(19)
(11)EP 3 409 765 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
27.02.2019 Bulletin 2019/09

(43)Date of publication A2:
05.12.2018 Bulletin 2018/49

(21)Application number: 18185054.6

(22)Date of filing:  22.06.2010
(51)International Patent Classification (IPC): 
C12N 9/02(2006.01)
A61P 7/04(2006.01)
C12P 13/02(2006.01)
C12N 15/53(2006.01)
C12P 7/28(2006.01)
C12P 17/02(2006.01)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

(30)Priority: 22.06.2009 US 21916209 P
10.02.2010 US 30305710 P

(62)Application number of the earlier application in accordance with Art. 76 EPC:
10797576.5 / 2446025

(71)Applicant: Codexis, Inc.
Redwood City, CA 94063 (US)

(72)Inventors:
  • BONG, Yong Koy
    117525 Singapore (SG)
  • VOGEL, Michael
    117525 Singapore (SG)
  • COLLIER, Steven, James
    117525 Singapore (SG)
  • MITCHELL, Vesna
    Redwood City, California 94063 (US)
  • MAVINAHALLI, Jagadeesh
    689674 Singapore (SG)

(74)Representative: Chapman, Desmond Mark 
Carpmaels & Ransford LLP One Southampton Row
London WC1B 5HA
London WC1B 5HA (GB)

  


(54)KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS


(57) The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.





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