(19) | |
| (11) | EP 3 626 832 A3 |
(12) | EUROPEAN PATENT APPLICATION |
(88) | Date of publication A3: | | 13.05.2020 Bulletin 2020/20 |
(43) | Date of publication A2: | | 25.03.2020 Bulletin 2020/13 |
(22) | Date of filing: 25.11.2015 |
| (51) | International Patent Classification (IPC): |
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(84) | Designated Contracting States: | | AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
(30) | Priority: | 25.11.2014 US 201462084127 P
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(62) | Application number of the earlier application in accordance with Art. 76 EPC: | | 15816941.7 / 3224381 |
(71) | Applicants: | | - The Brigham and Women's Hospital, Inc.
Boston, MA 02115 (US) - The General Hospital Corporation
Boston, MA 02114 (US)
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| (72) | Inventors: | | - EBERT, Benjamin, Levine
Brookline, MA 02445 (US) - JAISWAL, Siddhartha
Boston, MA 02115 (US) - KATHIRESAN, Sekar
Cambridge, MA 02145 (US)
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(74) | Representative: De Clercq & Partners | | Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem 9830 Sint-Martens-Latem (BE) |
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(54) | METHOD OF IDENTIFYING AND TREATING A PERSON HAVING A PREDISPOSITION TO OR AFFLICTED WITH A CARDIOMETABOLIC DISEASE |
(57) The invention relates to method for identifying and selecting a subject with increased risk of developing a cardiometabolic disease and optionally, providing a personalized medicine method. which may involve sequencing at least part of a genome of one or more cells in a blood sample of the subject and identifying from said sequencing one or more mutations in one or more somatic mutations.