(19)
(11)EP 3 957 321 A3

(12)EUROPEAN PATENT APPLICATION

(88)Date of publication A3:
13.07.2022 Bulletin 2022/28

(43)Date of publication A2:
23.02.2022 Bulletin 2022/08

(21)Application number: 21182143.4

(22)Date of filing:  15.01.2015
(51)International Patent Classification (IPC): 
A61K 39/02(2006.01)
A61K 39/09(2006.01)
A61P 31/04(2006.01)
A61P 43/00(2006.01)
A61K 39/385(2006.01)
A61K 39/00(2006.01)
A61P 37/04(2006.01)
(52)Cooperative Patent Classification (CPC):
A61K 39/385; A61K 2039/6037; A61K 2039/6068; A61K 39/092; A61P 31/04; A61P 37/04; A61P 43/00
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30)Priority: 21.01.2014 US 201461929598 P

(62)Application number of the earlier application in accordance with Art. 76 EPC:
15708579.6 / 3096783

(71)Applicant: Pfizer Inc.
New York, NY 10017 (US)

(72)Inventors:
  • GU, Jianxin
    Paramus, NJ 07652 (US)
  • KAINTHAN, Rajesh Kumar
    Tappan, NY 10983 (US)
  • KIM, Jin-Hwan
    Suffern, NY 10901 (US)
  • PRASAD, Avvari Krishna
    Chapel Hill, NC 27516 (US)
  • YANG, Yu-Ying
    Stamford, CT 06905 (US)

(74)Representative: Pfizer 
European Patent Department 23-25 avenue du Docteur Lannelongue
75668 Paris Cedex 14
75668 Paris Cedex 14 (FR)

  


(54)STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDES AND CONJUGATES THEREOF


(57) The invention relates to activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharides and processes for their preparation, the process comprising the steps of:
(a) reacting an isolated serotype 10A, 22F or 33F capsular polysaccharide with an oxidizing agent; and
(b) quenching the oxidation reaction by addition of a quenching agent resulting in an activated Streptococcus pneumoniae serotype 10A, 22F or 33F polysaccharide.
Comprised is wherein the oxidizing agent is periodate including sodium metaperiodate.
Comprised is wherein the temperature of the reaction in step (a) is maintained between 1 and 10°C.
Comprised is where the duration of step (a) is between 1 and 25 hours.
Comprised is wherein the quenching agent is selected from vicinal diols, 1,2-aminoalcohols, amino acids, glutathione, sulfite, bisulfate, dithionite, metabisulfite, thiosulfate, phosphites, hypophosphites or phosphorous acid, including glycerol, ethylene glycol, propan-1,2-diol, butan-1,2-diol or butan-2,3-diol.
Comprised is wherein the temperature of the reaction in step (b) is maintained between 1 and 10°C.







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