(19)
(11)EP 3 142 637 B1

(12)EUROPEAN PATENT SPECIFICATION

(45)Mention of the grant of the patent:
29.07.2020 Bulletin 2020/31

(21)Application number: 15725209.9

(22)Date of filing:  15.05.2015
(51)International Patent Classification (IPC): 
A61K 8/362(2006.01)
A61K 8/41(2006.01)
A61Q 5/10(2006.01)
A61K 8/46(2006.01)
A61Q 5/12(2006.01)
A61Q 5/08(2006.01)
A61K 8/36(2006.01)
(86)International application number:
PCT/US2015/031166
(87)International publication number:
WO 2015/175986 (19.11.2015 Gazette  2015/46)

(54)

KERATIN TREATMENT FORMULATIONS AND METHODS

KERATINBEHANDLUNGSFORMULIERUNGEN UND VERFAHREN

COMPOSITIONS DE TRAITEMENT DE LA KÉRATINE ET PROCÉDÉS ASSOCIÉS


(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)Priority: 16.05.2014 US 201461994709 P

(43)Date of publication of application:
22.03.2017 Bulletin 2017/12

(60)Divisional application:
20178358.6

(73)Proprietor: Olaplex, Inc.
Boston, MA 02199 (US)

(72)Inventors:
  • PRESSLY, Eric, D.
    Santa Barbara, CA 93108 (US)
  • HAWKER, Craig, J.
    Santa Barbara, CA 93108 (US)

(74)Representative: Potter Clarkson 
The Belgrave Centre Talbot Street
Nottingham NG1 5GG
Nottingham NG1 5GG (GB)


(56)References cited: : 
EP-A1- 2 295 029
WO-A2-2012/080321
KR-A- 20030 003 970
US-A- 4 532 950
US-A1- 2008 187 506
WO-A1-2015/017768
GB-A- 773 559
US-A- 4 425 132
US-A1- 2008 141 468
  
  • DATABASE GNPD [Online] MINTEL; 1 June 2003 (2003-06-01), XP002743522, Database accession no. 10141004
  • DATABASE GNPD [Online] MINTEL; 1 May 2013 (2013-05-01), XP002743523, Database accession no. 2061070
  • Michelle: "How does olaplex hair treatment work?", Lab Muffin, 13 April 2015 (2015-04-13), XP055344143, Retrieved from the Internet: URL:http://www.labmuffin.com/how-does-olap lex-hair-treatment-work/ [retrieved on 2017-02-09]
  • Beauty Launch Pad: "The power of one", , 1 May 2014 (2014-05-01), XP055372151, Retrieved from the Internet: URL:http://www.nxtbook.com/nxtbooks/creati veaqe/launchpad 201405/index.php?startid=40 [retrieved on 2017-05-12]
  • Posts: "Facebook Mentions", , 1 April 2014 (2014-04-01), XP055372154, Retrieved from the Internet: URL:https://www.facebook.com/olaprex/posts [retrieved on 2017-05-12]
  
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).


Description

FIELD OF THE INVENTION



[0001] The present invention generally relates to formulations and methods for reducing or preventing damage to the hair when treating hair with a first formulation formed by mixing bleach powder and developer.

BACKGROUND OF THE INVENTION



[0002] Hair coloring is currently a globally accepted fashion phenomenon. Color treatments include hair coloring, highlighting, and bleaching. Many hair coloring formulations use reducing agents to break the disulfide bonds in the hair allowing deeper penetration of bleaching agents into the hair.

[0003] Thioglycolic acid, particularly as the ammonium salt, is often used to cleave the cysteine disulfide bonds present in hair. Sodium bisulfite is another example of a known reducing agent commonly used in various dyes and bleaching agents in color treatments.

[0004] Typically, oxidation to restore the reduced bond is partially obtained when an oxidizing agent, such as hydrogen peroxide is present in a coloring formulation and/or by exposing the hair to atmospheric oxygen. However, this oxidation step can be very slow and can leave the hair frizzy and damaged.

[0005] Similarly, hair undergoing a permanent wave treatment is typically treated with a reducing agent followed by an oxidizing agent. Hydrogen peroxide is optionally added in a second step to restore the hair to its prior state. The newly formed disulfide bonds of the treated hair are under stress to maintain the hair's new shape; thus, they break easily resulting in a reversion of the hair style over time.

[0006] The use of peroxides in the hair styling process can result in damaged hair, removal of non-natural color from the hair, and/or leave the hair frizzy. Furthermore, some latent reduced thiols may remain in the hair even after oxidative treatment. Hair styling treatments with peroxides involve the following reaction with thiol groups:

        2 K-S-H + H2O2 → K-S-S-K + 2 H2O     (Reaction I)

where K represents keratin in the hair.

[0007] In the case where two K-S-H groups are not present for Reaction I to take place, it is believed that the following reaction takes place, which results in damaged hair:

        K-S-H + H2O2 → K-SO2-OH     (Reaction II).

KR20030003970 describes an oxidative hair dye composition comprising one or more dye precursors and a maleic acid derivative. WO2015017768 describes the use of binding agents having a structure according to Formula I: wherein A, B, C, and D are reactive moieties containing one or more charges, R is a linker that contains two or more charges, wherein the charges are opposite to the charges on the reactive moieties, and each occurrence of p, q, r, and s is independently an integer from 0 to 25, preferably from 0 to 10, more preferably from 0 to 2 and the sum of p + q + r + s is equal to or greater than 2 to treat hair.



[0008] It is an object of the present invention to provide methods for using formulations that repair and/or strengthen hair during treatments using a formulation formed by mixing bleach powder and developer.

[0009] There is also a need for hair formulations and treatments that can repair latent reduced thiols present in hair.

[0010] There is also a need for formulations and treatments that can repair damage to keratin present in hair.

[0011] There is a need provide improved formulations and methods for repairing and/or strengthening damaged hair.

[0012] There is a need to provide methods for using formulations that repair and/or strengthen hair after and/or during colouring treatments.

SUMMARY OF THE INVENTION



[0013] The present invention provides a method for reducing or preventing damage to the hair when treating hair with a first formulation formed by mixing bleach powder and developer, the method comprising:
  1. (a) mixing a bleach powder and a developer to form the first formulation;
  2. (b) applying the first formulation to the hair; and
  3. (c) applying to the hair a second formulation comprising an active agent, wherein the active agent is

    and wherein step (b) occurs simultaneously with step (c).


[0014] The present invention also provides the use of an active agent which is

simultaneously with a formulation formed by mixing bleach powder and developer to reduce or prevent hair damage due to a treatment with the formulation.

[0015] Formulations, kits, and methods for restoring hair that has been broken during a treatment with a formulation formed by mixing bleach powder and developer are disclosed. The formulations have similar benefits when used with different color chemical processes, such as bleaching, highlights, lowlights, semi-permanent, demi-permanent, and permanent color.

[0016] The methods disclosed herein use active agents to repair the hair; these active agents are washed from the individual's hair on the same day that they are applied to the hair. Under the same conditions, such as temperature and moisture, hair treated with the formulations disclosed herein takes a longer time to revert to its prior state as compared to the same hair that is treated with hydrogen peroxide.

[0017] The formulation is applied at the same time as the formulation formed by mixing bleach powder and developer.

DETAILED DESCRIPTION OF THE INVENTION


I. Definitions



[0018] The term "hair" refers to one or more than one strand of hair, as well as the natural components of hair, such as oil from a body. Hair also refers to virgin hair or processed hair, for example hair that has been exposed to hair waving or hair straightening formulations.

[0019] "Pharmaceutically acceptable" and "cosmetically acceptable" are used interchangeably and refer to those compounds, materials, and/or formulations, which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problems or complications commensurate with a reasonable benefit/risk ratio. More specifically, pharmaceutically acceptable refers to a material, compound, or formulation that is suitable for use in contact with the skin, scalp, or hair. Pharmaceutically acceptable materials are known to those of ordinary skill in the art.

[0020] "Shampoo", as used herein, generally refers to a liquid or semi-solid formulation applied to hair that contains detergent or soap for washing the hair.

[0021] "Conditioner", as used herein, generally refers to a formulation (e.g., liquid, cream, lotion, gel, semi-solid) applied to hair to soften the hair, smooth the hair, and/or change the sheen of the hair.

[0022] "Analog" and "derivative" are used herein interchangeably, and refer to a compound that possesses the same core as the parent compound, but differs from the parent compound in bond order, the absence or presence of one or more atoms and/or groups of atoms, or a combination thereof. The derivative can differ from the parent compound, for example, in one or more substituents present on the core, which may include one or more atoms, functional groups, or substructures. In general, a derivative can be formed, at least theoretically, from the parent compound via chemical and/or physical processes.

[0023] "Electrophilic group" or "electrophilic moiety" are used interchangeably and refer to one or more functional groups or moieties that have an affinity for or attract electrons.

[0024] "Nucleophilic group" or "nucleophilic moiety" are used interchangeably and refer to one or more functional groups or moieties that are electron rich and are capable of reacting with electrophilic groups.

[0025] "Michael acceptor", as used herein, is a species of electrophilic groups or moieties that participates in nucleophilic addition reactions. The Michael acceptor can be or can contain an α,β-unsaturated carbonyl-containing group or moiety, such as a ketone. Other Michael acceptors include pi-bonds, such as double or triple bonds conjugated to other pi-bond containing electron withdrawing groups, such as nitro groups, nitrile groups, and carboxylic acid groups.

[0026] "Carboxylic acid," as used in here refers to the group -COOH. Unless specified otherwise the term carboxylic acid embraces both the free acid and carboxylate salt.

[0027] "Water-soluble", as used herein, generally means at least 50, 75, 100, 125, 150, 200, 225, or 250 g is soluble in 1L of water at 25°C.

II. Formulations



[0028] The formulations and methods disclosed herein are concerned with treating keratin in hair. The formulations may reduce or prevent hair damage due to bleaching processes.

A. Formulations



[0029] The formulations contain maleic acid (also referred to herein as "active agent").

[0030] The active agent can be combined with one or more pharmaceutically acceptable carriers and/or excipients that are considered safe and effective to human hair and/or human scalp, and may be administered to an individual's hair without causing undesirable biological side effects, such as burning, itching, and/or redness, or similar adverse reactions. The formulations may further contain an excipient that renders the formulations neutral pH, or a pH ranging from about pH 3 to about pH 12, preferably from pH 5 to pH 8.

[0031] The active agent is typically present in an amount ranging from about 0.01 wt% to about 50 wt% of the formulation, preferably from about from about 1 wt% to about 25 wt% of the formulation, more preferably from about 1 wt% to about 15 wt%, most preferably from about 1 wt% to about 10 wt%. Typically, the active agent may be present in an amount ranging from about 0.5 to about 3 wt% of the formulation, or from about 1 to about 3 wt% of the formulation.

[0032] The active agent is stable in aqueous solution for a period of at least 2, 3, 4, 5, 6, 8, 9, 10, 11, or 12 months or longer at pH of 6 to 8 and a temperature of about 25-30°C, preferably about 25°C. "Stable" as used herein with respect to shelf-life means that at least 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, or 95% of the compound is unchanged over the specified period.

a. Active Agents



[0033] The active agent is


b. Excipients



[0034] The formulations typically contain one or more cosmetically acceptable excipients. Cosmetically acceptable excipients include, but are not limited to preservatives, antioxidants, chelating agents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubricants, butters, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, film formers, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusting agents (e.g. citric acid), neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, absorbents, and combinations thereof.

[0035] The formulations typically contain at least two cosmetically acceptable excipients. In some forms, the formulations contain the active agent, water, and optionally a preservative and/or fragrance.

[0036] The formulation for treating hair may be in any suitable physical form. Suitable forms include, but are not limited to low to moderate viscosity liquids, lotions, milks, mousses, sprays, gels, creams, shampoos, conditioners, and the like. Suitable excipients, such as those listed above, are included or excluded from the hair care formulation depending on the form of use of the formulation (e.g., hair spray, cream, conditioner, or shampoo).

[0037] The pharmaceutical excipient is typically present in an amount ranging from about 10 wt% to about 99.99 wt% of the formulation, preferably about 40 wt% to about 99 wt%, more preferably from about 80 wt% to about to about 99 wt%.

i. Surfactants



[0038] Surfactants are surface-active agents that are able to reduce the surface tension of water and cause the hair formulation to slip across or onto the skin or hair. Surfactants also include detergents and soap. The surfactants may be amphoteric, anionic, or cationic. Suitable surfactants that may be used in the formulation include, but are not limited to, 3-aminopropane sulfonic acid, almond amide, almond amidopropyl betaine, almond amidopropylamine oxide, aluminum hydrogenated tallow glutamate, aluminum lanolate, aminoethyl sulfate, aminopropyl lauryl glutamine, ammonium C12-15 alkyl sulfate, ammonium C12-15 pareth sulfate, ammonium C12-16 alkyl sulfate, ammonium C9-10 perfluoroalkylsulfonate, ammonium capryleth sulfate, ammonium capryleth-3 sulfate, ammonium monoglyceride sulfate, ammonium sulfate, ammonium isothionate, ammonium cocoyl sarcosinate, ammonium cumene sulfonate, ammonium dimethicone copolyol sulfate, ammonium dodecylbenzenesulfonate, ammonium isostearate, ammonium laureth sulfate, ammonium laureth-12 sulfate, ammonium laureth-5 sulfate, ammonium laureth-6 carboxylate, ammonium laureth-7 sulfate, ammonium laureth-8 carboxylate, ammonium laureth-9 sulfate, ammonium lauroyl sarcosinate, ammonium lauryl sulfate, ammonium lauryl sulfosuccinate, ammonium myreth sulfate, ammonium myristyl sulfate, ammonium nonoxynol-30 sulfate, ammonium nonoxynol-4 sulfate, ammonium oleate, ammonium palm kernel sulfate, ammonium polyacrylate, ammonium stearate, ammonium tallate, ammonium xylene sulfonate, ammonium xylene sulfonate, amp-isostearoyl gelatin/keratin amino acids/lysine hydroxypropyltrimonium chloride, amp-isostearoyl hydrolyzed collagen, apricot kernel oil PEG-6 esters, apricot amide, apricot amidopropyl betaine, arachideth-20, avocadamide, avocadamidopropyl betaine, babassuamide, babassuamidopropyl betaine, babassuamidopropylamine oxide, behenalkonium chloride, behenamide, behenamide, behenamidopropyl betaine, behenamine oxide, sodium laureth sulfate, sodium lauryl sulfate, a polyoxyether of lauryl alcohol or ceteareth-20, or combinations thereof.

[0039] Suitable anionic surfactants include, but are not limited to, those containing carboxylate, sulfonate and sulfate ions. Examples of anionic surfactants include sodium, potassium, ammonium of long chain alkyl sulfonates and alkyl aryl sulfonates such as sodium dodecylbenzene sulfonate; dialkyl sodium sulfosuccinates, such as sodium dodecylbenzene sulfonate; dialkyl sodium sulfosuccinates, such as sodium bis-(2-ethylthioxyl)-sulfosuccinate; and alkyl sulfates such as sodium lauryl sulfate. Cationic surfactants include, but are not limited to, quaternary ammonium compounds such as benzalkonium chloride, benzethonium chloride, cetrimonium bromide, stearyl dimethylbenzyl ammonium chloride, polyoxyethylene and coconut amine. Examples of nonionic surfactants include ethylene glycol monostearate, propylene glycol myristate, glyceryl monostearate, glyceryl stearate, polyglyceryl-4-oleate, sorbitan acylate, sucrose acylate, PEG-150 laurate, PEG-400 monolaurate, polyoxyethylene monolaurate, polysorbates, polyoxyethylene octylphenylether, PEG-1000 cetyl ether, polyoxyethylene tridecyl ether, polypropylene glycol butyl ether, Poloxamer® 401, stearoyl monoisopropanolamide, and polyoxyethylene hydrogenated tallow amide. Examples of amphoteric surfactants include sodium N-dodecyl-.beta.-alanine, sodium N-lauryl-β-iminodipropionate, myristoamphoacetate, lauryl betaine and lauryl sulfobetaine.

[0040] More than one surfactant may be included in the formulation.

[0041] The surfactants are optionally included in an amount ranging from about 0.1% to about 15% by weight of the formulation, preferably about 1% to about 10% by weight of the formulation.

ii. Emollients



[0042] Emollient refers to a material that protects against wetness or irritation, softens, soothes, coats, lubricates, moisturizes, protects, and/or cleanses the skin. Suitable emollients for use in the formulations include, but are not limited to, a silicone compound (e.g., dimethicone, cyclomethicone, dimethicone copolyol or a mixture of cyclopentasiloxane and dimethicone/vinyldimethicone cross polymer, cyclopentasiloxane polysilicone), polyols such as sorbitol, glycerin, propylene glycol, ethylene glycol, polyethylene glycol, caprylyl glycol, polypropylene glycol, 1,3-butane diol, hexylene glycol, isoprene glycol, xylitol; ethylhexyl palmitate; a triglyceride such as caprylic/capric triglyceride and fatty acid ester such as cetearyl isononanoate or cetyl palmitate. In a specific embodiment, the emollient is dimethicone, amidodimethicone, dimethiconol, cyclopentasiloxane, potassium dimethicone PEG-7 panthenyl phosphate, or combinations thereof. More than one emollient may be included in the formulation.

[0043] The emollient is optionally included in an amount ranging from about 0.5% to about 15% by weight of the formulation, preferably from about 1% to about 10% by weight of the formulation.

iii. Emulsifiers



[0044] The formulation may also contain one or more emulsifiers. Suitable emulsifiers include, but are not limited to, copolymers of an unsaturated ester and styrene sulfonate monomer, cetearyl alcohol, glyceryl ester, polyoxyethylene glycol ether of cetearyl alcohol, stearic acid, polysorbate-20, ceteareth-20, lecithin, glycol stearate, polysorbate-60, polysorbate-80, or combinations thereof. More than one emulsifier may be included in the formulation.

[0045] The emulsifier is optionally included in an amount ranging from about 0.05%-15% by weight of the formulation, preferably from about 0.1%-10% by weight of the formulation.

iv. Preservatives



[0046] One or more preservatives may be included in the formulation. Suitable preservatives include, but are not limited to, glycerin containing compounds (e.g., glycerin or ethylhexylglycerin or phenoxyethanol), benzyl alcohol, parabens (methylparaben, ethylparaben, propylparaben, butylparaben, isobutylparaben, etc.), sodium benzoate, ethylenediaminetetraacetic acid (EDTA), potassium sorbate, and/or grapefruit seed extract, or combinations thereof. More than one preservative may be included in the formulation. Other preservatives are known in the cosmetics industries and include salicylic acid, DMDM Hydantoin, Formaldahyde, Chlorphenism, Triclosan, Imidazolidinyl Urea, Diazolidinyl Urea, Sorbic Acid, Methylisothiazolinone, Sodium Dehydroacetate, Dehydroacetic Acid, Quaternium - 15, Stearalkonium Chloride, Zinc Pyrithione, Sodium Metabisulfite, 2-Bromo-2-Nitropropane, Chlorhexidine Digluconate, Polyaminopropyl biguanide, Benzalkonium Chloride, Sodium Sulfite, Sodium Salicylate, Citric Acid, Neem Oil, Essential Oils (various), Lactic Acid, and Vitamin E (tocopherol).

[0047] The preservative is optionally included in an amount ranging from about 0.1% to about 5% by weight of the formulation, preferably from about 0.3% to about 3% by weight of the formulation. Preferably, the formulations are paraben free.

v. Conditioning Agents



[0048] One or more conditioning agents may be included in the formulation. Suitable conditioning agents include, but are not limited to, silicone-based agents (e.g., silicone quaternium-8), panthenol, hydrolyzed wheat and/or soy protein, amino acids (e.g. wheat amino acids), rice bran wax, meadowfoam seed oil, mango seed oil, grape seed oil, jojoba seed oil, sweet almond oil, hydroxyethyl behenamidopropyl dimonium chloride, aloe leaf extract, aloe barbadensis leaf juice, phytantriol, panthenol, retinyl palmitate, behentrimonium methosulfate, cyclopentasiloxane, quaternium-91, stearamidopropyl dimethylamine, and combinations thereof.

[0049] The conditioning agent(s) is optionally included in an amount ranging from about 0.1% to about 5% by weight of the formulation, preferably from about 0.3% to about 3% by weight of the formulation.

vi. Diluents



[0050] Diluent, as used herein, refers to a substance(s) that dilutes the active agent. Water is the preferred diluent. The formulation typically contains greater than one percent (by wt) water, preferably greater than five percent (by wt) water, more preferably greater than 50% (by wt) water, and most preferably greater than 80% (by wt) water. Alcohols, such as ethyl alcohol and isopropyl alcohol, may be used at low concentrations (about 0.5% by weight of the formulation) to enhance hair penetration and/or reduce odor.

vii. Viscosity modifying agents



[0051] The formulations may contain one or more viscosity modifying agents, such as viscosity increasing agents. Classes of such agents include, but are not limited to, viscous liquids, such as polyethylene glycol, semisythetic polymers, such as semisynthetic cellulose derivatives, synthetic polymers, such as carbomers, poloxamers, and polyethyleneimines (e.g., PEI-10), naturally occurring polymers, such as acacia, tragacanth, alginates (e.g., sodium alginate), carrageenan, vegetable gums, such as xanthan gum, petroleum jelly, waxes, particulate associate colloids, such as bentonite, colloidal silicon dioxide, and microcrystalline cellulose, surfactants, such as PPG-2 hydroxyethyl coco/isostearamide, emulsifiers, such as disteareth-75 IPDI, and salts, such as sodium chloride, and combinations thereof.

viii. Antioxidants



[0052] The formulation may contain one or more antioxidants. Examples include, but are not limited to, tocopheryls, BHT, ascorbic acid, camellia sinensis leaf extract, ascorbyl palmitate, magnesium ascorbyl phosphate, carotenoids, resveratrol, triethyl citrate, arbutin, kojic acid, tetrahexydecyl ascorbate, superoxide dismutase, zinc, sodium metabisulfite, lycopene, ubiquinone, and combinations thereof.

ix. Opacifying agents



[0053] The formulation may contain one or more opacifying agents. Opacifying agents are added to the formulations to make it opaque. Suitable opacifying agents include, but are not limited to, glycol distearate and ethoxylated fatty alcohols.

c. Forms of the Formulation


i. Sprays



[0054] The formulation may be in the form of a spray. The spray typically includes the active agent and a cosmetically acceptable carrier. In some embodiments, the carrier is water or a water and alcohol mixture. The spray formulation optionally includes an antioxidant, sunscreen agent, vitamin, protein, peptide, plant extract, humectant, oil, emollient, lubricant, thickener, hair conditioning agent, polymer, and/or surfactant. Preferably, the spray formulation includes a preservative. In some embodiments, the formulation includes a fragrance. In some embodiments, the formulation includes a surfactant. In some embodiments, the formulation contains water, fragrance, a preservative, and an active agent. In some embodiments, the formulation contains water, fragrance, a preservative, and an active agent. In some embodiments, the formulation contains water, a preservative, fragrance, an active agent, and an anti-static agent. In some embodiments, the formulation contains water, a preservative, fragrance, an active agent, and a hair conditioning agent. In some embodiments, the formulation contains water, a preservative, fragrance, an active agent, and a surfactant.

[0055] The hair spray formulations may be dispensed from containers that include aerosol dispensers or pump spray dispensers. Such dispensers are known in the art and are commercially available from a variety of manufacturers.

Propellant



[0056] When the hair spray formulation is dispensed from a pressurized aerosol container, a propellant may be used to force the formulation out of the container. Suitable propellants include, but are not limited to, a liquefiable gas or a halogenated propellant. Examples of suitable propellants include dimethyl ether and hydrocarbon propellants such as propane, n-butane, iso-butane, CFCs, and CFC-replacement propellants. The propellants may be used singly or admixed.

[0057] The amount of propellant may range from about 10% to about 60% by weight of the formulation. The propellant may be separated from the hair repair formulation as in a two compartment container. Other suitable aerosol dispensers are those characterized by the propellant being compressed air, which can be filled into the dispenser using a pump or equivalent device prior to use. Conventional non-aerosol pump spray dispensers, i.e., atomizers, may also be used to apply the formulation to the hair.

ii. Conditioners



[0058] The formulation may be in the form of a conditioner. The conditioner typically includes the active agent in a suitable carrier. Additionally, the conditioner may include cationic polymers derived from polysaccharides, for example cationic cellulose derivatives, cationic starch derivatives, cationic guar derivatives and cationic locust bean gum derivatives, synthetic cationic polymers, mixtures or combinations of these agents. The formulation may comprise other synthetic or natural polymers or polymers derived from biological preparation processes, which are functionalized, where appropriate, for example with cationic or neutral groups. These polymers may have a stabilizing or strengthening action on the formulation, and/or a conditioning action (deposition on the surface of the skin or the hair).

[0059] The active agent may be included in any suitable concentration. Typical concentrations of active agent in the conditioner range from small amounts such as approximately 0.01% (by wt), preferably at least 0.1% (by wt), to large amounts, such as up to 50% (by wt). Preferably the conditioner contains the active agent in a concentration ranging from 0.1% (by wt) to 5% (by wt), more preferably from 0.1% wt to 3% (by wt). While greater concentrations of active agent could be present in the conditioner, they are generally not needed to achieve the desired results.

iii. Shampoos



[0060] The hair repair formulation may be in the form of a shampoo. The shampoo typically includes the active agent in a suitable carrier. The active agent may be included in any suitable concentration. Typical concentrations of the active agent in the shampoo range from small amounts such as approximately 0.01% (by wt), preferably at least 0.1% (by wt), to large amounts, such as up to 50% (by wt). Preferably the shampoo contains the active agent in a concentration ranging from 0.1% (by wt) to 5% (by wt), more preferably from 0.1% (by wt) to 3% (wt). While greater concentrations of active agent could be present in the shampoo, they are generally not needed to achieve the desired results.

[0061] Additionally, the shampoo may include from about 0.5% to about 20% by weight of a surfactant material. Surfactants utilized in shampoo compositions are well-known in the art and are disclosed, for example, in U.S. Patent No. 6,706,258 to Gallagher et al. and U.S. Patent No. 7,598,213 to Geary et al.

iv. Creams, Lotions, Gels, and Polish



[0062] The hair, skin, or nail repair formulation may be in the form of a cream, lotion, gel, or polish. The cream, lotion, gel, or polish typically includes the active agent in a suitable carrier. The active agent may be included in any suitable concentration. Typical concentrations of the active agent in the cream, lotion, gel, or polish range from small amounts such as approximately 0.01% (by wt), preferably at least 0.1% (by wt), to large amounts, such as up to 50% (by wt). Preferably the cream or lotion contains the active agent in a concentration ranging from 0.1% (by wt) to 5% (by wt), more preferably from 0.1% (by wt) to 3% (by wt). While greater concentrations of active agent could be present in the cream or lotion, they are generally not needed to achieve the desired results.

[0063] Additionally, the formulation, depending on use, may include an oil, a hair conditioning agent, and/or a thickening agent. The cream, lotion, gel, or polish may also include a fragrance, a plant extract, and/or a surfactant. The cream, lotion, gel, or polish may be packaged in a tube, tub, bottle, or other suitable container.

v. Liquid Active Agent Formulations



[0064] In some embodiments, a liquid active agent formulation is provided, which is mixed at the time of use with a second formulation, such as a coloring or highlighting formulation. In these embodiments, the liquid active agent formulation may contain any suitable concentration of active agent in a suitable carrier, typically a diluent, such as described above. The concentration of the active agent is suitable to provide a mixture with the appropriate final volume and final concentration of active agent.

[0065] For example, a liquid active agent formulation can contain a concentration of active agent ranging from about 5% (by wt) to about 50% (by wt) or greater. In a preferred embodiment, the liquid active agent formulation contains about 20% (by wt) active agent.

[0066] For highlighting applications, prior to use, a sufficient volume of a liquid active agent formulation is mixed with a sufficient volume of a highlighting formulation to form a highlighting mixture having the desired concentration of active agent. Typical concentrations of the active agent in the highlighting mixture range from small amounts, such as approximately at least 0.01% (by wt), preferably at least 0.1% (by wt), to large amounts, such as up to 50% (by wt). Preferably the highlighting mixture contains the active agent in a concentration ranging from 0.1% (by wt) to 5% (by wt), more preferably from 0.1% (by wt) to 3% (wt). While greater concentrations of active agent could be present in the highlighting mixture, they are generally not needed to achieve the desired results.

III. Methods of Use


A. Treatment of hair with coloring agents


a. Apply the coloring formulation to the hair



[0067] The coloring formulation is generally applied to an individual's hair following normal hair coloring procedures that are known to those skilled in the art. The hair coloring formulation may be a highlighting formulation, such as formed by mixing bleach powder and developer.

[0068] The process may be followed by a shampoo and conditioning treatment, a neutralizing rinse or an acid balanced shampoo containing in addition to cationic or amphoteric surfactants, cation-active emollients and quarternary polymers. Alternately, the hair dying process may be followed by application of the active agent formulations described herein, before a shampoo and/or conditioning treatment.

b. Apply the active agent formulation to the hair



[0069] The active agent formulation is applied simultaneously with the hair coloring formulation. For example, the active agent formulation may be mixed with the hair coloring treatment and the mixture, containing both the active agent and the hair coloring treatment, may be applied to the hair.

[0070] Typically, the amount of active agent formulation (or a mixture of the active agent formulation and the hair coloring formulation) applied is sufficient to saturate the hair. The active agent may be applied to the hair as a single application, or application of the active agent may be repeated one or more times. Typically, the amount of active agent formulation applied in each application is sufficient to saturate the hair. The volume of active agent formulation applied to the hair in each application may be about 1 to about 100 mL per person depending on their length and volume of hair. In some embodiments, application of the active agent could be repeated immediately (e.g. within 10 to 15 seconds) or approximately 1, 5, 7.5, 10, 12.5, 15, 17.5, or 20 minutes after the first application.

[0071] The active agent can be rinsed and shampooed from the hair immediately following application, for example within 10, 15, 25, 30, 45, or 60 seconds, or two, three, four, or five minutes after application. Alternatively, the active agent may be rinsed from the hair within about 30 minutes following application, preferably between about 5 minutes and about 20 minutes, more preferably about 10 minutes after application of the active agent to the hair, depending on hair type.

[0072] If the active agent formulation is combined with the hair coloring treatment and applied as a mixture to the hair, then the mixture remains on the hair as long as needed for the hair coloring treatment. Typically the mixture is applied for approximately 10 minutes. The mixture is removed from the hair in accordance with standard methods for hair coloring treatments, e.g., rinse and shampoo, approximately 10 minutes after applying the mixture.

[0073] The active agent formulation is rinsed from the hair after its application. The hair may be rinsed and subsequently washed immediately (e.g. within 10 to 15 seconds following application) after the final application of the active agent. Preferably, the hair is rinsed and/or washed about 10 minutes or later after the final application of the active agent, such as about 15 minutes to about 30 minutes, optionally about 20 minutes after repeated application of the active agent to the hair.

[0074] The active agents are generally washed from the individual's hair on the same day as they are applied.

[0075] The formulation described herein improves hair quality, such as appearance (e.g., sheen) and feel, and decreases hair breakage when the hair is subjected to treatments, such as coloring.

[0076] In some embodiments, hair breakage decreases by 5, 10, 15, 20, 25, 30, 35, 40, 45, or 50% or higher after treatment with the active agent compared to untreated hair from the same individual. Hair breakage is a significant problem encountered during coloring and other treatments.

B. Reference - Chemical treatment of hair with a reducing agent



[0077] Prior to treatment with the active agent, the hair has been subjected to a reducing agent used for waving (also referred to herein as hair perming or permanent waves), and/or curling of the hair.

a. Apply a reducing agent to the hair



[0078] The first step in waving or curling hair is breaking the cysteine disulfide bonds to form free thiol moieties. The process for breaking the cysteine disulfide bonds is via application of a reducing agent. The process for applying the reducing agent involves following normal perming or hair straightening procedures that are known to those skilled in the art. For example, to perm hair, the hair is first washed and set on perm rods of various sizes. Second, a reducing agent, such as thioglycolate reducing solution or lotion is applied to the hair. The hair is allowed to set for a specified period of time, and then the thioglycolate solution is rinsed from the hair.

[0079] The application of hydrogen peroxide in this process is optional. In some processes, such as when treating previously chemically treated hair, hydrogen peroxide is generally not used. In other processes, such as when perming virgin hair, hydrogen peroxide may be added. In these processes, hydrogen peroxide is typically added after the reducing agent is rinsed out. Then the hydrogen peroxide is rinsed from the hair prior to adding the active agent.

b. Apply the active agent



[0080] Subsequent to the reducing treatment, one or more of the active agent, or a formulation thereof is applied to the hair. Although the agent is typically applied on the same day as treatment with the reducing agent, it may be applied later such as within 1 to 2 weeks following treatment with the reducing agent.

[0081] Typically, the amount of active agent formulation applied is sufficient to saturate the hair. The agent is generally rinsed and shampooed from the hair after the desired level of hair waving or curling is achieved. In some embodiments, the active agent is rinsed from the hair immediately (e.g. within 10, 15, 25, 30, 45, or 60 seconds following application) following the final application of the active agent. Alternatively the hair may be rinsed and washed about within about 30 minutes following application, preferably between about 5 minutes and about 20 minutes, more preferably about 10 minutes after the final application of the active agent to the hair, depending on the hair type. The active agent can be rinsed from the hair within 10, 15, 25, 30, 45, 60 seconds from the hair after application, and still achieve a desired level of hair waving or curling.

[0082] The active agent may be applied to the hair as a single application, or application of the agent may be repeated one or more times. Typically, the amount of active agent formulation applied in each application is sufficient to saturate the hair. In some situations, the volume of active agent formulation applied to the hair in each application is about 1 to about 10 mL per perm rod. In some situations, application of the active agent could be repeated immediately (e.g. within 10 to 15 seconds) or approximately 1, 5, 7.5, 10, 12.5, 15, 17.5, or 20 minutes after the first application. In some situations, the second application is about 7 minutes to about 10 minutes after the first application.

[0083] The active agent is rinsed from the hair after its application. The hair may be rinsed and washed immediately (e.g. within 10 to 15 seconds following application) after final application of the active agent.

[0084] Alternatively the hair may be rinsed and washed about 10 minutes or later after the final application of the active agent, such as about 15 minutes to about 30 minutes, preferably about 20 minutes after repeated application of the active agent to the hair.

[0085] The active agents are generally washed from the individual's hair on the same day as they are applied. In contrast, traditional perms which use only hydrogen peroxide (and do not involve the addition of the active agent) are generally not washed for at least 48 hours following application (washing the hair prior to 48 hours following a traditional permanent treatment may result in significant loss in the amount of curl in the hair and/or cause damage to the hair).

[0086] The formulations described herein can be applied to hair to improve hair quality, such as appearance (e.g., sheen) and feel, and decrease hair breakage when the hair is subjected to subsequent treatments, such as coloring.

[0087] In some uses, hair breakage decreases by 5, 10, 15, 20, 25, 30, 35, 40, 45, or 50% or higher after application of the active agent compared to untreated hair from the same individual. Hair breakage is a significant problem encountered during coloring and other treatments.

C. Reference - Treatment of skin or nails with the active agent



[0088] A formulation containing one or more of the active agents is applied to the skin or nails. Application of the active agent formulation to skin or nails can help repair damaged disulfide bonds due to natural wear and tear or natural aging.

[0089] The active agent formulation may be in the form of a cream or lotion, which is suitable for application to the skin or nails. Alternatively, the active agent formulation is in the form of a gel or polish, which is suitable for application to the nails. Typically, the amount of active agent formulation applied is sufficient to treat the damaged keratin in the skin or nails. The active agent formulation may be applied to the skin or nails in a single application, or application of the formulation may be repeated one or more times, as needed, to achieve the desired effect of repairing keratin damage and/or strengthening the skin or nails.

IV. Kit



[0090] Kits for treating hair are described. The kit may contain a first formulation for coloring hair. The kit also includes a second formulation containing an effective amount of the active agent.

[0091] The kit may further include a developer bottle, gloves, shampoo, conditioner, and/or an odor eliminator. Instructions for use of the kit are also typically provided.

[0092] Typically the kit contains more than one container (or more than one compartment in a given container) to ensure that the lightening agent (e.g., peroxides) is stored separately from the active agent.

a. First Formulation



[0093] The first formulation in the kit can be a coloring treatment.

b. Active agent formulation



[0094] The second formulation contains one or more active agents in an effective amount. Suitable formulations containing the active agents are discussed above. The second formulation may be in any suitable form. Suitable forms include, but are not limited to, low to moderate viscosity liquids, lotions, milks, mousses, sprays, gels, creams, shampoos, conditioners, and the like. The second formulation will be present in a suitable container, which depends on the form of the formulation.

[0095] In one embodiment, the active agent formulation is provided as two or more separate ingredients. For example, the active agent may be provided as a dry powder in a sealed package and the excipient provided in a vial or other container. A suitable mixing container for the active agent and the excipient may be provided.

[0096] In some embodiments, the active agent formulation (or second formulation) is mixed with the first formulation (or hair coloring treatment), and the mixture is applied to the hair.

c. Other materials in the kit



[0097] The kit optionally contains shampoos and conditioners. Suitable shampoos and conditioners include, but are not limited to LiQWd® Hydrating Shampoo and LiQWd® Hydrating Conditioner.

[0098] The kit may further contain an odor eliminator. The odor eliminator can be incorporated into the first or second formulation, or a mixture thereof. Alternately, the odor eliminator is present in a suitable container for use before or after washing the second formulation from the hair. Some suitable odor eliminators are known to those of ordinary skill in the art.

Examples


Reference Example 1: Color retention and texture of colored hair treated with the active agent formulation.


General



[0099] Three hair samples were obtained from a human subject and cut in ½ inch wide wefts.

[0100] Coloring formulation: The permanent hair coloring formulation was obtained from a L'Oreal® permanent hair coloring service (L'Oreal® Majirel permanent color #10 with 20 volume peroxide).

[0101] Active agent formulation: Maleic acid, at a concentration of 200 mg in 10 g total solution (water) was used.

Methods



[0102] The hair samples were washed with a clarifying shampoo then towel dried. The samples were then colored with the L'Oreal® permanent hair color service, which was left on the hair samples for approximately 35-40 minutes.

[0103] The first color treated hair sample ("control") was subsequently rinsed and washed with Liqwd® Hydrating Shampoo and Conditioner five times before being photographed.

[0104] The active agent formulation was applied to the second and third color treated hair samples via a spray bottle and massaging using the fingers. The active agent formulation was left on the second hair sample for a period of about 1 minute and on the third sample for a period of about 10 minutes. The hair samples were subsequently rinsed, and then washed with Liqwd® Hydrating Shampoo and Conditioner five times before being examined.

Results:



[0105] The hair samples treated with the active agent formulation showed better color retention, more shine, and less frizz than the control. The hair samples treated with the active agent formulation felt smoother to the touch and combined with the lower frizz and added sheen gave an overall healthier appearance over the control.

Reference Example 2: Comparison of color retention in traditionally permed hair and hair permed using the active agent formulations.


Method



[0106] A ½ inch wide weft of hair sample, obtained from a human subject, was washed with clarifying shampoo then towel dried. Ammonium thioglycolate or dithiothreitol was mechanically pulled through the hair with a wide and a fine toothcomb several times then left on the hair for 10 minutes to 1 hour. The hair was then rinsed for 30 seconds to 1 minute with water, and then towel dried.

[0107] The active agent formulation, described in Example 1 (Maleic acid in water), was then applied via a needle nose applicator drenching the hair and leaving it on for 7.5 minutes. This step was repeated, for a total of 15 minutes. The hair was then rinsed for 1-2 minutes, shampooed, and then conditioned with various salon shampoo and conditioner brands, including LiQWd® Hydrating Shampoo and Hydrating Conditioner.

[0108] A second sample of hair was straightened, as described above, but using hydrogen peroxide instead of the active agent formulation. The hair samples were washed and conditioned repeatedly.

Comparison of hair color:



[0109] After both hair samples were washed five times using LiQWd® Hydrating Shampoo and LiQWd® Hydrating Conditioner, the samples were examined for their color retention.

Results



[0110] The hair sample treated with the active agent formulation displayed a color closer in intensity to the hair sample prior to the first washing, compared to the hair treated with hydrogen peroxide.

Example 3: Comparison of hair treated with highlighting formulation applied simultaneously with active agent formulation and hair treated with highlighting formulation alone



[0111] The active agent formulation in Example 1 contained maleic acid at concentrations of 2.0 g in 10 g total solution (water).

[0112] Two swatches of human hair were tested. A sample was taken from the same head, 1 inch wide, and split in half. The color was medium brown and had been previously color treated with an unknown professional hair color.

[0113] Swatch 1, 1/2 inch wide and 8 inches long, was lightened with traditional highlighting ingredients mixed with the active agent formulation. 1oz of Joico Verocolor Veroxide developer-20 volume was mixed with 1oz Joico Verolight powder bleach to form the highlighting formulation. Then 9mL of the active agent formulation was added to the highlighting formulation to form a mixture.

[0114] The mixture was applied on the Swatch 1 hair with an applicator brush as the hair lay on aluminum foil. The foil was then wrapped around the swatch and allowed to process for 35 minutes. The swatch was rinsed and shampooed one time.

[0115] Swatch 2, the control, 1/2 inch wide and 8 inches long, was lightened with traditional highlighting ingredients in the absence of the active agent formulation. 1oz of Joico Verocolor Veroxide developer-20 volume was mixed with 1oz Joico Verolight powder bleach to form a highlighting formulation with a creamy consistency.

[0116] The highlighting formulation was applied on the Swatch 2 hair with an applicator brush as the hair lay on aluminum foil. The foil was then wrapped around the swatch and allowed to process for 35 minutes. The swatch was rinsed and shampooed one time.

Results



[0117] A noticeable difference in hair quality between Swatch 1 and Swatch 2 was observed. Swatch 1 hair was softer, less frizzy, appeared hydrated, with more shine than the control, Swatch 2.

[0118] Both swatches were washed and conditioned 5 more times with the same noticeable benefits of Swatch 1 (treated with the mixture of highlighting formulation and active agent formulation) compared to the control, Swatch 2 (treated with highlighting formulation, alone).

Reference Example 4: Comparison of hair treated with bleaching formulation applied simultaneously with active agent formulation and hair treated with bleaching formulation alone


General



[0119] Two hair samples were obtained from a human subject and cut in ½ inch wide wefts.

Methods



[0120] 
  1. (1) 0.5 ounces of powder lightener (Clairol Professional, Basic White) and 0.5 ounces of conditioning cream developer (Redken, Blonde Icing) were combined to form a bleaching mixture. 3.5 g of 2-(methacryloyloxy)ethan-1-aminium (Z)-3-carboxyacrylate (12 wt % in water) was added to the bleaching mixture and thoroughly mixed with a brush.
  2. (2) The bleaching mixture prepared was brushed onto the swatches of hair with a brush in order to thoroughly coat the strands of hair. The mixture coated hair was wrapped in aluminum paper and allowed to stand under ambient conditions for a period of two hours.
  3. (3) After the two hour bleaching period the swatches of hair were washed with shampoo and the hair was subsequently allowed to air dry.

Results



[0121] A noticeable difference in hair quality between Swatch 1 and Swatch 2 was observed. Swatch 1 hair was demonstrated no discernible breakage, great feel, and a healthy appearance while the control (treated with bleaching formulation, alone) showed some breakage, had a rough feel, and was frayed with an unhealthy appearance.

Reference Example 5: Comparison of hair treated with bleaching formulation applied simultaneously with active agent formulation and hair treated with bleaching formulation alone


General



[0122] Two hair samples were obtained from a human subject and cut in ½ inch wide wefts.

Methods



[0123] 
  1. (1) 0.5 ounces of powder lightener (Clairol Professional, Basic White) and 0.5 ounces of conditioning cream developer (Redken, Blonde Icing) were combined to form a bleaching mixture. 3.5 g of prop-2-en-1-aminium (Z)-3-carboxyacrylate (10 wt% in water) was added to the bleaching mixture and thoroughly mixed with a brush.
  2. (2) The bleaching mixture prepared was brushed onto the swatches of hair with a brush in order to thoroughly coat the strands of hair. The mixture coated hair was wrapped in aluminum paper and allowed to stand under ambient conditions for a period of two hours.
  3. (3) After the two hour bleaching period the swatches of hair were washed with shampoo and the hair was subsequently allowed to air dry.

Results



[0124] A noticeable difference in hair quality between Swatch 1 and Swatch 2 was observed. Swatch 1 hair was demonstrated no discernible breakage, great feel, and a healthy appearance while the control (treated with bleaching formulation, alone) showed some breakage, had a rough feel, and was frayed with an unhealthy appearance.

Reference Example 6: Comparison of traditional perm versus perm using maleic acid


General



[0125] Hair samples were obtained from a human subject and cut in ½ inch wide wefts.

[0126] Reducing agents: Ammonium thioglycolate (ATG) was obtained from a permanent wave kit manufactured by Zotos. 300 mg of Dithiothreitol in a 10g solution was also used as the reducing agent.

[0127] Active agent formulation: Maleic acid at a concentration of 200 mg in 10 g total solution (water) was used.

Methods


Method for perming hair using the active agent



[0128] The hair was washed with clarifying shampoo, towel dried, and then rolled around a perm rod. Ammonium thioglycolate or dithiothreitol was then applied to the hair and left on the hair for 10 minutes to 1 hour. The hair was then rinsed for 30 seconds to 1 minute and then blotted dry with a towel.

[0129] The active agent formulation was applied to the hair, via a needle nose applicator, drenching the hair. The active agent formulation was left on the hair for a period of about 7.5 minutes. The hair was drenched for a second time with the active agent formulation and left for a second 7.5 minutes, for a total of 15 minutes. The hair was then rinsed with water for about 1-2 minutes then unrolled from the perm rods. After the hair was removed from the perm rods, the hair was shampooed and conditioned with various salon shampoo and conditioner brands, including LiQWd® Hydrating Shampoo and Hydrating Conditioner. The washing and drying steps were repeated 40 times.

[0130] A second portion of hair was permed as described above, except, hydrogen peroxide was used instead of the active agent formulation.

Results



[0131] Both perms (utilizing the active agent formulation or hydrogen peroxide) showed only slight reduction in the overall curl after 40 cycles of washing and drying with the same shampoo and conditioner. However, the appearance and texture of the perm using the active agent formulation showed more sheen and less frizz compared to the perm using hydrogen peroxide.

Reference Example 7: Comparison of hair breakage due to repeated application of traditional perm and the active agent formulation.


Methods



[0132] Two hair samples were obtained. Both samples were treated with dithiothreitol or ammonium thioglycolate as described in Example 4. One of the hair samples was subsequently treated with the active agent formulation (Maleic acid in water), while the other was neutralized with hydrogen peroxide. The process was completed the same day for the hair treated with the active agent formulation. The process was completed in three days with hydrogen peroxide (traditional perm).

[0133] The procedure was repeated three times for each hair sample over a 48 hour time period.

Results



[0134] Upon visual inspections, the second hair sample treated with the active agent formulation showed little or no signs of breakage. However, the first hair sample treated with hydrogen peroxide showed significant breakage.

Reference Example 8: Comparison of the extent of damage to hair previously relaxed with a Japanese relaxer


Methods



[0135] Two samples of hair, the first previously straightened with a Japanese relaxer (Yuko), and the second previously straightened with a no lye relaxer (African Pride Miracle Deep Conditioning) were obtained. The samples were treated as described in Examples 4 and 5 using the active agent formulation (Maleic acid in water).

[0136] Another hair sample, previously straightened with a no lye relaxer (African Pride Miracle Deep Conditioning) was obtained. The sample was treated with a traditional hair straightening perm (Zotos).

Results



[0137] The hair samples treated with the active agent formulation showed no noticeable damage. However, the sample treated with a traditional perm showed significant breaking, even during application.


Claims

1. A method for reducing or preventing damage to the hair when treating hair with a first formulation formed by mixing bleach powder and developer, the method comprising:

(a) mixing a bleach powder and a developer to form the first formulation;

(b) applying the first formulation to the hair; and

(c) applying to the hair a second formulation comprising an active agent, wherein the active agent is

and wherein step (b) occurs simultaneously with step (c).


 
2. A method according to claim 1, wherein the second formulation further comprises one or more cosmetically acceptable excipients selected from the group consisting of water, surfactants, vitamins, natural extracts, preservatives, chelating agents, perfumes, antioxidants, proteins, amino acids, humectants, fragrances, emollients, penetrants, thickeners, viscosity modifiers, hair fixatives, film formers, emulsifiers, opacifying agents, propellants, liquid vehicles, carriers, salts, pH adjusting agents, neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, and combinations thereof.
 
3. A method according to claim 2, wherein the one or more excipients are present in an amount ranging from 40 wt% to 99 wt% of the second formulation.
 
4. A method according to any one of the preceding claims, wherein the active agent is present in an amount ranging from 1 wt% to 25 wt% of the second formulation.
 
5. A method according to claim 4, wherein the active agent is present in an amount ranging from 1 wt% to 15 wt% of the second formulation.
 
6. A method according to claim 5, wherein the active agent is present in an amount ranging from 1 to 10 wt% of the second formulation.
 
7. A method according to any one of the preceding claims, wherein the second formulation has a pH in the range from 3 to 8.
 
8. A method according to any one of the preceding claims, wherein the second formulation is in the form of a liquid, a gel, a cream, or a lotion.
 
9. A method according to any one of claims 1 to 8, wherein the second formulation is an aqueous formulation.
 
10. A method according to any one of the preceding claims, further comprising: (d) rinsing, shampooing, and/or conditioning the hair, wherein step (d) occurs subsequent to step (c).
 
11. A method according to any one of the preceding claims, wherein the first formulation and the second formulation are mixed at the time of use and prior to application.
 
12. A method according to claim 11, wherein the active agent is present in an amount ranging from 0.1 wt% to 5 wt% of the mixture.
 
13. A method according to claim 12, wherein the active agent is present in an amount ranging from 0.1 wt% to 3 wt% of the mixture.
 
14. A method according to any one of the preceding claims, wherein the hair is human hair.
 
15. The use of an active agent which is

simultaneously with a formulation formed by mixing bleach powder and developer to reduce or prevent hair damage due to a treatment with the formulation.
 
16. The use of claim 15, wherein the active agent is present in an active agent formulation.
 
17. The use of claim 16, wherein the formulation formed by mixing bleach powder and developer and the active agent formulation are mixed before use to form a mixture.
 
18. The use of claim 17, wherein the active agent is present in an amount ranging from 0.1 wt% to 5 wt% of the mixture.
 
19. The use of claim 18, wherein the active agent is present in an amount ranging from 0.1 wt% to 3 wt% of the mixture.
 
20. The use of any one of claims 15 to 19, wherein the hair is human hair.
 
21. A use according to any one of claims 16 to 20 wherein the active agent formulation further comprises one or more cosmetically acceptable excipients selected from the group consisting of water, surfactants, vitamins, natural extracts, preservatives, chelating agents, perfumes, antioxidants, proteins, amino acids, humectants, fragrances, emollients, penetrants, thickeners, viscosity modifiers, hair fixatives, film formers, emulsifiers, opacifying agents, propellants, liquid vehicles, carriers, salts, pH adjusting agents, neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, and combinations thereof.
 
22. A use according to claim 21, wherein the one or more excipients are present in an amount ranging from 40 wt% to 99 wt% of the active agent formulation.
 
23. A use according to any one of claims 16 to 22, wherein the active agent is present in an amount ranging from 1 wt% to 25 wt% of the active agent formulation.
 
24. A use according to claim 23, wherein the active agent is present in an amount ranging from 1 wt% to 15 wt% of the active agent formulation.
 
25. A use according to claim 24, wherein the active agent is present in an amount ranging from 1 to 10 wt% of the active agent formulation.
 
26. A use according to any one of claims 16 to 25 wherein the active agent formulation has a pH in the range from 3 to 8.
 
27. A use according to any one of claims 16 to 26, wherein the active agent formulation is in the form of a liquid, a gel, a cream, or a lotion.
 
28. A use according to any one of claims 16 to 27, wherein the active agent formulation is an aqueous formulation.
 


Ansprüche

1. Verfahren zum Reduzieren oder Verhindern von Schäden am Haar, wenn das Haar mit einer ersten Formulierung behandelt wird, die durch Mischen von Bleichpulver und Entwickler gebildet wird, wobei das Verfahren umfasst:

(a) Mischen eines Bleichpulvers und eines Entwicklers, um die erste Formulierung zu bilden;

(b) Aufbringen der ersten Formulierung auf das Haar; und

(c) Aufbringen einer zweiten Formulierung auf das Haar, die einen Wirkstoff enthält, wobei der Wirkstoff

ist und wobei Schritt (b) gleichzeitig mit Schritt (c) stattfindet.


 
2. Verfahren nach Anspruch 1, wobei die zweite Formulierung ferner ein oder mehrere kosmetisch akzeptable Hilfsstoffe umfasst, ausgewählt aus der Gruppe bestehend aus Wasser, Tensiden, Vitaminen, natürlichen Extrakten, Konservierungsmitteln, Chelatbildnern, Parfüms, Antioxidantien, Proteinen, Aminosäuren, Feuchthaltemitteln, Duftstoffen, Weichmachern, Penetrationsmitteln, Verdickungsmitteln, Viskositätsmodifikatoren, Haarfixiermitteln, Filmbildnern, Emulgatoren, Trübungsmitteln, Treibmitteln, flüssigen Trägern, Trägerstoffen, Salzen, pH-Einstellmitteln, Neutralisationsmitteln, Puffern, Haarkonditionierungsmitteln, Anti-Statik-Mitteln, Anti-Frizz-Mitteln, Anti-Schuppen-Mitteln und Kombinationen davon.
 
3. Verfahren nach Anspruch 2, wobei der eine Hilfsstoff oder die mehreren Hilfsstoffe in einer Menge im Bereich von 40 Gew.-% bis 99 Gew.-% der zweiten Formulierung vorhanden sind.
 
4. Verfahren nach einem der vorhergehenden Ansprüche, wobei der Wirkstoff in einer Menge im Bereich von 1 Gew.-% bis 25 Gew.-% der zweiten Formulierung vorhanden ist.
 
5. Verfahren nach Anspruch 4, wobei der Wirkstoff in einer Menge im Bereich von 1 Gew.-% bis 15 Gew.-% der zweiten Formulierung vorhanden ist.
 
6. Verfahren nach Anspruch 5, wobei der Wirkstoff in einer Menge im Bereich von 1 Gew.-% bis 10 Gew.-% der zweiten Formulierung vorhanden ist.
 
7. Verfahren nach einem der vorhergehenden Ansprüche, wobei die zweite Formulierung einen pH-Wert im Bereich von 3 bis 8 aufweist.
 
8. Verfahren nach einem der vorhergehenden Ansprüche, wobei die zweite Formulierung in Form einer Flüssigkeit, eines Gels, einer Creme oder einer Lotion vorhanden ist.
 
9. Verfahren nach einem der Ansprüche 1 bis 8, wobei die zweite Formulierung eine wässrige Formulierung ist.
 
10. Verfahren nach einem der vorhergehenden Ansprüche, ferner umfassend:
(d) Spülen, Shamponieren und/oder Konditionieren des Haares, wobei Schritt (d) nach Schritt (c) erfolgt.
 
11. Verfahren nach einem der vorhergehenden Ansprüche, wobei die erste Formulierung und die zweite Formulierung zum Zeitpunkt der Verwendung und vor der Anwendung gemischt werden.
 
12. Verfahren nach Anspruch 11, wobei der Wirkstoff in einer Menge im Bereich von 0,1 Gew.-% bis 5 Gew.-% der Mischung vorliegt.
 
13. Verfahren nach Anspruch 12, wobei der Wirkstoff in einer Menge im Bereich von 0,1 Gew.-% bis 3 Gew.-% der Mischung vorliegt.
 
14. Verfahren nach einem der vorhergehenden Ansprüche, wobei das Haar menschliches Haar ist.
 
15. Verwendung eines Wirkstoffs, welcher

ist, gleichzeitig mit einer Formulierung, die durch Mischen von Bleichpulver und Entwickler gebildet wird, um Haarschäden aufgrund einer Behandlung mit der Formulierung zu verringern oder zu verhindern.
 
16. Verwendung nach Anspruch 15, wobei der Wirkstoff in einer Wirkstoffformulierung vorhanden ist.
 
17. Verwendung nach Anspruch 16, wobei die Formulierung vor der Verwendung durch Mischen von Bleichpulver und Entwickler und der Wirkstoffformulierung gebildet wird, um eine Mischung zu bilden.
 
18. Verwendung nach Anspruch 17, wobei der Wirkstoff in einer Menge im Bereich von 0,1 Gew.-% bis 5 Gew.-% der Mischung vorhanden ist.
 
19. Verwendung nach Anspruch 18, wobei der Wirkstoff in einer Menge im Bereich von 0,1 Gew.-% bis 3 Gew.-% der Mischung vorhanden ist.
 
20. Verwendung nach einem der Ansprüche 15 bis 19, wobei das Haar menschliches Haar ist.
 
21. Verwendung nach einem der Ansprüche 16 bis 20, wobei die Wirkstoffformulierung ferner einen oder mehrere kosmetisch akzeptable Hilfsstoffe umfasst, ausgewählt aus der Gruppe bestehend aus Wasser, Tensiden, Vitaminen, natürlichen Extrakten, Konservierungsmitteln, Chelatbildnern, Parfüms, Antioxidantien, Proteinen, Aminosäuren, Feuchthaltemitteln, Duftstoffen, Weichmachern, Penetrationsmitteln, Verdickungsmitteln, Viskositätsmodifikatoren, Haarfixiermitteln, Filmbildnern, Emulgatoren, Trübungsmitteln, Treibmitteln, flüssigen Trägern, Trägerstoffen, Salzen, pH-Einstellmitteln, Neutralisationsmitteln, Puffern, Haarkonditionierungsmitteln, Anti-Statik-Mitteln, Anti-Frizz-Mitteln, Anti-Schuppen-Mitteln und Kombinationen davon.
 
22. Verwendung nach Anspruch 21, wobei der eine Hilfsstoff oder die mehreren Hilfsstoffe in einer Menge im Bereich von 40 Gew.-% bis 99 Gew.-% der Wirkstoffformulierung vorhanden ist/sind.
 
23. Verwendung nach einem der Ansprüche 16 bis 22, wobei der Wirkstoff in einer Menge im Bereich von 1 Gew.-% bis 25 Gew.-% der Wirkstoffformulierung vorhanden ist.
 
24. Verwendung nach Anspruch 23, wobei der Wirkstoff in einer Menge im Bereich von 1 Gew.-% bis 15 Gew.-% der Wirkstofformulierung vorhanden ist.
 
25. Verwendung nach Anspruch 24, wobei der Wirkstoff in einer Menge im Bereich von 1 bis 10 Gew.-% der Wirkstoffformulierung vorhanden ist.
 
26. Verwendung nach einem der Ansprüche 16 bis 25, wobei die Wirkstoffformulierung einen pH-Wert im Bereich von 3 bis 8 aufweist.
 
27. Verwendung nach einem der Ansprüche 16 bis 26, wobei die Wirkstoffformulierung in Form einer Flüssigkeit, eines Gels, einer Creme oder einer Lotion vorliegt.
 
28. Verwendung nach einem der Ansprüche bis 16 bis 27, wobei die Wirkstoffformulierung eine wässrige Formulierung ist.
 


Revendications

1. Procédé pour réduire ou prévenir les dommages causés aux cheveux lors de leur traitement avec une première formulation obtenue par le mélange de la poudre de blanchiment et du révélateur, le procédé comprenant :

(a) le mélange d'une poudre de blanchiment et d'un révélateur pour obtenir la première formulation ;

(b) l'application de la première formulation sur les cheveux ; et

(c) l'application, sur les cheveux, d'une seconde formulation comprenant un agent actif, l'agent actif étant

et l'étape (b) se produisant simultanément avec l'étape (c).


 
2. Procédé selon la revendication 1, dans lequel la seconde formulation comprend en outre un ou plusieurs excipients cosmétiquement acceptables choisis dans le groupe constitué par de l'eau, des tensioactifs, des vitamines, des extraits naturels, des conservateurs, des agents chélateurs, des parfums, des antioxydants, des protéines, des acides aminés, des humectants, des fragrances, des émollients, des agents pénétrants, des épaississants, des modificateurs de viscosité, des fixateurs capillaires, des agents filmogènes, des émulsifiants, des agents opacifiants, des agents propulseurs, des véhicules liquides, des supports, des sels, des régulateurs de pH, des agents neutralisants, des tampons, des agents de traitement capillaire, des agents antistatiques, des agents anti-frisottis, des agents antipelliculaires et leurs combinaisons.
 
3. Procédé selon la revendication 2, dans lequel l'excipient ou les excipients sont présents en une quantité allant de 40 à 99 % en poids de la seconde formulation.
 
4. Procédé selon l'une quelconque des revendications précédentes, dans lequel l'agent actif est présent en une quantité allant de 1 à 25 % en poids de la seconde formulation.
 
5. Procédé selon la revendication 4, dans lequel l'agent actif est présent en une quantité allant de 1 à 15 % en poids de la seconde formulation.
 
6. Procédé selon la revendication 5, dans lequel l'agent actif est présent en une quantité allant de 1 à 10 % en poids de la seconde formulation.
 
7. Procédé selon l'une quelconque des revendications précédentes, dans lequel la seconde formulation a un pH dans la plage de 3 à 8.
 
8. Procédé selon l'une quelconque des revendications précédentes, dans lequel la seconde formulation est sous la forme d'un liquide, d'un gel, d'une crème ou d'une lotion.
 
9. Procédé selon l'une quelconque des revendications 1 à 8, dans lequel la seconde formulation est une formulation aqueuse.
 
10. Procédé selon l'une quelconque des revendications précédentes, comprenant en outre : (d) le rinçage, l'application de shampooing et/ou le traitement des cheveux, l'étape (d) se produisant après l'étape (c).
 
11. Procédé selon l'une quelconque des revendications précédentes, dans lequel la première formulation et la seconde formulation sont mélangées au moment de l'utilisation et avant l'application.
 
12. Procédé selon la revendication 11, dans lequel l'agent actif est présent en une quantité allant de 0,1 à 5 % en poids du mélange.
 
13. Procédé selon la revendication 12, dans lequel l'agent actif est présent en une quantité allant de 0,1 à 3 % en poids du mélange.
 
14. Procédé selon l'une quelconque des revendications précédentes, dans lequel les cheveux sont des cheveux humains.
 
15. Utilisation simultanée d'un agent actif

avec une formulation obtenue par le mélange de la poudre de blanchiment et du révélateur pour réduire ou prévenir les dommages causés aux cheveux en raison d'un traitement avec la formulation.
 
16. Utilisation selon la revendication 15, dans laquelle l'agent actif est présent dans une formulation d'agent actif.
 
17. Utilisation selon la revendication 16, dans laquelle la formulation est obtenue par le mélange de la poudre de blanchiment et du développeur et de la formulation d'agent actif, lesquels composants sont mélangés avant usage pour former un mélange.
 
18. Utilisation selon la revendication 17, dans laquelle l'agent actif est présent en une quantité allant de 0,1 à 5 % en poids du mélange.
 
19. Utilisation selon la revendication 18, dans laquelle l'agent actif est présent en une quantité allant de 0,1 à 3 % en poids du mélange.
 
20. Utilisation selon l'une quelconque des revendications 15 à 19, dans laquelle les cheveux sont des cheveux humains.
 
21. Utilisation selon l'une quelconque des revendications 16 à 20, dans laquelle la formulation d'agent actif comprend en outre un ou plusieurs excipients cosmétiquement acceptables choisis dans le groupe constitué par de l'eau, des tensioactifs, des vitamines, des extraits naturels, des conservateurs, des agents chélateurs, des parfums, des antioxydants, des protéines, des acides aminés, des humectants, des fragrances, des émollients, des agents pénétrants, des épaississants, des modificateurs de viscosité, des fixateurs capillaires, des agents filmogènes, des émulsifiants, des agents opacifiants, des agents propulseurs, des véhicules liquides, des supports, des sels, des régulateurs de pH, des agents neutralisants, des tampons, des agents de traitement capillaire, des agents antistatiques, des agents anti-frisottis, des agents antipelliculaires et leurs combinaisons.
 
22. Utilisation selon la revendication 21, dans laquelle l'excipient ou les excipients sont présents en une quantité allant de 40 à 99 % en poids de la formulation d'agent actif.
 
23. Utilisation selon l'une quelconque des revendications 16 à 22, dans laquelle l'agent actif est présent en une quantité allant de 1 à 25 % en poids de la formulation d'agent actif.
 
24. Utilisation selon la revendication 23, dans laquelle l'agent actif est présent en une quantité allant de 1 à 15 % en poids de la formulation d'agent actif.
 
25. Utilisation selon la revendication 24, dans laquelle l'agent actif est présent en une quantité allant de 1 à 10 % en poids de la formulation d'agent actif.
 
26. Utilisation selon l'une quelconque des revendications 16 à 25, dans laquelle la formulation d'agent actif a un pH dans la plage de 3 à 8.
 
27. Procédé selon l'une quelconque des revendications 16 à 26, dans lequel la formulation d'agent actif est sous la forme d'un liquide, d'un gel, d'une crème ou d'une lotion.
 
28. Utilisation selon l'une quelconque des revendications 16 à 27, dans laquelle la formulation d'agent actif est une formulation aqueuse.
 






Cited references

REFERENCES CITED IN THE DESCRIPTION



This list of references cited by the applicant is for the reader's convenience only. It does not form part of the European patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be excluded and the EPO disclaims all liability in this regard.

Patent documents cited in the description