(19)
(11)EP 3 764 092 A1

(12)EUROPEAN PATENT APPLICATION

(43)Date of publication:
13.01.2021 Bulletin 2021/02

(21)Application number: 19305930.0

(22)Date of filing:  11.07.2019
(51)Int. Cl.: 
G01N 27/414  (2006.01)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(71)Applicants:
  • Ecole Polytechnique
    91128 Palaiseau Cedex (FR)
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    75794 Paris Cedex 16 (FR)

(72)Inventors:
  • SHIRINSKAYA, Anna
    91400 ORSAY VILLE (FR)
  • BONNASSIEUX, Yvan
    75013 PARIS (FR)

(74)Representative: Nony 
11 rue Saint-Georges
75009 Paris
75009 Paris (FR)

  


(54)MULTI-GATE OECT BASED SENSOR


(57) The present invention relates to an Organic Electro-Chemical Transistor based sensor, comprising: at least one set of source (11) and drain (12) electrodes, a plurality of gate electrodes (14) for this set, at least one channel (13) connected to the source and drain electrodes of the at least one set. The OECT based sensor may be used if desired for sensing different analytes in a medium, by functionalizing each gate electrode for detecting a given analyte. A further advantage of the invention is the simplification of the production procedure since a same set of source and drain electrodes may be used for a plurality of gate electrodes.




Description

Field of the invention



[0001] The present invention relates to Organic Electro-Chemical Transistor (OECT) based sensors.

State of the art



[0002] OECT based sensors are known in the prior art.

[0003] A typical OECT consists in source, drain and gate electrodes and a conductive polymer layer that forms a conductive channel extending between the source and drain electrodes.

[0004] The gate electrode is usually immersed into an electrolyte in contact with the channel.

[0005] A main working principle of an OECT as a sensor is based on charge transfer between an analyte of interest and the gate electrode or charge accumulation on the surface of gate electrode, which results in a change of the potential of the electrolyte, as described by the Nernst equation. If the gate stays at a constant potential, a potential drop change at the gate/electrolyte interface leads to a potential drop at the electrolyte/channel interface, and therefore the drain current is influenced by analyte concentration. The current modulation is generated by a de-doping effect induced by a reduction of the conductive polymer to its neutral, non-conducting state. Since the amount of charge carriers in the conductive polymer is decreased, current between source and drain electrodes also decreases.

[0006] OECT based sensors may prove efficient devices for detecting various analytes in different liquid media.

[0007] Functionalized OECT gate electrodes have already been used for glucose, lactate, liposome, dopamine, DNA and bacteria detection as well as for ultrasensitive detection of proteins, such as Immunoglobulin G.

[0008] Examples of OECT based sensors are disclosed in WO2003046540 A1, US7482620B2, US88100888B2 and US9733209B2.

[0009] Further OECT based sensors are disclosed in Pappa, A et al, R.M. (2017) Organic electronics for point-of-care metabolic monitoring. Trends in biotechnology, Macaya, D et al, G.G. (2007) simple glucose sensors with micromolar sensitivity based on organic electrochemical transistors. Sensors and Actuators B: Chemical, 123(1), 374-378, Tang, H. et al, F. (2011). Highly sensitive dopamine biosensors based on organic electrochemical transistors. Biosensors and Bioelectronics, 26(11), 4559-4563, Piro, B. et al, S. (2018). Fabrication and use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media. Applied Sciences (2076-3417), 8(6).

[0010] There remains a need for improving further OECT based sensors, especially for reducing the cost of production of these sensors, improving reliability and durability thereof and/or increasing precision and compactness.

[0011] The invention aims at satisfying all or part of these needs.

Summary of the invention



[0012] Exemplary embodiments of the invention relate to an Organic Electro-Chemical Transistor based sensor, comprising:
  • at least one set of source and drain electrodes,
  • a plurality of gate electrodes for this set,
  • at least one channel connected to the source and drain electrodes of the at least one set.


[0013] Thanks to the invention, a same OECT based sensor may be used if desired for sensing different analytes in a medium, by functionalizing each gate electrode for detecting a given analyte.

[0014] A further advantage of the invention is the simplification of the production procedure since a same set of source and drain electrodes may be used for a plurality of gate electrodes. The quantity of materials used for making the source and drain electrodes may be reduced. This may also help reduce the space needed for the electrodes and help achieve greater miniaturization of the sensor. In addition, the electronics used for acquisition of the signals may be simplified as the number of connections is reduced thanks to the use of a same set of source and drain electrodes for more than one gate electrode.

[0015] The sensor is also compatible with the use of the relatively cheap technique of ink jet printing for its manufacture.

[0016] The sensor may comprise a depolarization gate.

[0017] The depolarization gate is useful to accelerate measurement.

[0018] During normal measurement, potential applied between source and the functionalized gate de-dopes the channel and pushes ions inside the conductive layer. For the next measurement, it is desirable to pull ions out from the channel; normally, this process starts slowly as soon as gate-source potential is off. Use of a depolarization potential which is opposite to previously applied functionalized gate - source potential accelerates ions extraction from the channel. The depolarization gate is preferably turned on after each measurement, to bring the channel to its initial state as fast as possible.

Gate electrodes



[0019] The gate electrodes may be two, three, four or more. The gate electrodes of a same sensor are individually addressable.

[0020] At least one gate electrode may be functionalized.

[0021] The gate electrodes may be identical or different.

[0022] At least two gate electrodes may be identical. At least two gate electrodes may be made of different materials.

[0023] If at least two gate electrodes are identical, or if more or all of them are identical, they may be used for increasing the accuracy of the measurements and/or reliability of the sensor. For example, the gate electrodes may be addressed in a sequence and the corresponding measured values of source-drain current averaged.

[0024] The gate electrodes may be different and at least two of them may be functionalized differently in order to detect different respective analytes.

[0025] Thus, the gate electrodes may be differently functionalized gate electrodes.

[0026] A functionalized gate electrode for detecting an analyte is preferably configured so that the analyte binds to this gate electrode and a flow of electrons results from this reaction, which can be detected by a variation of the source-drain current. Potential could change not only as a result of chemical reaction (faradaic process) but also as a result of charge accumulation on the surface of gate electrode, which is a non-faradaic process.

[0027] All gate electrodes may be functionalized differently for detecting a maximum number of different analytes.

[0028] The material of the gate electrodes may be selected based on the analyte to be detected and the medium in which said analyte is present.

[0029] The materials in which the gate electrodes are made include metals, alloys, organic and inorganic conductors or semi-conductors.

[0030] The gate electrodes may be left unfunctionalized or be functionalized. Functionalization of the gate makes it selectively sensitive to a given analyte. Functionalization of the gate could be achieved by biomolecules such as enzymes, proteins, organic or inorganic nanoparticles, RNA or DNA to assure enzymatic or non-enzymatic detection of inorganic molecules, small organic molecules and biological molecules in a liquid environment.

[0031] At least two gate electrodes may be functionalized to be sensitive to a same analyte, but to different concentrations thereof.

[0032] The gate electrode may comprise a conductive base layer of a metal or a conductive polymer, for example Ag, Au, Pt or other metals. This conductive base layer may be coated at least partially with a layer of a functionalized polymer. A metallic surface may also be functionalized directly, for example antibodies may be covalently attached to a surface of a gold electrode. The functionalized polymer may comprise a surface modified conductive polymer, such as for example PEDOT:PSS treated with a deposit of a functionalizing layer. The functionalized polymer may be printed on the electrode base layer. The electrode base layer may be produced by annealing a metallic ink layer, or by evaporation or sputtering.

[0033] The position of the gate electrodes with respect to each other and with respect to the other electrodes and the at least one channel may be selected based on the application.

[0034] The gate electrodes may be symmetrical relative to a center of symmetry or an axis of symmetry.

[0035] The gate electrodes may have a same outline, for example polygonal or circular, or different outlines.

[0036] The gate electrodes may be coplanar with the drain and source electrodes or may not be coplanar with them.

[0037] A coplanar configuration may prove advantageous as it renders easier the manufacture of the sensor by printing, with an inkjet printer for example.

[0038] The source and drain electrodes are preferably coplanar on a same substrate, for example glass. The gate electrodes may be coplanar with the source and drain electrodes.

[0039] The gate electrodes may in a variant be supported by a different substrate than the source and drain electrodes. This allows to use materials and methods for gate electrode fabrication that are not compatible with methods used to fabricate the channel, source and drain electrodes.

[0040] The gate electrodes on the one hand and the source and drain electrodes on the other hand may extend in respective parallel planes. For example, the gate electrodes are carried by a substrate and the source and drain electrodes are carried by a different substrate. This facilitates gate electrodes replacement and the adjustment of the distance between the gate electrodes and the channel by adjusting the space between the substrates.

[0041] The gates electrodes may be connected to a control circuit by wires or conductive tracks.

[0042] The gate electrodes may each have different geometries, planar or not planar.

[0043] As detailed below, the sensor may comprise at least one depolarizing electrode.

Channel(s)



[0044] The channel connects the source and drain electrodes, and is made of an electronically conductive material. The channel is able to change its conductivity by changing its redox state under an applied source-gate potential. The channel is connected with each gate electrode by means of an ionically conductive layer, in which all gates may be inserted simultaneously.

[0045] The channel could be fabricated from n- or p- type material to allow penetration and track an influence from different types of ions existing in the solution in which detection takes place.

[0046] The channel may be made of an electrically conductive polymer or a combination of polymers selected from polyfluorenes, polyphenylenes, polypyrenes, polyazulenes, polynaphthalenes, polypyrroles, polycarbazoles, polyindoles, polyazepines, polyanilines, polythiophenes, polyacetylenes, and copolymers thereof.

[0047] In a more particular implementation, the electrically conductive polymer is selected from poly(3,4-ethylenedioxythiophene) (PEDOT), polyaniline (PANI), polypyrrole (PPy), poly(phenylene vinylene) (PPV), poly(arylene), polyspirobifluorene, poly(3-hexylthiophene) (P3HT), poly(o-methoxyaniline) (POMA), poly(o-phenylenediamine) (PPD), poly(p-phenylene sulfide) or mixtures thereof.

[0048] The channel may comprise as conductive polymer a polythiophene-based polymer, especially poly(3,4-ethylenedioxythiophene) (PEDOT). The polythiophene-based polymer, in particular PEDOT, is generally combined with one or more counterions, such as triflate (OTf), triflimidate, tosylate (OTs), poly(styrenesulfonate) (PSS), mesylate (Ms). In particular, the conductive polymer may be PEDOT:PSS.

[0049] The sensor may comprise only one channel. This channel is connected to the source and drain electrodes. The material of the channel may contact the material of the source and drain electrodes, and partially overlap them.

[0050] The sensor may also comprise more than one channel. All channels may be connected to the same set of source and drain electrodes, and thus be submitted to the same applied potential between these electrodes.

[0051] In a variant, the sensor comprises more than one channel and each channel is connected to a respective set of source and drain electrodes. This enables to apply various potentials to the various channels for more precise study of an analyte of interest.

[0052] When the sensor comprises a plurality of channels, the channels may be identical or different.

[0053] At least two channels may differ by at least one of their geometric features, such as width, thickness or length. The at least two channels may also differ from the n- or p- type of material. For example, one channel is made of -n type material and the other channel is made of p- type material, which allows penetration and track from different types of ions existing in the solution in contact with the sensor.

[0054] By having at least one geometric feature, such as length, width and/or thickness, that is different between at least two channels, one may tune the sensitivity of the sensor and obtain different response time which may help in determining the nature of a charged species existing in the detected analyte.

[0055] The potential applied across each channel may also be different from one channel to the other, which allows to extract more information about the size, shape and/or charge of the ions that exist in the analyte under detection.

[0056] When the sensor comprises a plurality of channels, each channel is preferably individually addressable.

Method of production



[0057] The invention also relates to a method for producing a sensor according to the invention, as defined above, comprising ink jet printing of the source, drain and gate electrodes.

[0058] The method may comprise functionalizing differently at least two gate electrodes.

[0059] If the gates are closely situated, and are both functionalized, a hydrophobic layer may be deposited to cover a space extending around the gates to prevent a functionalization solution leaking and touching other gates.

Detection method



[0060] The invention also relates to a method of detecting at least one analyte in a medium, using a sensor according to the invention, as defined above, the method comprising:
  • selecting a gate electrode,
  • applying a predefined potential to the selected gate electrode, and
  • determining a concentration of an analyte based on a current measured between the source and drain electrodes during application of the predefined potential to the selected gate electrode.


[0061] During measurement by addressing one gate electrode, the potential of other gate electrodes may be left floating or grounded.

[0062] When at least two gate electrodes are identical, these at least two gates may be addressed in a sequence, and an average value computed based on the values measured for the successive selected gates.

[0063] The concentration of a specific analyte in the liquid to be analyzed, and thus of a corresponding analyte, may be determined by means of appropriate calibration curves of the sensor, in which the variation of the drain-source current is put into relation with a series of predetermined concentrations of the analyte in the sample.

[0064] The method may comprise applying a predefined depolarizing potential on the depolarizing electrode mentioned above, for de-doping the channel before applying the predefined potential to a selected gate.

[0065] The depolarizing potential is selected according to the nature of liquid media, analytes, ions and other dissolved species, as well as value of potential applied previously. Depolarizing potential should be chosen preferably not to provoke any additional electrochemical reactions in the liquid. The depolarizing potential applied between source and other electrodes lays preferably in the range that depends of the nature of conductive polymer (for example between -2V to 2V for PEDOT:PSS). This potential may be selected based on the value of the gate electrode potential immediately previously applied. Preferably, the higher in absolute value the gate electrode potential previously applied is, the lower the depolarizing potential is in absolute value. For example, the higher the positive gate potential previously applied is, the more negative the depolarizing potential applied after is.

[0066] A predefined time may elapse before two consecutive measurements. For example, elapse between addressing two different gates is at least 5 s for PEDOT:PSS based transistors, according to experiments.

[0067] The potential that is applied to a selected gate may differ depending the gate is functionalized of not.

[0068] The sensor made in accordance with the invention may be used for medical point of care diagnostics and preclinical analysis of different analytes concentrations in human or animal liquids such as saliva, sweat, serum, blood or urine.

[0069] The sensor may also be used for continuous analysis of food and beverage making process, such as fermentation and maturation of wine, beer or whiskey, fermentation of cheese and other dairy products, as well as pathogen and dangerous substance detection in food industry and for ecological purposes.

Detection device



[0070] The invention also relates to a detection device comprising at least one OECT based sensor of the invention.

[0071] This detection device may comprise a control circuit for selecting a gate electrode of the sensor by applying a predefined potential.

[0072] For example, during detection, the source electrode is grounded. A voltage is applied between the gate and source that is greater in absolute value than that applied between source and drain. The gate voltage may be constant during measurement. In case of potential variation at the gate/electrolyte interface, depending on analyte concentration, potential variation at the electrolyte/channel interface also takes place, which results in a change of the redox state of the conductive polymer of the channel. Since the amount of charge carriers in the conductive polymer changes, the current between source and drain electrodes also changes, and can be detected by the control circuit.

[0073] The control circuit may be configured for applying a predefined de-polarizing potential before addressing a gate electrode.

[0074] The sensor may be used in vitro or in vivo.

Detailed description



[0075] The invention will be better understood upon reading the detailed description that follows, of exemplary embodiments of the invention, and in view of the attached drawing, in which:
  • Fig. 1 is a schematic and partial representation in top view of an example of OECT based sensor made in accordance with the present invention,
  • Fig. 2. is a schematic and partial perspective view illustrating a first configuration of the electrodes,
  • Fig. 3 to Fig.5 are similar views to Fig.3 of variant embodiments of the invention,
  • Fig. 6 shows a measuring device including a sensor in accordance with the invention,
  • Fig 7 is a schematic and partial perspective view illustrating a variant embodiment with a depolarizing electrode, and
  • Fig. 8 is an example of possible chronogram of applied potentials for a sensor with source, drain, three functionalized gate electrode and one depolarized gate electrode.


[0076] Figure 1 shows an OECT sensor 10 made in accordance with the invention.

[0077] The sensor 10 comprises a source electrode 11, a drain electrode 12, a channel 13 and a plurality of gate electrodes 14.

[0078] In Figure 1, there are four gates 14a to 14d, but the number of gates could be different without departing from the invention.

[0079] Gates 14a to 14d are connected to a control device 20 by respective leads 15a to 15d, as shown in Figure 6.

[0080] The source 11 and drain 12 electrodes are connected to the control device 20 by respective leads 16 and 17.

[0081] The control device 20 is configured to apply predefined potentials on the gates 14a to 14d according to a measuring sequence. The control device may be microcontroller based.

[0082] The gates 14 may be functionalized to be sensitive to respective species and the gates may be controlled in a sequence to make measurements representatives of the concentration of these species.

[0083] In a variant, the gates 14 are sensitive to a same species, and the gates are controlled in a sequence to make successive measurements of a same analyte. These measurements may then be averaged. When the gates 14 are intended to measure a same analyte with measures averaged, then preferably the gates are identical. Extracting an average value may prove useful in case of highly inhomogeneous analytes in the medium under study.

[0084] The electrodes may be made by ink-jet printing on a suitable substrate, such as glass, using for example a silver ink such as Sigma Aldrich Silver Nanoparticle ink, which is then annealed to form conductive base layers.

[0085] The channel 13 electronically conductive layer may consist of small organic and inorganic molecules, conjugated polymers (CPs) in either intentionally doped or pristine form with electrochemical doping/dedoping properties. The conductive layer could conduct holes (p-type) or electrons (n-type).

[0086] CPs are composed of planar, rigid aromatic repeat units that typically template an extended ribbonlike macromolecular conformation. Most of the devices to date rely on well-established CPs such as polypyrrole (PPy), polyaniline, and, predominantly, polythiophene derivatives such as doped poly(3,4-ethylenedioxythiophene) (PEDOT).

[0087] PPy could be used in its pristine form or doped by various dopants, such as paratoluene-2-sulfonic acid (PTSA), sodium dodecylbenzene sulfonate (SDBS) or sodium dodecyl sulfate (SDS).

[0088] Polyaniline could be also used in a doped form (with phytic acid or HCl).

[0089] Poly(3,4-ethylenedioxythiophene) could be doped with various dopants, including chloride anions as well as small molecular anions such as tosylate, biodopants (negatively charged biomolecular agents such as synthetic lipids, sugars, and laminin peptides and even living cells) and polyanions such as PSS.

[0090] PEDOT:S is such a CP with pendant sulfonate groups anchored onto the PEDOT backbone.

[0091] Among n-type conductors one may use : perylene diimides (PDI), possibly functionalized with dioctyl side chains (i.e., PTCDI-C8), naphtalene diimide dithiophene copolymer P(NDI2OD-T2), thiophene based copolymer with oligoethylene glycol side chains p(g2T-TT); naphtalene diimide dithiophene copolymer with oligoethylene glycol based side chains p(gNDI-g2T) and ladder-type conducting polymers such as poly(benzimidazobenzophenathroline) BBL.

[0092] Currently the most used CP are PPy; polyaniline; PEDOT:PSS; PEDOT-S; PTHS (tetrabutylammonium poly(6-(thiophen-3-yl)hexane-1-sulfonate); p(g2T-TT); p(gNDI-g2T).

[0093] The channel conductive layer may be made of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). This polymer may be deposited by printing. Preparation of the PEDOT:PSS ink is disclosed by Pappa A.-M. et al Organic Electronics for Point-of-Care Metabolite Monitoring. Trends in Biotechnology (2017).

[0094] This PEDOT:PSS ink may also be printed on the gates for further functionalization thereof, for example by deposition of (3-glycidyloxypropyl)trimethoxysilane (GOPS). In such an example, the PEDOT:PSS ink may comprise polyvinyl alcohol because it has hydroxyl groups that are used for further bonding of GOPS through a reaction of condensation.

[0095] The gates may be functionalized for detection of glucose as disclosed by Zhu, Z-T et al, A simple poly(3,4-ethylenedioxythiophene) polystyrene sulfonate transistor for glucose sensing at neutral pH, Chemical Communications, 1556-1557 (2004), Macaya, D.J. et al, Simple Glucose sensors with micromolar sensitivity based on organic electrochemical transistors. Sensors and Actuators, B:Chemical 123, 374-378 (2007) or Bernards, D.A. et al, Enzymatic sensing with organic electrochemical transistors, Journal of Material Chemistry 18, 116-120 (2008), for detection of lactate, as disclosed by Jia, W. et al, Electrochemical tatoo biosensors for real-time non invasive lactate monitoring in human perspiration. Analytical Chemistry 85, 6553-6560 (2013), for detection of liposome as disclosed by Tarabella, G. et al. Liposome sensing and monitoring by organic electrochemical transistors integrated in microfluidics. Biochimica et Biophysica Acta (BBA)-General Subjects 1830, 4374-4380 (2013), for the detection of dopamine as disclosed by Tang, H. Lin, P. Chan, H.L. & Yan, F. Highly sensitive dopamine biosensors based on organic electrochemical transistors, Biosensors and Bioelectronics 26, 4559-4563 (2011), for the detection of DNA as disclosed by Lin P, Luo, X. Hsing, I & Yan, F. Organic electrochemical transistors integrated in flexible microfluidics systems and used for label-free DNA sensing, Advanced Materials 23, 4035-4040 (2011) or for the detection of IgG as disclosed by Macchia, E. et al, Ultra-sensitive protein detection with organic electrochemical transistors printed on plastic substrate.

[0096] In the example shown in Figure 1, the gates 14a to 14d have a same shape but in variants (not shown) the gates have different shapes and/or sizes.

[0097] The source and drain electrodes 11, 12 and the gate electrodes 14 may be coplanar on a same substrate 30, as shown in Figure 2. This allows a simultaneous and easy fabrication, for example by ink-jet printing, of all electrodes.

[0098] In a variant, as shown in Figure 3, the gates 14 are not coplanar with the source 11 and drain 12 electrodes.

[0099] The gates 14 may be carried by a substrate 40 that is parallel to the substrate 30 carrying the source 11 and drain 12 electrodes, as shown in Figure 4.

[0100] The sensor 10 may comprise only one set of source 11 and drain 12 electrodes connected to a corresponding channel 13.

[0101] In a variant, as shown in Figure 5, the sensor 10 comprises at least two such sets.

[0102] In the example of this Figure, the sensor comprises a first set of source 11a and drain 12a electrodes, connected to a respective channel 13a, and a second set of source 11b and drain 12b electrodes, connected to a respective channel 13b.

[0103] The channels 13a and 13b do not have the same geometric features or materials, so that their response is different. For example, one channel may be based on n-type material as one of those listed above and the other channel may be based on p- type material such as PEDOT: PSS for example.

[0104] The channels may be coplanar, as shown, or be non-coplanar (variant not shown).

[0105] The invention is not limited to the disclosed embodiments.

[0106] For example, the sensor may comprise a depolarization electrode 40 as shown in Figure 7, on which a specific potential is applied between measurements. Potential applied between this electrode 40 and the source electrode 11 between each functional gate-source potential application is assuring fast de-doping of the channel. The depolarization electrode 30 may extend on the substrate 30 parallel the channel 13, with the gate electrodes situated between the depolarizing electrode 40 and the channel 13.

[0107] Figure 8 is an example of possible chronogram of applied potential. In this Figure, SD is the potential applied between source and drain electrodes; SG1 is the potential applied between source and first gate electrodes; SG2 is the potential applied between source and second gate electrodes; SG3 is the potential applied between source and third gate electrodes; and SGD is the potential applied between source and depolarized gate electrodes.

[0108] For the duration of the measurements, i.e. from t1 until at least t7, the potential SD varies from 0V to a negative value of about -IV for example. SD remains constant at this negative value in the interval t1-t7.

[0109] For measurement with first gate electrode, the potential SG1 is set at a positive value of about 0,5V, while other potentials SG2, SG3 and SGD remains at 0V.

[0110] Then, at t2, SG1 is set back to 0V while SGD varies from 0V to a negative value of about a little less than -0,5 V for example.

[0111] At t3, the measurement is made using the second gate by setting SG2 to a positive value of about a little more than 1V for example.

[0112] The other potentials SG1, SG3 and SGD remain at 0V.

[0113] Then, at t4, a depolarizing potential SGD is applied until t5. SGD may be set to a lower negative value than between t2 and t3; to consider the fact that the gate potential SG2 was higher than SG1.

[0114] At t5, the measurement is made using the third gate by setting SG3 to a positive value less than SG1, for example about 0,3V.

[0115] The other potentials SG1, SG2 and SGD remain at 0V.

[0116] Then, at t6, a depolarizing potential SGD is applied until t7. SGD may be set to a higher negative value than between t2 and t3; to consider the fact that the gate potential SG3 was lower than SG1.


Claims

1. An Organic Electro-Chemical Transistor based sensor, comprising:

- at least one set of source (11) and drain (12) electrodes,

- a plurality of gate electrodes (14) for this set,

- at least one channel (13) connected to the source and drain electrodes of the at least one set.


 
2. The sensor of claim 1, at least one gate electrode (14) being functionalized.
 
3. The sensor of claim 2, the gate electrodes (14) being differently functionalized gate electrodes.
 
4. The sensor of any one of claims 1 to 3, the source and drain electrodes being coplanar on a same substrate (30).
 
5. The sensor of claim 4, the gate electrodes (14) being coplanar with the source and drain electrodes.
 
6. The sensor of claim 4, the gate electrodes (14) being supported by a different substrate (40) than the source and drain electrodes.
 
7. The sensor of claim 6, the gate electrodes (14) on the one hand and the source and drain electrodes on the other hand extending in respective parallel planes.
 
8. The sensor of any one of claims 1 to 7, at least two gate electrodes (14) being identical.
 
9. The sensor of any one of claims 1 to 8, at least two gate electrodes (14) being made of different materials.
 
10. The sensor of any one of claims 1 to 9, comprising at least two sets of source (11a; 11b) and drain (12a; 12b) electrodes, connected to respective channels (13a; 13b).
 
11. The sensor of any one of claims 1 to 10, comprising at least one depolarizing electrode (40).
 
12. A method for producing a sensor according to any one of claims 1 to 11, comprising ink jet printing of the source (11), drain (12) and gate (14) electrodes.
 
13. The method of claim 12, comprising functionalizing differently at least two gate electrodes (14).
 
14. A method of detecting at least one analyte in a medium, using a sensor according to any one of claims 1 to 11, comprising:

- selecting a gate electrode (14),

- applying a predefined potential to the selected gate electrode, and

- determining a concentration of an analyte based on a current measured between the source and drain electrodes during application of the predefined potential to the selected gate electrode.


 
15. The method of claim 14, the gate electrodes (14) being identical and at least two gate electrodes being selected in sequence, and an average value being computed based on the values measured for the successive selected gates.
 
16. The method of any one of claims 14 and 15, wherein the sensor comprises at least one depolarizing electrode (40), said method comprising applying a predefined potential on the depolarizing electrode for de-doping the channel before applying the predefined potential to a selected gate.
 




Drawing

















REFERENCES CITED IN THE DESCRIPTION



This list of references cited by the applicant is for the reader's convenience only. It does not form part of the European patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be excluded and the EPO disclaims all liability in this regard.

Patent documents cited in the description




Non-patent literature cited in the description