BLOOD BIOMARKERS FOR APPENDICITIS AND DIAGNOSTICS METHODS USING BIOMARKERS

(19)

(11)

EP 3 502 271 A3

(12)	EUROPEAN PATENT APPLICATION

(88)	Date of publication A3:
	14.08.2019 Bulletin 2019/33

(43)	Date of publication A2:
	26.06.2019 Bulletin 2019/26

(21)	Application number: 19153228.2

(22)	Date of filing: 22.10.2015

(51)

Int. Cl.:

C12Q 1/68 ^(2018.01)

G01N 33/49 ^(2006.01)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)

Priority:

22.10.2014 US 201462067414 P

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	15853565.8 / 3210021

(71)	Applicants:
	The George Washington University, A Congressionally Chartered Not-For-Profit Corporation Washington, District of Columbia 20052 (US) Astute Medical, Inc. San Diego, CA 92121-1122 (US)

(72)	Inventors:
	Chawla, Lakhmir S. San Diego, CA 92130 (US) McCaffrey, Timothy A. Silver Spring, MD 20902 (US) McPherson, Paul Encinitas, CA 92024 (US) Kampf, James Patrick San Diego, CA 92130 (US)

(74)	Representative: dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB
	Deichmannhaus am Dom Bahnhofsvorplatz 1 50667 Köln 50667 Köln (DE)

(54)	BLOOD BIOMARKERS FOR APPENDICITIS AND DIAGNOSTICS METHODS USING BIOMARKERS

(57) The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising performing one or more assays configured to detect one or more biomarkers on a body fluid sample obtained from the subject to provide one or more assay result(s) and correlating the assay result(s) to the occurrence or nonoccurrence of appendicitis in the subject or likelihood of the future outcome to the subject.