224   Me H CD3 H H H H
LA225   Me H H CD3 H H H
LA226   Me H H H CD3 H H
LA227   Me iPr H H H H H
LA228   Me H iPr H H H H
LA229   Me H H iPr H H H
LA230   Me H H H iPr H H
LA231   Me Ph H H H H H
LA232

Me H Ph H H H H
LA233 Me H H Ph H H H
LA234 Me H H H Ph H H
LA235 CD3 Me H H H H H
LA236 CD3 H Me H H H H
LA237 CD3 H H Me H H H
LA238 CD3 H H H Me H H
LA239 CD3 CD3 H H H H H
LA240   CD3 H CD3 H H H H
LA241   CD3 H H CD3 H H H
LA242   CD3 H H H CD3 H H
LA243   CD3 iPr H H H H H
LA244   CD3 H iPr H H H H
LA245   CD3 H H iPr H H H
LA246   CD3 H H H iPr H H
LA247   CD3 Ph H H H H H
LA248   CD3 H Ph H H H H
LA249   CD3 H H Ph H H H
LA250   CD3 H H H Ph H H
LA251   iPr Me H H H H H
LA252   iPr H Me H H H H
LA253   iPr H H Me H H H
LA254   iPr H H H Me H H
LA255   iPr CD3 H H H H H
LA256   iPr H CD3 H H H H
LA257   iPr H H CD3 H H H
LA258   iPr H H H CD3 H H
LA259   iPr iPr H H H H H
LA260   iPr H iPr H H H H
LA261   iPr H H iPr H H H
LA262   iPr H H H iPr H H
LA263   iPr Ph H H H H H
LA264   iPr H Ph H H H H
LA265   iPr H H Ph H H H
LA266   iPr H H H Ph H H
LA267   Ph Me H H H H H
LA268   Ph H Me H H H H
LA269   Ph H H Me H H H
LA270   Ph H H H Me H H
LA271   Ph CD3 H H H H H
LA272   Ph H CD3 H H H H
LA273   Ph H H CD3 H H H
LA274   Ph H H H CD3 H H
LA275   Ph iPr H H H H H
LA276   Ph H iPr H H H H
LA277   Ph H H iPr H H H
LA278   Ph H H H iPr H H
LA279   Ph Ph H H H H H
LA280   Ph H Ph H H H H
LA281   Ph H H Ph H H H
LA282   Ph H H H Ph H H
LA283   H Me Me H H H H
LA284   H Me H Me H H H
LA285

H Me H H Me H H
LA286 H Me CD3 H H H H
LA287 H Me H CD3 H H H
LA288 H Me H H CD3 H H
LA289 H Me iPr H H H H
LA290 H Me H iPr H H H
LA291 H Me H H iPr H H
LA292 H Me Ph H H H H
LA293   H Me H Ph H H H
LA294   H Me H H Ph H H
LA295   H CD3 Me H H H H
LA296   H CD3 H Me H H H
LA297   H CD3 H H Me H H
LA298   H CD3 CD3 H H H H
LA299   H CD3 H CD3 H H H
LA300   H CD3 H H CD3 H H
LA301   H CD3 iPr H H H H
LA302   H CD3 H iPr H H H
LA303   H CD3 H H iPr H H
LA304   H CD3 Ph H H H H
LA305   H CD3 H Ph H H H
LA306   H CD3 H H Ph H H
LA307   H iPr Me H H H H
LA308   H iPr H Me H H H
LA309   H iPr H H Me H H
LA310   H iPr CD3 H H H H
LA311   H iPr H CD3 H H H
LA312   H iPr H H CD3 H H
LA313   H iPr iPr H H H H
LA314   H iPr H iPr H H H
LA315   H iPr H H iPr H H
LA316   H iPr Ph H H H H
LA317   H iPr H Ph H H H
LA318   H iPr H H Ph H H
LA319   H Ph Me H H H H
LA320   H Ph H Me H H H
LA321   H Ph H H Me H H
LA322   H Ph CD3 H H H H
LA323   H Ph H CD3 H H H
LA324   H Ph H H CD3 H H
LA325   H Ph iPr H H H H
LA326   H Ph H iPr H H H
LA327   H Ph H H iPr H H
LA328   H Ph Ph H H H H
LA329   H Ph H Ph H H H
LA330   H Ph H H Ph H H
LA331   H H Me Me H H H
LA332   H H CD3 Me H H H
LA333   H H iPr Me H H H
LA334   H H Ph Me H H H
LA335   H H Me CD3 H H H
LA336   H H CD3 CD3 H H H
LA337   H H iPr CD3 H H H
LA338   H H Ph CD3 H H H
LA339

H H Me iPr H H H
LA340 H H CD3 iPr H H H
LA341 H H iPr iPr H H H
LA342 H H Ph iPr H H H
LA343 H H Me Ph H H H
LA344 H H CD3 Ph H H H
LA345 H H iPr Ph H H H
LA346 H H Ph Ph H H H
LA347   H H Me H Me H H
LA348   H H CD3 H Me H H
LA349   H H iPr H Me H H
LA350   H H Ph H Me H H
LA351   H H Me H CD3 H H
LA352   H H CD3 H CD3 H H
LA353   H H iPr H CD3 H H
LA354   H H Ph H CD3 H H
LA355   H H Me H iPr H H
LA356   H H CD3 H iPr H H
LA357   H H iPr H iPr H H
LA358   H H Ph H iPr H H
LA359   H H Me H Ph H H
LA360   H H CD3 H Ph H H
LA361   H H iPr H Ph H H
LA362   H H Ph H Ph H H
LA363   Me Me H Me H H H
LA364   H Me Me Me H H H
LA365   CD3 Me H Me H H H
LA366   H Me CD3 Me H H H
LA367   iPr Me H Me H H H
LA368   H Me iPr Me H H H
LA369   Ph Me H Me H H H
LA370   H Me Ph Me H H H
LA371   Me CD3 H CD3 H H H
LA372   H CD3 Me CD3 H H H
LA373   CD3 CD3 H CD3 H H H
LA374   H CD3 CD3 CD3 H H H
LA375   iPr CD3 H CD3 H H H
LA376   H CD3 iPr CD3 H H H
LA377   Ph CD3 H CD3 H H H
LA378   H CD3 Ph CD3 H H H
LA379   Me iPr H iPr H H H
LA380   H iPr Me iPr H H H
LA381   CD3 iPr H iPr H H H
LA382   H iPr CD3 iPr H H H
LA383

iPr iPr H iPr H H H
LA384 H iPr iPr iPr H H H
LA385 Ph iPr H iPr H H H
LA386 H iPr Ph iPr H H H
LA387 Me Ph H Ph H H H
LA388 H Ph Me Ph H H H
LA389 CD3 Ph H Ph H H H
LA390   H Ph CD3 Ph H H H
LA391   iPr Ph H Ph H H H
LA392   H Ph iPr Ph H H H
LA393   Ph Ph H Ph H H H
LA394   H Ph Ph Ph H H H
LA395   H H H H H H H
LA396   Me H H H H H H
LA397   H Me H H H H H
LA398   H H Me H H H H
LA399   H H H Me H H H
LA400

H H H H Me H H
LA401 CD3 H H H H H H
LA402 H CD3 H H H H H
LA403 H H CD3 H H H H
LA404 H H H CD3 H H H
LA405 H H H H CD3 H H
LA406 iPr H H H H H H
LA407 H iPr H H H H H
LA408 H H iPr H H H H
LA409   H H H iPr H H H
LA410   H H H H iPr H H
LA411   Ph H H H H H H
LA412   H Ph H H H H H
LA413   H H Ph H H H H
LA414   H H H Ph H H H
LA415   H H H H Ph H H
LA416   Me Me H H H H H
LA417   Me H Me H H H H
LA418   Me H H Me H H H
LA419   Me H H H Me H H
LA420   Me CD3 H H H H H
LA421   Me H CD3 H H H H
LA422   Me H H CD3 H H H
LA423   Me H H H CD3 H H
LA424   Me iPr H H H H H
LA425   Me H iPr H H H H
LA426   Me H H iPr H H H
LA427   Me H H H iPr H H
LA428   Me Ph H H H H H
LA429   Me H Ph H H H H
LA430   Me H H Ph H H H
LA431   Me H H H Ph H H
LA432   CD3 Me H H H H H
LA433   CD3 H Me H H H H
LA434   CD3 H H Me H H H
LA435   CD3 H H H Me H H
LA436   CD3 CD3 H H H H H
LA437   CD3 H CD3 H H H H
LA438   CD3 H H CD3 H H H
LA439   CD3 H H H CD3 H H
LA440   CD3 iPr H H H H H
LA441   CD3 H iPr H H H H
LA442   CD3 H H iPr H H H
LA443   CD3 H H H iPr H H
LA444   CD3 Ph H H H H H
LA445

CD3 H Ph H H H H
LA446 CD3 H H Ph H H H
LA447 CD3 H H H Ph H H
LA448 iPr Me H H H H H
LA449 iPr H Me H H H H
LA450 iPr H H Me H H H
LA451 iPr H H H Me H H
LA452 iPr CD3 H H H H H
LA453 iPr H CD3 H H H H
LA454   iPr H H CD3 H H H
LA455   iPr H H H CD3 H H
LA456   iPr iPr H H H H H
LA457   iPr H iPr H H H H
LA458   iPr H H iPr H H H
LA459   iPr H H H iPr H H
LA460   iPr Ph H H H H H
LA461   iPr H Ph H H H H
LA462   iPr H H Ph H H H
LA463   iPr H H H Ph H H
LA464   Ph Me H H H H H
LA465   Ph H Me H H H H
LA466   Ph H H Me H H H
LA467   Ph H H H Me H H
LA468   Ph CD3 H H H H H
LA469   Ph H CD3 H H H H
LA470   Ph H H CD3 H H H
LA471   Ph H H H CD3 H H
LA472   Ph iPr H H H H H
LA473   Ph H iPr H H H H
LA474   Ph H H iPr H H H
LA475   Ph H H H iPr H H
LA476   Ph Ph H H H H H
LA477   Ph H Ph H H H H
LA478   Ph H H Ph H H H
LA479   Ph H H H Ph H H
LA480   H Me Me H H H H
LA481   H Me H Me H H H
LA482   H Me H H Me H H
LA483   H Me CD3 H H H H
LA484   H Me H CD3 H H H
LA485   H Me H H CD3 H H
LA486   H Me iPr H H H H
LA487   H Me H iPr H H H
LA488   H Me H H iPr H H
LA489   H Me Ph H H H H
LA490   H Me H Ph H H H
LA491   H Me H H Ph H H
LA492   H CD3 Me H H H H
LA493   H CD3 H Me H H H
LA494   H CD3 H H Me H H
LA495   H CD3 CD3 H H H H
LA496   H CD3 H CD3 H H H
LA497   H CD3 H H CD3 H H
LA498

H CD3 iPr H H H H
LA499 H CD3 H iPr H H H
LA500 H CD3 H H iPr H H
LA501 H CD3 Ph H H H H
LA502 H CD3 H Ph H H H
LA503 H CD3 H H Ph H H
LA504 H iPr Me H H H H
LA505 H iPr H Me H H H
LA506 H iPr H H Me H H
LA507 H iPr CD3 H H H H
LA508   H iPr H CD3 H H H
LA509   H iPr H H CD3 H H
LA510   H iPr iPr H H H H
LA511   H iPr H iPr H H H
LA512   H iPr H H iPr H H
LA513   H iPr Ph H H H H
LA514   H iPr H Ph H H H
LA515   H iPr H H Ph H H
LA516   H Ph Me H H H H
LA517   H Ph H Me H H H
LA518   H Ph H H Me H H
LA519   H Ph CD3 H H H H
LA520   H Ph H CD3 H H H
LA521   H Ph H H CD3 H H
LA522   H Ph iPr H H H H
LA523   H Ph H iPr H H H
LA524   H Ph H H iPr H H
LA525   H Ph Ph H H H H
LA526   H Ph H Ph H H H
LA527   H Ph H H Ph H H
LA528   H H Me Me H H H
LA529   H H CD3 Me H H H
LA530   H H iPr Me H H H
LA531   H H Ph Me H H H
LA532   H H Me CD3 H H H
LA533   H H CD3 CD3 H H H
LA534   H H iPr CD3 H H H
LA535   H H Ph CD3 H H H
LA536   H H Me iPr H H H
LA537   H H CD3 iPr H H H
LA538   H H iPr iPr H H H
LA539   H H Ph iPr H H H
LA540   H H Me Ph H H H
LA541   H H CD3 Ph H H H
LA542   H H iPr Ph H H H
LA543   H H Ph Ph H H H
LA544   H H Me H Me H H
LA545   H H CD3 H Me H H
LA546   H H iPr H Me H H
LA547   H H Ph H Me H H
LA548   H H Me H CD3 H H
LA549   H H CD3 H CD3 H H
LA550   H H iPr H CD3 H H
LA551   H H Ph H CD3 H H
LA552

H H Me H iPr H H
LA553 H H CD3 H iPr H H
LA554 H H iPr H iPr H H
LA555 H H Ph H iPr H H
LA556 H H Me H Ph H H
LA557 H H CD3 H Ph H H
LA558 H H iPr H Ph H H
LA559 H H Ph H Ph H H
LA560 Me Me H Me H H H
LA561   H Me Me Me H H H
LA562   CD3 Me H Me H H H
LA563   H Me CD3 Me H H H
LA564   iPr Me H Me H H H
LA565   H Me iPr Me H H H
LA566   Ph Me H Me H H H
LA567   H Me Ph Me H H H
LA568   Me CD3 H CD3 H H H
LA569   H CD3 Me CD3 H H H
LA570   CD3 CD3 H CD3 H H H
LA571   H CD3 CD3 CD3 H H H
LA572   iPr CD3 H CD3 H H H
LA573   H CD3 iPr CD3 H H H
LA574   Ph CD3 H CD3 H H H
LA575   H CD3 Ph CD3 H H H
LA576   Me iPr H iPr H H H
LA577   H iPr Me iPr H H H
LA578   CD3 iPr H iPr H H H
LA579   H iPr CD3 iPr H H H
LA580   iPr iPr H iPr H H H
LA581   H iPr iPr iPr H H H
LA582   Ph iPr H iPr H H H
LA583   H iPr Ph iPr H H H
LA584   Me Ph H Ph H H H
LA585   H Ph Me Ph H H H
LA586   CD3 Ph H Ph H H H
LA587   H Ph CD3 Ph H H H
LA588   iPr Ph H Ph H H H
LA589   H Ph iPr Ph H H H
LA590   Ph Ph H Ph H H H
LA591   H Ph Ph Ph H H H
LA592

H H H H H H H
LA593 Me H H H H H H
LA594 H Me H H H H H
LA595 H H Me H H H H
LA596 H H H Me H H H
LA597 H H H H Me H H
LA598   CD3 H H H H H H
LA599   H CD3 H H H H H
LA600   H H CD3 H H H H
LA601   H H H CD3 H H H
LA602   H H H H CD3 H H
LA603   iPr H H H H H H
LA604   H iPr H H H H H
LA605   H H iPr H H H H
LA606

H H H iPr H H H
LA607 H H H H iPr H H
LA608 Ph H H H H H H
LA609 H Ph H H H H H
LA610 H H Ph H H H H
LA611 H H H Ph H H H
LA612 H H H H Ph H H
LA613 Me Me H H H H H
LA614 Me H Me H H H H
LA615   Me H H Me H H H
LA616   Me H H H Me H H
LA617   Me CD3 H H H H H
LA618   Me H CD3 H H H H
LA619   Me H H CD3 H H H
LA620   Me H H H CD3 H H
LA621   Me iPr H H H H H
LA622   Me H iPr H H H H
LA623   Me H H iPr H H H
LA624   Me H H H iPr H H
LA625   Me Ph H H H H H
LA626   Me H Ph H H H H
LA627   Me H H Ph H H H
LA628   Me H H H Ph H H
LA629   CD3 Me H H H H H
LA630   CD3 H Me H H H H
LA631   CD3 H H Me H H H
LA632   CD3 H H H Me H H
LA633   CD3 CD3 H H H H H
LA634   CD3 H CD3 H H H H
LA635   CD3 H H CD3 H H H
LA636   CD3 H H H CD3 H H
LA637   CD3 iPr H H H H H
LA638   CD3 H iPr H H H H
LA639   CD3 H H iPr H H H
LA640   CD3 H H H iPr H H
LA641   CD3 Ph H H H H H
LA642   CD3 H Ph H H H H
LA643   CD3 H H Ph H H H
LA644   CD3 H H H Ph H H
LA645   iPr Me H H H H H
LA646   iPr H Me H H H H
LA647   iPr H H Me H H H
LA648   iPr H H H Me H H
LA649   iPr CD3 H H H H H
LA650   iPr H CD3 H H H H
LA651   iPr H H CD3 H H H
LA652   iPr H H H CD3 H H
LA653   iPr iPr H H H H H
LA654   iPr H iPr H H H H
LA655   iPr H H iPr H H H
LA656   iPr H H H iPr H H
LA657   iPr Ph H H H H H
LA658   iPr H Ph H H H H
LA659   iPr H H Ph H H H
LA660

iPr H H H Ph H H
LA661 Ph Me H H H H H
LA662 Ph H Me H H H H
LA663 Ph H H Me H H H
LA664 Ph H H H Me H H
LA665 Ph CD3 H H H H H
LA666 Ph H CD3 H H H H
LA667   Ph H H CD3 H H H
LA668   Ph H H H CD3 H H
LA669   Ph iPr H H H H H
LA670   Ph H iPr H H H H
LA671   Ph H H iPr H H H
LA672   Ph H H H iPr H H
LA673   Ph Ph H H H H H
LA674   Ph H Ph H H H H
LA675   Ph H H Ph H H H
LA676   Ph H H H Ph H H
LA677   H Me Me H H H H
LA678   H Me H Me H H H
LA679   H Me H H Me H H
LA680   H Me CD3 H H H H
LA681   H Me H CD3 H H H
LA682   H Me H H CD3 H H
LA683   H Me iPr H H H H
LA684   H Me H iPr H H H
LA685   H Me H H iPr H H
LA686   H Me Ph H H H H
LA687   H Me H Ph H H H
LA688   H Me H H Ph H H
LA689   H CD3 Me H H H H
LA690   H CD3 H Me H H H
LA691   H CD3 H H Me H H
LA692   H CD3 CD3 H H H H
LA693   H CD3 H CD3 H H H
LA694   H CD3 H H CD3 H H
LA695   H CD3 iPr H H H H
LA696   H CD3 H iPr H H H
LA697   H CD3 H H iPr H H
LA698   H CD3 Ph H H H H
LA699   H CD3 H Ph H H H
LA700   H CD3 H H Ph H H
LA701   H iPr Me H H H H
LA702   H iPr H Me H H H
LA703   H iPr H H Me H H
LA704   H iPr CD3 H H H H
LA705   H iPr H CD3 H H H
LA706   H iPr H H CD3 H H
LA707   H iPr iPr H H H H
LA708   H iPr H iPr H H H
LA709   H iPr H H iPr H H
LA710   H iPr Ph H H H H
LA711   H iPr H Ph H H H
LA712   H iPr H H Ph H H
LA713   H Ph Me H H H H
LA714

H Ph H Me H H H
LA715 H Ph H H Me H H
LA716 H Ph CD3 H H H H
LA717 H Ph H CD3 H H H
LA718 H Ph H H CD3 H H
LA719 H Ph iPr H H H H
LA720   H Ph H iPr H H H
LA721   H Ph H H iPr H H
LA722   H Ph Ph H H H H
LA723   H Ph H Ph H H H
LA724   H Ph H H Ph H H
LA725   H H Me Me H H H
LA726   H H CD3 Me H H H
LA727   H H iPr Me H H H
LA728   H H Ph Me H H H
LA729   H H Me CD3 H H H
LA730   H H CD3 CD3 H H H
LA731   H H iPr CD3 H H H
LA732   H H Ph CD3 H H H
LA733   H H Me iPr H H H
LA734   H H CD3 iPr H H H
LA735   H H iPr iPr H H H
LA736   H H Ph iPr H H H
LA737   H H Me Ph H H H
LA738   H H CD3 Ph H H H
LA739   H H iPr Ph H H H
LA740   H H Ph Ph H H H
LA741   H H Me H Me H H
LA742   H H CD3 H Me H H
LA743   H H iPr H Me H H
LA744   H H Ph H Me H H
LA745   H H Me H CD3 H H
LA746   H H CD3 H CD3 H H
LA747   H H iPr H CD3 H H
LA748   H H Ph H CD3 H H
LA749   H H Me H iPr H H
LA750   H H CD3 H iPr H H
LA751   H H iPr H iPr H H
LA752   H H Ph H iPr H H
LA753   H H Me H Ph H H
LA754   H H CD3 H Ph H H
LA755   H H iPr H Ph H H
LA756   H H Ph H Ph H H
LA757   Me Me H Me H H H
LA758   H Me Me Me H H H
LA759   CD3 Me H Me H H H
LA760   H Me CD3 Me H H H
LA761   iPr Me H Me H H H
LA762   H Me iPr Me H H H
LA763   Ph Me H Me H H H
LA764   H Me Ph Me H H H
LA765   Me CD3 H CD3 H H H
LA766   H CD3 Me CD3 H H H
LA767

CD3 CD3 H CD3 H H H
LA768 H CD3 CD3 CD3 H H H
LA769 iPr CD3 H CD3 H H H
LA770 H CD3 iPr CD3 H H H
LA771 Ph CD3 H CD3 H H H
LA772 H CD3 Ph CD3 H H H
LA773 Me iPr H iPr H H H
LA774   H iPr Me iPr H H H
LA775   CD3 iPr H iPr H H H
LA776   H iPr CD3 iPr H H H
LA777   iPr iPr H iPr H H H
LA778   H iPr iPr iPr H H H
LA779   Ph iPr H iPr H H H
LA780   H iPr Ph iPr H H H
LA781   Me Ph H Ph H H H
LA782   H Ph Me Ph H H H
LA783   CD3 Ph H Ph H H H
LA784   H Ph CD3 Ph H H H
LA785   iPr Ph H Ph H H H
LA786   H Ph iPr Ph H H H
LA787   Ph Ph H Ph H H H
LA788   H Ph Ph Ph H H H
LA789   H H H H H H H
LA790   Me H H H H H H
LA791   H Me H H H H H
LA792   H H Me H H H H
LA793   H H H Me H H H
LA794   H H H H Me H H
LA795   CD3 H H H H H H
LA796   H CD3 H H H H H
LA797   H H CD3 H H H H
LA798   H H H CD3 H H H
LA799   H H H H CD3 H H
LA800

iPr H H H H H H
LA801 H iPr H H H H H
LA802 H H iPr H H H H
LA803 H H H iPr H H H
LA804 H H H H iPr H H
LA805 Ph H H H H H H
LA806 H Ph H H H H H
LA807   H H Ph H H H H
LA808   H H H Ph H H H
LA809   H H H H Ph H H
LA810   Me Me H H H H H
LA811   Me H Me H H H H
LA812   Me H H Me H H H
LA813   Me H H H Me H H
LA814   Me CD3 H H H H H
LA815   Me H CD3 H H H H
LA816   Me H H CD3 H H H
LA817   Me H H H CD3 H H
LA818   Me iPr H H H H H
LA819   Me H iPr H H H H
LA820   Me H H iPr H H H
LA821

Me H H H iPr H H
LA822 Me Ph H H H H H
LA823 Me H Ph H H H H
LA824 Me H H Ph H H H
LA825 Me H H H Ph H H
LA826 CD3 Me H H H H H
LA827   CD3 H Me H H H H
LA828   CD3 H H Me H H H
LA829   CD3 H H H Me H H
LA830   CD3 CD3 H H H H H
LA831   CD3 H CD3 H H H H
LA832   CD3 H H CD3 H H H
LA833   CD3 H H H CD3 H H
LA834   CD3 iPr H H H H H
LA835   CD3 H iPr H H H H
LA836   CD3 H H iPr H H H
LA837   CD3 H H H iPr H H
LA838   CD3 Ph H H H H H
LA839   CD3 H Ph H H H H
LA840   CD3 H H Ph H H H
LA841   CD3 H H H Ph H H
LA842   iPr Me H H H H H
LA843   iPr H Me H H H H
LA844   iPr H H Me H H H
LA845   iPr H H H Me H H
LA846   iPr CD3 H H H H H
LA847   iPr H CD3 H H H H
LA848   iPr H H CD3 H H H
LA849   iPr H H H CD3 H H
LA850   iPr iPr H H H H H
LA851   iPr H iPr H H H H
LA852   iPr H H iPr H H H
LA853   iPr H H H iPr H H
LA854   iPr Ph H H H H H
LA855   iPr H Ph H H H H
LA856   iPr H H Ph H H H
LA857   iPr H H H Ph H H
LA858   Ph Me H H H H H
LA859   Ph H Me H H H H
LA860   Ph H H Me H H H
LA861   Ph H H H Me H H
LA862   Ph CD3 H H H H H
LA863   Ph H CD3 H H H H
LA864   Ph H H CD3 H H H
LA865   Ph H H H CD3 H H
LA866   Ph iPr H H H H H
LA867   Ph H iPr H H H - H
LA868   Ph H H iPr H H H
LA869   Ph H H H iPr H H
LA870   Ph Ph H H H H H
LA871   Ph H Ph H H H H
LA872   Ph H H Ph H H H
LA873   Ph H H H Ph H H
LA874

H Me Me H H H H
LA875 H Me H Me H H H
LA876 H Me H H Me H H
LA877 H Me CD3 H H H H
LA878 H Me H CD3 H H H
LA879 H Me H H CD3 H H
LA880 H Me iPr H H H H
LA881   H Me H iPr H H H
LA882   H Me H H iPr H H
LA883   H Me Ph H H H H
LA884   H Me H Ph H H H
LA885   H Me H H Ph H H
LA886   H CD3 Me H H H H
LA887   H CD3 H Me H H H
LA888   H CD3 H H Me H H
LA889   H CD3 CD3 H H H H
LA890   H CD3 H CD3 H H H
LA891   H CD3 H H CD3 H H
LA892   H CD3 iPr H H H H
LA893   H CD3 H iPr H H H
LA894   H CD3 H H iPr H H
LA895   H CD3 Ph H H H H
LA896   H CD3 H Ph H H H
LA897   H CD3 H H Ph H H
LA898   H iPr Me H H H H
LA899   H iPr H Me H H H
LA900   H iPr H H Me H H
LA901   H iPr CD3 H H H H
LA902   H iPr H CD3 H H H
LA903   H iPr H H CD3 H H
LA904   H iPr iPr H H H H
LA905   H iPr H iPr H H H
LA906   H iPr H H iPr H H
LA907   H iPr Ph H H H H
LA908   H iPr H Ph H H H
LA909   H iPr H H Ph H H
LA910   H Ph Me H H H H
LA911   H Ph H Me H H H
LA912   H Ph H H Me H H
LA913   H Ph CD3 H H H H
LA914   H Ph H CD3 H H H
LA915   H Ph H H CD3 H H
LA916   H Ph iPr H H H H
LA917   H Ph H iPr H H H
LA918   H Ph H H iPr H H
LA919   H Ph Ph H H H H
LA920   H Ph H Ph H H ' H
LA921   H Ph H H Ph H H
LA922   H H Me Me H H H
LA923   H H CD3 Me H H H
LA924   H H iPr Me H H H
LA925   H H Ph Me H H H
LA926   H H Me CD3 H H H
LA927   H H CD3 CD3 H H H
LA928

H H iPr CD3 H H H
LA929 H H Ph CD3 H H H
LA930 H H Me iPr H H H
LA931 H H CD3 iPr H H H
LA932 H H iPr iPr H H H
LA933 H H Ph iPr H H H
LA934   H H Me Ph H H H
LA935   H H CD3 Ph H H H
LA936   H H iPr Ph H H H
LA937   H H Ph Ph H H H
LA938   H H Me H Me H H
LA939   H H CD3 H Me H H
LA940   H H iPr H Me H H
LA941   H H Ph H Me H H
LA942   H H Me H CD3 H H
LA943   H H CD3 H CD3 H H
LA944   H H iPr H CD3 H H
LA945   H H Ph H CD3 H H
LA946   H H Me H iPr H H
LA947   H H CD3 H iPr H H
LA948   H H iPr H iPr H H
LA949   H H Ph H iPr H H
LA950   H H Me H Ph H H
LA951   H H CD3 H Ph H H
LA952   H H iPr H Ph H H
LA953   H H Ph H Ph H H
LA954   Me Me H Me H H H
LA955   H Me Me Me H H H
LA956   CD3 Me H Me H H H
LA957   H Me CD3 Me H H H
LA958   iPr Me H Me H H H
LA959   H Me iPr Me H H H
LA960   Ph Me H Me H H H
LA961   H Me Ph Me H H H
LA962   Me CD3 H CD3 H H H
LA963   H CD3 Me CD3 H H H
LA964   CD3 CD3 H CD3 H H H
LA965   H CD3 CD3 CD3 H H H
LA966   iPr CD3 H CD3 H H H
LA967   H CD3 iPr CD3 H H H
LA968   Ph CD3 H CD3 H H H
LA969   H CD3 Ph CD3 H H H
LA970   Me iPr H iPr H H H
LA971   H iPr Me iPr H H H
LA972   CD3 iPr H iPr H H H
LA973   H iPr CD3 iPr H H H
LA974   iPr iPr H iPr H H H
LA975   H iPr iPr iPr H H H
LA976   Ph iPr H iPr H H H
LA977   H iPr Ph iPr H H H
LA978   Me Ph H Ph H H H
LA979   H Ph Me Ph H H H
LA980   CD3 Ph H Ph H H H
LA981   H Ph CD3 Ph H H H
LA982   iPr Ph H Ph H H H
LA983

H Ph iPr Ph H H H
LA984 Ph Ph H Ph H H H
LA985 H Ph Ph Ph H H H
LA986   H H H H H H H
LA987   Me H H H H H H
LA988   H Me H H H H H
LA989   H H Me H H H H
LA990   H H H Me H H H
LA991   H H H H Me H H
LA992   CD3 H H H H H H
LA993   H CD3 H H H H H
LA994   H H CD3 H H H H
LA995   H H H CD3 H H H
LA996   H H H H CD3 H H
LA997   iPr H H H H H H
LA998   H iPr H H H H H
LA999   H H iPr H H H H
LA1000   H H H iPr H H H
LA1001   H H H H iPr H H
LA1002   Ph H H H H H H
LA1003   H Ph H H H H H
LA1004   H H Ph H H H H
LA1005   H H H Ph H H H
LA1006   H H H H Ph H H
LA1007   Me Me H H H H H
LA1008   Me H Me H H H H
LA1009

Me H H Me H H H
LA1010 Me H H H Me H H
LA1011 Me CD3 H H H H H
LA1012 Me H CD3 H H H H
LA1013 Me H H CD3 H H H
LA1014 Me H H H CD3 H H
LA1015   Me iPr H H H H H
LA1016   Me H iPr H H H H
LA1017   Me H H iPr H H H
LA1018   Me H H H iPr H H
LA1019   Me Ph H H H H H
LA1020   Me H Ph H H H H
LA1021   Me H H Ph H H H
LA1022   Me H H H Ph H H
LA1023   CD3 Me H H H H H
LA1024   CD3 H Me H H H H
LA1025   CD3 H H Me H H H
LA1026   CD3 H H H Me H H
LA1027   CD3 CD3 H H H H H
LA1028   CD3 H CD3 H H H H
LA1029   CD3 H H CD3 H H H
LA1030   CD3 H H H CD3 H H
LA1031   CD3 iPr H H H H H
LA1032   CD3 H iPr H H H H
LA1033   CD3 H H iPr H H H
LA1034   CD3 H H H iPr H H
LA1035   CD3 Ph H H H H H
LA1036   CD3 H Ph H H H H
LA1037   CD3 H H Ph H H H
LA1038   CD3 H H H Ph H H
LA1039   iPr Me H H H H H
LA1040   iPr H Me H H H H
LA1041   iPr H H Me H H H
LA1042   iPr H H H Me H H
LA1043   iPr CD3 H H H H H
LA1044   iPr H CD3 H H H H
LA1045   iPr H H CD3 H H H
LA1046   iPr H H H CD3 H H
LA1047   iPr iPr H H H H H
LA1048   iPr H iPr H H H H
LA1049   iPr H H iPr H H H
LA1050   iPr H H H iPr H H
LA1051   iPr Ph H H H H H
LA1052   iPr H Ph H H H H
LA1053   iPr H H Ph H H H
LA1054   iPr H H H Ph H H
LA1055   Ph Me H H H H H
LA1056   Ph H Me H H H H
LA1057   Ph H H Me H H H
LA1058   Ph H H H Me H H
LA1059   Ph CD3 H H H H H
LA1060   Ph H CD3 H H H H
LA1061

Ph H H CD3 H H H
LA1062 Ph H H H CD3 H H
LA1063 Ph iPr H H H H H
LA1064 Ph H iPr H H H H
LA1065 Ph H H iPr H H H
LA1066 Ph H H H iPr H H
LA1067   Ph Ph H H H H H
LA1068   Ph H Ph H H H H
LA1069   Ph H H Ph H H H
LA1070   Ph H H H Ph H H
LA1071   H Me Me H H H H
LA1072   H Me H Me H H H
LA1073   H Me H H Me H H
LA1074   H Me CD3 H H H H
LA1075   H Me H CD3 H H H
LA1076   H Me H H CD3 H H
LA1077   H Me iPr H H H H
LA1078   H Me H iPr H H H
LA1079   H Me H H iPr H H
LA1080   H Me Ph H H H H
LA1081   H Me H Ph H H H
LA1082   H Me H H Ph H H
LA1083   H CD3 Me H H H H
LA1084   H CD3 H Me H H H
LA1085   H CD3 H H Me H H
LA1086   H CD3 CD3 H H H H
LA1087   H CD3 H CD3 H H H
LA1088   H CD3 H H CD3 H H
LA1089   H CD3 iPr H H H H
LA1090   H CD3 H iPr H H H
LA1091   H CD3 H H iPr H H
LA1092   H CD3 Ph H H H H
LA1093   H CD3 H Ph H H H
L1094   H CD3 H H Ph H H
LA1095   H iPr Me H H H H
LA1096   H iPr H Me H H H
LA1097   H iPr H H Me H H
LA1098   H iPr CD3 H H H H
LA1099   H iPr H CD3 H H H
LA1100   H iPr H H CD3 H H
LA1101   H iPr iPr H H H H
LA1102   H iPr H iPr H H H
LA1103   H iPr H H iPr H H
LA1104   H iPr Ph H H H H
LA1105   H iPr H Ph H H H
LA1106   H iPr H H Ph H H
LA1107   H Ph Me H H H H
LA1108   H Ph H Me H H H
LA1109   H Ph H H Me H H
LA1110   H Ph CD3 H H H H
LA1111   H Ph H CD3 H H H
LA1112   H Ph H H CD3 H H
LA1113   H Ph iPr H H H H
LA1114

H Ph H iPr H H H
LA1115 H Ph H H iPr H H
LA1116 H Ph Ph H H H H
LA1117 H Ph H Ph H H H
LA1118 H Ph H H Ph H H
LA1119 H H Me Me H H H
LA1120 H H CD3 Me H H H
LA1121   H H iPr Me H H H
LA1122   H H Ph Me H H H
LA1123   H H Me CD3 H H H
LA1124   H H CD3 CD3 H H H
LA1125   H H iPr CD3 H H H
LA1126   H H Ph CD3 H H H
LA1127   H H Me iPr H H H
LA1128   H H CD3 iPr H H H
LA1129   H H iPr iPr H H H
LA1130   H H Ph iPr H H H
LA1131   H H Me Ph H H H
LA1132   H H CD3 Ph H H H
LA1133   H H iPr Ph H H H
LA1134   H H Ph Ph H H H
LA1135   H H Me H Me H H
LA1136   H H CD3 H Me H H
LA1137   H H iPr H Me H H
LA1138   H H Ph H Me H H
LA1139   H H Me H CD3 H H
LA1140   H H CD3 H CD3 H H
LA1141   H H iPr H CD3 H H
LA1142   H H Ph H CD3 H H
LA1143   H H Me H iPr H H
LA1144   H H CD3 H iPr H H
LA1145   H H iPr H iPr H H
LA1146   H H Ph H iPr H H
LA1147   H H Me H Ph H H
LA1148   H H CD3 H Ph H H
LA1149   H H iPr H Ph H H
LA1150   H H Ph H Ph H H
LA1151   Me Me H Me H H H
LA1152   H Me Me Me H H H
LA1153   CD3 Me H Me H H H
LA1154   H Me CD3 Me H H H
LA1155   iPr Me H Me H H H
LA1156   H Me iPr Me H H H
LA1157   Ph Me H Me H H H.
LA1158   H Me Ph Me H H H
LA1159   Me CD3 H CD3 H H H
LA1160   H CD3 Me CD3 H H H
LA1161   CD3 CD3 H CD3 H H H
LA1162   H CD3 CD3 CD3 H H H
LA1163

iPr CD3 H CD3 H H H
LA1164 H CD3 iPr CD3 H H H
LA1165 Ph CD3 H CD3 H H H
LA1166 H CD3 Ph CD3 H H H
LA1167 Me iPr H iPr H H H
LA1168   H iPr Me iPr H H H
LA1169   CD3 iPr H iPr H H H
LA1170   H iPr CD3 iPr H H H
LA1171   iPr iPr H iPr H H H
LA1172   H iPr iPr iPr H H H
LA1173   Ph iPr H iPr H H H
LA1174   H iPr Ph iPr H H H
LA1175   Me Ph H Ph H H H
LA1176   H Ph Me Ph H H H
LA1177   CD3 Ph H Ph H H H
LA1178   H Ph CD3 Ph H H H
LA1179   iPr Ph H Ph H H H
LA1180   H Ph iPr Ph H H H
LA1181   Ph Ph H Ph H H H
LA1182   H Ph Ph Ph H H H
LA1183   H H H H H H H
LA1184   Me H H H H H H
LA1185   H Me H H H H H
LA1186

H H Me H H H H
LA1187 H H H Me H H H
LA1188 H H H H Me H H
LA1189 CD3 H H H H H H
LA1190 H CD3 H H H H H
LA1191   H H CD3 H H H H
LA1192   H H H CD3 H H H
LA1193   H H H H CD3 H H
LA1194   iPr H H H H H H
LA1195   H iPr H H H H H
LA1196   H H iPr H H H H
LA1197   H H H iPr H H H
LA1198   H H H H iPr H H
LA1199   Ph H H H H H H
LA1200   H Ph H H H H H
LA1201   H H Ph H H H H
LA1202   H H H Ph H H H
LA1203   H H H H Ph H H
LA1204   Me Me H H H H H
LA1205   Me H Me H H H H
LA1206   Me H H Me H H H
LA1207   Me H H H Me H H
LA1208   Me CD3 H H H H H
LA1209   Me H CD3 H H H H
LA1210   Me H H CD3 H H H
LA1211   Me H H H CD3 H H
LA1212   Me iPr H H H H H
LA1213   Me H iPr H H H H
LA1214   Me H H iPr H H H
LA1215   Me H H H iPr H H
LA1216   Me Ph H H H H H
LA1217   Me H Ph H H H H
LA1218   Me H H Ph H H H
LA1219   Me H H H Ph H H
LA1220   CD3 Me H H H H H
LA1221   CD3 H Me H H H H
LA1222

CD3 H H Me H H H
LA1223 CD3 H H H Me H H
LA1224 CD3 CD3 H H H H H
LA1225 CD3 H CD3 H H H H
LA1226 CD3 H H CD3 H H H
LA1227   CD3 H H H CD3 H H
LA1228   CD3 iPr H H H H H
LA1229   CD3 H iPr H H H H
LA1230   CD3 H H iPr H H H
LA1231   CD3 H H H iPr H H
LA1232   CD3 Ph H H H H H
LA1233   CD3 H Ph H H H H
LA1234   CD3 H H Ph H H H
LA1235   CD3 H H H Ph H H
L1236   iPr Me H H H H H
LA1237   iPr H Me H H H H
LA1238   iPr H H Me H H H
LA1239   iPr H H H Me H H
LA1240   iPr CD3 H H H H H
LA1241   iPr H CD3 H H H H
LA1242   iPr H H CD3 H H H
LA1243   iPr H H H CD3 H H
LA1244   iPr iPr H H H H H
LA1245   iPr H iPr H H H H
LA1246   iPr H H iPr H H H
LA1247   iPr H H H iPr H H
LA1248   iPr Ph H H H H H
LA1249   iPr H Ph H H H H
LA1250   iPr H H Ph H H H
LA1251   iPr H H H Ph H H
LA1252   Ph Me H H H H H
LA1253   Ph H Me H H H H
LA1254   Ph H H Me H H H
LA1255   Ph H H H Me H H
LA1256   Ph CD3 H H H H H
LA1257   Ph H CD3 H H H H
LA1258   Ph H H CD3 H H H
LA1259   Ph H H H CD3 H H
LA1260   Ph iPr H H H H H
LA1261   Ph H iPr H H H H
LA1262   Ph H H iPr H H H
L1263   Ph H H H iPr H H
LA1264   Ph Ph H H H H H
LA1265   Ph H Ph H H H H
LA1266   Ph H H Ph H H H
LA1267   Ph H H H Ph H H
LA1268   H Me Me H H H H
LA1269   H Me H Me H H H
LA1270   H Me H H Me H H
LA1271   H Me CD3 H H H H
LA1272   H Me H CD3 H H H
LA1273   H Me H H CD3 H H
LA1274   H Me iPr H H H H
LA1275

H Me H iPr H H H
LA1276 H Me H H iPr H H
LA1277 H Me Ph H H H H
LA1278 H Me H Ph H H H
LA1279 H Me H H Ph H H
LA1280 H CD3 Me H H H H
LA1281   H CD3 H Me H H H
LA1282   H CD3 H H Me H H
LA1283   H CD3 CD3 H H H H
LA1284   H CD3 H CD3 H H H
LA1285   H CD3 H H CD3 H H
LA1286   H CD3 iPr H H H H
LA1287   H CD3 H iPr H H H
LA1288   H CD3 H H iPr H H
LA1289   H CD3 Ph H H H H
LA1290   H CD3 H Ph H H H
LA1291   H CD3 H H Ph H H
LA1292   H iPr Me H H H H
LA1293   H iPr H Me H H H
LA1294   H iPr H H Me H H
LA1295   H iPr CD3 H H H H
LA1296   H iPr H CD3 H H H
LA1297   H iPr H H CD3 H H
LA1298   H iPr iPr H H H H
LA1299   H iPr H iPr H H H
LA1300   H iPr H H iPr H H
LA1301   H iPr Ph H H H H
LA1302   H iPr H Ph H H H
LA1303   H iPr H H Ph H H
LA1304   H Ph Me H H H H
LA1305   H Ph H Me H H H
LA1306   H Ph H H Me H H
LA1307   H Ph CD3 H H H H
LA1308   H Ph H CD3 H H H
LA1309   H Ph H H CD3 H H
LA1310   H Ph iPr H H H H
LA1311   H Ph H iPr H H H
LA1312   H Ph H H iPr H H
LA1313   H Ph Ph H H H H
LA1314   H Ph H Ph H H H
LA1315   H Ph H H Ph H H
LA1316   H H Me Me H H H
LA1317   H H CD3 Me H H H
LA1318   H H iPr Me H H H
LA1319   H H Ph Me H H H
LA1320   H H Me CD3 H H H
LA1321   H H CD3 CD3 H H H
LA1322   H H iPr CD3 H H H
LA1323   H H Ph CD3 H H H
LA1324   H H Me iPr H H H
LA1325   H H CD3 iPr H H H
LA1326   H H iPr iPr H H H
LA1327   H H Ph iPr H H H
LA1328

H H Me Ph H H H
LA1329 H H CD3 Ph H H H
LA1330 H H iPr Ph H H H
LA1331 H H Ph Ph H H H
LA1332 H H Me H Me H H
LA1333 H H CD3 H Me H H
LA1334 H H iPr H Me H H
LA1335   H H Ph H Me H H
LA1336   H H Me H CD3 H H
LA1337   H H CD3 H CD3 H H
LA1338   H H iPr H CD3 H H
LA1339   H H Ph H CD3 H H
LA1340   H H Me H iPr H H
LA1341   H H CD3 H iPr H H
LA1342   H H iPr H iPr H H
LA1343   H H Ph H iPr H H
LA1344   H H Me H Ph H H
LA1345   H H CD3 H Ph H H
LA1346   H H iPr H Ph H H
LA1347   H H Ph H Ph H H
LA1348   Me Me H Me H H H
LA1349   H Me Me Me H H H
LA1350   CD3 Me H Me H H H
LA1351   H Me CD3 Me H H H
LA1352   iPr Me H Me H H H
LA1353   H Me iPr Me H H H
LA1354   Ph Me H Me H H H
LA1355   H Me Ph Me H H H
LA1356   Me CD3 H CD3 H H H
LA1357   H CD3 Me CD3 H H H
LA1358   CD3 CD3 H CD3 H H H
LA1359   H CD3 CD3 CD3 H H H
LA1360   iPr CD3 H CD3 H H H
LA1361   H CD3 iPr CD3 H H H
LA1362   Ph CD3 H CD3 H H H
LA1363   H CD3 Ph CD3 H H H
LA1364   Me iPr H iPr H H H
LA1365   H iPr Me iPr H H H
LA1366   CD3 iPr H iPr H H H
LA1367   H iPr CD3 iPr H H H
LA1368   iPr iPr H iPr H H H
LA1369   H iPr iPr iPr H H H
LA1370   Ph iPr H iPr H H H
LA1371

H iPr Ph iPr H H H
LA1372 Me Ph H Ph H H H
LA1373 H Ph Me Ph H H H
LA1374 CD3 Ph H Ph H H H
LA1375 H Ph CD3 Ph H H H
LA1376 iPr Ph H Ph H H H
LA1377   H Ph iPr Ph H H H
LA1378   Ph Ph H Ph H H H
LA1379   H Ph Ph Ph H H H
LA1380   H H H H H H H
LA1381   Me H H H H H H
LA1382   H Me H H H H H
LA1383   H H Me H H H H
LA1384   H H H Me H H H
LA1385   H H H H Me H H
LA1386   CD3 H H H H H H
LA1387

H CD3 H H H H H
LA1388 H H CD3 H H H H
LA1389 H H H CD3 H H H
LA1390 H H H H CD3 H H
LA1391 iPr H H H H H H
LA1392 H iPr H H H H H
LA1393 H H iPr H H H H
LA1394 H H H iPr H H H
LA1395   H H H H iPr H H
LA1396   Ph H H H H H H
LA1397   H Ph H H H H H
LA1398   H H Ph H H H H
LA1399   H H H Ph H H H
LA1400   H H H H Ph H H
LA1401   Me Me H H H H H
LA1402   Me H Me H H H H
LA1403   Me H H Me H H H
LA1404   Me H H H Me H H
LA1405   Me CD3 H H H H H
LA1406   Me H CD3 H H H H
LA1407   Me H H CD3 H H H
LA1408   Me H H H CD3 H H
LA1409   Me iPr H H H H H
LA1410   Me H iPr H H H H
LA1411   Me H H iPr H H H
LA1412   Me H H H iPr H H
LA1413   Me Ph H H H H H
LA1414   Me H Ph H H H H
LA1415   Me H H Ph H H H
LA1416   Me H H H Ph H H
LA1417   CD3 Me H H H H H
LA1418   CD3 H Me H H H H
LA1419   CD3 H H Me H H H
LA1420   CD3 H H H Me H H
LA1421   CD3 CD3 H H H H H
LA1422   CD3 H CD3 H H H H
LA1423   CD3 H H CD3 H H H
LA1424   CD3 H H H CD3 H H
LA1425   CD3 iPr H H H H H
LA1426   CD3 H iPr H H H H
LA1427   CD3 H H iPr H H H
LA1428   CD3 H H H iPr H H
LA1429   CD3 Ph H H H H H
LA1430   CD3 H Ph H H H H
LA1431   CD3 H H Ph H H H
LA1432   CD3 H H H Ph H H
LA1433   iPr Me H H H H H
LA1434   iPr H Me H H H H
LA1435

iPr H H Me H H H
LA1436 iPr H H H Me H H
LA1437 iPr CD3 H H H H H
LA1438 iPr H CD3 H H H H
LA1439 iPr H H CD3 H H H
LA1440 iPr H H H CD3 H H
LA1441 iPr iPr H H H H H
LA1442   iPr H iPr H H H H
LA1443   iPr H H iPr H H H
LA1444   iPr H H H iPr H H
LA1445   iPr Ph H H H H H
LA1446   iPr H Ph H H H H
LA1447   iPr H H Ph H H H
LA1448   iPr H H H Ph H H
LA1449   Ph Me H H H H H
LA1450   Ph H Me H H H H
LA1451   Ph H H Me H H H
LA1452   Ph H H H Me H H
LA1453   Ph CD3 H H H H H
LA1454   Ph H CD3 H H H H
LA1455   Ph H H CD3 H H H
LA1456   Ph H H H CD3 H H
LA1457   Ph iPr H H H H H
LA1458   Ph H iPr H H H H
LA1459   Ph H H iPr H H H
LA1460   Ph H H H iPr H H
LA1461   Ph Ph H H H H H
LA1462   Ph H Ph H H H H
LA1463   Ph H H Ph H H H
LA1464   Ph H H H Ph H H
LA1465   H Me Me H H H H
LA1466   H Me H Me H H H
LA1467   H Me H H Me H H
LA1468   H Me CD3 H H H H
LA1469   H Me H CD3 H H H
LA1470   H Me H H CD3 H H
LA1471   H Me iPr H H H H
LA1472   H Me H iPr H H H
LA1473   H Me H H iPr H H
LA1474   H Me Ph H H H H
LA1475   H Me H Ph H H H
LA1476   H Me H H Ph H H
LA1477   H CD3 Me H H H H
LA1478   H CD3 H Me H H H
LA1479   H CD3 H H Me H H
LA1480   H CD3 CD3 H H H H
LA1481   H CD3 H CD3 H H H
LA1482   H CD3 H H CD3 H H
LA1483   H CD3 iPr H H H H
LA1484   H CD3 H iPr H H H
LA1485   H CD3 H H iPr H H
LA1486   H CD3 Ph H H H H
LA1487   H CD3 H Ph H H H
LA1488

H CD3 H H Ph H H
LA1489 H iPr Me H H H H
LA1490 H iPr H Me H H H
LA1491 H iPr H H Me H H
LA1492 H iPr CD3 H H H H
LA1493 H iPr H CD3 H H H
LA1494 H iPr H H CD3 H H
LA1495 H iPr iPr H H H H
LA1496   H iPr H iPr H H H
LA1497   H iPr H H iPr H H
LA1498   H iPr Ph H H H H
LA1499   H iPr H Ph H H H
LA1500   H iPr H H Ph H H
LA1501   H Ph Me H H H H
LA1502   H Ph H Me H H H
LA1503   H Ph H H Me H H
LA1504   H Ph CD3 H H H H
LA1505   H Ph H CD3 H H H
LA1506   H Ph H H CD3 H H
LA1507   H Ph iPr H H H H
LA1508   H Ph H iPr H H H
LA1509   H Ph H H iPr H H
LA1510   H Ph Ph H H H H
LA1511   H Ph H Ph H H H
LA1512   H Ph H H Ph H H
LA1513   H H Me Me H H H
LA1514   H H CD3 Me H H H
LA1515   H H iPr Me H H H
LA1516   H H Ph Me H H H
LA1517   H H Me CD3 H H H
LA1518   H H CD3 CD3 H H H
LA1519   H H iPr CD3 H H H
LA1520   H H Ph CD3 H H H
LA1521   H H Me iPr H H H
LA1522   H H CD3 iPr H H H
LA1523   H H iPr iPr H H H
LA1524   H H Ph iPr H H H
LA1525   H H Me Ph H H H
LA1526   H H CD3 Ph H H H
LA1527   H H iPr Ph H H H
LA1528   H H Ph Ph H H H
LA1529   H H Me H Me H H
LA1530   H H CD3 H Me H H
LA1531   H H iPr H Me H H
LA1532   H H Ph H Me H H
LA1533   H H Me H CD3 H H
LA1534   H H CD3 H CD3 H H
LA1535   H H iPr H CD3 H H
LA1536   H H Ph H CD3 H H
LA1537   H H Me H iPr H H
LA1538   H H CD3 H iPr H H
LA1539   H H iPr H iPr H H
LA1540   H H Ph H iPr H H
LA1541   H H Me H Ph H H
LA1542

H H CD3 H Ph H H
LA1543 H H iPr H Ph H H
LA1544 H H Ph H Ph H H
LA1545 Me Me H Me H H H
LA1546 H Me Me Me H H H
LA1547 CD3 Me H Me H H H
LA1548 H Me CD3 Me H H H
LA1549   iPr Me H Me H H H
LA1550   H Me iPr Me H H H
LA1551   Ph Me H Me H H H
LA1552   H Me Ph Me H H H
LA1553   Me CD3 H CD3 H H H
LA1554   H CD3 Me CD3 H H H
LA1555   CD3 CD3 H CD3 H H H
LA1556   H CD3 CD3 CD3 H H H
LA1557   iPr CD3 H CD3 H H H
LA1558   H CD3 iPr CD3 H H H
LA1559   Ph CD3 H CD3 H H H
LA1560   H CD3 Ph CD3 H H H
LA1561   Me iPr H iPr H H H
LA1562   H iPr Me iPr H H H
LA1563   CD3 iPr H iPr H H H
LA1564   H iPr CD3 iPr H H H
LA1565   iPr iPr H iPr H H H
LA1566   H iPr iPr iPr H H H
LA1567   Ph iPr H iPr H H H
LA1568   H iPr Ph iPr H H H
LA1569   Me Ph H Ph H H H
LA1570   H Ph Me Ph H H H
LA1571   CD3 Ph H Ph H H H
LA1572   H Ph CD3 Ph H H H
LA1573   iPr Ph H Ph H H H
LA1574   H Ph iPr Ph H H H
LA1575   Ph Ph H Ph H H H
LA1576   H Ph Ph Ph H H H
LA1577   H H H H H H H
LA1578   Me H H H H H H
LA1579

H Me H H H H H
LA1580 H H Me H H H H
LA1581 H H H Me H H H
LA1582 H H H H Me H H
LA1583 CD3 H H H H H H
LA1584 H CD3 H H H H H
LA1585 H H CD3 H H H H
LA1586   H H H CD3 H H H
LA1587   H H H H CD3 H H
LA1588   iPr H H H H H H
LA1589   H iPr H H H H H
LA1590   H H iPr H H H H
LA1591   H H H iPr H H H
LA1592   H H H H iPr H H
LA1593   Ph H H H H H H
LA1594   H Ph H H H H H
LA1595

H H Ph H H H H
LA1596 H H H Ph H H H
LA1597 H H H H Ph H H
LA1598 Me Me H H H H H
LA1599 Me H Me H H H H
LA1600 Me H H Me H H H
LA1601 Me H H H Me H H
LA1602 Me CD3 H H H H H
LA1603   Me H CD3 H H H H
LA1604   Me H H CD3 H H H
LA1605   Me H H H CD3 H H
LA1606   Me iPr H H H H H
LA1607   Me H iPr H H H H
LA1608   Me H H iPr H H H
LA1609   Me H H H iPr H H
LA1610   Me Ph H H H H H
LA1611   Me H Ph H H H H
LA1612   Me H H Ph H H H
LA1613   Me H H H Ph H H
LA1614   CD3 Me H H H H H
LA1615   CD3 H Me H H H H
LA1616   CD3 H H Me H H H
LA1617   CD3 H H H Me H H
LA1618   CD3 CD3 H H H H H
LA1619   CD3 H CD3 H H H H
LA1620   CD3 H H CD3 H H H
LA1621   CD3 H H H CD3 H H
LA1622   CD3 iPr H H H H H
LA1623   CD3 H iPr H H H H
LA1624   CD3 H H iPr H H H
LA1625   CD3 H H H iPr H H
LA1626   CD3 Ph H H H H H
LA1627   CD3 H Ph H H H H
LA1628   CD3 H H Ph H H H
LA1629   CD3 H H H Ph H H
LA1630   iPr Me H H H H H
LA1631   iPr H Me H H H H
LA1632   iPr H H Me H H H
LA1633   iPr H H H Me H H
LA1634   iPr CD3 H H H H H
LA1635   iPr H CD3 H H H H
LA1636   iPr H H CD3 H H H
LA1637   iPr H H H CD3 H H
LA1638   iPr iPr H H H H H
LA1639   iPr H iPr H H H H
LA1640   iPr H H iPr H H H
LA1641   iPr H H H iPr H H
LA1642   iPr Ph H H H H H
LA1643   iPr H Ph H H H H
LA1644   iPr H H Ph H H H
LA1645   iPr H H H Ph H H
LA1646   Ph Me H H H H H
LA1647   Ph H Me H H H H
LA1648   Ph H H Me H H H
LA1649

Ph H H H Me H H
LA1650 Ph CD3 H H H H H
LA1651 Ph H CD3 H H H H
LA1652 Ph H H CD3 H H H
LA1653 Ph H H H CD3 H H
LA1654 Ph iPr H H H H H
LA1655 Ph H iPr H H H H
LA1656   Ph H H iPr H H H
LA1657   Ph H H H iPr H H
LA1658   Ph Ph H H H H H
LA1659   Ph H Ph H H H H
LA1660   Ph H H Ph H H H
LA1661   Ph H H H Ph H H
LA1662   H Me Me H H H H
LA1663   H Me H Me H H H
LA1664   H Me H H Me H H
LA1665   H Me CD3 H H H H
LA1666   H Me H CD3 H H H
LA1667   H Me H H CD3 H H
LA1668   H Me iPr H H H H
LA1669   H Me H iPr H H H
LA1670   H Me H H iPr H H
LA1671   H Me Ph H H H H
LA1672   H Me H Ph H H H
LA1673   H Me H H Ph H H
LA1674   H CD3 Me H H H H
LA1675   H CD3 H Me H H H
LA1676   H CD3 H H Me H H
LA1677   H CD3 CD3 H H H H
LA1678   H CD3 H CD3 H H H
LA1679   H CD3 H H CD3 H H
LA1680   H CD3 iPr H H H H
LA1681   H CD3 H iPr H H H
LA1682   H CD3 H H iPr H H
LA1683   H CD3 Ph H H H H
LA1684   H CD3 H Ph H H H
LA1685   H CD3 H H Ph H H
LA1686   H iPr Me H H H H
LA1687   H iPr H Me H H H
LA1688   H iPr H H Me H H
LA1689   H iPr CD3 H H H H
LA1690   H iPr H CD3 H H H
LA1691   H iPr H H CD3 H H
LA1692   H iPr iPr H H H H
LA1693   H iPr H iPr H H H
LA1694   H iPr H H iPr H H
LA1695   H iPr Ph H H H H
LA1696   H iPr H Ph H H H
LA1697   H iPr H H Ph H H
LA1698   H Ph Me H H H H
LA1699   H Ph H Me H H H
LA1700   H Ph H H Me H H
LA1701   H Ph CD3 H H H H
LA1702

H Ph H CD3 H H H
LA1703 H Ph H H CD3 H H
LA1704 H Ph iPr H H H H
LA1705 H Ph H iPr H H H
LA1706 H Ph H H iPr H H
LA1707 H Ph Ph H H H H
LA1708 H Ph H Ph H H H
LA1709 H Ph H H Ph H H
LA1710   H H Me Me H H H
LA1711   H H CD3 Me H H H
LA1712   H H iPr Me H H H
LA1713   H H Ph Me H H H
LA1714   H H Me CD3 H H H
LA1715   H H CD3 CD3 H H H
LA1716   H H iPr CD3 H H H
LA1717   H H Ph CD3 H H H
LA1718   H H Me iPr H H H
LA1719   H H CD3 iPr H H H
LA1720   H H iPr iPr H H H
LA1721   H H Ph iPr H H H
LA1722   H H Me Ph H H H
LA1723   H H CD3 Ph H H H
LA1724   H H iPr Ph H H H
LA1725   H H Ph Ph H H H
LA1726   H H Me H Me H H
LA1727   H H CD3 H Me H H
LA1728   H H iPr H Me H H
LA1729   H H Ph H Me H H
LA1730   H H Me H CD3 H H
LA1731   H H CD3 H CD3 H H
LA1732   H H iPr H CD3 H H
LA1733   H H Ph H CD3 H H
LA1734   H H Me H iPr H H
LA1735   H H CD3 H iPr H H
LA1736   H H iPr H iPr H H
LA1737   H H Ph H iPr H H
LA1738   H H Me H Ph H H
LA1739   H H CD3 H Ph H H
LA1740   H H iPr H Ph H H
LA1741   H H Ph H Ph H H
LA1742   Me Me H Me H H H
LA1743   H Me Me Me H H H
LA1744   CD3 Me H Me H H H
LA1745   H Me CD3 Me H H H
LA1746   iPr Me H Me H H H
LA1747   H Me iPr Me H H H
LA1748   Ph Me H Me H H H
LA1749   H Me Ph Me H H H
LA1750   Me CD3 H CD3 H H H
LA1751   H CD3 Me CD3 H H H
LA1752   CD3 CD3 H CD3 H H H
LA1753   H CD3 CD3 CD3 H H H
LA1754   iPr CD3 H CD3 H H H
LA1755   H CD3 iPr CD3 H H H
LA1756

Ph CD3 H CD3 H H H
LA1757 H CD3 Ph CD3 H H H
LA1758 Me iPr H iPr H H H
LA1759 H iPr Me iPr H H H
LA1760 CD3 iPr H iPr H H H
LA1761 H iPr CD3 iPr H H H
LA1762 iPr iPr H iPr H H H
LA1763   H iPr iPr iPr H H H
LA1764   Ph iPr H iPr H H H
LA1765   H iPr Ph iPr H H H
LA1766   Me Ph H Ph H H H
LA1767   H Ph Me Ph H H H
LA1768   CD3 Ph H Ph H H H
LA1769   H Ph CD3 Ph H H H
LA1770   iPr Ph H Ph H H H
LA1771   H Ph iPr Ph H H H
LA1772   Ph Ph H Ph H H H
LA1773   H Ph Ph Ph H H H
LA1774   H H H H H H H
LA1775   Me H H H H H H
LA1776   H Me H H H H H
LA1777   H H Me H H H H
LA1778   H H H Me H H H
LA1779   H H H H Me H H
LA1780   CD3 H H H H H H
LA1781   H CD3 H H H H H
LA1782   H H CD3 H H H H
LA1783   H H H CD3 H H H
LA1784   H H H H CD3 H H
LA1785   iPr H H H H H H
LA1786   H iPr H H H H H
LA1787   H H iPr H H H H
LA1788

H H H iPr H H H
LA1789 H H H H iPr H H
LA1790 Ph H H H H H H
LA1791 H Ph H H H H H
LA1792 H H Ph H H H H
LA1793 H H H Ph H H H
LA1794   H H H H Ph H H
LA1795   Me Me H H H H H
LA1796   Me H Me H H H H
LA1797   Me H H Me H H H
LA1798   Me H H H Me H H
LA1799   Me CD3 H H H H H
LA1800   Me H CD3 H H H H
LA1801   Me H H CD3 H H H
LA1802   Me H H H CD3 H H
LA1803   Me iPr H H H H H
LA1804   Me H iPr H H H H
LA1805   Me H H iPr H H H
LA1806   Me H H H iPr H H
LA1807   Me Ph H H H H H
LA1808   Me H Ph H H H H
LA1809   Me H H Ph H H H
LA1810

Me H H H Ph H H
LA1811 CD3 Me H H H H H
LA1812 CD3 H Me H H H H
LA1813 CD3 H H Me H H H
LA1814 CD3 H H H Me H H
LA1815 CD3 CD3 H H H H H
LA1816   CD3 H CD3 H H H H
LA1817   CD3 H H CD3 H H H
LA1818   CD3 H H H CD3 H H
LA1819   CD3 iPr H H H H H
LA1820   CD3 H iPr H H H H
LA1821   CD3 H H iPr H H H
LA1822   CD3 H H H iPr H H
LA1823   CD3 Ph H H H H H
LA1824   CD3 H Ph H H H H
LA1825   CD3 H H Ph H H H
LA1826   CD3 H H H Ph H H
LA1827   iPr Me H H H H H
LA1828   iPr H Me H H H H
LA1829   iPr H H Me H H H
LA1830   iPr H H H Me H H
LA1831   iPr CD3 H H H H H
LA1832   iPr H CD3 H H H H
LA1833   iPr H H CD3 H H H
LA1834   iPr H H H CD3 H H
LA1835   iPr iPr H H H H H
LA1836   iPr H iPr H H H H
LA1837   iPr H H iPr H H H
LA1838   iPr H H H iPr H H
LA1839   iPr Ph H H H H H
LA1840   iPr H Ph H H H H
LA1841   iPr H H Ph H H H
LA1842   iPr H H H Ph H H
LA1843   Ph Me H H H H H
LA1844   Ph H Me H H H H
LA1845   Ph H H Me H H H
LA1846   Ph H H H Me H H
LA1847   Ph CD3 H H H H H
LA1848   Ph H CD3 H H H H
LA1849   Ph H H CD3 H H H
LA1850   Ph H H H CD3 H H
LA1851   Ph iPr H H H H H
LA1852   Ph H iPr H H H H
LA1853   Ph H H iPr H H H
LA1854   Ph H H H iPr H H
LA1855   Ph Ph H H H H H
LA1856   Ph H Ph H H H H
LA1857   Ph H H Ph H H H
LA1858   Ph H H H Ph H H
LA1859   H Me Me H H H H
LA1860   H Me H Me H H H
LA1861   H Me H H Me H H
LA1862   H Me CD3 H H H H
LA1863

H Me H CD3 H H H
LA1864 H Me H H CD3 H H
LA1865 H Me iPr H H H H
LA1866 H Me H iPr H H H
LA1867 H Me H H iPr H H
LA1868 H Me Ph H H H H
LA1869 H Me H Ph H H H
LA1870   H Me H H Ph H H
LA1871   H CD3 Me H H H H
LA1872   H CD3 H Me H H H
LA1873   H CD3 H H Me H H
LA1874   H CD3 CD3 H H H H
LA1875   H CD3 H CD3 H H H
LA1876   H CD3 H H CD3 H H
LA1877   H CD3 iPr H H H H
LA1878   H CD3 H iPr H H H
LA1879   H CD3 H H iPr H H
LA1880   H CD3 Ph H H H H
LA1881   H CD3 H Ph H H H
LA1882   H CD3 H H Ph H H
LA1883   H iPr Me H H H H
LA1884   H iPr H Me H H H
LA1885   H iPr H H Me H H
LA1886   H iPr CD3 H H H H
LA1887   H iPr H CD3 H H H
LA1888   H iPr H H CD3 H H
LA1889   H iPr iPr H H H H
LA1890   H iPr H iPr H H H
LA1891   H iPr H H iPr H H
LA1892   H iPr Ph H H H H
LA1893   H iPr H Ph H H H
LA1894   H iPr H H Ph H H
LA1895   H Ph Me H H H H
LA1896   H Ph H Me H H H
LA1897   H Ph H H Me H H
LA1898   H Ph CD3 H H H H
LA1899   H Ph H CD3 H H H
LA1900   H Ph H H CD3 H H
LA1901   H Ph iPr H H H H
LA1902   H Ph H iPr H H H
LA1903   H Ph H H iPr H H
LA1904   H Ph Ph H H H H
LA1905   H Ph H Ph H H H
LA1906   H Ph H H Ph H H
LA1907   H H Me Me H H H
LA1908   H H CD3 Me H H H
LA1909   H H iPr Me H H H
LA1910   H H Ph Me H H H
LA1911   H H Me CD3 H H H
LA1912   H H CD3 CD3 H H H
LA1913   H H iPr CD3 H H H
LA1914   H H Ph CD3 H H H
LA1915   H H Me iPr H H H
LA1916   H H CD3 iPr H H H
LA1917   H H iPr iPr H H H
LA1918

H H Ph iPr H H H
LA1919 H H Me Ph H H H
LA1920 H H CD3 Ph H H H
LA1921 H H iPr Ph H H H
LA1922   H H Ph Ph H H H
LA1923   H H Me H Me H H
LA1924   H H CD3 H Me H H
LA1925   H H iPr H Me H H
LA1926   H H Ph H Me H H
LA1927   H H Me H CD3 H H
LA1928   H H CD3 H CD3 H H
LA1929   H H iPr H CD3 H H
LA1930   H H Ph H CD3 H H
LA1931   H H Me H iPr H H
LA1932   H H CD3 H iPr H H
LA1933   H H iPr H iPr H H
LA1934   H H Ph H iPr H H
LA1935   H H Me H Ph H H
LA1936   H H CD3 H Ph H H
LA1937   H H iPr H Ph H H
LA1938   H H Ph H Ph H H
LA1939   Me Me H Me H H H
LA1940   H Me Me Me H H H
LA1941   CD3 Me H Me H H H
LA1942   H Me CD3 Me H H H
LA1943   iPr Me H Me H H H
LA1944   H Me iPr Me H H H
LA1945   Ph Me H Me H H H
LA1946   H Me Ph Me H H H
LA1947   Me CD3 H CD3 H H H
LA1948   H CD3 Me CD3 H H H
LA1949   CD3 CD3 H CD3 H H H
LA1950   H CD3 CD3 CD3 H H H
LA1951   iPr CD3 H CD3 H H H
LA1952   H CD3 iPr CD3 H H H
LA1953   Ph CD3 H CD3 H H H
LA1954   H CD3 Ph CD3 H H H
LA1955   Me iPr H iPr H H H
LA1956   H iPr Me iPr H H H
LA1957   CD3 iPr H iPr H H H
LA1958   H iPr CD3 iPr H H H
LA1959   iPr iPr H iPr H H H
LA1960   H iPr iPr iPr H H H
LA1961   Ph iPr H iPr H H H
LA1962   H iPr Ph iPr H H H
LA1963   Me Ph H Ph H H H
LA1964   H Ph Me Ph H H H
LA1965   CD3 Ph H Ph H H H
LA1966   H Ph CD3 Ph H H H
LA1967   iPr Ph H Ph H H H
LA1968   H Ph iPr Ph H H H
LA1969   Ph Ph H Ph H H H
LA1970   H Ph Ph Ph H H H
LA1971

H H H H H H H
LA1972   Me H H H H H H
LA1973   H Me H H H H H
LA1974   H H Me H H H H
LA1975   H H H Me H H H
LA1976   H H H H Me H H
LA1977   CD3 H H H H H H
LA1978   H CD3 H H H H H
LA1979   H H CD3 H H H H
LA1980   H H H CD3 H H H
LA1981   H H H H CD3 H H
LA1982   iPr H H H H H H
LA1983   H iPr H H H H H
LA1984   H H iPr H H H H
LA1985   H H H iPr H H H
LA1986   H H H H iPr H H
LA1987   Ph H H H H H H
LA1988   H Ph H H H H H
LA1989   H H Ph H H H H
LA1990   H H H Ph H H H
LA1991   H H H H Ph H H
LA1992   Me Me H H H H H
LA1993   Me H Me H H H H
LA1994   Me H H Me H H H
LA1995

Me H H H Me H H
LA1996 Me CD3 H H H H H
LA1997 Me H CD3 H H H H
LA1998 Me H H CD3 H H H
LA1999 Me H H H CD3 H H
LA2000 Me iPr H H H H H
LA2001   Me H iPr H H H H
LA2002   Me H H iPr H H H
LA2003   Me H H H iPr H H
LA2004   Me Ph H H H H H
LA2005   Me H Ph H H H H
LA2006   Me H H Ph H H H
LA2007   Me H H H Ph H H
LA2008   CD3 Me H H H H H
LA2009   CD3 H Me H H H H
LA2010   CD3 H H Me H H H
LA2011   CD3 H H H Me H H
LA2012   CD3 CD3 H H H H H
LA2013   CD3 H CD3 H H H H
LA2014   CD3 H H CD3 H H H
LA2015   CD3 H H H CD3 H H
LA2016   CD3 iPr H H H H H
LA2017   CD3 H iPr H H H H
LA2018   CD3 H H iPr H H H
LA2019   CD3 H H H iPr H H
LA2020   CD3 Ph H H H H H
LA2021   CD3 H Ph H H H H
LA2022   CD3 H H Ph H H H
LA2023   CD3 H H H Ph H H
LA2024   iPr Me H H H H H
LA2025   iPr H Me H H H H
LA2026   iPr H H Me H H H
LA2027   iPr H H H Me H H
LA2028   iPr CD3 H H H H H
LA2029   iPr H CD3 H H H H
LA2030   iPr H H CD3 H H H
LA2031   iPr H H H CD3 H H
LA2032   iPr iPr H H H H H
LA2033   iPr H iPr H H H H
LA2034   iPr H H iPr H H H
LA2035   iPr H H H iPr H H
LA2036   iPr Ph H H H H H
LA2037   iPr H Ph H H H H
LA2038   iPr H H Ph H H H
LA2039   iPr H H H Ph H H
LA2040   Ph Me H H H H H
LA2041   Ph H Me H H H H
LA2042   Ph H H Me H H H
LA2043   Ph H H H Me H H
LA2044   Ph CD3 H H H H H
LA2045   Ph H CD3 H H H H
LA2046   Ph H H CD3 H H H
LA2047   Ph H H H CD3 H H
LA2048

Ph iPr H H H H H
LA2049 Ph H iPr H H H H
LA2050 Ph H H iPr H H H
LA2051 Ph H H H iPr H H
LA2052 Ph Ph H H H H H
LA2053 Ph H Ph H H H H
LA2054 Ph H H Ph H H H
LA2055   Ph H H H Ph H H
LA2056   H Me Me H H H H
LA2057   H Me H Me H H H
LA2058   H Me H H Me H H
LA2059   H Me CD3 H H H H
LA2060   H Me H CD3 H H H
LA2061   H Me H H CD3 H H
LA2062   H Me iPr H H H H
LA2063   H Me H iPr H H H
LA2064   H Me H H iPr H H
LA2065   H Me Ph H H H H
LA2066   H Me H Ph H H H
LA2067   H Me H H Ph H H
LA2068   H CD3 Me H H H H
LA2069   H CD3 H Me H H H
LA2070   H CD3 H H Me H H
LA2071   H CD3 CD3 H H H H
LA2072   H CD3 H CD3 H H H
LA2073   H CD3 H H CD3 H H
LA2074   H CD3 iPr H H H H
LA2075   H CD3 H iPr H H H
LA2076   H CD3 H H iPr H H
LA2077   H CD3 Ph H H H H
LA2078   H CD3 H Ph H H H
LA2079   H CD3 H H Ph H H
LA2080   H iPr Me H H H H
LA2081   H iPr H Me H H H
LA2082   H iPr H H Me H H
LA2083   H iPr CD3 H H H H
LA2084   H iPr H CD3 H H H
LA2085   H iPr H H CD3 H H
LA2086   H iPr iPr H H H H
LA2087   H iPr H iPr H H H
LA2088   H iPr H H iPr H H
LA2089   H iPr Ph H H H H
LA2090   H iPr H Ph H H H
LA2091   H iPr H H Ph H H
LA2092   H Ph Me H H H H
LA2093   H Ph H Me H H H
LA2094   H Ph H H Me H H
LA2095   H Ph CD3 H H H H
LA2096   H Ph H CD3 H H H
LA2097   H Ph H H CD3 H H
LA2098   H Ph iPr H H H H
LA2099   H Ph H iPr H H H
LA2100   H Ph H H iPr H H
LA2101   H Ph Ph H H H H
LA2102

H Ph H Ph H H H
LA2103 H Ph H H Ph H H
LA2104 H H Me Me H H H
LA2105 H H CD3 Me H H H
LA2106 H H iPr Me H H H
LA2107 H H Ph Me H H H
LA2108   H H Me CD3 H H H
LA2109   H H CD3 CD3 H H H
LA2110   H H iPr CD3 H H H
LA2111   H H Ph CD3 H H H
LA2112   H H Me iPr H H H
LA2113   H H CD3 iPr H H H
LA2114   H H iPr iPr H H H
LA2115   H H Ph iPr H H H
LA2116   H H Me Ph H H H
LA2117   H H CD3 Ph H H H
LA2118   H H iPr Ph H H H
LA2119   H H Ph Ph H H H
LA2120   H H Me H Me H H
LA2121   H H CD3 H Me H H
LA2122   H H iPr H Me H H
LA2123   H H Ph H Me H H
LA2124   H H Me H CD3 H H
LA2125   H H CD3 H CD3 H H
LA2126   H H iPr H CD3 H H
LA2127   H H Ph H CD3 H H
LA2128   H H Me H iPr H H
LA2129   H H CD3 H iPr H H
LA2130   H H iPr H iPr H H
LA2131   H H Ph H iPr H H
LA2132   H H Me H Ph H H
LA2133   H H CD3 H Ph H H
LA2134   H H iPr H Ph H H
LA2135   H H Ph H Ph H H
LA2136   Me Me H Me H H H
LA2137   H Me Me Me H H H
LA2138   CD3 Me H Me H H H
LA2139   H Me CD3 Me H H H
LA2140   iPr Me H Me H H H
LA2141   H Me iPr Me H H H
LA2142   Ph Me H Me H H H
LA2143   H Me Ph Me H H H
LA2144   Me CD3 H CD3 H H H
LA2145   H CD3 Me CD3 H H H
LA2146   CD3 CD3 H CD3 H H H
LA2147   H CD3 CD3 CD3 H H H
LA2148   iPr CD3 H CD3 H H H
LA2149

H CD3 iPr CD3 H H H
LA2150 Ph CD3 H CD3 H H H
LA2151 H CD3 Ph CD3 H H H
LA2152 Me iPr H iPr H H H
LA2153 H iPr Me iPr H H H
LA2154 CD3 iPr H iPr H H H
LA2155 H iPr CD3 iPr H H H
LA2156   iPr iPr H iPr H H H
LA2157   H iPr iPr iPr H H H
LA2158   Ph iPr H iPr H H H
LA2159   H iPr Ph iPr H H H
LA2160   Me Ph H Ph H H H
LA2161   H Ph Me Ph H H H
LA2162   CD3 Ph H Ph H H H
LA2163   H Ph CD3 Ph H H H
LA2164   iPr Ph H Ph H H H
LA2165   H Ph iPr Ph H H H
LA2166   Ph Ph H Ph H H H
LA2167   H Ph Ph Ph H H H
LA2168   H H H H H H H
LA2169   Me H H H H H H
LA2170   H Me H H H H H
LA2171

H H Me H H H H
LA2172 H H H Me H H H
LA2173 H H H H Me H H
LA2174 CD3 H H H H H H
LA2175 H CD3 H H H H H
LA2176 H H CD3 H H H H
LA2177   H H H CD3 H H H
LA2178   H H H H CD3 H H
LA2179   iPr H H H H H H
LA2180   H iPr H H H H H
LA2181   H H iPr H H H H
LA2182   H H H iPr H H H
LA2183   H H H H iPr H H
LA2184   Ph H H H H H H
LA2185   H Ph H H H H H
LA2186   H H Ph H H H H
LA2187   H H H Ph H H H
LA2188   H H H H Ph H H
LA2189   Me Me H H H H H
LA2190   Me H Me H H H H
LA2191   Me H H Me H H H
LA2192   Me H H H Me H H
LA2193   Me CD3 H H H H H
LA2194   Me H CD3 H H H H
LA2195   Me H H CD3 H H H
LA2196   Me H H H CD3 H H
LA2197   Me iPr H H H H H
LA2198   Me H iPr H H H H
LA2199   Me H H iPr H H H
LA2200   Me H H H iPr H H
LA2201   Me Ph H H H H H
LA2202   Me H Ph H H H H
LA2203   Me H H Ph H H H
LA2204   Me H H H Ph H H
LA2205   CD3 Me H H H H H
LA2206   CD3 H Me H H H H
LA2207   CD3 H H Me H H H
LA2208   CD3 H H H Me H H
LA2209

CD3 CD3 H H H H H
LA2210 CD3 H CD3 H H H H
LA2211 CD3 H H CD3 H H H
LA2212 CD3 H H H CD3