(19)
(11)EP 3 158 073 B8

(12)CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15)Correction information:
Corrected version no 1 (W1 B1)

(48)Corrigendum issued on:
11.12.2019 Bulletin 2019/50

(45)Mention of the grant of the patent:
23.10.2019 Bulletin 2019/43

(21)Application number: 15810408.3

(22)Date of filing:  12.06.2015
(51)International Patent Classification (IPC): 
C12P 17/12(2006.01)
C12N 15/53(2006.01)
C12N 15/63(2006.01)
C12N 9/06(2006.01)
C12P 13/00(2006.01)
C12P 7/24(2006.01)
C12P 7/44(2006.01)
C12N 15/52(2006.01)
C12N 15/60(2006.01)
C12N 9/02(2006.01)
C12N 9/88(2006.01)
C12P 13/22(2006.01)
C12P 7/42(2006.01)
(86)International application number:
PCT/CA2015/050542
(87)International publication number:
WO 2015/192233 (23.12.2015 Gazette  2015/51)

(54)

COMPOSITIONS AND METHODS FOR MAKING (S)-NORCOCLAURINE AND (S)-NORLAUDANOSOLINE, AND SYNTHESIS INTERMEDIATES THEREOF

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HERSTELLUNG VON (S)-NORCOCLAURIN AND (S)-NORLAUDANOSOLIN UND SYNTHESEZWISCHENPRODUKTEN DAVON

COMPOSITIONS ET PROCÉDÉS DE FABRICATION (S)-NORCOCLAURINE ET (S)-NORLAUDANOSOLINE, ET INTERMÉDIAIRES DE SYNTHÈSE DE CELLES-CI


(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)Priority: 19.06.2014 US 201462014367 P

(43)Date of publication of application:
26.04.2017 Bulletin 2017/17

(73)Proprietor: Willow Biosciences Inc.
Calgary, AB T2L 1Y8 (CA)

(72)Inventor:
  • FACCHINI, Peter James
    Calgary, Alberta T3G 1W1 (CA)

(74)Representative: D Young & Co LLP 
120 Holborn
London EC1N 2DY
London EC1N 2DY (GB)


(56)References cited: : 
EP-A1- 2 169 075
WO-A1-2015/066642
WO-A2-2012/135389
EP-A1- 2 169 075
WO-A2-2008/067070
US-A1- 2007 298 481
  
  • KRISTY M HAWKINS ET AL: "Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae", NATURE CHEMICAL BIOLOGY, vol. 4, no. 9, 10 August 2008 (2008-08-10) , pages 564-573, XP055138483, ISSN: 1552-4450, DOI: 10.1038/nchembio.105
  • JUNG HYEOB ROH ET AL: "Purification, cloning, and three-dimensional structure prediction of Micrococcus luteus FAD-containing tyramine oxidase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICAT, ELSEVIER, AMSTERDAM, NL, vol. 268, no. 2, 16 February 2000 (2000-02-16), pages 293-297, XP008126682, ISSN: 0006-291X, DOI: 10.1006/BBC.2000.2113
  • NAKAGAWA, A. ET AL.: 'A bacterial platform for fermentative production of plant alkaloids''.' NATURE COMMUNICATIONS, [Online] vol. 2, no. 326, 2011, ISSN 2041-1723 XP055165160 ISSN: 2041-1723 Retrieved from the Internet: <URL:http://www. nature .com/ncomms/journal/v2/n5/full/ncomms1327.h tm1> [retrieved on 2015-08-04]
  • FACCHINI, P.J. ET AL.: 'Decreased cell wall digestibility in canola transformed with chimeric tyrosine decarboxylase genes from opium poppy''.' PLANT PHYSIOLOGY vol. 120, no. 3, 1999, ISSN 0032-0889 pages 653 - 664, XP055247488
  • HAGEL, J.M. ET AL.: 'Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world''.' PLANT CELL PHYSIOLOGY vol. 54, no. 5, 2013, ISSN 0032-0781 pages 647 - 672, XP055247491
  • ILARI, A. ET AL.: 'Structural basis of enzymatic (S)-norcoclaurine biosynthesis''.' JOURNAL OF BIOLOGICAL CHEMISTRY vol. 284, no. 2, 2009, ISSN 0021-9258 pages 897 - 904, XP055247494
  
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).