(19)
(11)EP 3 666 792 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
29.07.2020 Bulletin 2020/31

(43)Date of publication A2:
17.06.2020 Bulletin 2020/25

(21)Application number: 19211801.6

(22)Date of filing:  19.11.2015
(51)International Patent Classification (IPC): 
C07K 14/62(2006.01)
A61K 47/60(2017.01)
A61K 38/28(2006.01)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(30)Priority: 21.11.2014 US 201462082857 P
16.10.2015 US 201562242503 P

(62)Application number of the earlier application in accordance with Art. 76 EPC:
15807730.5 / 3221343

(71)Applicant: MERCK SHARP & DOHME CORP.
Rahway, NJ 07065-0907 (US)

(72)Inventors:
  • Lin, Songnian
    Kenilworth, New Jersey 07033 (US)
  • Yan, Lin
    Kenilworth, New Jersey 07033 (US)
  • Huo, Pei
    Kenilworth, New Jersey 07033 (US)
  • Pissarnitski, Dmitri
    Kenilworth, New Jersey 07033 (US)
  • Feng, Danqing
    Kenilworth, New Jersey 07033 (US)
  • Nargund, Ravi
    Kenilworth, New Jersey 07033 (US)
  • Zhu, Yuping
    Kenilworth, New Jersey 07033 (US)
  • Kekec, Ahmet
    Kenilworth, New Jersey 07033 (US)
  • Madsen-Duggan, Christina, B.
    Kenilworth, New Jersey 07033 (US)
  • Shi, Zhi-Cai
    Kenilworth, New Jersey 07033 (US)
  • Wu, Zhicai
    Kenilworth, New Jersey 07033 (US)
  • Mu, Yingjun
    Kenilworth, New Jersey 07033 (US)

(74)Representative: Jaap, David Robert 
MSD Hertford Road
Hoddesdon, Herts EN11 9BU
Hoddesdon, Herts EN11 9BU (GB)

  


(54)INSULIN RECEPTOR PARTIAL AGONISTS


(57) Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.







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