| (19) |  |
| (11) | EP 4 219 759 A3 |
| (12) | EUROPEAN PATENT APPLICATION |
| (88) | Date of publication A3: | | 06.09.2023 Bulletin 2023/36 |
| (43) | Date of publication A2: | | 02.08.2023 Bulletin 2023/31 |
| (22) | Date of filing: 04.05.2011 |
| | (51) | International Patent Classification (IPC): |
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| (84) | Designated Contracting States: | | AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
| (30) | Priority: | 06.05.2010 US 33217510 P
25.10.2010 US 45574310 P
25.02.2011 US 201161446822 P
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| (62) | Application number of the earlier application in accordance with Art. 76 EPC: | | 18201137.9 / 3456847 | | 16183402.3 / 3144673 | | 11777704.5 / 2567226 |
| (71) | Applicant: Adaptive Biotechnologies Corporation | | Seattle, Washington 98102 (US) |
| | (72) | Inventors: | | - FAHAM, Malek
Seattle (US) - WILLIS, Thomas
Seattle (US)
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| (74) | Representative: Boult Wade Tennant LLP | | Salisbury Square House
8 Salisbury Square
London EC4Y 8AP
London EC4Y 8AP (GB) |
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| (54) | MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILES |
(57) There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer, especially lymphoid neoplasms, such as lymphomas and leukemias. Provided herein are methods for using DNA sequencing to identify personalized, or patient-specific biomarkers in patients with lymphoid neoplasms, autoimmune disease and other conditions. Identified biomarkers can be used to determine and/or monitor the disease state for a subject with an associated lymphoid disorder or autoimmune disease or other condition. In particular, the invention provides a sensitive method for monitoring lymphoid neoplasms that undergo clonal evolutions without the need to development alternative assays for the evolved or mutated clones serving as patient-specific biomarkers.