(19)
(11)EP 4 011 307 A1

(12)EUROPEAN PATENT APPLICATION
published in accordance with Art. 153(4) EPC

(43)Date of publication:
15.06.2022 Bulletin 2022/24

(21)Application number: 20850145.2

(22)Date of filing:  31.07.2020
(51)International Patent Classification (IPC): 
A61B 18/00(2006.01)
A61N 1/00(2006.01)
H03K 3/53(2006.01)
(86)International application number:
PCT/CN2020/106412
(87)International publication number:
WO 2021/023129 (11.02.2021 Gazette  2021/06)
(84)Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
KH MA MD TN

(30)Priority: 06.08.2019 CN 201910720830

(71)Applicant: Shenzhen Neumann Technology Co., Ltd.
Shenzhen, Guangdong 518000 (CN)

(72)Inventor:
  • LAI, Shen
    Shenzhen, Guangdong 518000 (CN)

(74)Representative: Roberts, Peter David 
Marks & Clerk LLP 1 New York Street
Manchester M1 4HD
Manchester M1 4HD (GB)

  


(54)REAL-TIME PULSE MONITORING CIRCUIT AND TUMOR TREATMENT APPARATUS


(57) A real-time pulse monitoring circuit (520) and a tumor treatment apparatus, the real-time pulse monitoring circuit (520) comprising a capacitor group (111), a pulse generator (320) connected to the positive pole of the capacitor group (111), and a discharge panel (130) connected between the pulse generator (320) and the negative pole of the capacitor group (111); further comprised are a current detection module (440) of which detection ends are connected to two ends of the capacitor group (111), a voltage detection module (450) connected to two ends of the discharge panel (130), and a controller (460) connected to the current detection module (440) and the voltage detection module (450). The controller (460) acquires a first analog pulse signal and a second analog pulse signal which are outputted by the current detection module (440), and acquires a second analog pulse signal outputted by the voltage detection module (450) so as to obtain a pulse current corresponding to the first analog pulse signal, a pulse current corresponding to the second analog pulse signal and a pulse voltage corresponding to the second analog pulse signal, and transmits the pulse current and the pulse voltage to an upper computer (510). The real-time pulse monitoring circuit (520) has a simple circuit structure and the instantaneity of pulse monitoring is improved.




Description

TECHNICAL FIELD



[0001] The present application relates to the field of medical device technique, and particularly to a pulse real-time monitoring circuit and a tumor therapy instrument.

BACKGROUND



[0002] With the development of science and technology, the application of tumor therapy instruments has received wide attention. There are many types of tumor therapy instruments. The working process of the tumor therapy instrument based on an electric pulse technology is generally as follows: the instantaneous electric field intensity of the pulsed electric field applied to the cell is greater than IkV/cm (kilovolts per centimeter), accordingly, the molecular permeability of the cell is greatly increased, and then the electroporation is produced. As the pulsed electric field intensity continues to increase, irreversible electrical breakdown occurs, which leads to mechanical breakage of the cell membrane until the cell death. The tumor therapy instrument has strict requirements for output pulses. Therefore, the monitoring of the pulses has great significance.

[0003] In the implementation process, the inventors found that the conventional technology at least has the following problems: the design of the conventional circuit based on the pulse monitoring of the tumor therapy instrument is complicated, and the real-time performance of the pulse monitoring is unsatisfactory.

SUMMARY



[0004] In view of this, as for the problems of complicated design of the conventional circuit based on the pulse monitoring of the tumor therapy instrument and the unsatisfactory real-time performance of the pulse monitoring, it is necessary to provide a pulse real-time monitoring circuit and a tumor therapy instrument.

[0005] In order to achieve the above purpose, according to an embodiment of the present invention, a pulse real-time monitoring circuit is provided, including a capacitor bank, a pulse generator connected to a positive electrode of the capacitor bank, and a discharge panel connected between the pulse generator and a negative electrode of the capacitor bank; and further including:

a current detection module, a first detection terminal of the current detection module being provided between the pulse generator and the positive electrode of the capacitor bank, and a second detection terminal of the current detection module being provided between the negative electrode of the capacitor bank and the discharge panel, the current detection module being configured to detect a pulse signal outputted by the capacitor bank and obtain a first analog pulse signal;

a voltage detection module, a first detection terminal of the voltage detection module being connected to one end of the discharge panel, and a second detection terminal of the voltage detection module being connected to the other end of the discharge panel; the voltage detection module being configured to detect the pulse signal and obtain a second analog pulse signal;

a controller, the controller being connected to an output terminal of the current detection module and an output terminal of the voltage detection module respectively, the controller being configured to acquire and process the first analog pulse signal and the second analog pulse signal to obtain a pulse current corresponding to the first analog pulse signal and a pulse voltage corresponding to the second analog pulse signal, and transmit the pulse current and pulse voltage to an upper computer.



[0006] In an embodiment, the current detection module includes a first current detection sub-module and a second current detection sub-module;

the first current detection sub-module comprises a first signal conversion module, a second signal conversion module, and a first current sensor provided between the pulse generator and the positive electrode of the capacitor bank;

the second current detection sub-module comprises a third signal conversion module, a fourth signal conversion module, and a second current sensor provided between the negative electrode of the capacitor bank and the discharge panel;

a first input terminal of the first signal conversion module is connected to a first end of the first current sensor, a second input terminal of the first signal conversion module is connected to a second end of the first current sensor, and an output terminal of the first signal conversion module is connected to an input terminal of the second signal conversion module, an output terminal of the second signal conversion module is connected to the controller;

a first input terminal of the third signal conversion module is connected to a first end of the second current sensor, a second input terminal of the third signal conversion module is connected to a second end of the second current sensor, and an output terminal of the third signal conversion module is connected to an input terminal of the fourth signal conversion module, an output terminal of the fourth signal conversion module is connected to the controller.



[0007] In an embodiment, the circuit further includes a first primary isolation module connected between the first signal conversion module and the second signal conversion module, a first secondary isolation module connected between the second signal conversion module and the controller, a second primary isolation module connected between the third signal conversion module and the fourth signal conversion module, and a second secondary isolation module connected between the fourth signal conversion module and the controller.

[0008] In an embodiment, the first current sensor is an electromagnetic current transformer or an electronic current transformer;
the second current sensor is an electromagnetic current transformer or an electronic current transformer.

[0009] In an embodiment, the voltage detection module includes a fifth signal conversion module and a sixth signal conversion module;
a first input terminal of the fifth signal conversion module is connected to one end of the discharge panel, and a second input terminal of the fifth signal conversion module is connected to the other end of the discharge panel, and an output terminal of the fifth signal conversion module is connected to an input terminal of the sixth signal conversion module; an output terminal of the sixth signal conversion module is connected to the controller.

[0010] In an embodiment, the circuit further includes a third primary isolation module and a third secondary isolation module;
the third primary isolation module is connected between the output terminal of the fifth signal conversion module and the input terminal of the sixth signal conversion module, and the third secondary isolation module is connected between the output terminal of the fifth signal conversion module and the controller.

[0011] In an embodiment, the upper computer obtains a load impedance according to the received pulse current and the received pulse voltage.

[0012] In an embodiment, the controller includes a processing chip and an AD acquisition circuit connected to the processing chip.

[0013] In another aspect, according to an embodiment of the present invention, a tumor therapy instrument is provided, including an upper computer and the pulse real-time monitoring circuit according to any one of the above embodiments;
the upper computer is connected to the controller.

[0014] In an embodiment, the tumor therapy instrument further includes a high-voltage power supply; an output terminal of the high-voltage power supply is connected to a capacitor bank, and a control terminal of the high-voltage power supply is connected to the controller.

[0015] A technical solution in the above-mentioned embodiments has the following advantages and beneficial effects.

[0016] The pulse generator is connected to the positive electrode of the capacitor bank, the discharge panel is connected between the pulse generator and the negative electrode of the capacitor bank; and a pulse release loop is formed among the pulse generator, the discharge panel and the capacitor bank. The detection terminal of the current detection module (the first detection terminal and the second detection terminal) are connected to both ends of the capacitor bank, the current detection module can detect the pulse signal outputted by the capacitor bank, and then the first analog pulse signal and the second analog pulse signal are obtained. The voltage detection module is connected to both ends of the discharge panel; the voltage detection module can detect the pulse signal outputted by the pulse generator and obtain the third analog pulse signal. The controller is connected to the current detection module and the voltage detection module respectively; the controller acquires the first analog pulse signal, the second analog pulse signal and the third analog pulse signal, and then respectively transmits the acquired pulse current and pulse voltage to the upper computer, thereby implementing the real-time monitoring of the pulse outputted by the tumor therapy instrument. In the pulse real-time monitoring circuit of each embodiment of the present invention, the circuit structure is simple, and the real-time performance of pulse monitoring is improved.

BRIEF DESCRIPTION OF THE DRAWINGS



[0017] 

FIG 1 is a schematic structure diagram I of a pulse real-time monitoring circuit according to an embodiment of the present invention.

FIG 2 is a schematic structure diagram II of a pulse real-time monitoring circuit according to an embodiment of the present invention.

FIG 3 is a schematic structure diagram III of a pulse real-time monitoring circuit according to an embodiment of the present invention.

FIG 4 is a schematic block diagram I illustrating a tumor therapy instrument according to an embodiment of the present invention.

FIG 5 is a schematic block diagram II illustrating a tumor therapy instrument according to an embodiment of the present invention.


DETAILED DESCRIPTION



[0018] In order to facilitate the understanding of the present application, the application will be described in a more comprehensive manner with reference to the relevant accompanying drawings. Preferred embodiments of the present invention are shown in the accompanying drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. Rather, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0019] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field of the present application. The terms used in the description of the present application herein are merely for the purpose of describing the specific embodiments, and are not intended to limit the present application. The term "and/or" as used herein includes any and all combinations of one or more related listed items.

[0020] In order to solve the problem of the complicated design of the conventional circuit based on the pulse monitoring of the tumor therapy instrument and the unsatisfactory real-time performance of the pulse monitoring, according to an embodiment, as shown in FIG 1, a pulse real-time monitoring circuit is provided, which includes a capacitor bank 110, a pulse generator 120 connected to a positive electrode of the capacitor bank 110, and a discharge panel 130 connected between the pulse generator 120 and a negative electrode of the capacitor bank 110; and further includes:

a current detection module 140; a first detection terminal of the current detection module 140 is provided between the pulse generator 120 and the positive electrode of the capacitor bank 110, and a second detection terminal of the current detection module 140 is provided between the negative electrode of the capacitor bank 110 and the discharge panel; the current detection module 140 is configured to detect a pulse signal outputted by the capacitor bank 110 and obtain a first analog pulse signal;

a voltage detection module 150; a first detection terminal of the voltage detection module 150 is connected to one end of the discharge panel 130, and a second detection terminal of the voltage detection module 150 is connected to the other end of the discharge panel 130; the voltage detection module 150 is configured to detect the pulse signal and obtain a second analog pulse signal;

a controller 160; the controller 160 is respectively connected to an output terminal of the current detection module 140 and an output terminal of the voltage detection module 150; the controller 160 acquires and processes the first analog pulse signal and the second analog pulse signal to obtain a pulse current corresponding to the first analog pulse signal and a pulse voltage corresponding to the second analog pulse signal, and transmits the pulse current and pulse voltage to an upper computer.



[0021] The capacitor bank 110 can be configured to store electrical energy, and can also transmit the stored electrical energy to the pulse generator 120; the capacitor bank 110 can consist of multiple capacitors in parallel and the capacitor bank 110 can also consist of multiple capacitors in series. The pulse generator 120 refers to a system configured to transmit a signal, which is an electrical pulse signal instrument that generates required parameters. For example, the pulse generator 120 can be, but not limited to, a pulse boost pulse generator and a solid-state switch series pulse generator. The discharge panel 130 can be configured to strobe a probe-couple to release pulses; the probe-couple can be configured to output a pulse signal. For example, when the corresponding probe-couple is strobed, a pulse release loop consisting of the capacitor bank 110, the pulse generator 120 and the discharge panel 130 is connected.

[0022] The current detection module 140 can be configured to perform a current detection on the pulse signal outputted by the capacitor bank. For example, the current detection module 140 can acquire the pulse signal, and perform conversion (such as filtering and/or attenuation) processing on the pulse signal, to obtain the first analog pulse signal corresponding to the pulse signal. The voltage detection module 150 can be configured to perform a voltage detection on the pulse signal outputted by the pulse generator 120. For example, the voltage detection module 150 can acquire the pulse signal, and perform conversion (such as filtering and/or voltage division) processing on the acquired pulse signal, to obtain the second analog pulse signal corresponding to the pulse signal. The controller 160 refers to a processing device having functions such as signal transmission and signal acquisition and processing. The second analog pulse signal refers to an analog pulse signal obtained after the signal conversion processing; and the pulse voltage refers to a digital pulse voltage. The first analog pulse signal refers to an analog pulse signal obtained after the signal conversion processing; and the pulse current refers to a digital pulse current.

[0023] Specifically, the pulse generator 120 is connected to the positive electrode of the capacitor bank 110; and the discharge panel 130 is connected between the pulse generator 120 and the negative electrode of the capacitor bank 110, thereby forming the pulse release loop consisting of the pulse generator 120, the discharge panel 130 and the capacitor bank 110. The detection terminals (the first detection terminal and the second detection terminal) of the current detection module 140 are connected to both ends of the capacitor bank 110, so that the current detection module 140 can detect the pulse signal outputted by the capacitor bank 110, and then obtain the first analog pulse signal. The voltage detection module 150 is connected to both ends of the discharge panel 130; and the voltage detection module 150 can detect the pulse signal outputted by the pulse generator to obtain the second analog pulse signal. The controller 160 is connected to the current detection module 140 and the voltage detection module 150 respectively; and the controller 160 acquires the first analog pulse signal and the second analog pulse signal, and then transmits the acquired pulse current and pulse voltage to the upper computer respectively, to implement the real-time monitoring of the outputted pulse of the tumor therapy instrument.

[0024] In the above-mentioned pulse real-time monitoring circuit, the controller acquires the first analog pulse signal and the second analog pulse signal detected by the current detection module, and acquires the third analog pulse signal detected by the voltage detection module, to obtain the corresponding pulse current and pulse voltage, thereby implementing the real-time monitoring of pulse current and pulse voltage, simplifying the structure of pulse monitoring circuit, and improving the real-time performance of pulse monitoring.

[0025] In an example, the first analog pulse signal is the analog pulse signal of the first detection terminal; the second analog pulse signal is the analog pulse signal of the second detection terminal; and the control device can process the received analog pulse signal corresponding to the first detection terminal and the analog pulse signal corresponding to the second detection terminal; and the control device can trigger the alarm device timely when a difference value between the analog pulse signal corresponding to the first detection terminal and the analog pulse signal corresponding to the second detection terminal exceeds a leakage safety threshold, thereby implementing a timely response to the leakage alarm of the tumor therapy instrument, and improving the reliability of the leakage response.

[0026] In an embodiment, the upper computer obtains a load impedance according to the received pulse current and the received pulse voltage.

[0027] The upper computer may be, but not limited to, a tablet computer and a personal computer (PC).

[0028] Specifically, the upper computer can process the received pulse current and the received pulse voltage based on a law of resistance to obtain the corresponding load impedance. Thereby, the real-time monitoring of the pulse current, the pulse voltage and the load impedance can be implemented, and the real-time performance of the pulse monitoring is accordingly improved.

[0029] In an embodiment, as shown in FIG 2, a pulse real-time monitoring circuit is provided, which includes a capacitor bank 210, a pulse generator 220 connected to a positive electrode of the capacitor bank 210, and a discharge panel 230 connected between the pulse generator 220 and a negative electrode of the capacitor bank 210; and further includes a current detection module connected to both ends of the capacitor bank 110, a voltage detection module 250 connected to both ends of the discharge panel 230, and a controller 260 connected to the current detection module and the voltage detection module 250 respectively. The current detection module includes a first current detection sub-module 242 and a second current detection sub-module 244. The first current detection sub-module 242 includes a first signal conversion module, a second signal conversion module, and a first current sensor provided between the pulse generator and the positive electrode of the capacitor bank. The second current detection sub-module 244 includes a third signal conversion module, a fourth signal conversion module, and a second current sensor provided between the negative electrode of the capacitor bank and the discharge panel.

[0030] A first input terminal of the first signal conversion module is connected to a first end of the first current sensor, a second input terminal of the first signal conversion module is connected to a second end of the first current sensor, and an output terminal of the first signal conversion module is connected to an input terminal of the second signal conversion module; an output terminal of the second signal conversion module is connected to the controller. A first input terminal of the third signal conversion module is connected to a first end of the second current sensor, a second input terminal of the third signal conversion module is connected to a second end of the second current sensor, and an output terminal of the third signal conversion module is connected to an input terminal of the fourth signal conversion module; an output terminal of the fourth signal conversion module is connected to the controller.

[0031] The first current sensor refers to a device or module that can sense information of the detected current, and convert the sensed information into an electrical signal satisfying a certain standard according to a certain rule or into information outputs in other required forms. The second current sensor refers to a device or module that can sense information of the detected current, and convert the sensed information into an electrical signal satisfying a certain standard according to a certain rule or into information outputs in other required forms. The first signal conversion module refers to a module capable of scaling the first analog pulse signal; for example, the first signal conversion module can be configured to attenuate the first analog pulse signal of the positive electrode of the capacitor bank, to obtain a converted first analog pulse signal. The second signal conversion module refers to a module which can perform the zooming or scaling conversion on the first analog pulse signal. The third signal conversion module refers to a module that can perform the scaling conversion on the second analog pulse signal; for example, the second signal conversion module can be configured to attenuate the second analog pulse signal of the negative electrode of the capacitor bank, to obtain the converted second analog pulse signal. The fourth signal conversion module refers to a module which can perform the zooming or scaling conversion on the second analog pulse signal.

[0032] Specifically, the first current sensor is provided between the pulse generator and the positive electrode of the capacitor bank; the second current sensor is provided between the discharge panel and the negative electrode of the capacitor bank. In the process of outputting the pulse signal by the pulse generator, the first current sensor can acquire the pulse signal corresponding to the positive electrode of the capacitor bank, and process the acquired pulse signal to obtain the first analog pulse signal corresponding to the positive electrode of the capacitor bank. The second current sensor can acquire the pulse signal corresponding to the negative electrode of the capacitor bank, and process the acquired pulse signal to obtain the first analog pulse signal corresponding to the negative electrode of the capacitor bank. The first current sensor can transmit the first analog pulse signal corresponding to the positive electrode of the capacitor bank to the first signal conversion module; and the first signal conversion module can perform primary conversion processing on the received first analog pulse signal, and transmit the first analog pulse signal obtained after the primary conversion processing to the second signal conversion module; and then the second signal conversion module can perform secondary conversion processing on the received first analog pulse signal after the primary conversion processing to obtain the first analog pulse signal after the secondary conversion processing; so that the controller can acquire the first analog pulse signal after the two-stage processing, and transmit the acquired pulse current to the upper computer.

[0033] The second current sensor can transmit the first analog pulse signal corresponding to the negative electrode of the capacitor bank to the third signal conversion module, and the third signal conversion module can perform the primary conversion processing on the received second analog pulse signal, and transmit the second analog pulse signal obtained after the primary conversion processing to the fourth signal conversion module; and the fourth signal conversion module can perform secondary conversion processing on the received second analog pulse signal after the primary conversion processing, to obtain the second analog pulse signal after the secondary conversion processing; so that the controller can acquire the second analog pulse signal after the two-stage processing, and then transmit the acquired pulse current to the upper computer, to implement the real-time monitoring of the pulse current of the tumor therapy instrument.

[0034] It should be noted that the first analog pulse signal is an analog pulse voltage signal; the second analog pulse signal is an analog pulse voltage signal. The controller can acquire the analog pulse voltage signal to obtain a corresponding digital pulse voltage signal, and perform voltage-current conversion processing on the digital pulse voltage signal to obtain the pulse current.

[0035] In the above-mentioned pulse real-time monitoring circuit, the first signal conversion module performs the primary conversion processing on the first analog pulse signal transmitted by the first current sensor, and the second signal conversion module performs the secondary conversion processing on the first analog pulse signal after the primary conversion processing transmitted by the first signal conversion module, so that the first analog pulse signal after the two-stage conversion processing can meet the requirements of the parameter acquisition of the controller. The third signal conversion module performs the primary conversion processing on the second analog pulse signal transmitted by the second current sensor, and the fourth signal conversion module performs the secondary conversion processing on the second analog pulse signal after the primary conversion processing transmitted by the third signal conversion module, so that the second analog pulse signal after the two-stage conversion processing can meet the requirements of the parameter acquisition of the controller, and meanwhile the accuracy of the pulse current monitoring is improved.

[0036] In an embodiment, as shown in FIG 2, the pulse real-time monitoring circuit further includes a first primary isolation module connected between the first signal conversion module and the second signal conversion module, a first secondary isolation module connected between the second signal conversion module and the controller, a second primary isolation module connected between the third signal conversion module and the fourth signal conversion module, and a second secondary isolation module connected between the fourth signal conversion module and the controller.

[0037] The first primary isolation module may be, but not limited to, an external optical circuit photocoupler and an internal optical circuit photocoupler; the first secondary isolation module may be, but not limited to, an external optical circuit photocoupler and an internal optical circuit photocoupler. The second primary isolation module can be, but is not limited to, an external optical circuit photocoupler and an internal optical circuit photocoupler; the second secondary isolation module can be, but is not limited to, an external optical circuit photocoupler and an internal optical circuit photocoupler.

[0038] Specifically, the first primary isolation module is connected between the first signal conversion module and the second signal conversion module; the first signal conversion module transmits the converted signal to the first primary isolation module to perform the isolation conversion processing on the pulse signal by the first primary isolation module, and transmits the processed pulse signal to the second signal conversion module, so that the second signal conversion module performs the conversion processing on the pulse signal, and transmits the first analog pulse signal obtained after the conversion processing to the first secondary isolation module, thereby isolating the pulse signal from the first analog pulse signal obtained after the primary conversion processing, and improving the anti-interference capability of the signal transmission on the pulse generator side. The first secondary isolation module is connected between the second signal conversion module and the controller. The first secondary isolation module receives the converted first analog pulse signal transmitted by the second signal conversion module, and performs the isolation conversion processing on the first analog pulse signal obtained after the secondary conversion processing, and transmits the processed first analog pulse signal to the controller, so that the controller obtains the pulse current according to the first analog pulse signal, thereby isolating the first analog pulse signal after the secondary conversion processing from the pulse current, and improving the anti-interference capability of the signal transmission on the controller side.

[0039] The second primary isolation module is connected between the third signal conversion module and the fourth signal conversion module; and the third signal conversion module transmits the converted signal to the second primary isolation module to perform the isolation conversion processing on the pulse signal by the second primary isolation module, and transmits the processed pulse signal to the fourth signal conversion module, so that the fourth signal conversion module performs the conversion processing on the pulse signal, and transmits the second analog pulse signal obtained after the conversion processing to the second secondary isolation module, thereby isolating the pulse signal from the second analog pulse signal after the primary conversion processing, and improving the anti-interference capability of the signal transmission on the pulse generator side. The second secondary isolation module is connected between the fourth signal conversion module and the controller. The second secondary isolation module receives the converted second analog pulse signal transmitted by the fourth signal conversion module and performs the isolation conversion processing on the second analog pulse signal obtained after the secondary conversion processing, and transmits the processed second analog pulse signal to the controller, so that the controller obtains the pulse current according to the second analog pulse signal, thereby isolating the second analog pulse signal obtained after the secondary conversion processing from the pulse current, and improving the anti-interference capability of the signal transmission on the controller side.

[0040] It should be noted that the number of the first primary isolation modules is at least one. For example, when the pulse real-time monitoring circuit includes two or more first primary isolation modules, each of the first primary isolation modules is connected in series between the first signal conversion module and the second signal conversion module. The number of the first secondary isolation modules is at least one. For example, when the pulse real-time monitoring circuit includes two or more first secondary isolation modules, each of the first secondary isolation modules is connected in series between the second signal conversion module and the controller. The number of the second primary isolation modules is at least one. For example, when the pulse real-time monitoring circuit includes two or more second primary isolation modules, each of the second primary isolation modules is connected in series between the third signal conversion module and the fourth signal conversion module. The number of the second secondary isolation modules is at least one. For example, when the pulse real-time monitoring circuit includes two or more second secondary isolation modules, each of the second secondary isolation modules is connected in series between the fourth signal conversion module and the controller.

[0041] In an example, the first primary isolation module can be a linear optocoupler isolator; the first secondary isolation module can be a linear optocoupler isolator. The second primary isolation module can be a linear optocoupler isolator; the second secondary isolation module can be a linear optocoupler isolator.

[0042] In a specific embodiment, the first current sensor is an electromagnetic current transformer or an electronic current transformer. The second current sensor is an electromagnetic current transformer or an electronic current transformer.

[0043] In an embodiment, as shown in FIG 3, a pulse real-time monitoring circuit is provided, which includes a capacitor bank 310, a pulse generator 320 connected to a positive electrode of the capacitor bank 310, and a discharge panel 330 connected between the pulse generator 320 and a negative electrode of the capacitor bank 310; and further includes a current detection module 340 connected to both ends of the capacitor bank 310, a voltage detection module 350 connected to both ends of the discharge panel 330, and a controller 360 connected to the current detection module 340 and the voltage detection module 350 respectively. The voltage detection module 350 includes a fifth signal conversion module 352 and a sixth signal conversion module 354.

[0044] A first input terminal of the fifth signal conversion module 352 is connected to one end of the discharge panel 330, and a second input terminal of the fifth signal conversion module 352 is connected to the other end of the discharge panel 330, and an output terminal of the fifth signal conversion module 352 is connected to an input terminal of the sixth signal conversion module 354; an output terminal of the sixth signal conversion module 354 is connected to the controller 360.

[0045] Specifically, the fifth signal conversion module 352 may include a first detection terminal, a second detection terminal and an output terminal. The first detection terminal of the fifth signal conversion module 352 is connected to one end of the discharge panel 330; the second detection terminal of the voltage detection circuit 352 is connected to the other end of the discharge panel 330; and the output terminal of the voltage detection circuit 352 is connected to the sixth signal conversion module 354; the output terminal of the sixth signal conversion module 354 is connected to the controller 360. The pulse signal outputted by the pulse generator 320 can be scaled by the fifth signal conversion module 352 and the sixth signal conversion module 354 in sequence, and then a third analog pulse signal after the two-stage conversion processing can be obtained, so that the controller 360 can acquire the processed third analog pulse signal and transmit the acquired pulse voltage to the upper computer, thereby implementing the real-time monitoring of the pulse voltage of the tumor therapy instrument.

[0046] In the above-mentioned pulse real-time monitoring circuit, the fifth signal conversion module and the sixth signal conversion module sequentially perform the proportional scaling conversion on the pulse signal, so that the converted third analog pulse signal can meet the requirements of the parameter acquisition of the controller, and meanwhile the accuracy of the monitoring of the pulse voltage is improved.

[0047] In an embodiment, as shown in FIG 3, the circuit further includes a third primary isolation module 370 and a third secondary isolation module 380. The third primary isolation module 370 is connected between the output terminal of the fifth signal conversion module 352 and the input terminal of the sixth signal conversion module 354; the third secondary isolation module 380 is connected between the output terminal of the sixth signal conversion module 354 and the controller 360.

[0048] The third primary isolation module 370 may be, but not limited to, an external optical circuit photocoupler and an internal optical circuit photocoupler; the third secondary isolation module 380 may be, but not limited to, an external optical circuit photocoupler and an internal optical circuit photocoupler.

[0049] Specifically, the third primary isolation module 370 is connected between the fifth signal conversion module 352 and the sixth signal conversion module 354; the pulse generator 320 can transmit the outputted pulse signal to the third primary isolation module 370 to perform the isolation conversion processing on the pulse signal by the third primary isolation module 370, and transmit the second analog pulse signal after the primary conversion processing to the sixth signal conversion module 354, thereby isolating the third analog pulse signal after the primary conversion processing from the third analog pulse signal after the secondary conversion processing, and further improving the anti-interference capability of the signal transmission on the pulse generator side. The third secondary isolation module 380 is connected between the sixth signal conversion module 354 and the controller 360, such that the sixth signal conversion module 354 performs the isolation conversion processing on the received signal, and transmits the third analog pulse signal obtained after the secondary conversion processing to the controller 360, so that the controller 360 obtains the pulse voltage according to the third analog pulse signal, thereby isolating the third analog pulse signal after the secondary conversion processing from the pulse voltage, and further improving the anti-interference capability of the signal transmission on the controller side.

[0050] It should be noted that the number of the third primary isolation modules is at least one. For example, when the pulse real-time monitoring circuit includes two or more third primary isolation modules, each of the third primary isolation modules is connected in series between the output terminal of the fifth signal conversion module and the input terminal of the sixth signal conversion module. The number of the third secondary isolation modules is at least one. For example, when the pulse real-time monitoring circuit includes two or more third secondary isolation modules, each of the third secondary isolation modules is connected in series between the output terminal of the sixth signal conversion module and the controller.

[0051] In an example, the third primary isolation module 370 can be a linear optocoupler isolator; the third secondary isolation module 380 can be a linear optocoupler isolator.

[0052] In an embodiment, as shown in FIG 4 , a pulse real-time monitoring circuit is provided, which includes a capacitor bank 410, a pulse generator 420 connected to a positive electrode of the capacitor bank 410, and a discharge panel 430 connected between the pulse generator 420 and a negative electrode of the capacitor bank 410; and further includes a current detection module 440 connected to both ends of the capacitor bank 410, a voltage detection module 450 connected to both ends of the discharge panel 430, and a controller 460 connected to the current detection module 440 and the voltage detection module 450 respectively. The controller 460 includes a processing chip 462 and an AD acquisition circuit 464 connected to the processing chip 462.

[0053] The processing chip 462 may be, but not limited to, a single-chip microcomputer chip, an ARM processing chip, and an FPGA processing chip. The AD acquisition circuit 464 refers to an acquisition circuit capable of performing an analog-to-digital conversion on the signal.

[0054] Specifically, the processing chip 462 is connected to the AD acquisition circuit 464, and the AD acquisition circuit 464 may include a first acquisition port and a second acquisition port. The first acquisition port is connected to the current detection module 440; the second acquisition port is connected to the voltage detection module 450. The processing chip 462 can drive the AD acquisition circuit 464 to operate, and the AD acquisition circuit 464 can acquire the first analog pulse signal and then the second analog pulse signal through the first acquisition port, and convert the first analog pulse signal and the second analog pulse signal into the digital pulse current through the analog-to-digital conversion processing, and transmit the digital pulse current to the processing chip 462; the processing chip 462 can transmit the digital pulse current to the upper computer, and the upper computer monitors the pulse current in real time.

[0055] Similarly, the processing chip 462 can drive the AD acquisition circuit 464 to operate, and then the AD acquisition circuit 464 can acquire the third analog pulse signal through the second acquisition port, and convert the third analog pulse signal into the digital pulse voltage through the analog-to-digital conversion processing, and transmit the digital pulse voltage to the processing chip 462; the processing chip 462 can transmit the digital pulse voltage to the upper computer, and the upper computer monitors the pulse voltage in real time. In the above-mentioned pulse real-time monitoring circuit, the pulse monitoring circuit has a simple structure, which improves the real-time performance of the pulse monitoring.

[0056] In an embodiment, as shown in FIG 5, a tumor therapy instrument is provided, which includes an upper computer 510 and a pulse real-time monitoring circuit 520 in any one of the above-mentioned embodiments; the upper computer 510 is connected to a controller.

[0057] The upper computer 510 may be, but not limited to, a tablet computer and a personal computer (PC).

[0058] Specifically, the pulse real-time monitoring circuit 520 may include a capacitor bank, a pulse generator connected to the positive electrode of the capacitor bank, and a discharge panel connected between the pulse generator and the negative electrode of the capacitor group; and may further include a current detection module connected to both ends of the capacitor bank, a voltage detection module connected to both ends of the discharge board, and a controller connected to the current detection module and the voltage detection module respectively. The current detection module can detect the pulse signals of the positive and negative electrodes of the capacitor bank, and then obtain the first analog pulse signal and the second analog pulse signal; the controller acquires the first analog pulse signal and the second analog pulse signal, and then can transmit the acquired pulse current to the upper computer to implement the real-time monitoring of the pulse current of the pulse outputted by the tumor therapy instrument. The voltage detection module can detect the pulse signal outputted by the pulse generator, and obtain the third analog pulse signal, and then obtain the third analog pulse signal; the controller acquires the third analog pulse signal, and then transmits the acquired pulse voltage to the upper computer, to implement the real-time monitoring of the pulse voltage of the pulse outputted by the tumor therapy instrument. The circuit structure of the tumor therapy instrument is simple, and the real-time performance of the pulse monitoring is improved.

[0059] Further, the upper computer 510 can also process the acquired pulse current and pulse voltage based on a law of resistance, and then obtain the corresponding load impedance, thereby implementing the real-time monitoring of the pulse current, pulse voltage and the load impedance. The upper computer can also display a waveform diagram corresponding to the pulse current, the pulse voltage and the load impedance, so that the user can observe the corresponding waveform diagram and control the tumor therapy instrument according to the waveform diagram.

[0060] In an embodiment, the tumor therapy instrument further includes a high-voltage power supply; an output terminal of the high-voltage power supply is connected to the capacitor bank, and a control terminal of the high-voltage power supply is connected to the controller.

[0061] The high-voltage power supply may be a DC high-voltage power supply, and an output power supply of the high-voltage power supply may be a kilovolt-level power supply.

[0062] The high-voltage power supply is connected between the controller and the capacitor bank; the controller may control the high-voltage power supply, so that the high-voltage power supply charges the capacitor bank.

[0063] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, all possible combinations of the various technical features in the above-mentioned embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, all should be considered as the scope of the present application.

[0064] The above-mentioned embodiments are merely some embodiments of the present invention, and their descriptions are more specific and detailed, but they should not be understood as limiting the scope of the present application. It should be pointed out that those of ordinary skill in the art can make several modifications and improvements without departing from the concept of the present application, and these all fall within the protection scope of the present application. Therefore, the scope of protection of the present application shall be subject to the appended claims.


Claims

1. A pulse real-time monitoring circuit, characterized by comprising a capacitor bank, a pulse generator connected to a positive electrode of the capacitor bank, and a discharge panel connected between the pulse generator and a negative electrode of the capacitor bank; and further comprising:

a current detection module, wherein a first detection terminal of the current detection module is provided between the pulse generator and the positive electrode of the capacitor bank, and a second detection terminal of the current detection module is provided between the negative electrode of the capacitor bank and the discharge panel, the current detection module is configured to detect a pulse signal outputted by the capacitor bank and obtain a first analog pulse signal;

a voltage detection module, wherein a first detection terminal of the voltage detection module is connected to one end of the discharge panel, and a second detection terminal of the voltage detection module is connected to the other end of the discharge panel; the voltage detection module is configured to detect the pulse signal and obtain a second analog pulse signal;

a controller, wherein the controller is connected to an output terminal of the current detection module and an output terminal of the voltage detection module respectively, the controller is configured to acquire and process the first analog pulse signal and the second analog pulse signal to obtain a pulse current corresponding to the first analog pulse signal and a pulse voltage corresponding to the second analog pulse signal, and transmit the pulse current and pulse voltage to an upper computer.


 
2. The pulse real-time monitoring circuit according to claim 1, wherein the current detection module comprises a first current detection sub-module and a second current detection sub-module;

the first current detection sub-module comprises a first signal conversion module, a second signal conversion module, and a first current sensor provided between the pulse generator and the positive electrode of the capacitor bank;

the second current detection sub-module comprises a third signal conversion module, a fourth signal conversion module, and a second current sensor provided between the negative electrode of the capacitor bank and the discharge panel;

a first input terminal of the first signal conversion module is connected to a first end of the first current sensor, a second input terminal of the first signal conversion module is connected to a second end of the first current sensor, and an output terminal of the first signal conversion module is connected to an input terminal of the second signal conversion module, an output terminal of the second signal conversion module is connected to the controller;

a first input terminal of the third signal conversion module is connected to a first end of the second current sensor, a second input terminal of the third signal conversion module is connected to a second end of the second current sensor, and an output terminal of the third signal conversion module is connected to an input terminal of the fourth signal conversion module, an output terminal of the fourth signal conversion module is connected to the controller.


 
3. The pulse real-time monitoring circuit according to claim 2, further comprising a first primary isolation module connected between the first signal conversion module and the second signal conversion module, a first secondary isolation module connected between the second signal conversion module and the controller, a second primary isolation module connected between the third signal conversion module and the fourth signal conversion module, and a second secondary isolation module connected between the fourth signal conversion module and the controller.
 
4. The pulse real-time monitoring circuit according to claim 3, wherein the first current sensor is an electromagnetic current transformer or an electronic current transformer;
the second current sensor is an electromagnetic current transformer or an electronic current transformer.
 
5. The pulse real-time monitoring circuit according to claim 1, wherein the voltage detection module comprises a fifth signal conversion module and a sixth signal conversion module;
a first input terminal of the fifth signal conversion module is connected to one end of the discharge panel, and a second input terminal of the fifth signal conversion module is connected to the other end of the discharge panel, and an output terminal of the fifth signal conversion module is connected to an input terminal of the sixth signal conversion module; an output terminal of the sixth signal conversion module is connected to the controller.
 
6. The pulse real-time monitoring circuit according to claim 5, further comprising a third primary isolation module and a third secondary isolation module;
wherein the third primary isolation module is connected between the output terminal of the fifth signal conversion module and the input terminal of the sixth signal conversion module, and the third secondary isolation module is connected between the output terminal of the fifth signal conversion module and the controller.
 
7. The pulse real-time monitoring circuit according to claim 1, wherein the upper computer obtains a load impedance according to the received pulse current and the received pulse voltage.
 
8. The pulse real-time monitoring circuit according to any one of claims 1 to 7, wherein the controller comprises a processing chip and an AD acquisition circuit connected to the processing chip.
 
9. A tumor therapy instrument, comprising an upper computer, and the pulse real-time monitoring circuit according to any one of claims 1 to 8;
wherein the upper computer is connected to the controller.
 
10. The tumor therapy instrument according to claim 9, further comprising a high-voltage power supply; wherein an output terminal of the high-voltage power supply is connected to a capacitor bank, and a control terminal of the high-voltage power supply is connected to the controller.
 




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