(19)
(11)EP 3 633 032 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
29.07.2020 Bulletin 2020/31

(43)Date of publication A2:
08.04.2020 Bulletin 2020/15

(21)Application number: 19196063.2

(22)Date of filing:  27.08.2015
(51)International Patent Classification (IPC): 
C12N 9/22(2006.01)
C12N 15/11(2006.01)
C12N 9/96(2006.01)
C12N 15/113(2010.01)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)Priority: 28.08.2014 US 201462043204 P
29.08.2014 US 201462043882 P

(62)Application number of the earlier application in accordance with Art. 76 EPC:
15836709.4 / 3186375

(71)Applicant: North Carolina State University
Raleigh, North Carolina 27606 (US)

(72)Inventors:
  • BARRANGOU, Rodolphe
    Raleigh, North Carolina 27695 (US)
  • BRINER, Alexandra E.
    Cary, North Carolina 27511 (US)

(74)Representative: HGF 
1 City Walk
Leeds LS11 9DX
Leeds LS11 9DX (GB)

  


(54)NOVEL CAS9 PROTEINS AND GUIDING FEATURES FOR DNA TARGETING AND GENOME EDITING


(57) The present invention is directed to methods and compositions comprising novel CRISPR polypeptides and polynucleotides for site-specific cleavage and nicking of nucleic acids, transcriptional control and genome editing.





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