(19)
(11)EP 3 777 909 A1

(12)EUROPEAN PATENT APPLICATION
published in accordance with Art. 153(4) EPC

(43)Date of publication:
17.02.2021 Bulletin 2021/07

(21)Application number: 18914757.2

(22)Date of filing:  30.05.2018
(51)Int. Cl.: 
A61M 1/00  (2006.01)
(86)International application number:
PCT/CN2018/089107
(87)International publication number:
WO 2019/196175 (17.10.2019 Gazette  2019/42)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30)Priority: 11.04.2018 WO PCT/CN2018/082719

(71)Applicant: Zhongshan Opththalmic Center of Sun Yat-sen University
Guangzhou, Guangdong 510060 (CN)

(72)Inventors:
  • LIU, Yizhi
    Guangzhou, Guangdong 510060 (CN)
  • LUO, Yan
    Guangzhou, Guangdong 510060 (CN)
  • LIN, Xiaofeng
    Guangzhou, Guangdong 510060 (CN)
  • LV, Lin
    Guangzhou, Guangdong 510060 (CN)

(74)Representative: Isern Patentes y Marcas S.L. 
Avda. Diagonal, 463 Bis, 2°
08036 Barcelona
08036 Barcelona (ES)

  


(54)LIQUID SAMPLE COLLECTION APPARATUS WITH VALVE


(57) This invention provides a collection device with a valve for a liquid specimen, comprising of a reservoir having a sealed cavity, wherein the sealed cavity is under negative pressure; a delivery tube in communication with the sealed cavity of the reservoir. and having a delivery inlet, a delivery outlet, and a valve disposed between the delivery inlet and the delivery outlet, wherein the valve is configured to control the communication and blocking between the delivery inlet and the delivery outlet, and an angle is formed by an extension line of the delivery inlet an extension line of the delivery outlet, and a piercing component for piercing a tissue is connected with the delivery inlet of the delivery tube. According to the present invention, a doctor or others can collect a liquid specimen conveniently and safely via an automatic process by piercing a tissue (such as the anterior chamber of the eye) with the piercing component, and can conveniently perform subsequent tests directly on the collected liquid specimen stored in the reservoir.




Description

Field of Invention



[0001] The present invention relates to the field of medical instruments, in particular to a collection device with a valve for a liquid specimen.

Description of Related Art



[0002] In medical research, liquid specimens obtained from tissues are largely used in clinical practice and scientific research. For example, for clinical specimen commonly used in ophthalmology, such as aqueous humor and vitreous humor, is very valuable for etiological diagnosis and treatment guidance of various retinal diseases and uveitis, as well as lowering intraocular pressure (IOP) for glaucoma. Therefore, effective collection and preservation of liquid specimens is also an important part of clinical surgeries and other treatment processes.

[0003] For liquid specimens, for example, in ophthalmology, paracentesis was once the main method for obtaining liquid specimens, but this method has high demand on doctors' surgical skills, collection positions. Besides, the operation process of paracentesis is poorly controllable, since doctors need to extract liquid specimens from tissues manually. Currently, the commonly used method for liquid specimen collection in ophthalmology has the following problems: (1)first, intraocular liquid available to be collected for a specimen is spare. For example, assuming that when a paracentesis is ongoing on a anterior chamber to collect the humor, complications may be caused easily since the eyeball must be pressed for multiple times in order to obtain a sufficient amount of specimen; (2)furthermore, the syringe is used as a collection device for a liquid specimen, but this method requires the surgeon to operate with both hands at the same time, which is poorly controllable. Therefore, it may be prone to cause an excessive extraction and thereby causing surgical complications ; (3)moremover, a great loss might be caused, since the specimen, hard to be obtained, is stored in the needle portion; (4)in addition, there are multiple procedures to transfer a specimen collected on an operating table to a reservoir for storage, increasing the workload of the doctor to take the specimen; (5)lastly, there is no good minimally invasive method for collecting vitreous humor, effective minimally invasive methods for collecting vitreous humor are not yet developed except vitrectomy in which surgeon obtains vitreous humor in large amount.

SUMMARY OF INVENTION



[0004] The present invention has been completed given the above-mentioned state of the prior art and aims to provide a collection device with a valve for a liquid specimen, which is not only simple and convenient to operate, but also safe and reliable.

[0005] For this purpose, the present invention provides a collection device with a valve for a liquid specimen, including a reservoir having a sealed cavity, wherein the sealed cavity is under negative pressure; a delivery tube in communication with the sealed cavity of the reservoir and having a delivery inlet, a delivery outlet, and a valve disposed between the delivery inlet and the delivery outlet, wherein the valve is configured to control the communication and blocking between the delivery inlet and the delivery outlet, and an angle is formed by an extension line of the delivery inlet and an extension line of the delivery outlet; and a piercing component for piercing a tissue and in communication with the delivery inlet of the delivery tube.

[0006] According to the present invention, an operator such as a doctor, a nurse or any other professional person can conveniently collect a liquid specimen via an automatic process under negative pressure by piercing a tissue (such as in the anterior chamber or in the vitreous body of the eye) with the piercing component. They can also conveniently perform subsequent tests directly on the collected liquid specimen stored in the reservoir, so that the collection device is particularly functional for collecting aqueous humor and vitreous humor in ophthalmology.

[0007] Optionally, in the collection device according to the present invention, the reservoir is detachably connected to the delivery tube. In this way, after the liquid specimen has been collected into the reservoir, the reservoir may be conveniently separated in order to perform subsequent test steps directly.

[0008] Optionally, in the collection device according to the present invention, the valve may be a press-type mechanical valve. In this way, it can be convenient for an operator such as a doctor to operate the valve of the delivery tube so as to control the collection of the liquid specimen conveniently.

[0009] Optionally, in the collection device according to the present invention, in the collection device, the liquid specimen may be aqueous humor in the eye. In this case, aqueous humor in the eye can be collected in an automatic and convenient way by taking the advantage of the negative pressure (for example, lower than intraocular pressure) within the reservoir.

[0010] Optionally, in the collection device according to the present invention, the piercing component may be provided with a limit mechanism for limiting a piercing position. By doing this, the piercing position pierced by the piercing component can be controlled in a more accurate way, and thereby improving the reliability of the surgery.

[0011] Optionally, in the collection device according to the present invention, the angle formed by the extension line of the delivery inlet and the extension line of the delivery outlet may be 30-120 degrees or 180-300 degrees. In such case, a doctor or the like can conveniently operate the piercing component, and adverse effects by the reservoir and the delivery tube on the operation of the piercing component can be avoided.

[0012] Optionally, in the collection device according to the present invention, the reservoir may be a transparent tube. In this way, it can be convenient for the operator such as a doctor to observe the state of collection of the liquid specimen in the reservoir in real time.

[0013] Optionally, in the collection device according to the present invention, the reservoir may be provided with scales. In this way, the operator such as a doctor can get to know the amount of the liquid specimen that has been collected in real time.

[0014] Optionally, in the collection device according to the present invention, the collection device includes a sleeve cap which detachably covers the piercing component. In this way, it can be ensured that the collection device is in a sealed state, and an operator can be prevented from being injured by the piercing component.

[0015] Optionally, in the collection device according to the present invention, the piercing component may be a syringe. In this way, it can be convenient for the operator such as a doctor to pierce a tissue to collect a liquid specimen.

[0016] Optionally, in the collection device according to the present invention, the reservoir may be provided with non-slip ribs on an outer surface. In this way, it can be convenient for the operator such as a doctor to remove the reservoir.

[0017] According to the present invention, the collection device with a valve for a liquid specimen, which is simple and convenient to operate and is safe and reliable, can be provided.

BRIEF DESCRIPTION OF THE DRAWINGS



[0018] 

FIG. 1 is a schematic diagram of the collection device with a valve for a liquid specimen, according to an embodiment of the present invention.

FIG. 2 is a three-dimensional structural diagram of the collection device with a valve for the liquid specimen according to an embodiment of the present invention.

FIG. 3 is a decomposition diagram of the collection device shown in FIG. 2 according to an embodiment of the present invention.

FIG. 4 is a schematic diagram of the delivery tube of the collection device shown in FIG. 2 according to an embodiment of the present invention.

FIG. 5 is a three-dimensional structural diagram of the delivery tube of the collection device shown in FIG. 2 according to an embodiment of the present invention.

FIG. 6 is a schematic cross-sectional diagram of the delivery tube along a section line A-A' in FIG. 5 according to an embodiment of the present invention.

FIG. 7 is a three-dimensional structural diagram of a piercing component of the collection device according to an embodiment of the present invention.

FIG. 8 is a schematic diagram showing a usage state of the piercing component of the collection device according to an embodiment of the present invention.

FIG. 9 is a three-dimensional structural diagram of a sleeve cap of the collection device according to an embodiment of the present invention.

FIG. 10 is a schematic diagram of the channel of the collection device according to an embodiment of the present invention.

FIG. 11 is a schematic diagram of the collection device according to another embodiment of the present invention.


DETAILED DESCRIPTION



[0019] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description, the same reference numerals are given to the same components, and repeated descriptions are omitted. In addition, the accompanying drawings are for illustrative purposes only, and the ratio of the dimensions of the components to each other or the shapes of the components may be different from the actual.

[0020] It should be noted that the terms "comprises" and "has", as well as any variations thereof, for example a process, method, system, product or apparatus that comprises or has a series of steps or elements are not necessarily limited to those steps or elements expressly listed, but may comprise or have other steps or elements that are not expressly listed or inherent to the process, method, system, product or apparatus.

[0021] FIG. 1 is a schematic diagram of the collection device with a valve, according to an embodiment of the present invention. FIG. 2 is a three-dimensional structural diagram of the collection device with a valve for the liquid specimen, according to an embodiment of the present invention. FIG. 3 is a decomposition schematic diagram of the collection device shown in FIG. 2.

[0022] As shown in FIG. 1, the collection device with a valve for the liquid specimen (hereinafter sometimes referred to as "collection device") 1 includes a reservoir 10, a delivery tube 20, and a piercing component 30. The delivery tube 20 has valve 23(described later) configured to control communication between the reservoir 10 and the piercing component 30 Therefore, an operator such as a doctor, a nurse or other professional person can conveniently collect a liquid specimen via an automatic process under negative pressure by piercing a tissue (such as the anterior chamber of the eye) with the piercing component 30, and can conveniently perform subsequent tests directly on the collected liquid specimen stored in the reservoir.

[0023] In this embodiment, the reservoir 10 may have a sealed cavity 11, wherein the sealed cavity 11 is under negative pressure. Here, the negative pressure is set according to different uses, that is, the sealed cavity 11 of the reservoir 10 may be made to be under different negative pressures according to liquid specimens to be collected from different tissues, and then the negative pressure is defined as the air pressure in the sealed cavity 11 being lower than the air pressure in the tissues. For example, for a liquid specimen in the eye, such as aqueous humor, the corresponding negative pressure is lower than the intraocular pressure.

[0024] In some examples, the sealed cavity 11 may form a negative pressure environment with an air pressure lower than a specified air pressure, which may help to implement an automatic collection of a liquid specimen. In addition, to better utilize negative pressure for automatic collection, the pressure in the sealed cavity 11 is generally lower than the pressure within a tissue. In some examples, the air pressure in the sealed cavity 11 may be set to, for example, 5000 Pa, 1000 Pa, 500 Pa, 100 Pa, etc., depending on different uses.

[0025] In addition, the capacity of the sealed cavity 11 of the reservoir 10 is not particularly limited, and may be 1 mL to 20 mL, 20 mL to 50 mL, or 1 mL to 100 mL. For example, for a liquid specimen in ophthalmology, the volume (capacity) of the sealed cavity 11 might be 0.05 mL to 0.1 mL, 0.1 mL to 0.20 mL, or 0.20 mL to 0.50 mL.

[0026] In some examples, the collection device 1 according to this embodiment may be configured into different models, and accordingly, the capacity and the magnitude of negative pressure in the reservoir 10 may be different. Therefore, the applicability of the collection device 1 can be improved.

[0027] In some examples, the reservoir 10 may be a hollow cylinder. In addition, in other examples, the reservoir 10 may be a hollow cuboid, a hollow polygonal prism, or the like. Therefore, the collection device can be adapted to collection of liquid specimens for different purposes.

[0028] In some examples, the bottom of the reservoir 10 may be flat, which may facilitate placement of the reservoir 10. In addition, in some examples, the bottom of the reservoir 10 may be concave. In such case, the placement of the reservoir 10 is also facilitated.

[0029] In some examples, the reservoir 10 may be made of a material such as plastic, glass, or metal. In this way, in practical clinical applications, an operator such as a doctor can select reservoirs 10 made of different materials for different liquid specimens.

[0030] In some examples, the reservoir 10 may be a transparent tube. Therefore, it can be convenient for the operator to observe the state of collection of the liquid specimen in the reservoir in real time. In some examples, the reservoir 10 may be a transparent glass or plastic tube. Furthermore, in some examples, the reservoir 10 may be provided with scales. For example, the reservoir 10 is provided with scales indicating the volume of the reservoir on an outer surface of the reservoir 10. In this case, an operator such as a doctor can get to know the amount of the liquid specimen that has been collected in real time.

[0031] In some examples, the scales on the reservoir 10 may be provided along with the outer surface of the reservoir 10, and the readings of the graduated markings increase in order from the bottom of the reservoir 10, for example, 0 µL, 5 µL, 10 µL, ..., 100 µL, 200 µL, etc. However, the disclosure is not limited thereto, for example, the readings of the graduated markings may increase in order from a joint between the reservoir 10 and the delivery tube 20 to the bottom of the reservoir 10, for example, 0 µL, 5 µL, 10 µL, ..., 100 µL, 200 µL, etc.

[0032] In some examples, the liquid specimen collected by the collection device 1 may be the aqueous humor in the eye. In this case, aqueous humor in the eye can be collected conveniently via an automatic process through the characteristics of negative pressure (lower than intraocular pressure) feature within the reservoir 10.

[0033] In an clinical surgery of ophthalmology, the collection of a liquid specimen is generally difficult, for example, the amount of collected aqueous humor is generally no more than 100 µL, therefore, how to guarantee the amount of a liquid specimen to be collected and prevent excessive collection is always difficult for clinical practice in ophthalmology. In this embodiment, by adopting the negative pressure collection device 1 having a controlling valve, those previous difficulties can be effectively overcome, and it is ensured that a doctor or others can collect a liquid specimen such as aqueous humor in a required amount safely and reliably.

[0034] In some examples, when the collection device 1 is used to collect aqueous humor in the eye, the collection amount of aqueous humor is small, for example, only 20-100 µL, and then, in order to effectively read the sealed cavity 11 of the reservoir 10, the reservoir 10 may be provided in a long and narrow shape. In another word, the sealed cavity 11 of the reservoir 10 is configured to have a lumen with a small bottom area and a large height.

[0035] In some examples, the reservoir 10 may be provided with a non-slip mechanism on the outer surface. Therefore, it can be convenient for an operator such as a doctor remove the reservoir 10. In other examples, the reservoir 10 may be provided with multiple projections on the outer surface, so that it can be convenient for the operator to remove the reservoir 10, and the reservoir 10 is prevented from slipping and falling off from the operator's hand.

[0036] In some examples, the reservoir 10 may be further provided with a sealing cover (not shown). For example, when a liquid specimen has been collected into the reservoir 10, the reservoir 10 may be removed from the delivery tube 20 and covered by the sealing cover, thereby it can be ensured that the liquid specimen in the reservoir 10 is not polluted by the outside during subsequent operations, and subsequent storage or tests of the liquid specimen in the reservoir 10 is facilitated.

[0037] FIG. 4 is a schematic diagram of a delivery tube of the collection device shown in FIG. 2. FIG. 5 is a three-dimensional structural diagram of the delivery tube of the collection device shown in FIG. 2. FIG. 6 is a schematic cross-sectional diagram of the delivery tube along a line A-A' in FIG. 5.

[0038] In the collection device 1 according to this embodiment, the delivery tube 20 is connected to and in communication with the reservoir 10. That is, a channel is formed between the delivery tube 20 and the reservoir 10 (see FIG. 6 described later). Specifically, the delivery tube 20 may be in communication with the sealed cavity 11 of the reservoir 10, and as the sealed cavity 11 is under negative pressure, the liquid specimen can flow into the sealed cavity 11 of the reservoir 10 through the delivery tube 20.

[0039] In some examples, the delivery tube 20 may form a Luer connection with the reservoir 10. For example, one end of the delivery tube 20 is a Luer fitting which forms a Luer connection with the reservoir 10. In this case, the delivery tube 20 can be removably mounted to the reservoir 10.

[0040] In addition, the delivery tube 20 has a delivery inlet 21, a delivery outlet 22, and a valve 23 disposed between the delivery inlet 21 and the delivery outlet 22.

[0041] In this embodiment, the delivery inlet 21 may be connected to a piercing component 30 (described later), the delivery outlet 22 may be in communication with the reservoir 10, and the communication and blocking between the delivery inlet 21 and the delivery outlet 22 are controlled by the valve 23. In this case, the communication and blocking between the reservoir 10 and the piercing component 30, in particular the liquid specimen in the tissue pierced by the piercing component 30, can be conveniently controlled by controlling the valve 23.

[0042] As described above, in the delivery tube 20, the valve 23 may control the communication and blocking between the delivery inlet 21 and the delivery outlet 22. In addition, an angle θ is formed by an extension line L1 of the delivery inlet 21 forms and an extension line L2 of the delivery outlet 22 (see FIG. 4). In some examples, the angle θ formed by the extension line of the delivery inlet 21 and the extension line of the delivery outlet 22 may be 30-330 degrees. In this case, a doctor or others can operate the piercing component 30 conveniently, and adverse effects caused by the reservoir 10 and the delivery tube 20 on the operation of the piercing component 30 is avoided.

[0043] Furthermore, in other examples, the angle θ formed by the extension line of the delivery inlet 21 and the extension line of the delivery outlet 22 may be 30-120 degrees or 180-300 degrees. In other examples, the angle θ formed by the extension line of the delivery inlet 21 and the extension line of the delivery outlet 22 may be 90 degrees or 270 degrees (see FIG. 4), so that it is easier for the operator such as a doctor to operate the collection device 1.

[0044] In some examples, the reservoir 10 is detachably connected to the delivery tube 20. Therefore, after the liquid specimen has been collected into the reservoir 10, the reservoir 10 may be conveniently separated in order to perform subsequent test steps directly. For example, the reservoir 10 may be removed from the delivery tube 20, and then perform subsequent medical tests directly on the reservoir 10 with the liquid specimen, thereby test time can be saved, which in turn improve the clinical and medical efficiency. In some examples, the valve 23 may be a press-type mechanical valve. In this case, it can be convenient for an operator such as a doctor to use the valve 23 of the delivery tube so as to control the collection of the liquid specimen conveniently. Specifically, an operator such as a doctor can easily control the automatic collection of the liquid specimen by pressing the valve 23, thereby improving the clinical surgery efficiency of the doctor or others.

[0045] As shown in FIG. 5 and FIG. 6, in this embodiment, the valve 23 may generally include a pressing unit 231, a rod body 232 connected to the pressing unit 231, an inner cavity cooperating with the rod body 232, seal ring 233 and seal ring 234 separately arranged at different positions on the rod body 232, and an elastic component 235 provided in the inner cavity 236.

[0046] In some examples, the pressing unit 231 may be circular pie-shaped, so that it can be convenient for an operator such as a doctor to access and operate such as to press. In addition, as shown in FIG. 2, a case where the pressing unit 231 is disposed on one side of the valve 23 is shown, but the present disclosure is not limited thereto, in some examples, the pressing unit 231 may also be disposed on the other side of the valve 23.

[0047] In the valve 23, the elastic component 235 is changed by pressing the pressing unit 231, so that the rod body 232 is provided with at least a first position and a second position in the inner cavity 236. For example, when the rod body 232 presses the spring 235 to be at the first position, one end 21a of the delivery inlet 21 and one end 22a of the delivery outlet 22 are between the sealing ring 233 and the sealing ring 234. In this case, the delivery inlet 21 is in communication with the delivery outlet 22 via a space 236, and the reservoir 10 is in communication with the outside (tissue) via the delivery inlet 21, the delivery outlet 22 and the piercing component 30. For example, when the rod body 232 presses the spring 235 to be at the second position, for example, one end 21a of the delivery inlet 21 is between the sealing ring 233 and the sealing ring 234. In this case, the delivery inlet 21 is not in communication with the delivery outlet 22, and the reservoir 10 is isolated from the outside. In this way, the opening and closing of the valve 23 can be controlled by pressing the pressing unit 231, thereby conveniently controlling communication and isolation between the reservoir 10 having a negative pressure environment and the outside.

[0048] In this embodiment, the material for making the valve 23 is not particularly limited, and in some examples, the valve 23 may be made of materials such as plastic, glass, metal, and etc. From the perspective of durability, the valve 23 is preferably made of a metal material.

[0049] Furthermore, the delivery tube 20 can provided with an airtight plug 24 for evacuation in order to form negative pressure in the reservoir 10. Specifically, in a case where the delivery tube 20 (specifically, the delivery outlet 22 of the delivery tube 20) is in communication with the reservoir 10, for example, by inserting a syringe into a channel from the airtight plug 24 to the delivery outlet 22, and evacuating while keeping the valve 23 closed (at this time the delivery inlet 21 is not in communication with the delivery outlet 22). In this way, a specified negative pressure (for example lower than intraocular pressure) environment can be formed in the sealed cavity 11 of the reservoir 10 conveniently.

[0050] In addition, the airtight plug 24 can also maintain the negative pressure in the reservoir 10. Specifically, after evacuation via the airtight plug 24, the channel can be blocked as the airtight plug 24 can recover its original state. Therefore, the airtight plug 24 can still maintain the negative pressure environment of the reservoir 10. In some examples, the airtight plug 24 may be a rubber plug.

[0051] Furthermore, as described above, the reservoir 10 is connected to the delivery tube 20, and the airtight plug 24 is formed at one end close to the delivery outlet 22 of the delivery tube 20. In order to ensure that the airtight plug 24 can be used to provide an inlet for the negative pressure processing of the reservoir 10, at least one part of the airtight plug 24 needs to protrude from the reservoir 10 when the reservoir 10 is connected to the delivery tube 20, so as to allow, for example, a syringe for evacuation to be inserted into the airtight plug 24.

[0052] In some examples, the seal ring 233 and the seal ring 234 may be made of medical rubber such as silicone. In other examples, the seal ring 233 and the seal ring 234 may be alternatively made of other medical materials such as plastics, glass resins, artificial compounds, etc. Therefore, the air tightness of the valve 23 can be ensured while the requirements on material of medical instruments are satisfied.

[0053] In addition, in some examples, the valve 23 may be an electric valve. For example, the valve may be designated to detect both the change of the air pressure or the hydraulic pressure, the application of the electric valve allows it to automatically shut down as long as the electric valve detects the excessively low value of either the air pressure or hydraulic pressure, so that the delivery inlet 21 is no longer in communication with the delivery outlet 22. In this case, it can be more convenient for an operator to control the valve 23.

[0054] FIG. 7 is a three-dimensional structural diagram of a piercing component of the collection device according to an embodiment of this invention. FIG. 8 is a diagram showing a usage state of the piercing component of the collection device in use, according to an embodiment of the present invention. FIG. 9 is a three-dimensional structural diagram of a sleeve cap of the collection device according to an embodiment of the present invention. FIG. 10 is a schematic diagram of the channel this collection device use, according to an embodiment of the present invention. In FIG. 8, for the convenience of illustration of application examples, an example in which the collection device 1 is used to collect aqueous humor in an eyeball 2 is shown, but the present invention is not limited thereto.

[0055] As shown in FIG. 7, the piercing component 30 may include a main body 31 and a piercing portion 32 connected to the main body 31. In addition, the main body 31 may be in communication with the piercing portion 32, so that a liquid specimen can flow to the delivery tube 20 through the piercing component 30.

[0056] In some examples, in the piercing component 30, a narrow channel is formed between the main body 31 and the piercing portion 32 (see FIG. 10). Thereby it can be ensured that no loss of the liquid specimen will be caused because the liquid specimen will be retained in the main body 31 or in the piercing portion 32 when flowing through the piercing component 30. This structure is particularly suitable for use in cases where a small amount of liquid specimen, such as aqueous humor, is extracted.

[0057] In some examples, the piercing component 30 may form a Luer connection with the delivery tube 20. For example, one end, close to the delivery inlet 21, of the delivery tube 20 forms a Luer fitting so as to form a Luer connection with the piercing component 30.

[0058] In addition, in some examples, the piercing component 30 may be integrally formed with the delivery tube 20. In this case, the piercing component 30 may be a portion extending from the delivery tube 20.

[0059] In some examples, the piercing component 30 may be provided with a limit mechanism 33 for limiting a piercing position. Specifically, the limit mechanism 33 is provided between the main body 31 and the piercing portion 32 of the piercing component 30 to limit the piercing position. In this case, when a doctor or the like penetrates into a tissue with the piercing component 30, the piercing (penetration) position of the piercing component 30 is limited, so that the doctor or the like can control the depth of penetration of the piercing component 30 when they collect aqueous humor. Because of that, the piercing position of the piercing component 30 can be more accurately controlled, thereby effectively preventing the patient from receiving a secondary injury due to excessive penetration and improving the reliability of the surgery.

[0060] In the description herein, the piercing position refers to a position where the piercing component 30 penetrates into a tissue. Specifically, by penetrating into the tissue containing the liquid specimen, the liquid specimen in the tissue is allowed to communicate with the sealed cavity 11 of the reservoir 10, and then the liquid specimen in the tissue is automatically collected under the negative pressure in the reservoir 10.

[0061] In the example of the piercing component 30 penetrating into the eyeball 2 to obtain an aqueous humor specimen as shown in FIG. 8, the piercing position should avoid where the iris and the cornea is, in order to prevent damages on the afore-mentioned tissues. In addition, it should be noted that the operating direction of the piercing component 30 as shown in FIG. 8 is exemplary only. For example, the piercing component 30 may also penetrate into the anterior chamber of the eyeball in a direction substantially parallel to the iris to obtain an aqueous humor specimen.

[0062] In some examples, the limit mechanism 33 may be designed to conform to the surface of the tissue, thereby achieving an effect of automatically aligning the piercing portion 32 of the piercing component 30 to the piercing position. Therefore, it can be convenient for an operator such as a doctor to perform the piercing operation.

[0063] In some examples, the piercing component 30 may have a protrusion 34. With the protrusion 34, the piercing component 30 can be removed from or mounted to the delivery tube 20 easily. A pair of opposite protrusion 34 may be provided, so that the piercing component 30 can be removed from or mounted to the delivery tube 20 more easily.

[0064] In some examples, the piercing component 30 may also be tapered along its length. Therefore, it can be convenient for the operator such as a doctor to pierce a tissue conveniently, thereby improving the reliability and stability.

[0065] In addition, in some examples, the piercing component 30 may be a syringe. In this case, as the front end of the syringe is sharp, a tissue such as an eyeball can be easily pierced. Therefore, it can be convenient for an operator such as a doctor to pierce a tissue to collect a liquid specimen.

[0066] In some examples, a needle of the syringe works as the piercing component 30 may have an outer diameter of 0.31-4.57 mm and an inner diameter of 0.15-3.81 mm. For the collection of liquid specimens in ophthalmology, the needle of the syringe has an outer diameter of preferably 0.31 mm to 0.64 mm and an inner diameter of preferably 0.15 mm to 0.33 mm, so that liquid specimens can be effectively collected with a minimized wound, thereby achieving safe and minimally invasive collection of specimens.

[0067] As described above, the reservoir 1, the delivery tube 2 and the piercing component 3 are connected and a narrow channel is formed therein (as shown in FIG. 10), so that the liquid specimen can be automatically collected into the reservoir 1 via the piercing component 3 and the delivery tube 2. In this case, the liquid specimen can be effectively collected as much as possible with a minimized wound, thereby achieving safe and minimally invasive collection of specimens.

[0068] In addition, in this embodiment, the length of the piercing portion 32 of the piercing component 30 is not particularly limited, for example, for a liquid specimen in ophthalmology such as aqueous humor, a length that can allow piercing the anterior chamber of the eye and penetration into the interior of the anterior chamber is enough.

[0069] In this embodiment, the collection device 1 may further have a sleeve cap 40 (see FIG. 3). In some examples, the sleeve cap 40 is detachably mounted to the piercing component 30. As shown in FIG. 3 and FIG. 9, by assembling the reservoir 10, the delivery tube 20, the piercing component 30, and the sleeve cap 40 together, it can be ensured that the collection device 1 is under protection, and the piercing component 40 is prevented from injuring an operator such as a doctor by improper operation. Furthermore, the sleeve cap 40 may also block dust and prevent the piercing component 30 from being contaminated by dust or other pollutants.

[0070] In some examples, the sleeve cap 40 may be an airtight cap covering the piercing component 30. Therefore, the negative pressure state of the reservoir 10 can be further ensured.

[0071] In addition, in some examples, the sleeve cap 40 may cover both the piercing component 30 and the valve 23. In this case, the valve 23 can also be protected by the sleeve cap 40, so that the valve 23 can prevented from a misoperation. Here, the tail end of the sleeve cap 40 may be subjected to adaptive adjustment according to the structure of the valve 23 so as to matingly cover the valve 23.

[0072] In some examples, the sleeve cap 40 may be made of materials such as plastics, glass, or metal. In some examples, the sleeve cap 40 may be in a variety of shapes such as a cylinder, a cuboid, a polygonal prism, or an irregular shape.

[0073] In some examples, the sleeve cap 40 may be provided with non-slip ribs on an outer wall (see FIG. 9). In some examples, numerous non-slip ribs 41 may be provided, for example, four, eight or twelve non-slip ribs are provided in a peripheral direction of the sleeve cap 40. In some examples, the non-slip ribs 41 may be provided in a length direction of the sleeve cap 40 and formed to have an elongated shape.

[0074] In addition, in some other examples, the sleeve cap 40 may be further provided with projections on the outer wall. In some other examples, the sleeve cap 40 may be further provided with a non-slip sleeve on the outer wall. Therefore, slipping during use can be prevented.

[0075] While the invention has been particularly described with reference to the drawings and embodiments, it will be understood that the foregoing description is not intended to limit the invention in any way. This invention may be modified and changed by those skilled in the art without deviating from the spirit and scope of the present invention, and such modifications and changes all fall within the protection scope of the claims of the present invention.

[0076] For example, in the collection device 1, the angle θ formed by the extension line of the delivery inlet 21 and the extension line of the delivery outlet 22 is 180 degrees, that is, the delivery tube 20 is formed to have an elongated shape. At the same time, the piercing component 30, particularly the piercing portion 32 of the piercing component 30, may be configured to have a bent shape, as shown in FIG. 11. In this case, the piercing portion 32 of the piercing component 30 may have a bent portion 321. Therefore, the operator can push the delivery tube 20 from different angles, and such a structure is particularly suitable for the collection of a liquid specimen in the eye, such as aqueous humor.

[0077] In some examples, the bent portion 321 may have a bent angle of, for example, 30 degrees, 45 degrees, 60 degrees, 90 degrees, etc. In some examples, the bent portion 321 may be made of a memory metal material. Therefore, the bent angle can be adjusted depending on the case so as to adapt to collection at different sites.


Claims

1. A collection device with a valve for a liquid specimen, characterized by comprising:

a reservoir having a sealed cavity, wherein the sealed cavity is under negative pressure;

a delivery tube in communication with the sealed cavity of the reservoir and having a delivery inlet, a delivery outlet and a valve disposed between the delivery inlet and the delivery outlet, wherein the valve is configured to control communication and blocking between the delivery inlet and the delivery outlet, and an angle is formed by an extension line of the delivery inlet and an extension line of the delivery outlet; and

a piercing component for piercing a tissue and in communication with the delivery inlet of the delivery tube.


 
2. The collection device according to Claim 1, wherein,
the reservoir is detachably connected to the delivery tube.
 
3. The collection device according to Claim 1, wherein,
the valve is a press-type mechanical valve.
 
4. The collection device according to Claim 1, wherein,
the liquid specimen is aqueous humor in the eye.
 
5. The collection device according to Claim 4, wherein,
the piercing component is provided with a limit mechanism for limiting a piercing position.
 
6. The collection device according to Claim 1, wherein,
the angle formed by the extension line of the delivery inlet and the extension line of the delivery outlet is 30-120 degrees or 180-330 degrees.
 
7. The collection device according to Claim 1, wherein,
the reservoir is a transparent tube.
 
8. The collection device according to Claim 7, wherein,
the reservoir is provided with scales.
 
9. The collection device according to Claim 1, wherein,
further comprises a sleeve cap detachably covering the piercing component.
 
10. The collection device according to Claim 1, wherein,
the piercing component is a syringe.
 
11. The collection device according to Claim 4, wherein,
the sealed cavity has a volume of 0.05 mL to 0.50 mL.
 
12. The collection device according to Claim 1, wherein,
the sealed cavity is under negative pressure relative to intraocular pressure.
 
13. The collection device according to Claim 1, wherein,
the connection between the reservoir and the delivery tube is a Luer connection.
 
14. The collection device according to Claim 1, wherein,
the connection between the reservoir and the delivery tube is a Luer connection.
 
15. The collection device according to Claim 1, wherein,
the piercing component is integrally formed with the delivery tube.
 
16. The collection device according to Claim 1, wherein,
a narrow channel is formed inside the reservoir, the delivery tube and the piercing component.
 
17. The collection device according to Claim 1, wherein,
the delivery tube is further provided with an airtight plug for evacuation in order to form negative pressure.
 
18. The collection device according to Claim 9, wherein,
the sleeve cap is further provided with non-slip ribs.
 
19. The collection device according to Claim 3, wherein,
when a pressing unit is pressed, the delivery inlet is in communication with the delivery outlet.
 
20. A collection device with a valve for a liquid specimen, comprising:

a reservoir having a sealed cavity, wherein the sealed cavity is under negative pressure;

a delivery tube in communication with the sealed cavity of the reservoir and having a delivery inlet, a delivery outlet and a valve disposed between the delivery inlet and the delivery outlet, wherein the valve is configured to control communication and blocking between the delivery inlet and the delivery outlet; and

a piercing component for piercing a tissue and in communication with the delivery inlet of the delivery tube,

wherein the piercing component comprises a main body and a piercing portion connected to the main body, and the piercing portion has a bent shape.


 




Drawing