ISOMER-SELECTIVE SYNTHESIS OF METHANOFULLERENES

Description

FIELD OF THE INVENTION

[0001] The invention addresses the synthesis of specific isomers of methano-adducts of C₇₀ and higher fullerenes.

BACKGROUND OF THE INVENTION

[0002] Methanofullerenes such as phenyl-C₆₁-butyric acid methyl ester (PC₆₀BM) and phenyl-C₇₁-butyric acid methyl ester (PC₇₀BM) are widely used as electron acceptor materials in organic photovoltaic devices (OPV) and organic photodetectors (OPD) (G. Dennler et al., Adv. Mater. 2009, 21, 1-16; F. He and L. Yu., J. Phys. Chem. Lett. 2011, 2, 3102-3113; I. Etxebarria et al., Journal of Photonics for Energy 2015, 5, 057214).

[0003] The synthesis of methanofullerenes is most commonly based on [3+2] cycloadditions by the reaction of diazomethanes, diazoacetates, diazoamides or diazoketones (A. Hirsch and M. Brettreich, Fullerenes: Chemistry and Reactions, 2005, Wiley-VCH, ISBN: 3-527-60820-2, pp. 119ff). Also, cyclopropanation reactions by nucleophilic addition of deprotonated α-halo-esters or ketones have been used successfully (C. Bingel, Chem. Ber. 1993, 126, 1957-1959). It has been demonstrated that addition of unsymmetrically substituted diazoalkanes leads to two isomers, i.e., [5,6]fulleroids having an open C-C bond on the fullerene cage and [6,6]methanofullerenes (Hummelen et al., J. Org. Chem. 1995, 60, 532-538). While fulleroids are formed first, when submitted to heat or irradiation by light they convert quantitative to the latter, resulting in [6,6]methanofullerenes as the thermodynamically stable compound used for OPV and OPD applications (Hummelen et al., J. Org. Chem. 1995, 60, 532-538) (Kooistra et al., Org. Lett. 2007, 9, 551-554). An additional degree of complexity is reached when C₇₀ instead of C₆₀ is the reactant. Whereas C₆₀ contains only one type of 6-6 bond (a bond between two six membered rings), C₇₀ has four, leading to mixtures of regioisomers. Even larger numbers of different regioisomers are formed in the case of multiple (such as bis- and tris-) adducts. A general discussion of isomers among fullerene adducts in the case of fullerene larger than C₆₀ (such as C₇₀, C₇₆, C₇₈ and C₈₄) can be found in Thilgen et al. (Angew. Chem. Int. Ed. Engl. 1997, 36, 2268-2280.). A more specific description of isomers of phenyl-C₇₁-butyric acid methyl ester (PC₇₀BM) has been provided by Wienk et al. (Angew. Chem. Int. Ed. 2003, 42, 3371-3375, US 7,906,797 B2, US 8,481,996 B2). Using a [3+2] cycloaddition of substituted diazomethane (using tosylhydrazone as reactant), products were analyzed using ¹H NMR and ¹³C NMR. It was concluded that the major isomer (~ 85%) is the α-type compound formed by 1,3-dipolar addition to the most "polar" double bond (the C(8)-C(25) bond) yielding a chiral enantiomeric mixture. Two minor isomers (a combined proportion of ~ 15%) were also identified as achiral stereoisomeric "type" addends, in which the addend is bound to the C(9)-C(10) double bond (the second most "polar" C=C bond in the C₇₀ skeleton, after the C(8)-C(25) bond). For simplification, in this document, it will not be differentiated between the enantiomers of the α-isomer, which are referred to collectively as the "α-isomer" or "α-PC₇₀BM." Similarly, the two achiral isomers are not addressed individually, and they are collectively referred to as the "β-isomers" or "β-PC₇₀BM." The chromatographic separation of these isomers has been found to be extremely challenging and no viable preparative solution exists.

[0004] Reactions of semistabilized sulfur ylides generated in situ from corresponding sulfonium salts with C₇₀ have been investigated. Such synthetic approach has been initially reported by Ito et al. (Synlett. 2013, 24, 1988-1992; JP2014-034519A), who prepared dimethyl (5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate by bromination of methyl 5-phenylpentanoate at the benzyl position, followed by nucleophilic substitution of the bromide with dimethyl sulfide. After optimization of the reaction with C₆₀ resulting in [6,6]-Phenyl-C₆₁-butyric acid methyl ester (PC₆₀BM) without initial formation of the [5,6] isomer, the reaction was carried out with C₇₀, in o-dichlorobenzene (ODCB). [6,6] PC₇₀BM was obtained with 45% isolated yield and the products consisted of the same isomers having a similar component ratio (e.g., α:β 85:15) as in the conventional substituted diazoalkane addition approach by Wienk et al. (Angew. Chem. Int. Ed. 2003, 42, 3371-3375, US 7,906,797 B2, US 8,481,996 B2), e.g., 85:15.

[0005] While the reaction of C₇₀ with dimethyl (5-methoxy-5-oxo-1-phenylpentyl) sulfonium salt resulted in an isomeric mixture, reactions of dimethyl-sulfonium ylides with C₇₀ produced methanofullerenes of the type C₇₀CHCOR with regioselectivity (Wang et al., J. Org. Chem. 1996, 61, 5198-5199). In yet other instances, using the methyl-, iso-propyl-substituted sulfonium ylide of methyl 5-phenylpentanoate resulted in enrichment of α-PC₇₀BM to 95% (based on ¹H NMR spectroscopy)(JP2014-034519A).

[0006] No systematic correlation of the structure of the substituted sulfonium ylide and the extent of regioselectivity has been established.

SUMMARY

[0007] The regioselective synthesis of α-PC₇₀BR₃ is achieved by reaction of di-alkyl sulfonium salts (1) with C₇₀. Di-alkyl-(5-alkoxy-5-oxo-1-phenylpentyl) sulfonium salts I used for the isomer-selective synthesis of phenyl-C₇₁-butyric acid alkyl esters (PC₇₀BR₃) includes:

where R₁ and R₂ are each independently iso-propyl or sec-butyl;

where R₃ is selected from H, optionally substituted C₁-C₁₂ aliphatic wherein one or more carbon units, including terminal carbon, are optionally and independently replaced by - O-, -S-, carbonyl (-CO-), -CF₂-, thiophenyl, phenyl, pyridinyl or -NR_a-; optionally substituted C₃-C₁₂ cycloaliphatic wherein one or more carbon units are optionally and independently replaced by -O-, -S-, carbonyl (-CO-), -CF₂-, or NR_a; or optionally substituted aryl;

where R_a is independently selected from H, optionally substituted C₁-C₆ aliphatic; optionally substituted C₃-C₆ cycloaliphatic or optionally substituted phenyl;

where X is an anion selected from Br^-, I^-, Cl^-, F^-, BF₄^-, PF₆^-, SbF₆^-, AsF₆^-, OSO₂CH₃^-, OSO₂CF₃^-, OSO₂C₄F₉^-, OSO₂OCH₃^-, OCOCH₃^-, OCOCF₃^-, OSO₂(C₆H₄)CH₃^-, OSO₂(C₆H₄)CF₃^-, N(SO₂CF₃)₂^-, OSO₂CH₂CH₂CH₂CH₂SO₂O^-, OH^-, I₃^-, N(CN)₂^-, 7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonate, B(C₆H₅)₄^- or OSO₂OH^-.

[0008] In one or more embodiments R₁ and R₂ are both iso-propyl.

[0009] In one or more embodiments R₁ and R₂ are both sec-butyl.

[0010] In one or more embodiments R₁ is iso-propyl and R₂ is sec-butyl.

[0011] In one or more embodiments R₃ is selected from Hand C₁-C₁₂ alkyl.

[0012] In one or more embodiments R₃ is branched or straight C₁-C₆ alkyl.

[0013] In one or more embodiments R₃ is branched or straight C₆ alkyl.

[0014] In one or more embodiments wherein R₃ is n-hexyl.

[0015] In one or more embodiments one or more carbon units, including terminal carbon, are optionally and independently replaced by -O-.

[0016] In one or more embodiments R₃ is a glycolyl.

[0017] In one or more embodiments, R₃ is a polyglycolyl group with terminal OH group being optionally replaced by alkyl or alkoxy.

[0018] In one or more embodiments X is BF₄^-.

[0019] In one or more embodiments the reaction provides greater than 97% selectivity of the α-isomer.

[0020] In one or more embodiments the reaction provides greater than 97.5% selectivity of the α-isomer.

[0021] In one or more embodiments the reaction provides greater than 98 wt% selectivity of the α-isomer.

[0022] In one or more embodiments reacting includes reacting the fullerene C₇₀ and the dialkyl sulfonium tetrafluoroborate in the presence of a base.

[0023] In one or more embodiments the base comprises an organic base.

[0024] In one or more embodiments the base includes 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).

[0025] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid methyl ester (C₇₀-PCBR₃) comprising greater than 98 % of the α-isomer, wherein R₃ is selected from H, optionally substituted C₁-C₁₂ aliphatic wherein one or more carbon units, including terminal carbon, are optionally and independently replaced by -O-, -S-, carbonyl (-CO- ), -CF₂-, thiophenyl, phenyl, pyridinyl or -NR_a-; optionally substituted C₃-C₁₂ cycloaliphatic wherein one or more carbon units are optionally and independently replaced by -O-, -S-, carbonyl (-CO-), -CF₂-, or NR_a; or optionally substituted aryl. No post-synthesis enhancement of isomer is required.

[0026] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid methyl ester (C₇₀-PCBR₃) comprising greater than 99 % of the α-isomer, wherein R₃ is selected from H, optionally substituted C₁-C₁₂ aliphatic wherein one or more carbon units, including terminal carbon, are optionally and independently replaced by -O-, -S-, carbonyl - CO-), -CF₂-, thiophenyl, phenyl, pyridinyl or -NR_a-; optionally substituted C₃-C₁₂ cycloaliphatic wherein one or more carbon units are optionally and independently replaced by -O-, -S-, carbonyl (-CO-), -CF₂-, or -NR_a-; or optionally substituted aryl. No post-synthesis enhancement of isomer is required.

[0027] The [6,6]-Phenyl C₇₁ butyric acid alkyl derivative may be [6,6]-Phenyl C₇₁ butyric acid methyl ester.

[0028] In one or more embodiments, the reaction provides greater than 95% of the α-isomer.

[0029] In one or more embodiments, the reaction provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) comprising greater than 95% of the α-isomer.

Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) having greater than 97% of the α-isomer

Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) having greater than 98% of the α-isomer

[0030] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) having greater than 99% of the α-isomer.

[0031] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) having greater than 99.5% of the α-isomer.

[0032] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) having greater than 99.9% of the α-isomer.

[0033] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) having 97- 99.9% of the α-isomer.

[0034] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) having 98-99.5% of the α-isomer.

[0035] Although not claimed, the present disclosure provides [6,6]-Phenyl C₇₁ butyric acid alkyl ester (C₇₀-PCBR₃) is provided having greater than 97-99% of the α-isomer. The high α-isomer content is achieved by isomer-selective synthesis, without enhancement by separation or removal of the β-isomer.

[0036] As used herein the term "aliphatic" encompasses the terms alkyl, alkenyl, alkynyl, each of which being optionally substituted as set forth below.

[0037] As used herein, an "alkyl" group refers to a saturated aliphatic hydrocarbon group containing 1-12 (e.g., 1-8, 1-6, or 1-4) carbon atoms. In other embodiments, "alkyl" is a linear, cyclic or branched, saturated or unsaturated hydrocarbon. An alkyl group can be straight or branched. Examples of alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, n-heptyl, or 2-ethylhexyl. An alkyl group can be substituted (i.e., optionally substituted) with one or more substituents such as halo, phospho, cycloaliphatic [e.g., cycloalkyl or cycloalkenyl], heterocycloaliphatic [e.g., heterocycloalkyl or heterocycloalkenyl], aryl, heteroaryl, alkoxy, aroyl, heteroaroyl, acyl [e.g., (aliphatic)carbonyl, (cycloaliphatic)carbonyl, or (heterocycloaliphatic )carbonyl], nitro, cyano, amido [e.g., (cycloalkylalkyl)carbonylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkylalkyl)carbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino alkylaminocarbonyl, cycloalkylaminocarbonyl, heterocycloalkylaminocarbonyl, arylaminocarbonyl, or heteroarylaminocarbonyl], amino [e.g., aliphaticamino, cycloaliphaticamino, or heterocycloaliphaticamino], sulfonyl [e.g., aliphatic-SO₂], sulfinyl, sulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, carboxy, carbamoyl, cycloaliphaticoxy, heterocycloaliphaticoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroarylalkoxy, alkoxycarbonyl, alkylcarbonyloxy, or hydroxy. Without limitation, some examples of substituted alkyls include carboxyalkyl (such as HOOCalkyl, alkoxycarbonylalkyl, and alkylcarbonyloxyalkyl), cyanoalkyl, hydroxyalkyl, alkoxyalkyl, acylalkyl, aralkyl, (alkoxyaryl)alkyl, (sulfonylamino)alkyl (such as (alkyl-SO₂ -amino)alkyl), aminoalkyl, amidoalkyl, (cycloaliphatic)alkyl, or haloalkyl.

[0038] As used herein, an "alkenyl" group refers to an aliphatic carbon group that contains 2-12 (e.g., 2-12, 2-6, or 2-4) carbon atoms and at least one double bond. Like an alkyl group, an alkenyl group can be straight or branched. Examples of an alkenyl group include, but are not limited to allyl, isoprenyl, 2-butenyl, and 2-hexenyl. An alkenyl group can be optionally substituted with one or more substituents such as halo, phospho, cycloaliphatic [e.g., cycloalkyl or cycloalkenyl], heterocycloaliphatic [e.g., heterocycloalkyl or heterocycloalkenyl], aryl, heteroaryl, alkoxy, aroyl, heteroaroyl, acyl [e.g., (aliphatic) carbonyl, (cycloaliphatic)carbonyl, or (heterocycloaliphatic) carbonyl], nitro, cyano, amido [e.g., (cycloalkylalkyl) carbonylamino, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (heterocycloalkylalkyl)carbonylamino, heteroarylcarbonylamino, heteroaralkylcarbonylamino alkylaminocarbonyl, cycloalkylaminocarbonyl, heterocycloalkylaminocarbonyl, arylaminocarbonyl, or heteroarylaminocarbonyl,] amino [e.g., aliphaticamino, cycloaliphaticamino, heterocycloaliphaticamino, or aliphaticsulfonylamino], sulfonyl [e.g., alkyl-SO₂, cycloaliphatic-SO₂ , or aryl-SO₂ ], sulfinyl, sulfanyl, sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, carboxy, carbamoyl, cycloaliphaticoxy, heterocycloaliphaticoxy, aryloxy, heteroaryloxy, aralkyloxy, heteroaralkoxy, alkoxycarbonyl, alkylcarbonyloxy, or hydroxy.

[0039] As used herein, an "alkynyl" group refers to an aliphatic carbon group that contains 2-12 (e.g., 2-12, 2-6, or 2-4) carbon atoms and has at least one triple bond. An alkynyl group can be straight or branched. Examples of an alkynyl group include, but are not limited to, propargyl and butynyl. An alkynyl group can be optionally substituted with one or more substituents such as aroyl, heteroaroyl, alkoxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, aralkyloxy, nitro, carboxy, cyano, halo, hydroxy, sulfo, mercapto, sulfanyl [e.g., aliphaticsulfanyl or cycloaliphaticsulfanyl], sulfinyl [e.g., aliphaticsulfinyl or cycloaliphaticsulfinyl], sulfonyl [e.g., aliphatic-SO₂ , aliphaticamino-SO₂ , or cycloaliphatic-SO₂ ], amido [e.g., aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, cycloalkylaminocarbonyl, heterocycloalkylaminocarbonyl, cycloalkylcarbonylamino, arylaminocarbonyl, arylcarbonylamino, aralkylcarbonylamino, (heterocycloalkyl)carbonylamino, (cycloalkylalkyl)carbonylamino, heteroaralkylcarbonylamino, heteroarylcarbonylamino or heteroarylaminocarbonyl], urea, thiourea, sulfamoyl, sulfamide, alkoxycarbonyl, alkylcarbonyloxy, cycloaliphatic, heterocycloaliphatic, aryl, heteroaryl, acyl [e.g., (cycloaliphatic)carbonyl or (heterocycloaliphatic) carbonyl], amino [e.g., aliphaticamino], sulfoxy, oxo, carboxy, carbamoyl, (cycloaliphatic)oxy, (heterocycloaliphatic) oxy, or (heteroaryl)alkoxy.

[0040] As used herein, a "cycloaliphatic" group encompasses a "cycloalkyl" group and a "cycloalkenyl" group, each of which being optionally substituted as set forth below.

[0041] As used herein, a "cycloalkyl" group refers to a saturated carbocyclic mono- or bicyclic (fused or bridged) ring of 3-10 (e.g., 5-10) carbon atoms. Examples of cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, adamantyl, norbornyl, cubyl, octahydro-indenyl, decahydro-naphthyl, bicyclo[3.2.1]octyl, bicyclo[2.2.2] octyl, bicyclo[3.3.1]nonyl, bicyclo[3.3.2.]decyl, bicycle [2.2.2]octyl, adamantyl, or ((aminocarbonyl)cycloalkyl) cycloalkyl.

[0042] A "cycloalkenyl" group, as used herein, refers to a nonaromatic carbocyclic ring of 3-12 (e.g., 4-8) carbon atoms having one or more double bonds. Examples of cycloalkenyl groups include cyclopentenyl, 1,4-cyclohexa-di-enyl, cycloheptenyl, cyclooctenyl, hexahydro-indenyl, octahydronaphthyl, cyclohexenyl, cyclopentenyl, bicyclo[2.2.2]octenyl, or bicyclo [3.3.1]nonenyl.

[0043] A cycloalkyl or cycloalkenyl group can be optionally substituted with one or more substituents such as phosphor, aliphatic [e.g., alkyl, alkenyl, or alkynyl], cycloaliphatic, (cycloaliphatic) aliphatic, heterocycloaliphatic, (heterocycloaliphatic) aliphatic, aryl, heteroaryl, alkoxy, (cycloaliphatic) oxy, (heterocycloaliphatic)oxy, aryloxy, heteroaryloxy, (araliphatic)oxy, (heteroaraliphatic)oxy, aroyl, heteroaroyl, amino, amido [e.g., (aliphatic)carbonylamino, (cycloaliphatic)carbonylamino, ((cycloaliphatic)aliphatic) carbonylamino, (aryl)carbonylamino, (araliphatic)carbonylamino, (heterocycloaliphatic)carbonylamino, ((heterocycloaliphatic) aliphatic)carbonylamino, (heteroaryl) carbonylamino, or (heteroaraliphatic)carbonylamino], nitro, carboxy [e.g., HOOC , alkoxycarbonyl, or alkylcarbonyloxy], acyl [e.g., (cycloaliphatic)carbonyl, ((cycloaliphatic) aliphatic)carbonyl, (araliphatic)carbonyl, (heterocycloaliphatic) carbonyl, ((heterocycloaliphatic)aliphatic)carbonyl, or (heteroaraliphatic)carbonyl], cyano, halo, hydroxy, mercapto, sulfonyl [e.g., alkyl-SO₂ and aryl-SO₂, sulfinyl [e.g., alkyl-S(O)] sulfanyl [e.g., alkyl-S], sulfoxy, urea, thiourea, sulfamoyl, sulfamide, oxo, or carbamoyl.

[0044] As used herein, an "aryl" group used alone or as part of a larger moiety as in "aralkyl", "aralkoxy", or "aryloxyalkyl" refers to C₆-C₁₂ monocyclic (e.g., phenyl); bicyclic (e.g., indenyl, naphthalenyl, tetrahydronaphthyl, tetrahydroindenyl); and tricyclic (e.g., fluorenyl tetrahydxofluorenyl, or tetrahydxoanthracenyl, anthracenyl) ring systems in which the monocyclic ring system is aromatic or at least one of the rings in a bicyclic or tricyclic ring system is aromatic. The bicyclic and tricyclic groups include benzofused 2-3 membered carbocyclic rings. For example, a benzofused group includes phenyl fused with two or more C₄-C₈ carbocyclic moieties. An aryl is optionally substituted with one or more substituents including aliphatic [e.g., alkyl, alkenyl, or alkynyl]; cycloaliphatic; (cycloaliphatic) aliphatic; heterocycloaliphatic; (heterocycloaliphatic) aliphatic; aryl; heteroaryl; alkoxy; (cycloaliphatic) oxy; (heterocycloaliphatic)oxy; aryloxy; heteroaryloxy; (araliphatic)oxy; (heteroaraliphatic)oxy; aroyl; heteroaroyl; amino; oxo (on a non-aromatic carbocyclic ring of a benzofused bicyclic or tricyclic aryl); nitro; carboxy; amido; acyl [e.g., (aliphatic)carbonyl; (cycloaliphatic) carbonyl; ((cycloaliphatic)aliphatic)carbonyl; (araliphatic)carbonyl; (heterocycloaliphatic)carbonyl; ((heterocycloaliphatic) aliphatic)carbonyl; or (heteroaraliphatic) carbonyl]; sulfonyl [e.g., aliphatic-SO₂ or amino-SO₂ ;sulfinyl [e.g., aliphatic-S(O) or cycloaliphatic-S(O)]; sulfanyl [e.g., aliphatic-S]; cyano; halo; hydroxy; mercapto; sulfoxy; urea; thiourea; sulfamoyl; sulfamide; or carbamoyl. Alternatively, an aryl can be unsubstituted.

BRIEF DESCRIPTION OF THE DRAWING

[0045] The invention is described with reference to the following figures, which are presented for the purpose of illustration only and are not intended to be limiting of the invention.

FIG. 1 is an ¹H NMR of a concentrated sample (30 mg/mL) of α-PC₇₀BM in deuterated chloroform showing the full spectrum (above) and an enlarged view of trace region in the box (below), illustrating the presence of α-PC₇₀BM (3.65 ppm) and the β-PC₇₀BM impurity (3.72 ppm and 3.48 ppm). The abundance of α-PC₇₀BM is measured here to be 98.1% (3.65 ppm + 3.89 ppm + 3.40 ppm) taking into account the satellites signals for the α-PC₇₀BM methyl singlet (3.89 ppm and 3.40 ppm, indicating the natural occurrence of ¹³C).

FIG. 2 is an analytical HPLC chromatograph overlay of PC₇₀BM samples made using a range of precursors (R₁ = R₂ = isopropyl falling within the scope of the claims, the remaining precursors falling outside the scope of the claims), in which the leading shoulder is β-PC₇₀BM and the main signal is α-PC₇₀BM (Cosmosil Buckyprep material was used as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene was used as the mobile phase at 1 mL/min.).

FIG. 3 is a ¹H NMR spectrum of mixed PC₇₁BC₆ using conventional tosylhydrazone method (upper trace) and α-PC₇₁BC₆ using sulfonium reagent (lower trace) according to one or more embodiment of the invention.

FIG. 4 is an analytical HPLC chromatograph overlay of mixed PC₇₀BC₆ using conventional tosylhydrazone method (upper trace 400) and α-PC₇₀BC₆ using sulfonium reagent (lower trace 410) according to one or more embodiment of the invention. The leading shoulder is β-PC₇₀BC₆ and the main signal is α-PC₇₀BC₆ (Cosmosil Buckyprep material was used as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene was used as the mobile phase at 1 mL/min.).

FIG. 5 is an expanded view of ¹H NMR spectrum of FIG. 3 between 4.2-3.8 ppm of mixed PC₇₀BC₆ using conventional tosylhydrazone method (upper trace) and α- PC₇₀BC₆ using sulfonium reagent (lower trace) according to one or more embodiment of the invention.

DETAILED DESCRIPTION

[0046] Di-alkyl-(5-alkoxy-5-oxo-1-phenylpentyl) sulfonium salts I is used for the isomer-selective synthesis of phenyl-C₇₁-butyric acid alkyl esters (PC₇₀BR₃). The di-alkyl-(5-alkoxy-5-oxo-1-phenylpentyl) sulfonium salts I are defined in the claims.

[0047] In a particular embodiment, R₁ and R₂ are both iso-propyl. In a particular embodiment, R₁ is iso-propyl and R₂ is sec-butyl. In a particular embodiment, R₁ and R₂ are both sec-butyl.

[0048] In one or more embodiments, R₃ includes methyl.

[0049] In one or more embodiments, the di-alkyl-(5-alkoxy-5-oxo-1-phenylpentyl) can be compound Ia.

where R₁ and R₂ are iso-propyl.

[0050] In one or more embodiments, R₁ and R₂ are iso-propyl are preferred groups. Isopropyl has been identified as a substituent that provides enhanced isomer enrichment of the α- PC₇₀BR₃ product. Enhanced α- PC₇₀BR₃ can be obtained for a range of R₃ groups using Compound Ia.

[0051] In one or more embodiments R₃ is selected to impart desirable properties in the α-PC₇₀BR₃ product. For example, R₃ is selected for α- PC₇₀BR₃ products having enhanced photoactive properties, such as improved electron-accepting or -donating properties. In such embodiments, short chain alkyl groups can be used. In one or more embodiments, wherein R₃ is independently selected from Hand C₁-C₁₂ aliphatic. In one or more embodiments, wherein R₃ is independently selected from Hand C₁-C₁₂ alkyl. In one or more embodiments, wherein R₃ is C₁-C₆ alkyl. In one or more embodiments, wherein R₃ is C₆ alkyl.

[0052] In other examples, R₃ can be selected to improve solubility of the product α-PC₇₀BR₃ and to tailor the product α-PC₇₀BR₃ for improved solubility in selected solvents. Thus, where it is desirable to improve solubility in aromatic solvents, R₃ can be an optionally substituted alkyl groups (particularly C₆ and higher).

[0053] In other embodiments, where it is desirable to improve solubility in polar solvents, R₃ can be aliphatic or cycloaliphatic groups in which polar substituents are inserted in the R₃ backbone or as substituents.

[0054] In one or more embodiments, R₃ is optionally substituted branched or straight C₁-C₁₂ aliphatic wherein one or more carbon units, including terminal carbon, are optionally and independently replaced by -O-, -S-, carbonyl (-CO-), -CF₂-, thiophenyl, pyridinyl or -NR_a-.

[0055] In one or more embodiments, R₃ is optionally substituted branched or straight C₁-C₁₂ alkyl wherein one or more CH₂ units, including the terminal carbon, are optionally and independently replaced by -O-, -S-, carbonyl (-CO-), -CF₂-, thiophenyl, pyridinyl or -NR_a-.

[0056] In one or more embodiments, R₃ is optionally substituted branched or straight C₁-C₁₂ alkyl wherein one or more CH₂ units, including the terminal carbon, are replaced by -O-.

[0057] In one or more embodiments, in order to improve solubility in water and other polar solvents such as alcohols including but not limited to methanol, ethanol, n- and i-propanol, R₃ is a polyglycolyl group with terminal OH group being optionally replaced by alkyl or alkoxy. Polyglycolyl groups include but are not limited to polyethylene glycolyl and polypropylene glycolyl containing between 2 and 100 monomer units with 2 to 12 being preferred.

[0058] A synthetic path targeting selectively α-PC₇₀BR₃ (where R₃ is as described above) and specifically α-PC₇₀BM (where M is methyl) has been developed. In one or more embodiments, reaction of C₇₀ with sulfonium salts of the formula I and Ia provide α-PC₇₀BR₃ (where R₃ is as described above) and specifically α-PC₇₀BM with a selectivity of greater than 95%, 97% or higher, 98% or higher, 99% or higher, 99.5% or higher and as high as 99.9%. In one or more embodiments, reaction of C₇₀ with sulfonium salts of the formula I and Ia provide α-PC₇₀BR₃ (where R₃ is as described above) and specifically α-PC₇₀BM with a selectivity bounded by any of the values noted above.

[0059] Systematic investigation of the reaction of di-alky-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetraborates with C₇₀ was conducted. The abundance of the different isomers was assessed based on analytical HPLC using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase. For selected experiments, the isomer distribution was also determined by means of peak integration ¹H NMR of purified final products.

[0060] Correlations between the identity of the alkyl-groups R₁ and R₂ in di-alkyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborates and the relative abundance of α-PC₇₀BM compared to β-PC₇₀BM were found to be counterintuitive. For example, the α-to-β ratio decreased in changing from iso-propylmethyl- to iso-propylethyl-substitution, while the α-to-β ratio increased in changing from iso-propylethyl- to di-iso-propyl-substitution. While not being bound by any particular mode of operation, it is proposed that the presence of an alkyl substitution at the α-carbon position for both R₁ and R₂ increases the α-isomer selectivity of the reaction.

[0061] Di-alkyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborates were synthesized beginning with the bromination of methyl 5-phenylpentanoate followed by nucleophilic substitution of the bromide with the corresponding dialkyl sulfide in presence of silver tetrafluoroborate (Synlett. 2013, 24, 1988-1992.). The detailed experimental procedures are described below for the different examples.

[0062] Two different general schemes (Scheme 1 and Scheme 2), shown below, have been demonstrated for the synthesis of di-alkyl-(5-alkoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborates. In addition, other counter ions such as trifluoromethanesulfonate (triflate, CF₃SO₃^-) can be used. Also the use of different leaving groups which may or not become the ion can be envisioned.

[0063] "LG" = Leaving Group. "Ion" = Counter Ion. "LG" may or may not become "Ion". "Ion" may or may not derive from an additional reagent. In Scheme 1, nucleophilic substitution of the leaving group with dialkyl sulfide provides the desired sulfonium salt.

[0064] "LG" = Leaving Group. "Ion" = Counter Ion. "LG₁" can be the same as"LG₂". "LG₁" can be the same as "Ion". "LG₂" may or may not become "Ion". "Ion" may or may not derive from an additional reagent. In Scheme 2, nucleophilic substitution of the leaving group with an alkyl thiol to provide a thioether is followed by reaction with an alkylating reagent (and optionally other reagents) to obtain the desired sulfonium salt.

[0065] The leaving groups in Scheme 1 (LG) and 2 (LG1 and LG2) can be selected among -Br, -I, -Cl, -F, -BF₄, -PF₆, -SbF₆, -AsF₆, -OSO₂CH₃, -OSO₂CF₃, -OSO₂C₄F₉, - OSO₂OCH₃, -OCOCH₃, -OCOCF₃, -OSO₂(C₆H₄)CH₃, -OSO₂(C₆H₄)CF₃, -N(SO₂CF₃)₂, - OSO₂CH₂CH₂CH₂CH₂SO₂O-, -OH, -I₃, -N(CN)₂, 7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonate, -B(C₆H₅)₄ and -OSO₂OH. The counter ion (^-Ion) may be the same as one of leaving groups, except that it bears a negative charge.

[0066] The di-alkyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborates used as reactants are given in Table 1, together with the yield of their synthesis. Different from the other reactions, methyl, dodecyl functionalization has been carried out in two subsequent steps as described in JP2014-034519A beginning with the substitution of bromine by S-C₁₂H₂₅.

Table 1. Synthesis of Di-alkyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborates

Experiment n°	R1	R2	Yield of sulfonium salt synthesis (%)
1*	CH3	C12H25	66 (over two steps)
2*	CH3	i-C3H7	37
3	i-C3H7	i-C3H7	34
4*	C2H5	i-C3H7	41
5*	C12H25	C12H25	74
6	sec-butyl	sec-butyl	57

The experiment numbers having a * indicate examples falling outside the scope of what is claimed.

[0067] Subsequent reaction of di-alkyl-(5-alkoxy-5-oxo-1-phenylpentyl) sulfonium salts with C₇₀ to provide phenyl-C₇₁-butyric acid alkyl esters (PC₇₀BX) is shown in Scheme 3.

[0068] Reaction of di-alkyl-(5-alkoxy-5-oxo-1-phenylpentyl) sulfonium salts with C₇₀ to phenyl-C₇₁-butyric acid alkyl esters (PC₇₀BR₃); "Ion" = Counter Ion.

[0069] In one or more embodiments, the reaction is carried out at room temperature (or in slightly elevated temperatures up to ca. 40-50°C) in presence of base such as DBU (1,8-diazabicyclo[5.4.0]undec-7-ene), DBN (1,5-diazabicyclo[4.3.0]non-5-ene), DABCO (1,4-diazabicyclo(2.2.2)octane), pyridine, 2,6-dimethylpyridine, 2,4,6-trimethylpyridine, DMAP (dimethylaminopyridine), trimethylamine, triethylamine, Hunig's base (N,N-diisopropylethylamine), DMA (dimethylaniline), TMP (2,2,6,6-tetramethylpiperidine), PMP (1,2,2,6,6-pentamethylpiperidine), sodium borohydride, lithium aluminum hydride, sodium hydride, sodium methoxide, lithium methoxide, potassium methoxide, sodium t-butoxide, lithium t-butoxide, potassium t-butoxide, n-butyllithium, t-butyllithium, n-butylmagnesium chloride, t-butylmagnesium chloride, and LiHMDS (lithium hexamethyldisilazide).

[0070] In one or more embodiments, the reaction is conducted in an aromatic solvent, such as in o-dichlorobenzene (ODCB).

[0071] HPLC chromatograms of [6,6]-Phenyl C₇₁ butyric acid methyl ester produced using different dialkyl sulfonium salts shown in Table 1 in each of the examples are shown in FIG. 2. In addition, the chromatogram of the product mixture resulting from the currently best established synthesis based on the reaction of tosylhydrazone (a substituted diazoalkane) as described by Hummelen et al. (J. Org. Chem. 1995, 60, 532-538.) and Wienk et al. (Angew. Chem. Int. Ed. 2003, 42, 3371-3375, US 7,906,797 B2, US 8,481,996 B2) but using irradiation by light for the isomerization of fulleroid to methanofullerene (Kooistra et al., Org. Lett. 2007, 9, 551-554) is included as curve 600.

[0072] Assessing the results of Examples 1c, 2b, 3b, 4b and 5b below (curves 100, 200, 300, 400 and 500, respectively), it can be established that the identity of the alkyl-groups in the di-alkyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborates has an effect on the abundance of α-PC₇₀BM relative to β-PC₇₀BM. The conventional tosylhydrazone route (curve 600) yielded the expected α-to-β ratio of ca. 85:15, similar to that obtained using a dimethyl substituted sulfonium salt (Ito et al., Synlett. 2013, 24, 1988-1992; JP2014-034519A). Surprisingly, when both methyl groups are replaced by the more bulky dodecyl groups, the ratio of the obtained α-PC₇₀BM and β-PC₇₀BM (curve 500) is substantially unaffected. Based on a steric argument one would expect the dodecyl groups to enhance selectivity to produce more α-PC₇₀BM and less β-PC₇₀BM. It is similarly counterintuitive that the product obtained from the methyldodecyl sulfonium salt (curve 100) actually gives less selectivity (more β-PC₇₀BM), despite also being more bulky than the dimethyl sulfonium salt precursor. Investigating sulfonium salts substituted with at least one iso-propyl-substitution, it can be seen in FIG. 2 that the relative amount of β-PC₇₀BM decreases along the trend iso-propylethyl- > to iso-propylmethyl > di-iso-propyl, when dialkylsulfonium salts are used in the preparation of C₇₀PCBM. Thus, while the observed change in relative abundance from iso-propylethyl- to iso-propylmethyl sulfonium salts would suggest that decreased steric bulk enhances selectivity, the selectivity surprisingly is improved when di-iso-propyl sulfonium salt (with increased steric bulk) is used in the preparation of C₇₀PCBR₃ compounds.

[0073] While the assessment of the relative evolution of the α-to-β ratio by means of HPLC can be considered as being accurate, the determination of absolute values is more difficult, particularly due to incomplete separation of the peaks assigned to α- and β-PC₇₀BM. In an effort to determine the upper limit of the β-PC₇₀BM present, additional analytical HPLC using again a Buckyprep stationary phase but 4:1 cyclohexane:toluene for elution in order to increase the resolution of product of Example 3b was conducted. Peak integration showed the β-PC₇₀BM being at 1.2%. In order to increase even further the level of confidence of our purity assessment, ¹H NMR using a higher concentration of the analyzed PC₇₀BM (30 mg/mL in CDCl₃) was conducted for the product of Example 3b. The resulting ¹NMR spectrum is given in FIG. 1. FIG. 1 shows the ¹NMR spectrum of a concentrated sample (30 mg/mL) of α-PC₇₀BM (3.65 ppm) in deuterated chloroform. The full spectrum is shown first, followed by a larger image of the area shown in the box. Using the procedure described by Wienk et al. (Angew. Chem. Int. Ed. 2003, 42, 3371-3375), i.e., the integration of the three signals representing methoxy groups (3.48 ppm, 3.65 ppm, and 3.72 ppm, as reported by Wienk et al.) shows an area of ≤1.9% for signals representing β-PC₇₀BM. However, integration of the baseline at different points (for example ~3.55 ppm and -3.33 ppm) shows that the noise in proximity to the 3.65 ppm signal for the α-PC₇₀BM methyl singlet may be artificially inflating the measured abundance of β-PC₇₀BM. We therefore set 1.9% as the upper limit for the abundance of β-PC₇₀BM, however, the actual value can be less.

[0074] Integration of ¹H NMR peaks was reported by Wienk et al. (Angew. Chem. Int. Ed. 2003, 42, 3371-3375.) to show an abundance of α-PC₇₀BM of approximately 85% in the case of the tosylhydrazone approach whereas, using the same ¹H NMR analysis, reaction of C₇₀ with i-propylmethyl-substituted sulfonium salt resulted in 95.0% of α-PC₇₀BM. Finally, after reaction of di-iso-propyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate with C₇₀ using the conditions described in Example 3b, less than or equal to 1.9% β-PC₇₀BM could be identified my means of the same analytical approach, that is, greater than 98% α-isomer.

[0075] Examples 6a-6d demonstrate that α-PC₇₀BR₃, where R₃ is greater than methyl can be prepared at greater than 97% abundance according to one or more embodiments.

[0076] Examples provided herein demonstrate that sulfonium salts substituted with R₁ and R₂ (R₁, R₂: are the same or different), where R₁ and R₂ are independently -CR₄R₅R₆, wherein R₄, R₅, and R₆ are independently selected from H, or C₁-C₁₂ alkyl, and wherein for any one of R₁ and R₂ no more than one of R₄, R₅, and R₆ can be H, allow for isomer-selective [70]PCBR₃ formation.

[0077] The invention is described with reference to the following examples, which are presented for the purpose of illustration only and are not intended to be limiting of the invention.

Example 1a 5-dodecylthio-5-phenylpentanoic acid methyl ester (not within the scope of the claims)

[0078] 

[0079] To a clean, dry 250 mL round bottom flask was added a stir bar and 5.41 g (16.6 mmol, 3 eq) of cesium carbonate. The round bottom was sealed and purged three times with inert gas and vacuum. Anhydrous acetonitrile (27.7 mL) was added to the flask via syringe. The solution was cooled to 0°C, allowed to equilibrate for 15 minutes, and 1-dodecanethiol (3.975 mL, 3.36 g, 16.6 mmol, 3 eq) was added cautiously by syringe. Shortly thereafter, a solution of the bromide (1.5 g, 5.53 mmol, 1 eq) in 5.5 mL of anhydrous acetonitrile was added dropwise (over 30 minutes by syringe pump) with the reaction still at 0°C. Once the addition was complete and an additional 15 minutes had passed, the reaction was allowed to warm to room temperature for 5 hours. The reaction was then filtered and 277 mL of ethyl acetate was added to the filtrate. The organic later was washed with brine 3 times in a separatory funnel, dried with magnesium sulfate, filtered, and solvent was removed by rotary evaporation to give crude product. Silica gel chromatography was used with 9:1 hexane : ethyl acetate as eluent to isolate 1.52 g of the product (an oil which then solidified, 70% yield). ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.35-7.15 (m, 5H), 3.74 (t, J = 12.5 Hz, 1H), 3.64 (s, 3H), 2.35-1.1 (m, 28H), 0.88 (t, J = 11.0 Hz, 3H).

Example 1b Methyldodecyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate (2) (not within the scope of the claims)

[0080] 

[0081] To a clean, dry 50 mL round bottom flask was added a stir bar and 0.886 g (5.99 mmol, 1.5 eq) of trimethyloxonium tetrafluoroborate. The round bottom was sealed and purged three times with inert gas and vacuum. Anhydrous dichloromethane (6 mL) was added and the mixture was cooled to 0°C. To a second round bottom flask was added the thioether starting material. This flask was also sealed and purged three times with inert gas and vacuum. Anhydrous dichloromethane (10 mL) was added to the second flask by syringe, the thioether starting material was dissolved and the solution was taken back up into the same syringe. The solution containing the thioether starting material was then added dropwise by syringe pump to the flask containing the trimethyloxonium tetrafluoroborate over 30 minutes at 0°C. Once the addition was complete, plus an additional 15 minutes, the reaction was allowed to warm to room temperature for 4.5 hours. Dichloromethane was added and the reaction was extracted twice with water. The DCM layer was dried with magnesium sulfate, filtered, and solvent was removed by rotary evaporation to give 1.805 g (94.8% yield) of product. ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.55-7.4 (m, 5H), 4.97 (t, J = 13.0 Hz, 1H), 3.64 (s, 1.5H), 3.63 (s, 1.5H), 3.43 (t, J = 13.0 Hz, 1H), 3.26-3.14 (m, 0.5H), 3.04 (s, 1.5H), 2.87-2.74 (m, 0.5H), 2.56 (s, 1.5H), 2.43-1.05 (m, 26H), 0.87 (t, J = 11.3 Hz, 3H).

Example 1c [6,6]-Phenyl C₇₁ butyric acid methyl ester (not within the scope of the claims)

[0082] 

[0083] To a clean, dry 250 mL round bottom flask was added a stir bar, 59.3 mg (0.120 mmol, 1 eq) of the sulfonium salt 1, synthesized as described in JP2014-034519A, and 100.8 mg (0.120 mmol, 1 eq) of C₇₀. The round bottom was sealed and purged three times with inert gas and vacuum. 84 mL of ODCB (1,2-dichlorobenzene) anhydrous solvent was added by syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene, 0.0179 mL, 0.120 mmol, 1 eq) was added over 5 minutes at 0°C in 4 mL of anhydrous ODCB via syringe. The reaction was allowed to warm slowly with stirring overnight to room temperature. The abundance of α-PC₇₀BM was qualitatively determined to be <85% based on analytical HPLC using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase.

Example 2a Methyl-i-propyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate (2) (not within the scope of the claims)

[0084] 

[0085] To a clean, dry 50 mL round bottom flask was added a stir bar and 1 g (3.69 mmol, 1 eq) of the bromide. The round bottom was sealed and purged three times with inert gas and vacuum. Dichloromethane (4 mL) and methyl isopropyl sulfide (0.998 g, 1.2 mL, 11.1 mmol, 3 eq) were added to the flask sequentially via syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. Silver tetrafluoroborate (718 mg, 3.69 mmol, 1 eq) was added and the reaction was stirred for 4 hours while warming to room temperature slowly. During this time, the reaction was kept in the dark. Dichloromethane was added and the reaction was extracted twice with water. The DCM layer was dried with magnesium sulfate, filtered, and solvent was removed by rotary evaporation. The crude product was taken up in ethyl acetate and loaded onto a small column which was then flushed with copious ethyl acetate to remove impurities. Product was then eluted with acetone. The acetone was removed by rotary evaporation and a small amount of DCM was added to precipitate silica gel that had come through with the acetone. The DCM was filtered to remove silica gel and once again the solution was rotary evaporated to dryness. 500 mg of product was obtained (37% yield). ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.55-7.4 (m, 5H), 4.92 (t, J = 13.0 Hz, 0.5H), 4.82 (t, J = 13.0 Hz, 0.5H), 3.94 (septet, J = 11.3 Hz, 0.5H), 3.63 (s, 1.5H), 3.62 (s, 1.5H), 3.31 (septet, J = 11.5 Hz, 0.5H), 3.01 (s, 1.5H), 3.47 (s, 1.5H), 2.45-2.1 (m, 4H), 1.75-1.4 (m, 2H), 1.65 (d, J = 11.5 Hz, 1.5H), 1.57 (d, J = 11.5 Hz, 1.5H), 1.40 (d, J = 11.5 Hz, 1.5H), 1.28 (d, J = 11.5 Hz, 1.5H).

Example 2b [6,6]-Phenyl C₇₁ butyric acid methyl ester (not within the scope of the claims)

[0086] 

[0087] To a clean, dry 250 mL round bottom flask was added a stir bar, 44.2 mg (0.120 mmol, 1 eq) of the sulfonium salt (2), synthesized as described in JP2014-034519A, and 100.8 mg (0.120 mmol, 1 eq) of C₇₀. The round bottom was sealed and purged three times with inert gas and vacuum. 84 mL of ODCB (1,2-dichlorobenzene) anhydrous solvent was added by syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene, 0.0179 mL, 0.120 mmol, 1 eq) was added over 5 minutes at 0°C in 4 mL of anhydrous ODCB via syringe. The reaction was allowed to warm slowly with stirring overnight to room temperature. The reaction mixture was rotary evaporated to a small volume of ODCB and subjected to chromatography (silica gel, ODCB to elute C₇₀, followed by toluene to collect PC₇₀BM). The PC₇₀BM solution was concentrated to a small volume. PC₇₀BM was then precipitated in methanol and isolated by filtration to obtain 60 mg of material (48% crude yield). The abundance of α-PC₇₀BM (desired product, depicted) was determined to be 95.0% based on NMR analysis. ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.95-7.40 (m, 5H), 3.75 (β, s, 0.08H), 3.68 (α, s, 2.85H), 3.51 (β, s, 0.07H), 2.53-2.40 (m, 4H), 2.27-2.02 (m, 6H). This abundance was qualitatively corroborated by analytical HPLC using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase.

Example 3a di-i-propyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate (3)

[0088] 

[0089] To a clean, dry 50 mL round bottom flask was added a stir bar and 1 g (3.69 mmol, 1 eq) of the bromide. The round bottom was sealed and purged three times with inert gas and vacuum. Dichloromethane (4 mL) and diisopropyl sulfide (1.31g, 1.61 mL, 11.1 mmol, 3 eq) were added to the flask sequentially via syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. Silver tetrafluoroborate (718 mg, 3.69 mmol, 1 eq) was added and the reaction was stirred for 4 hours while warming to room temperature slowly. During this time, the reaction was kept in the dark. Dichloromethane was added and the reaction was extracted twice with water. The DCM layer was dried with magnesium sulfate, filtered, and solvent was removed by rotary evaporation. The crude product was taken up in ethyl acetate and loaded onto a small column which was then flushed with copious ethyl acetate to remove impurities. Product was then eluted with acetone. The acetone was removed by rotary evaporation and a small amount of DCM was added to precipitate silica gel that had come through with the acetone. The DCM was filtered to remove silica gel and once again the solution was rotary evaporated to dryness. 500 mg of product was obtained (34% yield). ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.6-7.3 (m, 5H), 5.37 (dd, J = 5.5 Hz, J = 17.0 Hz, 0.1H), 4.94 (t, J = 12.8 Hz, 0.9H), 4.12 (septet, J = 11.5 Hz, 0.9H), 3.64 (s, 3H), 3.14 (septet, J = 11.5 Hz, 0.9H), 2.99 (septet, J = 11.1 Hz, 0.2H), 2.8-1.0 (m, 6H), 1.76 (d, J = 11.5 Hz, 3H), 1.70 (d, J = 11.5 Hz, 3H), 1.43 (d, J = 11.5 Hz, 3H), 1.24 (d, J = 11.5 Hz, 3H).

Example 3b [6,6]-Phenyl C₇₁ butyric acid methyl ester

[0090] 

[0091] To a clean, dry 500 mL round bottom flask was added a stir bar and 955 mg (1.136 mmol, 1 eq) of C₇₀. The round bottom was sealed and purged three times with inert gas and vacuum. 220 mL of ODCB (1,2-dichlorobenzene) anhydrous solvent was added by cannula. Sulfonium salt (3) (450 mg, 1.136 mmol, 1 eq) was taken into 20 mL of anhydrous ODCB and added to the reaction by syringe. The reaction was cooled to 0°C and allowed to equilibrate for 30 minutes. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene, 0.170 mL, 1.136 mmol, 1 eq) was added dropwise over 10 minutes at 0°C in 20 mL of anhydrous ODCB via syringe. The reaction was allowed to warm slowly to room temperature and stir over 3 days. The reaction mixture was rotary evaporated to a small volume of ODCB and subjected to chromatography (silica gel, ODCB used to elute C₇₀, followed by increasing ratio of toluene to ODCB to collect PC₇₀BM). The PC₇₀BM solution was concentrated to dryness and dissolved in a small volume of toluene. The PC₇₀BM solution was then subjected to high pressure sodium lamp irradiation in order to convert minor amounts of [5,6] adduct to [6,6] adduct. A small amount of PC₆₀BM impurity was then removed by preparative intermediate pressure liquid chromatography using a column with Cosmosil PBB material as the stationary phase (from Nacalai Tesque; pentabromobenzyl group bonded silica) and toluene as the mobile phase. The collected material was then further purified by preparative intermediate pressure liquid chromatography using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase. Fractions containing pure product were combined. The solution was concentrated to a small volume. PC₇₀BM was then precipitated in methanol and isolated by filtration to obtain 250 mg of material (21% yield). The sample was left in an oven overnight at 70°C under reduced pressure to remove residual solvent. α-PC₇₀BM (desired product, depicted) was obtained exclusively, based on NMR analysis. ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.95-7.40 (m, 5H), 3.68 (α, s, 3.00H), 2.53-2.40 (m, 4H), 2.27-2.02 (m, 6H). β-PC₇₀BM was not detected by regular ¹H NMR, nor was it detected by analytical HPLC using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase.

Example 4a ethyl-i-propyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate (4) (not within the scope of the claims)

[0092] 

[0093] To a clean, dry 50 mL round bottom flask was added a stir bar and 0.5 g (1.84 mmol, 1 eq) of the bromide. The round bottom was sealed and purged three times with inert gas and vacuum. Dichloromethane (2 mL) and isopropyl ethyl sulfide (576.5 mg, 0.698 mL, 5.53 mmol, 3 eq) were added to the flask via syringe. The reaction was cooled to 0°C and allowed to equilibrate for 40 minutes. Silver tetrafluoroborate (359 mg, 1.84 mmol, 1 eq) was added and the reaction was stirred overnight while warming to room temperature slowly. During this time, the reaction was kept in the dark. Dichloromethane was added and the reaction was extracted twice with water. The DCM layer was dried with magnesium sulfate, filtered, and solvent was removed by rotary evaporation. The crude product was taken up in ethyl acetate, and left in the freezer overnight. It was then loaded onto a small column which was flushed with copious ethyl acetate to remove impurities. Product was then eluted with acetone. The acetone was removed by rotary evaporation and a small amount of DCM was added to precipitate silica gel that had come through with the acetone. The DCM was filtered to remove silica gel and once again the solution was rotary evaporated to dryness. 286 mg of product (6) was obtained (41% yield). ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.6-7.4 (m, 5H), 4.99 (t, J = 12.9 Hz, 0.5H), 4.86 (t, J = 12.9 Hz, 0.5H), 4.08 (septet, J = 11.5 Hz, 0.65H), 3.7-3.4 (m, 3.65H), 3.31 (quintet, J = 11.3 Hz, 0.5H), 3.18 (sextet, J = 12.0 Hz, 0.6H), 2.98 (sextet, J = 12.0 Hz, 0.6H), 2.5-2.1 (m, 4.5H), 1.8-1.2 (m, 9H), 1.01 (t, J = 12.5 Hz, 1.5H).

Example 4b [6,6]-Phenyl C₇₁ butyric acid methyl ester (not within the scope of the claims)

[0094] 

[0095] To a clean, dry 50 mL round bottom flask was added a stir bar, 45.5 mg (0.119 mmol, 1 eq) of the sulfonium salt (6) and 100 mg (0.119 mmol, 1 eq) of C₇₀. The round bottom was sealed and purged three times with inert gas and vacuum. 9 mL of ODCB (1,2-dichlorobenzene) anhydrous solvent was added by syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene, 0.0178 mL, 0.119 mmol, 1 eq) was added over 5 minutes at 0°C in 1 mL of anhydrous ODCB via syringe. The reaction was allowed to warm slowly with stirring overnight to room temperature. This abundance of α-PC₇₀BM (desired product, depicted) was qualitatively greater than that obtained from the didodecyl precursor but surprisingly less than that obtained from the methyl isopropyl precursor. α-Isomer abundance was determined by analytical HPLC using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase.

Example 5a didodecyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate (5) (not within the scope of the claims)

[0096] 

[0097] To a clean, dry 50 mL round bottom flask was added a stir bar and 0.5 g (1.84 mmol, 1 eq) of the bromide. The round bottom was sealed and purged three times with inert gas and vacuum. Solid isopropyl ethyl sulfide (2.05 g, 5.53 mmol, 3 eq) dissolved in dichloromethane (2 mL) was added to the flask via syringe. The reaction was cooled to 0°C and allowed to equilibrate for 40 minutes. The reaction mixture was observed to freeze. Silver tetrafluoroborate (359 mg, 1.84 mmol, 1 eq) was added and the reaction was stirred overnight while warming to room temperature. During this time, the reaction was kept in the dark. Dichloromethane was added and the reaction was extracted twice with water. The DCM layer was dried with magnesium sulfate, filtered, and solvent was removed by rotary evaporation. The crude product was taken up in ethyl acetate, and left in the freezer overnight. Silica TLC was used to adjust the conditions used for further isolation versus other sulfonium salt examples. Ethyl Acetate was removed by evaporation and the product mixture was redissolved in a 7:3 ratio of cyclohexane and ethyl acetate. This solution was loaded onto a small column which was flushed with copious amounts of a 7:3 ratio of cyclohexane : ethyl acetate to remove impurities. Product was then eluted with ethyl acetate. The ethyl acetate was removed by rotary evaporation to give 884 mg of the desired product (7) (74% yield). ¹H NMR (500 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.6-7.4 (m, 5H), 5.07 (t, J = 13.0 Hz, ¹H), 3.63 (s, 3H), 3.52 (octet, J = 12.5 Hz, 2H), 3.20 (quintet, J = 9.3 Hz, 1H), 2.92 (quintet, J = 9.3, Hz, 1H), 2.4-1.0 (m, 46H), 0.88 (t, J = 11.5 Hz, 6H).

Example 5b [6,6]-Phenyl C₇₁ butyric acid methyl ester (not within the scope of the claims)

[0098] 

[0099] To a clean, dry 50 mL round bottom flask was added a stir bar, 77.2 mg (0.119 mmol, 1 eq) of the sulfonium salt (7) and 100 mg (0.119 mmol, 1 eq) of C₇₀. The round bottom was sealed and purged three times with inert gas and vacuum. 9 mL of ODCB (1,2-dichlorobenzene) anhydrous solvent was added by syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene, 0.0178 mL, 0.119 mmol, 1 eq) was added over 5 minutes at 0°C in 1 mL of anhydrous ODCB via syringe. The reaction was allowed to warm slowly with stirring overnight to room temperature. This abundance of α-PC₇₀BM (desired product, depicted) was qualitatively similar to the product mixture that is obtained from the more traditional tosylhydrazone precursor (~85%). α-Isomer abundance was determined by analytical HPLC using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase.

Example 6a Hexyl 5-phenylpentanoate

[0100] 

[0101] An oil bath was preheated to 40°C. To a clean, dry 2 L round bottom flask was added a stir bar, 0.84 L of deionized water, 35.2 mL (280 mmol, 2 eq) of hexanol, 4.32 mL of DBSA (4-dodecylbenzenesulfonic acid mixture of isomers, 14 mmol, 0.1 eq), and 25 g (140 mmol, 1 eq) of phenyl valeric acid. The mixture was allowed to stir at 40°C for 3 days. The reaction was cooled, quenched with saturated aqueous sodium bicarbonate, and extracted 3X with ethyl acetate. The combined ethyl acetate layer was dried with magnesium sulfate, filtered, and solvent was removed by rotary evaporation. Excess hexanol was removed from the product by rotary evaporation at 65°C and high vacuum. To remove DBSA, the remaining oil was diluted with a mixture of cyclohexane and ethyl acetate in a 19:1 ratio and run through a plug of silica gel using a mixture of cyclohexane and ethyl acetate in a 19:1 ratio as eluent. The product band was collected and concentrated to constant weight to give 32.05 g (87.1% yield) of product as a near colorless oil. ¹H NMR (300 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.31-7.13 (m, 5H), 4.05 (t, J = 6.7 Hz, 2H), 2.63 (t, J = 7.1 Hz, 2H), 2.32 (t, J = 7.9 Hz, 2H), 1.74-1.53 (m, 6H), 1.40-1.21 (m, 6H), 0.89 (t, J = 6.7 Hz, 3H).

Example 6b Hexyl 5-phenyl-5-bromopentanoate

[0102] 

[0103] An oil bath was preheated to 85°C. To a clean, dry 1 L round bottom flask was added a stir bar, 32.05 g of the starting material (122 mmol, 1 eq), 23.91 g of NBS (134 mmol, 1.1 eq) and 87.5 mg of benzoyl peroxide (0.361 mmol, 0.003 eq). The flask was fitted with a condenser, sealed, pump purged 3X with inert gas and vacuum, and anhydrous cyclohexane (329 mL) was added by cannula. The mixture was allowed to stir and reflux over two nights. The reaction was cooled, filtered, rinsed with cyclohexane, and rotary evaporated to constant weight to give a quantitative yield of product as a light orange oil. ¹H NMR (300 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.42-7.23 (m, 5H), 4.95 (t, J = 7.5 Hz, 1H), 4.05 (t, J = 6.8 Hz, 2H), 2.38-2.09 (m, 4H), 1.93-1.52 (m, 4H), 1.40-1.19 (m, 6H), 0.88 (t, J = 6.7 Hz, 3H).

Example 6c di-i-propyl-(5-hexyloxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate

[0104] 

[0105] To a clean, dry 50 mL round bottom flask was added a stir bar and 2 g (5.86 mmol, 1 eq) of the brominated starting material. The round bottom was sealed and purged three times with inert gas and vacuum. Anhydrous acetonitrile (6.36 mL) and diisopropyl sulfide (2.08g, 2.55 mL, 17.6 mmol, 3 eq) were added to the flask sequentially via syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. Silver tetrafluoroborate (1.141 g, 5.86 mmol, 1 eq) was added and the reaction was stirred overnight while warming to room temperature (the bath was removed after the addition). The reaction was kept in the dark. The crude reaction mixture was filtered and rinsed with acetonitrile to remove solid silver byproduct. The filtrate was concentrated to an oil by rotary evaporation. The crude product was taken up in a mixture of cyclohexane and ethyl acetate (7:3 ratio) and loaded onto a plug of silica. The plug was flushed with copious amount of a mixture of cyclohexane and ethyl acetate (9:1 ratio), followed by 100% ethyl acetate, followed by acetone. Less polar impurities were removed by the less polar eluent. The desired product was found in the ethyl acetate and acetone fractions. The combined solvents were removed by rotary evaporation and a small amount of DCM was added to precipitate silica gel that had come through with the acetone. The DCM was filtered to remove silica gel and once again the solution was rotary evaporated to dryness. 1.287 g of product was obtained (47.1% yield). ¹H NMR (300 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.55-7.20 (m, 5H), 5.37 (dd, J = 3.4 Hz, J = 9.4 Hz, 0.15H), 4.88 (dd, J = 5.6 Hz, J = 9.8 Hz, 0.85H), 4.20-3.95 (m, 2.85H), 3.41 (septet, J = 6.9 Hz, 0.85H), 3.22 (septet, J = 6.5 Hz, 0.3H), 2.4-2.1 (m, 4H), 1.75 (d, J = 6.8 Hz, 3H), 1.7-1.2 (m, 10H), 1.69 (d, J = 6.9 Hz, 3H), 1.43 (d, J = 7.0 Hz, 3H), 1.21 (d, J = 6.93 Hz, 3H), 0.87 (t, J = 6.7 Hz, 3H).

Example 6d [6,6]-Phenyl C₇₁ butyric acid hexyl ester

[0106] 

[0107] To a clean, dry 100 mL round bottom flask was added a stir bar, 0.6 g of sulfonium salt (1.286 mmol, 1 eq) by pipette, 1.08 g of C₇₀ (1.286 mmol, 1 eq) and 54.1 mL of reagent grade ODCB (1,2-dichlorobenzene). The round bottom was sealed and purged three times with inert gas and vacuum. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene, 0.192 mL, 1.286 mmol, 1 eq) was added dropwise over 45 minutes. The reaction was allowed to stir at room temperature overnight. The reaction mixture was rotary evaporated to ~25 mL of ODCB and subjected to chromatography (silica gel, ODCB used to elute C₇₀, followed by increasing ratio of toluene to ODCB to collect PC₇₀BC₆). The PC₇₀BC₆ solution was concentrated to dryness and dissolved in a small volume of toluene (-100 mL). The PC₇₀BC₆ solution was then subjected to high pressure sodium lamp irradiation for 10 minutes at room temperature (except for any small heating resulting from the irradiation) to convert a minor amount of [5,6] adduct to [6,6] adduct. Solvent was once again removed by rotary evaporation and replaced with 40 mL of toluene. The material was then further purified in one injection by preparative intermediate pressure liquid chromatography using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase. The fraction containing pure product was collected. The solution was concentrated to a small volume. PC₇₀BC₆ was then precipitated in methanol and isolated by filtration. The sample was left in an oven overnight at 70°C under vacuum to remove residual solvent. α-PC₇₀BC₆ (desired product, depicted) was obtained (323 mg, 23% yield) based on HPLC and NMR analysis, which is shown in FIGs. 3 and 5. ¹H NMR (300 MHz, CDCl₃ (set to 7.26 ppm)) δ 8.00-7.30 (m, 5H), 4.06 (alpha, t, J= 6.8 Hz, 2H), 2.55-2.35 (m, 6H), 2.30-1.95 (m, 2H), 1.70-1.50 (m, 2H), 1.40-1.15 (m, 6H), 0.89 (t, J = 6.8 Hz, 3H). As in can be seen in Fig.4, a very pronounced decrease of the shoulder reflecting the β-PC₇₀BC₆ in the HPLC chromatogram in comparison to the conventional tosylhydrazone method has occurred. Due to the low concentration of β-PC₇₀BC₆ and the limited resolution of the chromatogram, no meaningful integration, necessary to quantify the relative abundances, could be conducted by HPLC. ¹NMR data shown in Figures 3 and 5 also demonstrate the sharp reduction in the abundance of the β-PC₇₀BC₆. While these spectra were taken at a concentration not suitable for a quantitative evaluation, additional NMR analysis at 30 mg/mL did confirm an abundance of β-PC₇₀BC₆ below 3.0%.

Example 7a di-sec-butyl-(5-methoxy-5-oxo-1-phenylpentyl) sulfonium tetrafluoroborate

[0108] 

[0109] To a clean, dry 50 mL round bottom flask was added a stir bar and 2 g (7.38 mmol, 1 eq) of the brominated starting material. The round bottom was sealed and purged three times with inert gas and vacuum. Anhydrous acetonitrile (8 mL) and disecbutyl sulfide (3.24 g, 3.86 mL, 22.1 mmol, 3 eq) were added to the flask sequentially via syringe. The reaction was cooled to 0°C and allowed to equilibrate for 15 minutes. Silver tetrafluoroborate (1.44 g, 7.40 mmol, 1 eq) was added and the reaction was stirred overnight in the dark while warming to room temperature (the bath was removed after the addition). The reaction was kept in the dark using aluminum foil. The crude reaction mixture was filtered and rinsed with acetonitrile to remove solid silver byproduct. The filtrate was concentrated to an oil by rotary evaporation. The crude product was taken up in a mixture of cyclohexane and ethyl acetate (9:1 ratio), sonicated, and loaded onto a plug of silica. The crude product was not completely soluble in the 9:1 cyclohexane and ethyl acetate. Rather two phases were observed, one of the solvent, and one of a viscous oil. Both phases were loaded onto the silica concurrently. The plug was flushed with copious amount of a mixture of cyclohexane and ethyl acetate (9:1 ratio), followed by 100% ethyl acetate, followed by acetone. Upon addition of the ethyl acetate, all glassware was rinsed with the ethyl acetate first to mobilize the remaining oil residue and deposit it on the silica. Less polar impurities were removed by the less polar eluent. The desired product was found in the ethyl acetate and acetone fractions. The combined solvents were removed by rotary evaporation and a small amount of DCM was added to precipitate silica gel that had come through with the acetone. The DCM was filtered to remove silica gel and once again the solution was rotary evaporated to dryness. 1.782 g of product was obtained (57% yield). ¹H NMR (300 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.55-7.20 (m, 5H), 5.45-4.80 (m, 1H), 3.9-0.7 (m, 27H).

Example7b [6,6]-Phenyl C₇₁ butyric acid methyl ester

[0110] 

[0111] To a clean, dry 100 mL round bottom flask was added a stir bar, 0.545 g of sulfonium salt (1.285 mmol, 1 eq) by pipette, 1.08 g of C₇₀ (1.285 mmol, 1 eq) and 54.1 mL of reagent grade ODCB (1,2-dichlorobenzene). The round bottom was sealed and purged three times with inert gas and vacuum. DBU (1,8-diazabicyclo[5.4.0]undec-7-ene, 0.192 mL, 1.287 mmol, 1 eq) was added dropwise over 45 minutes. The reaction was allowed to stir at room temperature for two nights. The reaction mixture was rotary evaporated to ~25 mL of ODCB and subjected to chromatography (silica gel, ODCB used to elute C₇₀, followed by 3 : 1 ratio of ODCB to toluene to elute PC₇₀BM). The PC₇₀BM solution was concentrated to dryness and dissolved in a small volume of toluene (~50 mL). The PC₇₀BM solution was then subjected to high pressure sodium lamp irradiation for 10 minutes at room temperature (except for any small heating resulting from the irradiation) to convert a minor amount of [5,6] adduct to [6,6] adduct. Solvent was once again removed by rotary evaporation down to 25 mL of toluene. The material was then further purified in one injection by preparative intermediate pressure liquid chromatography using a column with Cosmosil Buckyprep material as the stationary phase (from Nacalai Tesque; pyrenylpropyl group bonded silica) and toluene as the mobile phase. The fraction containing pure product was collected. The solution was concentrated to a small volume. PC₇₀BM was then precipitated in methanol and isolated by filtration. The sample was left in an oven overnight at 70°C under vacuum to remove residual solvent. α-PC₇₀BM (desired product, depicted) was obtained (116 mg, 8.8% yield, 99.96% purity) based on HPLC (Cosmosil Buckyprep material as the stationary phase and toluene as the mobile phase) and NMR analysis. The abundance of the beta isomer was measured to be 2.95% by analytical HPLC (Cosmosil Buckyprep material as the stationary phase and a 4 : 1 ratio of cyclohexane to toluene as the mobile phase) and 2.96% by NMR (at a concentration of 30 mg/mL). ¹H NMR (300 MHz, CDCl₃ (set to 7.26 ppm)) δ 7.95-7.40 (m, 5H), 3.68 (alpha, s, 3.00H), 2.53-2.40 (m, 4H), 2.27-2.02 (m, 6H).

[0112] Unless otherwise defined, used or characterized herein, terms that are used herein (including technical and scientific terms) are to be interpreted as having a meaning that is consistent with their accepted meaning in the context of the relevant art and are not to be interpreted in an idealized or overly formal sense unless expressly so defined herein.

[0113] Although the terms, first, second, third, etc., may be used herein to describe various elements, these elements are not to be limited by these terms. These terms are simply used to distinguish one element from another. Thus, a first element, discussed below, could be termed a second element without departing from the teachings of the exemplary embodiments. Spatially relative terms, such as "above," "below," "left," "right," "in front," "behind," and the like, may be used herein for ease of description to describe the relationship of one element to another element, as illustrated in the figures. It will be understood that the spatially relative terms, as well as the illustrated configurations, are intended to encompass different orientations of the apparatus in use or operation in addition to the orientations described herein and depicted in the figures. For example, if the apparatus in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary term, "above," may encompass both an orientation of above and below. The apparatus may be otherwise oriented (e.g., rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly. Further still, in this disclosure, when an element is referred to as being "on," "connected to," "coupled to," "in contact with," etc., another element, it may be directly on, connected to, coupled to, or in contact with the other element or intervening elements may be present unless otherwise specified.

[0114] The terminology used herein is for the purpose of describing particular embodiments and is not intended to be limiting of exemplary embodiments. As used herein, singular forms, such as "a" and "an," are intended to include the plural forms as well, unless the context indicates otherwise.

[0115] It will be appreciated that while a particular sequence of steps has been shown and described for purposes of explanation, the sequence may be varied in certain respects, or the steps may be combined, while still obtaining the desired configuration.

Claims

1. A method of making an α-isomer of a [6,6]-Phenyl C₇₁ butyric acid ester comprising:

reacting fullerene C₇₀ with a dialkyl sulfonium salt having the formula:

where R₁ and R₂ are each independently iso-propyl or sec-butyl;

where R₃ is selected from H, optionally substituted C₁-C₁₂ aliphatic wherein one or more carbon units, including terminal carbon, are optionally and independently replaced by -O-, -S-, carbonyl (-CO-), -CF₂-, thiophenyl, phenyl, pyridinyl or -NR_a-; optionally substituted C₃-C₁₂ cycloaliphatic wherein one or more carbon units are optionally and independently replaced by - O-, -S-, carbonyl (-CO-), -CF₂-, or -NR_a-; or optionally substituted aryl;

where R_a is independently selected from H, optionally substituted C₁-C₆ aliphatic; optionally substituted C₃-C₆ cycloaliphatic or optionally substituted phenyl; and

where X^- is an anion selected from Br^-, I^-, Cl^-, F^-, BF₄^-, PF₆^-, SbF₆^-, AsF₆^-, OSO₂CH₃^-, OSO₂CF3^-, OSO₂C₄F₉^-, OSO₂OCH₃^-, OCOCH₃^-, OCOCF₃^-, OSO₂(C₆H₄)CH₃^-, OSO₂(C₆H₄)CF₃^-, N(SO₂CF₃)₂^-, OSO₂CH₂CH₂CH₂CH₂SO₂O^--, OH^-, I₃^-, N(CN)₂^-, 7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonate, B(C₆H₅)₄^- or OSO₂OH^-;

2. The method of claim 1, wherein R₁ and R₂ are both iso-propyl.

3. The method of claim 1, wherein R₁ and R₂ are both sec-butyl.

4. The method of claim 1, wherein R₁ is iso-propyl and R₂ is sec-butyl

5. The method of any one of claims 1-4, wherein R₃ is selected from H and C₁-C₁₂ alkyl.

6. The method of claim 5, wherein R₃ is branched or straight C₁-C₆ alkyl.

7. The method of claim 5, wherein R₃ is branched or straight C₆ alkyl.

8. The method of claim 5, wherein R₃ is n-hexyl.

9. The method of claim 5, wherein one or more carbon units in R₃, including terminal carbon, are optionally and independently replaced by -O-.

10. The method of claim 9, wherein R₃ is a glycolyl.

11. The method of any one of claims 1-10, wherein X^- is BF₄^-.

12. The method of any one of claims 1-11, wherein reacting comprises reacting the fullerene C₇₀ and the dialkyl sulfonium salt in the presence of a base.

13. The method of claim 12 wherein the base comprises an organic base.

14. The method of claim 13 wherein the base comprises 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU).

Ansprüche

1. Verfahren zum Herstellen eines α-Isomers eines [6,6]-Phenyl-C₇₁-buttersäureesters, umfassend:

Umsetzen von Fulleren C₇₀ mit einem Dialkylsulfoniumsalz mit der Formel:

wobei R₁ und R₂ jeweils unabhängig voneinander Isopropyl oder sec-Butyl sind;

wobei R₃ ausgewählt ist aus H, optional substituiertem C₁-C₁₂-Aliphat, wobei eine oder mehrere Kohlenstoffeinheiten, einschließlich endständigem Kohlenstoff, optional und unabhängig voneinander durch -O-, -S-, Carbonyl (-CO-), -CF₂-, Thiophenyl, Phenyl, Pyridinyl oder -NR_a-ersetzt sind; optional substituiertem C₃-C₁₂-Cycloaliphat, wobei eine oder mehrere Kohlenstoffeinheiten optional und unabhängig voneinander durch -O-, -S-, Carbonyl (-CO-), - CF₂- oder -NR_a- ersetzt sind; oder optional substituiertem Aryl;

wobei R_a unabhängig ausgewählt ist aus H, optional substituiertem C₁-C₆-Aliphat; optional substituiertem C₃-C₆-Cycloaliphat oder optional substituiertem Phenyl; und

wobei X^- ein Anion ist, das ausgewählt ist aus Br^-, I^-, Cl^-, F^-, BF₄^-, PF₆^-, SbF₆^-, AsF₆^-, OSO₂CH₃^-, OSO₂CF₃^-, OSO₂C₄F₉^-, OSO₂OCH₃^-, OCOCH₃^-, OCOCF₃^-, OSO₂(C₆H₄)CH₃^-, OSO₂(C₆H₄)CF₃^-, N(SO₂CF₃)₂^-, OSO₂CH₂CH₂CH₂CH₂SO₂O^--, OH^-, I₃^-, N(CN)₂^-, 7,7-Dimethyl-2- oxobicyclo[2.2.]heptan-1-methansulfonat, B(C₆H₅)₄^- oder OSO₂OH^-.

2. Verfahren nach Anspruch 1, wobei R₁ und R₂ beide Isopropyl sind.

3. Verfahren nach Anspruch 1, wobei R₁ und R₂ beide sec-Butyl sind.

4. Verfahren nach Anspruch 1, wobei R₁ Isopropyl ist und R₂ sec-Butyl ist.

5. Verfahren nach einem der Ansprüche 1-4, wobei R₃ aus H und C₁-C₁₂-Alkyl ausgewählt ist.

6. Verfahren nach Anspruch 5, wobei R₃ verzweigtes oder gerades C₁-C₆-Alkyl ist.

7. Verfahren nach Anspruch 5, wobei R₃ verzweigtes oder gerades C₆-Alkyl ist.

8. Verfahren nach Anspruch 5, wobei R₃ n-Hexyl ist.

9. Verfahren nach Anspruch 5, wobei eine oder mehrere Kohlenstoffeinheiten in R₃, einschließlich endständigem Kohlenstoff, optional und unabhängig voneinander durch -O- ersetzt sind.

10. Verfahren nach Anspruch 9, wobei R₃ ein Glykolyl ist.

11. Verfahren nach einem der Ansprüche 1-10, wobei X^- BF₄^- ist.

12. Verfahren nach einem der Ansprüche 1-11, wobei das Umsetzen Umsetzen des Fullerens C₇₀ und des Dialkylsulfoniumsalzes in Gegenwart einer Base umfasst.

13. Verfahren nach Anspruch 12, wobei die Base eine organische Base umfasst.

14. Verfahren nach Anspruch 13, wobei die Base 1,8-Diazabicyclo[5.4.0]undec-7-en (DBU) umfasst.

Revendications

1. Procédé de production d'un isomère-α d'un ester de l'acide [6,6]-phényl C₇₁ butyrique comprenant :

la mise en réaction d'un C₇₀ fullerène avec un sel dialkylsulfonium comportant la formule :

dans laquelle R₁ et R₂ sont chacun indépendamment l'isopropyle ou le sec-butyle ;

dans laquelle R₃ est choisi parmi H, C₁-C₁₂ aliphatique éventuellement substitué dans lequel une ou plusieurs unités carbone, y compris le carbone terminal, sont éventuellement et indépendamment remplacées par -O-, -S-, carbonyle (-CO-), -CF₂-, thiophényle, phényle, pyridinyle ou -NR_a- ; un C₃-C₁₂ cycloaliphatique éventuellement substitué, dans lequel une ou plusieurs unités carbone sont éventuellement et indépendamment remplacées par -O-, -S-, carbonyl (-CO-), -CF₂-, ou -NR_a- ; ou un aryle éventuellement substitué ;

dans laquelle R_a est choisi indépendamment parmi H, C₁-C₆ aliphatique éventuellement substitué ; C₃-C₆ cycloaliphatique éventuellement substitué ou phényle éventuellement substitué ; et

dans laquelle X^- est un anion choisi parmi Br^-, I^-, Cl^-, F^-, BF₄^-, PF₆^-, SbF₆^-, AsF₆^-, OSO₂CH₃, OSO₂CF₃^-, OSO₂C₄F₉^-, OSO₂OCH₃; OCOCH₃^-, OCOCF₃^-, OSO₂(C₆H₄)CH₃^-, OSO₂(C₆H₄)CF₃^-, N(SO₂CF₃)₂^-, OSO₂CH₂CH₂CH₂CH₂SO₂O^--, OH^-, I₃^-, N(CN)₂^-, 7,7-diméthyl-2-oxobicyclo[2.2.1]heptane-1-méthanesulfonate, B(C₆H₅)₄^- ou OSO₂OH^-.

2. Procédé de la revendication 1, dans lequel R₁ et R₂ sont tous deux l'isopropyle.

3. Procédé de la revendication 1, dans lequel R₁ et R₂ sont tous deux le sec-butyle.

4. Procédé de la revendication 1, dans lequel R₁ est l'isopropyle et R₂ est le sec-butyle.

5. Procédé de l'une quelconque des revendications 1 à 4, dans lequel R₃ est choisi parmi H et un C₁-C₁₂ alkyle.

6. Procédé de la revendication 5, dans lequel R₃ est un C₁-C₆ alkyle ramifié ou linéaire.

7. Procédé de la revendication 5, dans lequel R₃ est un C₆ alkyle ramifié ou linéaire.

8. Procédé de la revendication 5, dans lequel R₃ est le n-hexyle.

9. Procédé de la revendication 5, dans lequel une ou plusieurs unités carbone dans R₃, y compris le carbone terminal, sont éventuellement et indépendamment remplacés par -O-.

10. Procédé de la revendication 9, dans lequel R₃ est un glycolyle.

11. Procédé de l'une quelconque des revendications 1 à 10, dans lequel X^- est BF₄^-.

12. Procédé de l'une quelconque des revendications 1 à 11, dans lequel la mise en réaction comprend la mise en réaction du fullerène C₇₀ et du sel dialkylsulfonium en présence d'une base.

13. Procédé de la revendication 12 dans lequel la base comprend une base organique.

14. Procédé de la revendication 13 dans lequel la base comprend du 1,8-diazabicyclo[5.4.0]undéc-7-ène (DBU).

Drawing