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WO0209696A   [0029] 
WO9951223A   [0029] 
US6210974B1   [0029] 
WO0202123A   [0029] 
WO200500300A1   [0037] 
WO0053169A   [0038] 
WO03041643A2   [0039] 
WO2004050087A1   [0040] 
WO2004056782A1   [0040] 
WO03055860A1   [0041] 
WO0236075A2   [0042] 
WO0172779A   [0043]  [0044]  [0045]  [0046] 
WO2004108080A2   [0047] 
WO2005002506A2   [0047] 
WO20051000211A2   [0047] 
WO2005000212A2   [0047] 
WO2005000213A2   [0047] 
WO2005000214A2   [0047] 
WO2005000314A1   [0047] 
WO0207761PCT   [0048] 

Hum. Mol. Genet.   [0030] 
Proc. Nat. Acad. Sci.   [0030] 
J. Biol. Chem.   [0030] 
Trends in Molecular Medicine   [0031] 
Grp94, an ER chaperone with protein and peptide binding properties   [0048] 
Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Srckinase p56lck   [0048] 
Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti-inflammatory effects and interacts with glucocorticoid receptor in vivo   [0048] 
Filter binding assay for the geldanamycin-heat shock protein 90 interaction   [0048] 
A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock   [0048] 
A small molecule designed to bind to the adenine nucleotide pocket of HSP90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells   [0048] 
Development of a purine-scaffold novel class of HSP90 binders that inhibit the proliferation of cancer cells and induce the degradation of her2 tyrosine kinase   [0048] 
Do heat shock proteins have a role in breast cancer?   [0048] 
The HSP90-related protein TRAP1 is a mitochondrial protein with distinct functional properties   [0048] 
Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular Chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate   [0048] 
Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein   [0048] 
A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma   [0048] 
Inhibition of signal transduction by the HSP90 inhibitor 17-allylamino-1 7-demethoxygeldanamycin results in cytostasis and apoptosis   [0048] 
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1α/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol   [0048] 
Clinical   [0048] 
Role of the heat shock response and molecular chaperones in oncogenesis and cell death   [0048] 
Prognostic significance of heat shock proteins 27 and 70 in patients with squamous cell carcinoma of the esophagus   [0048] 
Preclinical antitumour evaluation of bisacetalo-amino-dichloro-cyclohexylamine platinum (IV): an orally active platinum drug   [0048] 
DT-diaphorase expression and tumor cell sensitivity to 17-allylamino,17-demethoxygeldanamycin, an inhibitor of heat shock protein 90   [0048] 
A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1α and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts   [0048] 
Radicicol, an agent inducing the reversal of transformed phentoype of srctransformed fibroblasts   [0048] 
Constitutive overexpression of 89 kDa heat shock protein gene in the HBL100 mammary cell line converted to a tumorigenic phenotype by the EJE24 Harvey-ras oncogene   [0048] 
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone   [0048] 
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins   [0048] 
Linking gene expression patterns to therapeutic groups in breast cancer   [0048] 
Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity   [0048] 
Comparison of geldanamycin (NSC-122750) and 17-allylaminogeldanamycin (NSC-330507D) toxicity in rats   [0048] 
ATP binding and hydrolysis are essential to the function of the HSP90 molecular chaperone in vivo   [0048] 
The role of the HSP90-based chaperone system in signal transduction by nuclear receptors and receptors signalling via MAP kinase   [0048] 
Identification and structural characterization of the ATP/ADP-binding site in the HSP90 molecular chaperone   [0048] 
The ATPase cycle of HSP90 drives a molecular ''clamp'' via transient dimerization of the N-terminal domains   [0048] 
Structural basis for inhibition of the HSP90 molecular chaperone by the antitumour antibiotics radicicol and geldanamycin   [0048] 
HSP90 as a capacitor for morphological evolution   [0048] 
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones   [0048] 
Antibiotic radicicol binds to the N-terminal domain of HSP90 and shares important biologic activities with geldanamcyin   [0048] 
The benzoquinone ansamycin 17-allylamino-1 7-demethoxygeldanamcyin binds to HSP90 and shares important biologic activities with geldanamycin   [0048] 
Chaperones in signal transduction   [0048] 
Molecular chaperones: Biology and prospects for pharmacological intervention   [0048] 
Identification of a protein with homology to hsp90 that binds the type 1 tumour necrosis factor receptor   [0048] 
Crystal structure of an HSP90-geldanamcyin complex: targeting of a protein chaperone by an antitumor agent   [0048] 
Preclinical pharmacologic evaluation of geldanamycin as an antitumour agent   [0048] 
Heat shock proteins: new keys to the development of cytoprotective therapies   [0048] 
Phenotypic change from transformed to normal induced by benzoquinoid ansamycins accompanies inactivation of p6Osrc in rat kidney cells infected with Rous sarcoma virus   [0048] 
Inhibiting hepatitis C virus processing and replication   [0048] 
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation   [0048] 
Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases   [0048] 
HSP90: a specialized but essential protein-folding tool   [0048] 
Suppression of RAS and MOS transformation by radicicol   [0048] 
Int. J. Pharm.   [0055] 
Pharmaceutical Research   [0145]